Welfare and health of fish fed vegetable oils as alternative lipid sources to fish oil

Fish Oil Replacement and Alternative Lipid Sources in Aquaculture Feeds

Volumn , Issue , 2010, Pages 439-486

  Montero, Daniel ^a,b   Izquierdo, Marisol ^a,b  

^a UNIVERSITY OF LAS PALMAS DE GRAN CANARIA   (Spain)

^b Instituto Canario de Ciencias Marinas   (Spain)

Author keywords

Fish health; Fish welfare; FO replacement; Immune system; Morphological and behavioral alterations; VO

Indexed keywords

EID: 78651514199     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1201/9781439808634     Document Type: Chapter

References (272)

1. Ainsworth, A.J., 1992. Fish granulocytes: morphology, distribution, and function. Ann. Rev. Fish Dis. 2, 123-148.
2. Alexander, J.B., Ingram, G.A., 1992. Noncellular nonspecific defense mechanisms of fish. Ann. Rev. Fish Dis. 2, 249-279.
3. Alexis, M.N., 1997. Fish meal and fish oil replacers in Mediterranean marine fish diets. Cah. Opt. Med. 22, 183-204.
4. Aluru, M., Vijayan, M.M., 2009. Stress transcriptomics in fish: a role for genomic cortisol signalling. Gen. Comp. Endocrinol. 164, 142-151.
5. Ander, B.P., Weber, A.R., Rampersad, P.P., Gilchrist, J.S., Pierce, G.N., Lukas, A., 2004. Dietary flaxseed protects against ventricular fibrillation induced by ischemia-reperfusion in normal and hypercholesterolemic rabbits. J. Nutr. 134, 3250-3256.
6. Aoik, T., Takano, T., Santos, M.D., Kondo, H., Hirono, I., 2008. Molecular innate immunity in teleost fish: review and future perspectives. In: Tsukamoto, K., Kawamura, T., Takeuchi, T., Beard, T.D. Jr., Kaiser, M.J. (Eds), Fisheries for Global Welfare and Environment, 5th World Fisheries Congress 2008. Tokyo, Terrapub, pp. 263-276.
7. Appleby, M.C., 1999. Tower of Babel: variation in ethical approaches, concepts of welfare and attitudes to genetic manipulation. Animal Welfare 8, 381-390.
8. Ashton, I., Clements, K., Barrow, S.E., Secombes, C.J., Rowley, A.F., 1994. Effects of dietary fatty acids on eicosanoid-generating capacity, fatty acid composition and chemotactic activity of rainbow trout (Oncorhynchus mykiss) leucocytes. Biochim. Biophys. Acta 1214, 253-262.
9. Bagga, D., Wang, L., Farias-Eisner, R., Glaspy, J.A., Reddy, S.T., 2003. Differential effects of prostaglandin derived from n-6 and n-3 polyunsaturated fatty acids on COX-2 expression and IL-6 secretion. Proc. Natl. Acad. Sci. USA 100, 1751-1756.
10. Balfry, S.K. Higgs, D.A., 2001. Influence of dietary lipid composition on the immune system and disease resistance of finfish. In: Lim, C., Webster, C.D. (Eds), Nutrition and Fish Health. Binghamton, NY, Food Products Press, pp. 213-234.
11. Balfry, S.K., Oakes, J., Rowshandeli, M., Deacon, G., Skura, B.J., Higgs, D.A., 2006. Efficacy of an equal blend of canola oil and poultry fat as an alternate dietary lipid source for Atlantic salmon (Salmo salar L.) in seawater. II: effects on haematology and immunocompetence. Aquac. Res. 37, 192-199.
12. Barton, R.G., Cerra, F.B., Wells, C.L., 1992. Effect of a diet deficient in essential fatty acids on the translocation of intestinal bacteria. J. Parenter. Enteral. Nutr. 16, 122-128.
13. Beck, G., Habicht, G.S., 1996. Immunity and the invertebrates. Sci. Am. 275, 60-63.
14. Bell, J.G., Pirie, B.J.S., Andron, J.W., Cowey, C.B., 1986. Some effects of selenium deficiency on glutathione peroxidase activity and tissue pathology in rainbow trout Salmo gairdneri. Br. J. Nutr. 55, 305-311.
15. Bell, J.G., McVicar, A.H., Park, M.T., Sargent, J.R., 1991. High dietary linoleic acid affects the fatty acid compositions of individual phospholipids from tissues of Atlantic salmon (Salmo salar): association with stress susceptibility and cardiac lesion. J. Nutr. 121, 1163-1211.
16. Bell, J.G., McVicar, A.H., Sargent, J.R., Thompson, K.D., 1993. Dietary sunflower, linseed and fish oils affect phospholipid fatty acid copostition, development of cardiac lesions, phospholipase activity and eicosanoid production in Atlantic salmon (Salmo salar). Prostaglandins Leukotrienes Essent. Fatty Acids 49, 665-673.
17. Bell, J.G., Tocher, D.R., MacDonald, F.M., Sargent, J.R., 1994a. Effects of diets rich in linoleic (18: 2n-6) and α-linolenic (18: 3n-3) acids on the growth, lipid class and fatty acid compositions and eicosanoid production in juvenile turbot (Scophthalmus maximus L.). Fish Physiol. Biochem. 13, 105-118.
18. Bell, J.G., Ghioni, C., Sargent, J.R., 1994b. Fatty acid compositions of 10 freshwater invertebrates which are natural food organisms of Atlantic salmon parr (Salmo salar): a comparison with commercial diets. Aquaculture 128, 301-313.
19. Bell, J.G., Castell, J.D., Tocher, D.R., MacDonald, F.M., Sargent, J.R., 1995. Effects of different dietary arachidonic acid: docosahexaenoic acid ratios on phospholipid fatty acid compositions and prostaglandin production in juvenile turbot (Scophthalmus maximus). Fish Physiol. Biochem. 14, 139-151.
20. Bell, J.G., Henderson, R.J., Tocher, D.R., Sargent, J.R., 2004. Replacement of dietary fish oil with increasing levels of linseed oil: modification of flesh fatty acid compositions in Atlantic salmon (Salmo salar) using a fish oil finishing diet. Lipids 39, 223-232.
21. Bell, J.G., Strachan, F., Good, J.E., Tocher, D.R., 2006. Effect of dietary echium oil on growth, fatty acid composition and metabolism, gill prostaglandin production and macrophage activity in Atlantic cod (Gadus morhua L.). Aquac. Res. 37, 606-617.
22. Benedito-Palos, L., Navarro, J.C., Sitjá-Bobadilla, A., Bell, J.G., Kaushik, S., Pérez-Sánchez, J., 2008. High levels of vegetable oils in plant protein-rich diets fed to gilthead seabream (Sparus aurata L.): growth performance, muscle fatty acid profiles and histological alterations of target tissues. Br. J. Nutr. 100, 992-1003.
23. Benítez-Santana, T., Masuda, R., Juárez-Carrillo, E., Ganuza, E., Valencia, A., Hernández-Cruz, C.M., Izquierdo, M.S., 2007. Dietary n-3 LC-PUFA deficiency induces a reduced visual response in gilthead seabream Sparus aurata larvae. Aquaculture 264, 408-417.
24. Bird, I.M., Walker, S.W., Williams, B.C., 1990. Agonist-stimulated turnover of the phosphoinositides and the regulation of adrenocortical steroidogenesis. J. Mol. Endocrinol. 5, 191-209.
25. Björnsson, B.T., Sundell, K., Jonsson, E., Jutfelt, F., Geurden, I., Ruohonen, K., Forsman, A., Olsen, R.E., Ringø, E., 2004. Gutintegrity: gastrointestinal functions and food intake regulation in salmonids: impact of dietary vegetable lipids. Report from the EU project Gutintegrity. Gothenburg, Sweden, Göteborgs Universitet.
26. Blanchard, G., Gardeur, J.N., Mathis, N., Brun-Bellut, J., Kestemont, P., 2008. Ultrastructural features of hepatocytes in cultured Eurasian perch (Perca fluviatilis L.) as affected by nutritional and husbandry conditions. Br. J. Nutr. 100, 317-331.
27. Blazer, V.S., 1991. Piscine macrophage function and nutritional influences: a review. J. Aquat. Anim. Health 3, 77-86.
28. Blazer, V.S., 1992. Nutrition and disease resistance in fish. Ann. Rev. Fish Dis. 2, 309-323.
29. Brandsen, M.P., Carter, C.G., Nichols, P.D., 2003. Replacement of fish oil with sunflower oil in feeds for Atlantic salmon (Salmo salar L.): effect on growth performance, tissue fatty acid composition and disease resistance. Comp. Biochem. Physiol. 135B, 611-625.
30. Brodtkorb, B.T., Rosenlund, G., Lie, Ø., 1997. Effects of 20: 5n-3 and 22: 6n-3 on tissue lipid composition in juvenile Atlantic salmon, Salmo salar, with emphasis on brain and eye. Aquac. Nutr. 3, 175-187.
31. Bryan, D.L., Hart, P., Forsyth, K., Gibson, R., 2001. Incorporation of α-linolenic acid and linoleic acid into human respiratory epithelial cell lines. Lipids 36, 713-717.
32. Bureau, D.P., Hua, K., Harris, A.M., 2008. The effect of dietary lipid and long-chain n-3 PUFA levels on growth, energy utilization, carcass quality, and immune function of rainbow trout, Oncorhynchus mykiss. J. World Aquac. Soc. 39, 1-21.
33. Caballero, M.J., López-Calero, G., Socorro, J., Roo, F.J., Izquierdo, M.S., Fernández, A.J., 1999. Combined effect of lipid level and fish meal quality on liver histology of gilthead seabream (Sparus aurata). Aquaculture 179, 277-290.
34. Caballero, M.J., Obach, A., Rosenlund, G., Montero, D., Gisvold, M., Izquierdo, M.S., 2002. Impact of different dietary lipid sources on growth, lipid digestibility, tissue fatty acid composition and histology of rainbow trout, Oncorhynchus mykiss. Aquaculture 214, 253-271.
35. Caballero, M.J., Izquierdo, M.S., Kjorsvik, E., Montero, D., Socorro, J., Fernández, A., Rosenlund, G., 2003. Morphological aspects of the intestinal cells from gilthead seabream (Sparus aurata) fed diets containing different lipid sources. Aquaculture 225, 325-340.
36. Caballero, M.J., Izquierdo, M.S., Kjørsvik, E., Fernández, A.J., Rosenlund, G., 2004. Histological alterations in the liver of seabream, Sparus aurata L., caused by short- or long-term feeding with vegetable oils: recovery of normal morphology after feeding fish oil as the sole lipid source. J. Fish Dis. 27, 531-541.
37. Caballero, M.J., Gallardo, G., Robaina, L., Montero, D., Fernández, A., Izquierdo, M.S., 2006. Vegetable lipid sources affect in vitro biosynthesis of triacylglycerols and phospholipids in the intestine of seabream (Sparus aurata). Br. J. Nutr. 95, 448-454.
38. Cahu, C.L., Infante, J.L.Z., Corraze, G., Coves, D., 2000. Dietary lipid level affects fatty acid composition and hydrolase activities of intestinal brush border membrane in seabass. Fish Physiol. Biochem. 23, 165-172.
39. Cairns, M.T., Johnson, M.C., Talbot, A.T., Pemmasani, J.K., McNeill, R.E., Houeix, B., Sangrador-Vegas, A., Pottinger, T.G., 2008. A cDNA microarray assessment of gene expression in the liver of rainbow trout (Oncorhynchus mykiss) in response to a handling and confinement stressor. Comp. Biochem. Physiol. 3D, 51-66.
40. Calder, P.C., 1996. Effects of fatty acids and dietary lipids on cells of the immune system. Proc. Nutr. Soc. 55, 127-150.
41. Calder, P.C., 2002. Dietary modification of inflammation with lipids. Proc. Nutr. Soc. 61, 345-358.
42. Calder, P.C., 2006. Polyunsaturated fatty acids and inflammation. Prostaglandins Leukotrienes Essent. Fatty Acids 75, 197-202.
43. Calder, P.C., Burdge, G.C., 2004. Fatty acids. In: Nicolaou, A, Kokotos, G. (Eds), Bioactive Lipids. Bridgewater, UK, Oily Press, pp. 1-36.
44. Calder, P.C., Bond, J.A., Harvey, D.J., Gordon, S., Newsholme, E.A., 1990. Uptake and incorporation of saturated and unsaturated fatty acids into macrophage lipids and their effects upon macrophage adhesion and phagocytosis. Biochem. J. 269, 807-814.
45. Calder, P.C., Yaqoob, P., Thies, F., Wallace, F.A., Miles, E.A., 2002. Fatty acids and lymphocyte functions. Br. J. Nutr. 87, S31-S48.
46. Chandroo, K.P., Yue, S., Moccia, R.D., 2004a. An evaluation of current perspectives on consciousness and pain in fishes. Fish Fish. 5, 281-295.
47. Chandroo, K.P., Duncan, I.J.H., Moccia, R.D., 2004b. Can fish suffer? Perspectives on sentience, pain, fear and stress. Appl. Anim. Behav. Sci. 86, 225-250.
48. Chatelier, A., McKenzie, D.J., Prinet, A., Galois, R., Robin, J. Zambonino, J., Claireaux, G., 2006. Associations between tissue fatty acid composition and physiological traits of performance and metabolism in sea bass (Dicentrarchus labrax). J. Exp. Biol. 209, 3429-3439.
49. Chilton, F.H., Patel, M., Fonteh, A.N., Hubbard, W.C., Triggiani, M., 1993. Dietary n-3 fatty acid effects on neutrophil lipid composition and mediator production: influence of duration and dosage. J. Clin. Invest. 91, 115-122.
50. Chrysohoou, C., Panagiotakos, D.B., Pitsavos, C., Skoumas, J., Krinos, X., Chloptsios, Y., Nikolaou, V., Stefanadis, C., 2007. Long-term fish consumption is associated with protection against arrhythmia in healthy persons in a Mediterranean region: the ATTICA study. Am. J. Clin. Nutr. 85, 1385-1391.
51. Chung, S., Secombes, C.J., 1988. Analysis of events occurring within teleost macrophages during the respiratory burst. Comp. Biochem. Physiol. 89B, 539-544.
52. Conte, F.S., 2004. Stress and the welfare of cultured fish. Appl. Anim. Beh. Sci. 86, 205-223.
53. Cooke, S.J., Sneddon, L.U., 2007 Animal welfare perspectives on recreational angling. Appl. Anim. Behav. Sci. 104, 176-198.
54. Cooper, E.L., 2000. Immune response: evolution. In: Nature Encyclopedia of Life Sciences. London: Nature Publishing.
55. Crocker, I.P., Lawson, N., Baker, P.N., Fletcher, J., 2001. The anti-inflammatory effects of circulating fatty acids in obstructive jaundice: similarities with pregnancy-induced immunosuppression. Quart. J. Med. 94, 475-484.
56. Díaz-López, M., Perez, M.J., Acosta, N.G., Tocher, D.R., Jerez, S., Lorenzo, A., Rodriguez, C., 2009. Effect of dietary substitution of fish oil by echium oil on growth, plasma parameters and body lipid composition in gilthead seabream (Sparus aurata). Aquacult. Nutr., 15, 500-512
57. Du Pasquier, L., 2001. The immune system of invertebrates and vertebrates. Comp. Biochem. Physiol. 129B, 1-15.
58. Ellis, A.E., 2001. Innate host defence mechanism of fish against viruses and bacteria. Dev. Comp. Immunol. 25, 827-839.
59. Erdal, J.I., Evensen, O, Kaurstad, O.K., Lillehaug, A., Solbakken, R., Throud, K., 1991. Relationship between diet and immune response in Atlantic salmon (Salmo salar, L.) after feeding various levels of ascorbic acid and omega-3 fatty acids. Aquaculture 98, 363-379.
60. Farndale, B.M., Bell, J.G., Bruce, M.P., Bromage, N.R., Oyen, F., Zanuy, S., Sargent, J.R., 1999. Dietary lipid composition affects blood leucocyte fatty acid compositions and plasma eicosanoid concentrations in European sea bass (Dicentrarchus labrax). Aquaculture 179, 335-350.
61. Farrell, A.P., 2002. Coronary arteriosclerosis in salmon: growing old or growing fast? Comp. Biochem. Physiol. 132A, 723-735.
62. Farrell, A.P., Davie, P.S., 1991a. Coronary artery reactivity in the mako shark, Isurus oxyrinchus. Can. J. Zool. 69, 375-379.
63. Farrell, A.P., Davie, P.S., 1991b. Coronary vascular reactivity in the skate, Raja nasuta. Comp. Biochem. Physiol. 99C, 555-560.
64. Farrell, A.P., Johansen, J.A., 1995. Vasoactivity of the coronary artery of rainbow trout, steelhead trout, and dogfish: lack of support for endothelium-derived relaxation factors. Can. J. Zool. 73, 1899-1911.
65. Fearon, D.T., 1997. Seeking wisdom in innate immunity. Nature 388, 323-324.
66. Fearon, D.T., Locksley, R.M., 1996. The instructive role of innate immunity in the acquired immune response. Science 272, 50-54.
67. Figueiredo-Silva, A., Rocha, E., Dias, J., Silva, P., Rema, P., Gomes, E., Valente, L.M.P., 2005. Partial replacement of fish oil by soybean oil on lipid distribution and liver histology in European sea bass (Dicentrarchus labrax) and rainbow trout (Oncorhynchus mykiss) juveniles. Aquacult. Nutr. 11, 147-155.
68. Fisheries Society of the British Isles (FSBI), 2002. Fish welfare. Briefing Paper no. 2. Cambridge, Granta Information Systems.
69. Fletcher, T.C., Secombes, C.J., 1999. Immunology of fish. In: Nature Encyclopedia of Life Sciences. London: Nature Publishing.
70. Fracalossi, D.M., Lovell, R.T., 1994. Dietary lipid sources influence responses of channel catfish (Ictalurus punctatus) to challenge test with the pathogen Edwardsiella ictaluri. Aquaculture 119, 287-298.
71. Fritsche, K., 2007. Important differences exist in the dose-response relationship between diet and immune cell fatty acids in humans and rodents. Lipids 42, 961-979.
72. Furuita, H., Takeuchi, T., Uematsu, K., 1998. Effects of eicosapentaenoic and docosahexaenoic acids on growth, survival and brain development of larval Japanese flounder (Paralichthys olivaceus). Aquaculture 161, 59-69.
73. Ganga, R., Bell, J.G., Montero, D., Robaina, L., Caballero, M.J., Izquierdo, M.S., 2005. Effect of dietary lipids on plasma fatty acid profiles and prostaglandin and leptin production in gilthead seabream (Sparus aurata). Comp. Biochem. Physiol. 142B, 410-418.
74. Ganga, R., Bell, J.G., Montero, D., Atalah, E., Vraskou, Y., Tort, L., Fernandez, L., Izquierdo, M.S., in press. ACTH-stimulated cortisol-release by the head-kidney-interrenal tissue from sea bream (Sparus aurata) fed with linseed and soybean oil. Br. J. Nut.
75. Ganga, R., Tort, L., Acerete, L., Montero, D., Izquierdo, M.S., 2006. Modulation of ACTHinduced cortisol release by polyunsaturated fatty acids in interrenal cells from gilthead seabream, Sparus aurata. J. Endocrinol. 190, 39-45.
76. Gatlin, D.M., 2002. Nutrition and fish health. In: Halver, J.E., Hardy, R.W. (Eds), Fish Nutrition. San Diego, CA, Academic Press, pp. 671-702.
77. Genc, E., Yilmaz, E., Akyurt, I., 2005. Effects of dietary fish oil, soy-acid oil, and yellow grease on growth and hepatic lipidosis of hybrid tilapia fry. Israeli J. Aquacult. - Bamidgeh 55, 90-96.
78. Gjøen, T., Obach, A., Røsjø, C., Helland, B.G., Rosenlund, G., Hvattum, E., Ruyter, B., 2004. Effect of dietary lipids on macrophage function, stress susceptibility and disease resistance in Atlantic salmon (Salmo salar). Fish Physiol. Biochem. 30, 149-161.
79. Glencross, B.D., Hawkins, W.E., Curnow, J.G., 2003. Evaluation of canola oils as alternative lipid resources in diets for juvenile red seabream, Pagrus auratus. Aquacult. Nutr. 9, 305-315.
80. Greene, D.H.S, Selivonchick, D.P., 1990. Effects of dietary vegetable, animal and marine lipids on muscle lipid and hematology of rainbow trout (Oncorhynchus mykiss). Aquaculture 89, 165-182.
81. Grisdale-Helland, B., Ruyter, B., Rosenlund, G., Obach, A., Helland, S.J., Sandberg, M.G., Standal, H., Rosjo, C., 2002. Influence of high contents of dietary soybean oil on growth, feed utilization, tissue fatty acid composition, heart histology and standard oxygen consumption of Atlantic salmon (Salmo salar) raised at two temperatures. Aquaculture 207, 311-329.
82. Guarner, F., Malagelada, J.R., 2003. Gut flora in health and disease. Lancet 361, 512-519.
83. Hac-Wydro, K., Wydro, P., 2007. The influence of fatty acids on model cholesterol/phospholipid membranes. Chem. Phys. Lipids 150, 66-81.
84. Hagave, T.A., Johansen, Y., Christophersen, B., 1991. The effect of n-3 fatty acids on osmotic fragility of rat erythrocytes. Biochim. Biophys. Acta 1084, 251-254.
85. Halvorsen, B., Rustan, A.C., Madsen, L., Reseland, J., Berge, R.K., Sletnes, P., Christiansen, E.N., 2001. Effects of long-chain monounsaturated and n-3 fatty acids on fatty acid oxidation and lipid composition in rats. Annals Nutr. Metab. 45, 30-37.
86. Harbige, L.S., 2003. Fatty acids, the immune response and autoimmunity: a question of n-6 essentiality and the balance between n-6 and n-3. Lipids 38, 323-341.
87. Hardy, R.W., Tacon, A.G.J., 2002. Fish meal: historical uses, production trends and future outlook for supplies. In: Stickney, R.R., MacVey, J.P. (Eds), Responsible Marine Aquaculture. New York, CABI Publishing, pp. 311-325.
88. Hardy, R.W., Higgs, D.A., Lall, S.P., Tacon, A.G.J., 2001. Alternative dietary protein and lipid sources for sustainable production of salmonids. Fisken og Havet 8, 53pp.
89. Harper, C.R., Edwards, M.J., DeFilipis, A.P., Jacobson, T.A., 2006. Flaxseed oil increases the plasma concentrations of cardioprotective (n-3) fatty acids in humans. J. Nutr. 136, 83-87.
90. Harris, J., Bird, D.J., 2000. Modulation of the fish immune response by hormones. Vet. Immunol. Immunopathol. 77, 163-176.
91. Henderson, R.J., Tocher, D.R., 1987. The lipid composition and biochemistry of freshwater fish. Prog. Lipid Res. 26, 281-347.
92. Holland, J.W., Pottinger, T.G., Secombes, C.J., 2002. Recombinant interleukin-1 beta activates the hypothalamic-pituitary-interrenal axis in rainbow trout, Oncorhynchus mykiss. J. Endocrinol. 175, 261-267.
93. Hsu, C.S., Chiu, W.C., Yeh, C.L., Hou, Y.C., Chou, S.Y., Yeh, S.L., 2006. Dietary fish oil enhances adhesion molecule and interleukin-6 expression in mice with polymicrobial sepsis. Br. J. Nutr. 96, 854-860.
94. Huising, M.O., Kruiswijk, C.P., Flik, G., 2006. Phylogeny and evolution of class-I helical cytokines. J. Endocrinol. 189, 1-25.
95. Ide, T., 2000. Effect of dietary alpha-linolenic acid on the activity and gene expression of hepatic fatty acid oxidation enzymes. Biofactors 13, 9-14.
96. Idler, D.R., Truscot, B., 1972. Corticosteroids in fish. In: Idler, D.R. (Ed), Steroids in Non-Mammalian Vertebrates. London, Academic Press, pp. 127-252.
97. Ikeda, I., Cha, J.Y., Yanagita, T., Nakatani, N., Oogami, K., Imaizumi, K., Yazama, K., 1998. Effects of dietary alphalinolenic, eicosapentaenoic and docosahexaenoic acids on hepatic lipogenesis and β-oxidation in rats. Biosci. Biotechnol. Biochem. 62, 675-680.
98. Iliev, D.B., Liarte, C.Q., MacKenzie, S., Goetz, F.W., 2005. Activation of rainbow trout (Oncorhynchus mykiss) mononuclear phagocytes by different pathogen associated molecular pattern (PAMP) bearing agents. Mol. Immunol. 42, 1215-1223.
99. Izquierdo, M.S., 1996. Essential fatty acid requirement of marine fish larvae. Aquacult. Nutr. 2, 183-191.
100. Izquierdo, M.S., Socorro, J., Arantzamendi, L., Hernández-Cruz, C.M., 2000. Recent advances in lipid nutrition in fish larvae. Fish Physiol. Biochem. 22, 97-107.
101. Izquierdo, M.S., Tandler, A., Salhi, M., Kolkovski, S., 2001. Influence of dietary polar lipids’ quantity and quality on ingestion and assimilation of labelled fatty acids by larval gilthead seabream. Aquacult. Nutr. 7, 153-160.
102. Izquierdo, M.S., Obach, A. Arantzamendi, L., Montero, D., Robaina, L.E., Rosenlund, G., 2003. Dietary lipid sources for seabream and sea bass: growth performance, tissue composition and flesh quality. Aquacult. Nutr. 9, 397-407.
103. Izquierdo, M.S., Montero, D., Robaina, L.E., Caballero, M.J., Rosenlund, G., Ginés, R., 2005. Alteration in fillet fatty acid profile and flesh quality in gilthead seabream (Sparus aurata) fed vegetable oils for a long period. Recovery of fatty acid profiles by fish oil feeding. Aquaculture 250, 431-444.
104. Izquierdo, M.S., Robaina, L., Juárez, E., Oliva, R., Hernández-Cruz, C.M., Afonso, J.M., 2008. Regulation of growth, fatty acid composition and delta 6 desaturase expression by dietary lipids in gilthead seabream larvae (Sparus aurata). Fish Physiol. Biochem. 34, 117-127.
105. Janeway, C., 1989. Immunogenicity signals 1,2,3, and 0. Immunol. Today 10, 283-286.
106. Janeway, C., Medzhitov, R., 2002. Innate immune recognition. Ann. Rev. Immunol. 20, 197-216.
107. Jutfelt, F., Olsen, R.E., Björnsson, B.T., Sundell, K., 2007. Parr-smolt transformation and dietary vegetable lipids affect intestinal nutrient uptake, barrier function and plasma cortisol levels in Atlantic salmon. Aquaculture 273, 298-311.
108. Kaattari, S.L., Evans, D., Klemer, J., 1998. Varied redox forms of teleost IgM: an alternative to isotypic diversity? Immunol. Rev. 166, 133-142.
109. Kamara, K., Eskay, R., Castonguay, T., 1998. High-fat diets and stress responsivity. Physiol. Behav. 64, 1-6.
110. Kanazawa, A., 1985. Essential fatty acid and lipid requirement of fish. In: Cowey, C.B., Mackie, A.M., Bell, J.G. (Eds), Nutrition and Feeding in Fish. London, Academic Press, pp. 281-298.
111. Kanazawa, A., 1997. Effects of docosahexaenoic acid and phospholipids on stress tolerance of fish. Aquaculture 155, 129-134
112. Kew, S., Banerjee, T., Minihane, A.M., Finnegan, Y.E., Williams, C.M., Calder, P., 2003. Relation between the fatty acid composition of peripheral blood mononuclear cells and measures of immune cell function in healthy, free-living subjects aged 25-72 y. Am. J. Clin. Nutr. 77, 1278-1286.
113. Kiron, V., Fukuda, H., Takeuchi, T., Watanabe, T., 1995. Essential fatty acid nutrition and defence mechanisms in rainbow trout Oncorhynchus mykiss. Comp. Biochem. Physiol. 111A, 361-367.
114. Kjaer, M.A., Vegusdal, A., Gjøen, T., Rustan, A.C., Todorčević, M., Ruyter, B., 2008. Effect of rapeseed oil and dietary n-3 fatty acids on triacylglycerol synthesis and secretion in Atlantic salmon hepatocytes. Biochim. Biophys. Acta 1781, 112-122.
115. Kjaer, M.A., Vegusdal, A., Berge, G.M., Galloway, T.F., Hillestad, M., Krogdahl, A., Holm, H., Ruyter, B., 2009. Characterisation of lipid transport in Atlantic cod (Gadus morhua) when fasted and fed high or low fat diets. Aquaculture 288, 325-336.
116. Klinger, R.C., Blazer, V.S., Echevarria, C., 1996. Effects of dietary lipid on the hematology of channel catfish, Ictalurus punctatus. Aquaculture 147, 225-233.
117. Knight, J., Holland, J.W., Bowden, L.A., Halliday, K., Rowley, A.F., 1995. Eicosanoid generating capacities of different tissues from the rainbow trout, Oncorhynchus mykiss. Lipids 30, 451-458.
118. Koven, W.M., Barr, Y., Lutzky, S., Ben-Atia, I., Weiss, R., Harel, M., Behrens, P., Tandler, A., 2001. The effect of dietary arachidonic acid (20: 4n-6) on growth, survival and resistance to handling stress in gilthead seabream (Sparus aurata) larvae. Aquaculture 193, 107-122.
119. Koven, W.M., Van Anholt, R.D., Lutsky, S., Ben Atia, I., Nixon, O., Ron, B., Tandler, A., 2003. The effect of dietary arachidonic acid on growth, survival, and cortisol levels in different-age gilthead seabream larvae (Sparus aurata) exposed to handling or daily salinity change. Aquaculture 228, 307-320.
120. Lacroix, M., Hontela, A., 2001. Regulation of acute cortisol synthesis by cAMP-dependant protein kinase and protein kinase C in teleost species, the rainbow trout (Oncorhynchus mykiss). J. Endocrinol. 169, 71-78.
121. Lall, S.P., 2000. Nutrition and health of fish. In: Cruz -Suárez, L.E., Ricque-Marie, D., Tapia-Salazar, M., Olvera-Novoa, M.A., Civera-Cerecedo, R. (Eds), Avances en Nutrición Acuícola V: Memorias del V Simposium Internacional de Nutrición Acuícola, 19-22 Noviembre, Mérida, Yucatán, Mexico.
122. Leaver, M.J., Villenueve, L.A., Obach, A., Jensen, L., Bron, J.E., Tocher, D.R., Taggart, J.B., 2008. Functional genomics reveals increases in cholesterol biosynthetic genes and highly unsaturated fatty acid biosynthesis after dietary substitution of fish oil with vegetable oils in Atlantic salmon (Salmo salar). BMG Genomics 9, 299-314.
123. Lee, J.Y., Hirono, I., Aoki, T., 2000. Cloning and análisis of expression of Mx cDNA in Japanese flounder, Paralichthys olivaceus. Dev. Comp. Immunol. 24, 407-415.
124. Leray, C., Chapelle, S., Duportail, G., Florentz, A., 1984. Changes in fluidity and 22: 6n-3 content in phospholipids of trout Salmo gairdneri intestinal brush-border membrane as related to environmental salinity. Biochim. Biophys. Acta 778, 233-238.
125. Leray, C., Nonnotte, G., Nonnotte, L., 1986. The effect of dietary lipids on the trout erythrocyte membrane. Fish Physiol Biochem. 1, 27-35.
126. Lessard, M., Gagnon, N., Godson, L., Petit, H.V., 2004. Influence of parturition and diets enriched in n-3 or n-6 polyunsaturated fatty acids on immune response of dairy cows during the transition period. J. Dairy Sci. 87, 2197-2210.
127. Li, J., Barreda, D.R., Zhang, Y.A., Boshra, H., Gelman, A.E., LaPatra, S., Tort, L., Sunyer, J.O., 2006. B lymphocytes from early vertebrates have potent phagocytic and microbicidal abilities. Nature Immunol. 7, 1116-1124.
128. Li, M.H., Wise, D.J., Johnson, M.R., Robinson, E.H., 1994. Dietary menhaden oil reduced resistance of channel catfish (Ictalurus punctatus) to Edwarsiella ictaluri. Aquaculture, 128, 335-344.
129. Lin, Y.H., Shiau, S.Y., 2007. Effects of dietary blend of fish oil with corn oil on growth and non-specific immune responses of grouper Epinephelus malabaricus. Aquacult. Nutr. 13, 137-144.
130. Liu, J., Caballero, M.J., Izquierdo, M.S., El-Sayed Ali, T., Hernández-Cruz, C.M., Valencia, A., Fernández-Palacios, H., 2002. Necessity of dietary lecithin and eicosapentaenoic acid for growth, survival, stress resistance and lipoprotein formation in gilthead seabream Sparus aurata. Fish. Sci. 68, 1165-1172.
131. Lodemel, J.B., Mayhew, T.M., Myklebust, R., Olsen, R.E., Espelid, S., Ringø, E., 2001. Effect of three dietary oils on disease susceptibility in Artic charr (Salvelinus alpinus L.) during cohabitant challenge with Aeromonas salmonicida subsp. salmonicida. Aquacult. Res. 32, 935-945.
132. MacKenzie, S., Iliev, D., Liarte, C., Koskinen, H., Planas, J.V., Goetz, F.W., Molsa, H., Krasnov, A., Tort, L., 2006. Transcriptional analysis of LPS-stimulated activation of trout (Oncorhynchus mykiss) monocyte/macrophage cells in primary culture treated with cortisol. Mol. Immunol. 43, 1340-1348.
133. Magnadóttir, B., 2006. Innate immunity of fish (overview). Fish Shellfish Immunol. 20, 137-151.
134. Magnadóttir, B., Lange, S., Gudmundsdottir, S., Bogwald, J., Dalmo, R.A., 2005. Ontogeny of humoral immune parameters in fish. Fish Shellfish Immunol. 19, 429-439.
135. Mai, V., Colbert, L.H., Perkins, S.N., Schatzkin, A., Hursting, S.D., 2007. Intestinal microbiota: a potential diet-responsive prevention target in ApcMin mice. Mol. Carcinogenesis 46, 42-48.
136. Manning, M.J., Nakanishi, T., 1996. The specific immune system: cellular defenses. In: Iwama, G.K., Nakanishi, T. (Eds), The Fish Immune System. Fish Physiology, vol. 15. London, Academic Press, pp. 159-205.
137. Mantzioris, E., James, M.J., Gibson, R.A., Cleland, L.G., 1995. Differences exist in the relationships between dietary linoleic and α-linolenic acids and their respective long-chain metabolites. Am. J. Clin. Nutr. 61, 320-324.
138. Marcheselli, V.L., Hong, S., Lukiw, W.J., Tian, X.H., Gronert, K., Musto, A., Hardy, M., Gimenez, J.M., Chiang, N., Serhan, C.N., Bazan, N.G., 2003. Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression. J. Biol. Chem. 278, 43807-43817.
139. Masuda, R., Takeuchi, T., Tsukamoto, K., Sato, H., Shimizu, K., Imaizumi, K., 1999. Incorporation of dietary docosahexaenoic acid into the central nervous system of the yellowtail Seriola quinqueradiata. Brain Behav. Evol. 53, 173-179.
140. McKenzie, D.J., Piraccini, G., Steffensen, J.F., Bolis, C.G., Bronzi, P., Taylor, E.W., 1995. Effects of diet on spontaneous locomotor activity and oxygen consumption in Adriatic sturgeon (Acipenser naccarii). Fish Physiol. Biochem. 14, 341-355.
141. McKenzie, D.J., Piraccini, G., Papini, N., Galli, C., Bronzi, P., Bolis, C.L., Taylor, E.W., 1997a. Oxygen consumption and ventilatory reflex responses are influenced by dietary lipids in sturgeon. Fish Physiol. Biochem. 16, 365-379.
142. McKenzie, D.J., Piraccini, G., Piccolella, M., Steffensen, J.F., Bolis, C.L., Taylor, E.W., 1997b. Effects of dietary fatty acid composition on metabolic rate and responses to hypoxia in the European eel (Anguilla anguilla). Fish Physiol. Biochem. 22, 281-296.
143. McKenzie, D.J., Higgs, D.A., Dosanjh, B.S., Deacon, G., Randall, D.J., 1998. Dietary fatty acid composition influences swimming performance in Atlantic salmon (Salmo salar) in seawater. Fish Physiol. Biochem. 19, 111-122.
144. McKenzie, D.J., Piraccini, G., Agnisaola, C., Steffensen, J.F., Bronzi, P., Bolis, C.L., Tota, B., Taylor, E.W., 1999. The influence of dietary fatty acid composition on the respiratory and cardiovascular physiology of Adriatic sturgeon (Acipenser naccarii): a review. J. Appl. Ichthyol. 15, 265-269.
145. McKenzie, D.J., Piraccini, G., Piccolella, M., Steffensen, J.F., Bolis, C.L., Taylor, E.W., 2000. Effects of dietary fatty acid composition on metabolic rate and responses to hypoxia in the European eel (Anguilla anguilla). Fish Physiol. Biochem. 22, 281-296.
146. McLennan, P.L., Bridle, T.M., Abeywardena, M.Y., Charnock, J.S., 1993. Comparative efficacy of n-3 and n-6 polyunsaturated fatty acids in modulating ventricular fibrillation threshold in marmoset monkeys. Am. J. Clin. Nutr. 58, 666-669.
147. Medzhitov, R., Janeway, C.A. Jr., 1998. An ancient system of host defence. Curr. Opin. Immunol. 10, 12-15.
148. Medzhitov, R., Janeway, C.A. Jr., 2002. Decoding the patterns of self and nonself by the innate immune system. Science 296, 298-300.
149. Mellor, D.J., Stafford, K.J., 2001. Integrating practical, regulatory and ethical strategies for enhancing farm animal welfare. Australian Vet. J. 79, 762-768.
150. Menoyo, D., Izquierdo, M.S., Robaina, L., Ginés, R., López-Bote, C.J., Bautista, J.M., 2004. Adaptation of lipid metabolism, tissue composition and flesh quality in gilthead seabream (Sparus aurata) to the fish oil replacement by linseed and soybean oils. Br. J. Nutr. 92, 41-52.
151. Midtlyng, P.J., Ahrend, M., Bjerkas, E., Waagbø R., Wall, T., 1999. Current research on cataracts in fish. Bull. Eur. Assoc. Fish Pathologists 19, 299-301.
152. Miller, M.R., Nichols, P.D., Carter, C.G., 2008. The digestibility and accumulation of dietary phytosterols in Atlantic salmon (Salmo salar L.) smolt fed diets with replacement plant oils. Lipids 43, 549-557.
153. Momoda, T.S., Schwindt, A.R., Feist, G.W., Gerwick, L., Bayne, C.J., Schreck, C.B., 2007. Gene expression in the liver of rainbow trout, Oncorhynchus mykiss, during the stress response. Comp. Biochem. Physiol. 2D, 303-315.
154. Montero, D., Tort, L., Izquierdo, M.S., Robaina, L., Vergara, J.M., 1998. Depletion of serum alternative complement pathway activity in gilthead seabream caused by alpha-tocopherol and n-3 LC-PUFA dietary deficiencies. Fish. Physiol. Biochem. 18, 399-407.
155. Montero, D., Robaina, L.E., Socorro, J., Vergara, J.M., Tort, L., Izquierdo, M.S., 2001. Alteration of liver and muscle fatty acid composition in gilthead seabream (Sparus aurata) juveniles held at high stocking density and fed an essential fatty acid deficient diet. Fish Physiol. Biochem. 24, 63-72.
156. Montero, D., Kalinowski, T., Obach, A., Robaina, L., Tort, L., Caballero, M.J., Izquierdo, M.S., 2003. Vegetable lipid sources for gilthead seabream (Sparus aurata): effects on fish health. Aquaculture, 225, 353-370.
157. Montero, D., Socorro, J., Tort, L., Caballero, M-J., Robaina, L.E., Vergara, J.M., Izquierdo, M.S., 2004. Glomerulonephritis and immunosuppression associated with dietary essential fatty acid deficiency in gilthead seabream, Sparus aurata L., juveniles. J. Fish Dis. 27, 297-306.
158. Montero, D., Robaina, L.E., Caballero, M.J., Ginés, R., Izquierdo, M.S., 2005. Growth, feed utilization and flesh quality of European sea bass (Dicentrarchus labrax) fed diets containing vegetable oils: a time-course study on the effects of re-feeding period with a 100% fish oil diet. Aquaculture 248, 121-134.
159. Montero, D., Grasso, V., Izquierdo, M.S., Ganga, R., Real, F., Tort, L., Caballero, M.J., Acosta, F., 2008. Total substitution of fish oil by vegetable oils in gilthead seabream (Sparus aurata) diets: effects on hepatic Mx expression and some immune parameters. Fish Shellfish Immunol. 24, 147-155.
160. Morais, S., Bell, J.G., Robertson, D.A., Roy, W.J., Morris, P.C., 2001. Protein/lipid ratios in extruded diets for Atlantic cod (Gadus morhua L.): effects on growth, feed utilisation, muscle composition and liver histology. Aquaculture 203, 101-119.
161. Mourente, G., Good, J.E., Bell, J.G., 2005. Partial substitution of fish oil with rapeseed, linseed and olive oils in diets for European sea bass (Dicentrarchus labrax L.): effects on flesh fatty acid composition, plasma prostaglandins E2 and F2α, immune function and effectiveness of a fish oil finishing diet. Aquacult. Nutr. 11, 25-40.
162. Mourente, G., Good, J.E., Thompson, K.D., Bell, J.G., 2007. Effects of partial substitution of dietary fish oil with blends of vegetable oils, on blood leucocyte fatty acid compositions, immune function and histology in European sea bass (Dicentrarchus labrax L.). Br. J. Nutr. 98, 770-779.
163. Mukaro, V.R., Costabile, M., Murphy, K.J., Hii, C.S. Howe, P.R., Ferrante, A., 2008. Leukocyte numbers and function in subjects eating n-3 enriched foods: selective depression of natural killer cell levels. Arthritis Res. Ther. 10, R57.
164. Mustafa, T., Srivastava, K.C., 1989. Prostaglandins (eicosanoids) and their role in ectothermic organisms. Adv. Comp. Environ. Physiol. 5, 157-207.
165. Narnaware, Y.K., Baker, B.I., 1996. Evidence that cortisol may protect against the immediate effects of stress on circulating leukocytes in the trout. Gen. Comp. Endocrinol. 103, 359-366.
166. Nordmo, R., Ramstad, A., 1999. Variables affecting the challenge pressure of Aeromonas salmonicida and Vibrio salmonicida in Atlantic salmon (Salmo salar L.). Aquaculture 171, 1-12.
167. Ng, W.K., Lim, P.K., Sidek, H., 2001. The influence of a dietary lipid source on growth, muscle fatty acid composition and erythrocyte osmotic fragility of hybrid tilapia. Fish Physiol. Biochem 25, 301-310.
168. Ng, W.K., Sigholt, T., Bell, J.G., 2004. The influence of environmental temperature on the apparent nutrient and fatty acid digestibility in Atlantic salmon (Salmo salar L.) fed finishing diets containing different blends of fish oil, rapeseed oil and palm oil. Aquacult. Res. 35, 1228-1237.
169. Oarada, M., Gonoi, T., Tsuzuki, T., Igarashi, M., Hirasaka, K., Nikawa, T., 2007. Effect of dietary oils on lymphocyte immunological activity in psychologically stressed mice. Biosci. Biotechnol. Biochem. 71, 174-182.
170. Ochang, S.N., Fagbenro, O.A., Adebayo, O.T., 2007. Growth performance, body composition, haematology and product quality of the African catfish (Clarias gariepinus) fed diets with palm oil. Pakistan J. Nutr. 6, 452-459.
171. Ohtani, M., Hayashi, N., Hashimoto, K., Nakanishi, T., Dijkstra, J.M., 2008. Comprehensive clarification of two paralogous interleukin 4/13 loci in teleost fish. Immunogenetics 60, 383-397.
172. Olsen, R.E., Myklebust, R., Kaino, T., Ringø, E., 1999. Lipid digestibility and ultrastructural changes in the enterocytes of Arctic charr (Salvelinus alpinus L.) fed linseed oil and soybean lecithin. Fish Physiol. Biochem. 21, 35-44.
173. Olsen, R.E., Myklebust, R., Ringø, E., Mayhew, T.M., 2000. The influences of dietary linseed oil and saturated fatty acids on caecal enterocytes in Arctic charr (Salvelinus alpinus L.): a quantitative ultrastructural study. Fish Physiol. Biochem. 22, 207-216.
174. Olsen, R.E., Dragnes, B.T., Myklebust, R., Ringø, E., 2003. Effect of soybean oil and soybean lecithin on intestinal lipid composition and lipid droplet accumulation of rainbow trout, Oncorhynchus mykiss Walbaum. Fish Physiol. Biochem. 29, 181-192.
175. Olsen, R.E., Sundell, K., Mayhew, T.M., Myklebust, R., Ringø, E., 2005. Acute stress alters intestinal function of rainbow trout, Oncorhynchus mykiss (Walbaum). Aquaculture 250, 480-495.
176. Olsen, Y.A., Reitan, L.J., Roed, K.H., 2005. Gill Na+, K+-ATPase activity, plasma cortisol level, and non-specific immune response in Atlantic salmon (Salmo salar) during parr- smolt transformation. J. Fish Biol. 43, 559-573.
177. Pagniello, K.B., Bols, N.C., Lee, L.E., 2002. Effect of corticosteroids on viability and proliferation of the rainbow trout monocyte/macrophage cell line, RTS11. Fish Shellfish Immunol. 13, 199-214.
178. Person-Le Ruyet, J., Skalli, A., Dulau, B., Le Bayon, N., Le Delliou, H., Robin, J.H., 2004. Does dietary n-3 highly unsaturated fatty acids level influence the European sea bass (Dicentrarchus labrax) capacity to adapt to a high temperature?. Aquaculture 242, 571-588.
179. Petropoulos, I.K., Thompson, K.D., Morgan, A., Dick, J.R., Tocher, D.R., Bell, J.G., 2009. Effects of substitution of dietary fish oil with a blend of vegetable oils on liver and peripheral blood leucocyte fatty acid composition, plasma prostaglandin E2 and immune parameters in three strains of Atlantic salmon (Salmo salar). Aquaculture Nutr. 15, 596-607.
180. Pettitt, T.R., Rowley, A.F., Barrow, S.E., 1989. Synthesis of leukotriene B and other conjugated triene lipoxigenase products by blood cells of the rainbow trout, Salmo gairdneri. Biochim. Biophys. Acta 1003, 1-8.
181. Pettitt, T.R., Rowley, A.F., Barrow, S.E., Mallet, A.I., Secombes, C.J., 1991. Synthesis of lipoxins and other lipoxygenase products by macrophages from the rainbow trout, Oncorhynchus mykiss. J. Biol. Chem. 226, 8720-8726.
182. Petursdottir, D.H., Hardardottir, I., 2007. Dietary fish oil increases the number of splenic macrophages secreting TNF-alpha and IL-10 but decreases the secretion of these cytokines by splenic T cells from mice. J. Nutr. 137, 665-670.
183. Pickering, A.D., Pottinger, T.G., 1989. Stress response and disease resistance in salmonid fish: effects of chronic elevation of plasma cortisol. Fish Physiol. Biochem. 7, 253-258.
184. Pickova, J., Mørkøre, T., 2007. Alternate oils in fish feeds. Eur. J. Lipid Sci. Tech. 109, 256-263.
185. Piedecausa, M.A., Mazón, M.J., García García, B., Hernández, M.D., 2007. Effects of total replacement of fish oil by vegetable oils in the diet of sharpsnout seabream (Diplodus puntazzo). Aquaculture 263, 211-219.
186. Plouffe, D.A., Hanington, P.C., Walsh, J.G., Wilson, E.C., Belosevic, M., 2005. Comparison of select innate immune mechanisms of fish and mammals. Xenotransplantation 12, 266-277.
187. Poisa-Beiro, L., Dios, S., Montes, A., Aranguren, R., Figueras, A., Novos, A., 2008. Nodavirus increases the expression on Mx and inflammatory cytokines in fish brain. Mol. Immunol. 45, 218-225.
188. Portz, D.E., Woodley, C.M., Cech, J.J., 2006. Stress-associated impacts of short-term holding on fishes. Rev. Fish Biol. Fish. 16, 125-170.
189. Press, C.L., Evensen, O., 1999. The morphology of the immune system in teleost fish. Fish Shellfish Immunol. 9, 309-318.
190. Puangkaew, J., Kiron, V., Somamoto, T., Okamoto, N., Satoh, S., Takeuchi, T., Watanabe, T., 2004. Nonspecific immune response of rainbow trout (Oncorhynchus mykiss Walbaum) in relation to different status of vitamin E and highly unsaturated fatty acids. Fish Shellfish Immunol. 16, 25-39.
191. Raynard, R.S., Snow, M., Bruno, D.W., 2001. Experimental infection models and susceptibility of Atlantic salmon Salmo salar to a Scottish isolate of infectious salmon anaemia virus. Dis. Aquat. Org. 47, 169-174.
192. Regost, C., Arzel, J. Robin, J., Rosenlund, G., Kaushik, S.J., 2003. Total replacement of fish oil by soybean oil with return to fish oil in turbot (Psetta maxima). I. Growth performance, flesh fatty acid profile, and lipid metabolism. Aquaculture 217, 465-482.
193. Researching Alternatives to Fish Oil in Aquaculture, n.d. Project results. www.rafoa.stir.ac.uk/project_results.html (accessed 1 March 2010).
194. Richard, N., Kaushik, S., Larroquet, L., Panserat, S., Corraze, G., 2006. Replacing dietary fish oil by vegetable oils had little effect on lipogenesis, lipid transport and tissue lipid uptake in rainbow trout (Oncorhynchus mykiss). Br. J. Nutr. 96, 299-309.
195. Richards, J.G., Mercado, A.J., Clayton, C.A., Heigenhauser, G.J.F., Wood, C.M., 2002. Substrate utilization during graded aerobic exercise in rainbow trout. J. Exp. Biol. 205, 2067-2077.
196. Riediger, N.D., Azordegan, N., Harris-Janz, S., Ma, D.W.L., Suh, M., Moghadasian, M.H., 2009. “Designer oils” low in n-6: n-3 fatty acid ratio beneficially modifies cardiovascular risks in mice. Eur. J. Nutr. 48, 307-314.
197. Ringø, E., Lodemel, J.B., Myklebust, R. Jensen, L., Lund, V., Mayhew, T.M., Olsen, R.E., 2002. The effect of soybean, linseed and marine oils on aerobic gut microbiota of Arctic charr Salvelinus alpinus L. before and after challenge with Aeromonas salmonicida ssp. salmonicida. Aquaculture Res. 33, 591-606.
198. Robaina, L., Izquierdo, M.S., Moyano, F.J., Socorro, J., Vergara, J.M., Montero, D., 1998. Increase of the dietary n3/n6 fatty acids ratio and addition of phosphorus improves liver histology alterations induced by feeding diets containing soybean meal in gilthead seabream (Sparus aurata). Aquaculture 161, 281-293.
199. Roberts, R.J., 2002. Nutritional pathology. In: Halver, J.E., Hardy, R.W. (Eds), Fish Nutrition. San Diego, CA, Academic Press, pp. 453-504.
200. Robertson, O.H., Wexler, B.C., Miller, B.F., 1961. Degenerative changes in the cardiovascular system of the spawning Pacific salmon (Oncorhynchus tshawytscha). Circulation Res. 9, 826-832.
201. Rombout, J.H.W.M., Joosten, E.P.H.M., 1998. Mucosal immunity. In: Pastoret, P-P., Griebel, P., Bazin, H., Govaerts, A. (Eds), Handbook of Vertebrate Immunology. New York, Academic Press, pp. 39-40.
202. Rønneseth, A., Pettersen, E.F., Wergeland, H.I., 2006. Neutrophils and B-cells in blood and head kidney of Atlantic salmon (Salmo salar L.) challenged with infectious pancreatic necrosis virus (IPNV). Fish Shellfish Immunol. 20, 610-620
203. Rosa, L.F.B.P., Sa, D.A., Guimares, A.R.P., 1996. The effect of n-3 PUFA rich diets upon macrophage and lymphocyte metabolism and function. Biochem. Mol. Biol. Internat. 40, 833-842.
204. Rosenberg, I.H., 1994. Nutrient requirements for optimal health: what does that means? J. Nutr. 124, 1777S-1779S.
205. Rosenlund, G., Obach, A., Sandberg, M.G., Standal, H., Tveit, K., 2001. Effect of alternative lipid sources on long-term growth performance and quality of Atlantic salmon (Salmo salar L.). Aquacult. Res. 32, 323-328.
206. Rowley, A.F., Hunt, T., Page, M., Mainwaring, G., 1988. Fish. In: Rowley, A.F, Ratcliffe, N.A. (Eds), Vertebrate Blood Cells. Cambridge, Cambridge University Press, pp. 19-128.
207. Rowley, A.F., Pettitt, T.R., Secombes, C.J., Sharp, G.J.E., Barrow, S.E., Vickers, P.J., 1995. Eicosanoids and their role in immune modulation in fish: a brief overview. Fish Shellfish Immunol. 5, 63-105.
208. Rustan, A.C., Christiansen, E.N., Drevon, C.A., 1992. Serum lipids, hepatic glycerolipid metabolism and peroxisomal fatty acid oxidation in rats fed omega-3 and omega-6 fatty acids. Biochem. J. 283, 333-339.
209. Ruyter, B., Moya-Falcón, C., Rosenlund, G., Vegusdal, A., 2006. Fat content and morphology of liver and intestine of Atlantic salmon (Salmo salar): effects of temperature and dietary soybean oil. Aquaculture 441-452.
210. Saeij, J.P., Verburg-van Kemenade, L.B., van Muiswinkel, W.B., Wiegertjes, G.F., 2003. Daily handling stress reduces resistance of carp to Trypanoplasma borreli: in vitro modulatory effects of cortisol on leukocyte function and apoptosis. Dev. Comp. Immunol. 27, 233-245.
211. Sargent, J.R., Tocher, D.R., Bell, J.G., 2002. The lipids. In: Halver, J.E., Hardy, R.W. (Eds), Fish Nutrition. San Diego, CA, Academic Press, pp. 181-257.
212. Schimmer, B.P., 1995. The 1994 Upjohn Award Lecture: molecular and genetic approaches to the study of signal transduction in the adrenal cortex. Can. J. Physiol. Pharmacol. 73, 1097-1107.
213. Scrimshaw, N.S., 2007. Immunonutrition in health and disease. Br. J. Nut. 98, 83-84.
214. Secombes, C.J., 1996. The non-specific immune system: cellular defenses. In: Iwama, G.K., Nakanishi, T. (Eds), The Fish Immune System. Fish Physiology, vol. 15. London, Academic Press, pp. 63-103.
215. Secombes, C.J., Clements, K., Ashton, I., Rowley, A.F., 1994. The effect of eicosanoids on rainbow trout, Oncorhynchus mykiss, leucocyte proliferation. Vet. Immunol. Immunopathol. 42, 367-378.
216. Secombes, C.J., Wang, T., Hong, S., Peddie, S., Crampe, M., Laing, K.J., Cunningham, C., Zou, J., 2001. Cytokines and innate immunity of fish. Dev. Comp. Immunol. 25, 713-723.
217. Seierstad, S.L., Poppe, T.T., Koppang, E.O., Svindland, A., Rosenlund, G., Frøyland, L., Larsen, S., 2005. Influence of dietary lipid composition on cardiac pathology in farmed Atlantic salmon, Salmo salar L. J. Fish Dis. 28, 677-690.
218. Seierstad, S.L., Svindland, A., Larsen, S., Rosenlund, G., Torstensen, B.E., Evensen, O., 2008. Development of intimal thickening of coronary arteries over the lifetime of Atlantic salmon, Salmo salar L., fed different lipid sources. J. Fish Dis. 31, 401-413.
219. Seierstad, S.L., Hauland, O., Larsen, S., Waagbø, R., Evensen, O., 2009. Pro-inflammatory cytokine expression and respiratory burst activity following replacement of fish oil with rapeseed oil in the feed for Atlantic salmon (Salmo salar L.). Aquaculture 289, 212-218.
220. Serhan, C.N., 2006. Novel chemical mediators in the resolution of inflammation: resolvins and protectins. Anesthesiol. Clinics North Am. 24, 341-347.
221. Sheldon, W.H., Blazer, V.S., 1991. Influence of dietary lipid and temperature on bactericidal activity of channel catfish macrophages. J. Aqua. Anim. Health 3, 87-93.
222. Simopoulos, A.P., 2008. The omega-6/omega-3 fatty acid ratio, genetic variation, and cardiovascular disease. Asia Pac. J. Clin. Nutr. 17, 131-134.
223. Sitja-Bobadilla, A., Perez-Sanchez, J., 1999. Diet related changes in non-specific immune response of European sea bass (Dicentrarchus labrax L.). Fish Shellfish Immunol. 9, 637-640.
224. Spisni, E., Tugnoli, M., Ponticelli, A., Mordenti, T., Tomasi, V., 1998. Hepatic steatosis in artificially fed marine teleosts. J. Fish Dis. 21, 177-184.
225. Stenslokken, K.O., Sundin, L., Nilsson, G.E., 2002. Cardiovascular effects of prostaglandins F2α and prostaglandin E2 in Atlantic cod (Gadus morhua). J. Comp. Physiol. 172, 363-369.
226. Sundell, K., Jutfelt, F., Agustsson, T., Olsen, R-E., Sandblom, E., Hansen, T., Björnsson, B.T., 2003. Intestinal transport mechanisms and plasma cortisol levels during normal and out-of-season parr-smolt transformation of Atlantic salmon, Salmo salar. Aquaculture 222, 265-285.
227. Sunyer, J.O., Tort, L., 1995. Natural hemolytic and bactericidal activities of seabream Sparus aurata are affected by the alternative complement pathway. Vet. Immunol. Immunopathol. 45, 333-345.
228. Sunyer, J.O., Tort, L., Lambris, J.D., 1997. Diversity of the third form of complement, C3, in fish: functional characterization of five forms of C3 in the diploid fish Sparus aurata. Biochem. J. 326, 877-881.
229. Tacon, A.G.J., 1993. Nutritional pathology: morphological signs of nutrient deficiency and toxicity in farmed fish. FAO Fisheries Technical Paper, no. 330. Rome, Food and Agriculture Organization, pp. 1-75.
230. Tacon, A.G.J., 1996. Lipid nutritional pathology in farmed fish. Arch. Anim. Nutr. 49, 33-39.
231. Tacon, A.G.J., Metian, M., 2008. Global overview on the use of fish meal and fish oil in industrially compounded aquafeeds: trends and future prospects. Aquaculture 285, 146-158.
232. Tafalla, C., Medina, I., Figueras, A., Novoa, B., 1999. Production of leukotriene B4 and prostaglandin E2 by turbot (Scophthalmus maximus) leucocytes determined by high performance liquid chromatography-diode array. Comp. Biochem. Physiol. 23B, 351-356.
233. Tafalla, C., Aranguren, R., Secombes, C.J., Figueras, A., Novoa, B., 2004. Cloning and analysis of expression of a gilthead seabream (Sparus aurata) Mx cDNA. Fish Shellfish Immunol. 16, 11-24.
234. Tannenbaum, B.M, Brindley, D.N., Tannenbaum, G.S., Dallman, M.F., McArthur, M.D., Meaney, M.J., 1997. High fat feeding alters both basal and stress-induced hypothalamicpituitary- adrenal activity in the rat. Am. J. Physiol. 273, 1168-1177.
235. Tatner, M.F., 1996. Natural changes in the immune system of fish. In: Iwama, G.K., Nakanishi, T. (Eds), The Fish Immune System. Fish Physiology, vol. 15. London, Academic Press, pp. 255-287.
236. Thompson, K.D., Tatner, M.F., Henderson, R.J., 1996. Effects of dietary (n-3) and (n-6) polyunsaturated fatty acid ratio on the immune response of Atlantic salmon (Salmo salar L.). Aquacult. Nutr. 2, 21-31.
237. Tocher, D.R., Sargent, J.R., 1986. Incorporation of (1-14C) arachidonic and (1-14C) eicosapentaenoic acids into the phospholipids of peripheral blood neutrophils from the plaice, Pleuronectes platessa L. Biochim. Biophys. Acta 876, 592-600.
238. Tocher, D.R., Bell, J.G., Farndale, B.M., Sargent, J.R., 1997. Effects of dietary γ-linolenic acid-rich borage oil combined with marine fish oils on tissue phospholipid fatty acid composition and production of prostaglandins E and F of the 1-, 2- and 3-series in a marine fish deficient in Δ5 fatty acyl desaturase. Prostaglandins Leukotrienes Essent. Fatty Acids 57, 125-134.
239. Torstensen, B.E., Bell, J.G., Sargent, J.R., Rosenlund, G., Henderson, R.J., Graff, I.E., Lie, Ø., Tocher, D.R., 2005. Tailoring of Atlantic salmon (Salmo salar L.) flesh lipid composition and sensory quality by replacing fish oil with a vegetable oil blend. J. Agricult. Food Chem. 53, 10166-10178.
240. Ushio, H., Ohshima, T., Koizumi, C., 1996. Fatty acid compositions in glycerophospholipids from brain lobes of rainbow trout, carp and skipjack tuna. Fish. Sci. 62, 126-133.
241. Van Anholt, R.D., Spanings, F.A.T., Koven, W.M., Nixon, O., Wendelaar Bonga, S.E., 2004. Arachidonic acid reduces the stress response of gilthead seabream Sparus aurata L. J. Exp. Biol. 207, 3419-3430.
242. Vegusdal, A., Gjøen, T., Berge, R.K., Thomassen, M.S., Ruyter, B., 2005. Effect of 8: 1n-9, 20: 5n-3, and 22: 6n-3 on lipid accumulation and secretion by Atlantic salmon hepatocytes. Lipids 40, 477-486.
243. Veillette, P.A., Sundell, K., Specker, J.L., 1995. Cortisol mediates the increase in intestinal fluid absorption in Atlantic salmon during parr-smolt transformation. Gen. Comp. Endocrinol. 97, 250-258.
244. Velin, A.K., Ericson, A.C., Braaf, Y., Wallon, C., Söderholm, J.D., 2004. Increased antigen and bacterial uptake in follicle associated epithelium induced by chronic psychological stress in rats. Gut 53, 494-500.
245. Waagbø, R., 1994. The impact of nutritional factors on the immune system in Atlantic salmon, Salmo salar L.: a review. Aquaculture Fisheries Management 25, 175-197.
246. Waagbø, R., 2006. Feeding and disease resistance in fish. In: Mosenthin, R., Zentec, J., Zebrowska, T. (Eds), Biology of Nutrition in Growing Animals. London, Elsevier, pp. 387-415.
247. Waagbø, R., Sandnes, K., Lie, Ø., Nilsen, E.R., 1993. Health aspects of dietary lipid sources and vitamin E in Atlantic salmon (Salmo salar): 1. Erythrocyte total lipid fatty acid composition, haematology and humoral immune response. Fiskeridir. Skr. Ser. Ernaer. 6, 47-62
248. Waagbø, R., Hemre, J., Holm, C.H.R., Lie, Ø., 1995. Tissue fatty acid composition, haematology and immunity in adult cod, Gadus morhua L., fed three dietary lipid sources. J. Fish Dis. 18, 615-622.
249. Waagbø, R., Bjerkas, E., Sveier, H., Breck, O., Bjørnestad, E., Maage, A., 1996. Nutritional status assessed in groups of smolting Atlantic salmon, Salmo salar L., developing cataracts. J. Fish Dis. 19, 365-373.
250. Waagbø, R., Hamre, K., Bjerkas, E., Berge, R., Wathne, E., Lie, Ø., Torstensen, B., 2003. Cataract formation in Atlantic salmon, Salmo salar L., smolt relative to dietary pro- and antioxidants and lipid level. J. Fish Dis. 26, 213-229.
251. Wagner, G.N., Balfry, S.K., Higgs, D.A., Lall, S.P., Farrell, A.P., 2004. Dietary fatty acid composition affects the repeat swimming performance of Atlantic salmon in seawater. Comp. Biochem. Physiol. 137A, 567-576.
252. Wallace, F.A., Miles, E.A., Evans, C., Stock, T.E., Yaqoob, P., Calder, P.C., 2001. Dietary fatty acids influence the production of Th1- but not Th2-type cytokines. J. Leuk. Biol. 69, 449-457.
253. Wassef, E.A., Wahby, O.M., Sakr, E.M., 2007. Effect of dietary vegetable oils on health and liver histology of gilthead seabream (Sparus aurata) growers. Aquacult. Res. 38, 852-861.
254. Watanabe, T., 2002. Strategies for further development of aquatic feeds. Fish. Sci. 68, 242-252.
255. Watanabe, T., Izquierdo, M.S., Takeuchi, T., Satoh, S.Y., Kitajima, C., 1989. Comparison between eicosapentaenoic and docosahexaenoic acids in terms of essential fatty acid efficacy in larval red seabream. Bull. Japan. Soc. Sci. Fish 55, 1635-1640.
256. Wedemeyer, G.A., 1997. Effects of rearing conditions on the health and physiological quality of fish in intensive culture. In: Iwama, G.K., Pickering, A.D., Sumpter, J.P., Schreck, C.B. (Eds), Fish Stress and Health in Aquaculture. Cambridge, Cambridge University Press, pp. 35-71.
257. Wendelaar-Bonga, S.E., 1997. The stress response in fish. Physiol. Rev. 77, 591-625.
258. Weyts, F.A., Verburg-van Kemenade, B.M., Flik, G., Lambert, J.G., Wendelaar-Bonga, S.E., 1997. Conservation of apoptosis as an immune regulatory mechanism: effects of cortisol and cortisone on carp lymphocytes. Brain Behav. Immun. 11, 95-105.
259. Wilson, C.M., Friesen, E.N., Higgs, D.A., Farrell, A.P., 2007. The effect of dietary and protein source on the swimming performance, recovery ability and oxygen consumption of Atlantic salmon (Salmo salar). Aquaculture 273, 687-699.
260. Wiseman, S.B., Osachoff, H., Bassett, E., Malhotra, J., Bruno, J., VanAggelen, G., Mommsen, T.P., Vijayan, M.M., 2007. Gene expression pattern in the liver during recovery from an acute stressor in rainbow trout. Comp. Biochem. Physiol. 2D, 234-244.
261. Yada, T., Nakanishi, T., 2002. Interaction between endocrine and immune system in fish. International Review of Cytology: A Survey of Cell Biology 220, 35-92.
262. Yamashita, T., Oda, E., Sano, T., Yamashita, T., Ijiru, Y., Giddings, J.C., Yamamoto, J., 2005. Varying the ratio of dietary n-6: n-3 polyunsaturated fatty acids alters the tendency to thrombosis and progress of atherosclerosis in apoE-/-LDLR-/- double knockout mouse. Thromb. Res. 116, 393-401.
263. Yano, T., 1996. The non-specific immune system: humoral defense. In: Iwama, G.K., Nakanishi, T. (Eds), The Fish Immune System. Fish Physiology, vol. 15. London, Academic Press, pp. 106-157.
264. Yaqoob, P., 2004. Fatty acids and the immune system: from basic science to clinical applications. Proc. Nutr. Soc. 63, 89-104.
265. Yaqoob, P., Calder, P.C., 1995. Effects of dietary lipid manipulation upon inflammatory mediator production by murine macrophages. Cell. Immunol. 163, 120-128.
266. Yaqoob, P., Calder, P.C., 2007. Fatty acid and immune function: new insights into mechanisms. Br. J. Nutr. 98, S41-S45.
267. Yaqoob, P., Newsholme, E.A., Calder, P.C., 1994a. The effect of dietary lipid manipulation on rat lymphocyte subsets and proliferation. Immunology 82, 603-610.
268. Yaqoob, P., Newsholme, E.A., Calder, P.C., 1994b. Inhibition of natural killer cell activity by dietary lipids. Immunol. Lett. 41, 241-247.
269. Yildiz, M., Sener, E., 2004. The effect of dietary oils of vegetable origin on performance, body composition and fatty acid profiles of sea bass (Dicentrarchus labrax L., 1758) juveniles. Turk. J. Vet. Anim. Sci. 28, 553-556.
270. Zapata, A.G., Varas, A., Torroba, M., 1992. Seasonal variations in the immune system of lower vertebrates. Immunol. Today 13, 142-147.
271. Zapata, A.G., Chibá, A., Varas, A., 1996. Cells and tissues of the immune system of fish. In: Iwama, G., Nakanish, T. (Eds), The Fish Immune System: Organism, Pathogen and Environment. London: Academic Press, pp. 1-62.
272. Zarkadis, I.K., Mastellos, D., Lambris, J.D., 2001. Phylogenetic aspects of the complement system. Dev. Comp. Immunol. 25, 745-762.