Relation between the fatty acid composition of peripheral blood mononuclear cells and measures of immune cell function in healthy, free-living subjects aged 25-72 y

American Journal of Clinical Nutrition

Volumn 77, Issue 5, 2003, Pages 1278-1286

  Kew, Samantha ^a   Banerjee, Tapati ^a   Minihane, Anne M ^b   Finnegan, Yvonne E ^b   Williams, Christine M ^b   Calder, Philip C ^a,c  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b UNIVERSITY OF READING   (United Kingdom)

^c UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

Cytokines; Fatty acid; Immunity; Lymphocytes; Monocytes; Neutrophils; Oxidative burst; Phagocytosis

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CONCANAVALIN A; FATTY ACID; GAMMA INTERFERON; OMEGA 3 FATTY ACID; PHOSPHOLIPID; POLYUNSATURATED FATTY ACID; CYTOKINE; UNSATURATED FATTY ACID;

ADULT; AGED; ARTICLE; BLOOD SAMPLING; CELL FUNCTION; CELL ISOLATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; FATTY ACID BLOOD LEVEL; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; LYMPHOCYTE PROLIFERATION; MONOCYTE; NEUTROPHIL; NORMAL HUMAN; NUTRITIONAL ASSESSMENT; PERIPHERAL BLOOD MONONUCLEAR CELL; PHAGOCYTOSIS; PHOSPHOLIPID BLOOD LEVEL; T LYMPHOCYTE; BIOSYNTHESIS; BLOOD; CHEMISTRY; CYTOLOGY; FEMALE; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; MONONUCLEAR CELL; REFERENCE VALUE; RESPIRATORY BURST;

BACTERIA (MICROORGANISMS);

ADULT; AGED; CYTOKINES; FATTY ACIDS, UNSATURATED; FEMALE; HUMANS; INTERFERON TYPE II; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; NEUTROPHILS; PHAGOCYTOSIS; PHOSPHOLIPIDS; REFERENCE VALUES; RESPIRATORY BURST;

EID: 0038474035     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/77.5.1278     Document Type: Article

References (46)

1. Calder PC. Dietary fatty acids and the immune system. Nutr Rev 1998;56:S70-83.
2. Calder PC, Yaqoob P, Thies F, Wallace FA, Miles EA. Fatty acids and lymphocyte functions. Br J Nutr 2002;87:S31-48.
3. Calder PC. Polyunsaturated fatty acids, inflammation and immunity. Lipids 2001;36:1007-24.
4. Calder PC. n-3 Polyunsaturated fatty acids, inflammation and immunity: pouring oil on troubled waters or just another fishy tale? Nutr Res 2001;21:309-41.
5. Caughey GE, Mantzioris E, Gibson RA, Cleland LG, James MJ. The effect on human tumor factor α and interleukin 1β production of diets enriched in n-3 fatty acids from vegetable oil or fish oil. Am J Clin Nutr 1996;63:116-22.
6. Kelley DS, Branch LB, Love JE, Taylor PC, Rivera YM, Iacono JM. Dietary alpha-linolenic acid and immunocompetence in humans. Am J Clin Nutr 1991;53:40-6.
7. Meydani SN, Endres S, Woods MM, et al. Oral (n-3) fatty acid supplementation suppresses cytokine and lymphocyte proliferation: comparison between young and older women. J Nutr 1991;121:547-55.
8. Meydani SN, Lichtenstein AH, Cornwall S, et al. Immunologic effects of national cholesterol education step-2 diets with and without fish-derived n-3 fatty acid enrichment. J Clin Invest 1993;92:105-13.
9. Endres S, Meydani SN, Ghorbani R, Schindler R, Dinarello CA. Dietary supplementation with n-3 fatty acids suppresses interleukin-2 production and mononuclear cell proliferation. J Leukoc Biol 1993;54:599-603.
10. Thies F, Nebe-von-Caron G, Powell JR, Yaqoob P, Newsholme EA, Calder PC. Dietary supplementation with gamma linolenic acid or fish oil decreases T lymphocyte proliferation in healthy older humans. J Nutr 2001;131:1918-27.
11. Endres S, Ghorbani R, Kelley VE, et al. The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. N Engl J Med 1989;320:265-71.
12. Gallai V, Sarchielli P, Trequattrini A, et al. Cytokine secretion and eicosanoid production in the peripheral blood mononuclear cells of MS patients undergoing dietary supplementation with n-3 polyunsaturated fatty acids. J Neuroimmunol 1993;56:143-53.
13. Thompson PJ, Misso NLA, Passarelli M, Phillips MJ. The effect of eicosapentaenoic acid consumption on human neutrophil chemiluminescence. Lipids 1991;26:1223-6.
14. Luostarinen R, Saldeen T. Dietary fish oil decreases superoxide generation by human neutrophils: relation to cyclooxygenase pathway and lysosomal enzyme release. Prostaglandins Leukot Essent Fatty Acids 1996;55:167-72.
15. Varming K, Schmidt EB, Svaneborg N, et al. The effect of n-3 fatty acids on neutrophil chemiluminescence. Scand J Clin Lab Invest 1995;55:47-52.
16. Fisher M, Levine PH, Weiner BH, et al. Dietary n-3 fatty acid supplementation reduces superoxide production and chemiluminescence in monocyte enriched preparation of leukocytes. Am J Clin Nutr 1990;51:804-8.
17. British Nutrition Foundation. Briefing paper: n-3 fatty acids and health. London: British Nutrition Foundation, 1999.
18. Lee TH, Hoover RL, Williams JD, et al. Effects of dietary enrichment with eicosapentaenoic and docosahexaenoic acids on in vitro neutrophil and monocyte leukotriene generation and neutrophil function. N Engl J Med 1985;312:1217-24.
19. Molvig J, Pociot F, Worsaae H, et al. Dietary supplementation with omega 3 polyunsaturated fatty acids decreases mononuclear cell proliferation and interleukin 1 beta content but not monokine secretion in healthy and insulin dependent diabetic individuals. Scand J Immunol 1991;34:399-410.
20. Sperling RI, Benincaso AI, Knoell CT, Larkin JK, Austen KF, Robinson DR. Dietary omega 3 polyunsaturated fatty acids inhibit phosphoinositide formation and chemotaxis in neutrophils. J Clin Invest 1993;91:651-60.
21. Gibney MJ, Hunter B. The effects of short term and long term supplementation with fish oil on the incorporation of n-3 polyunsaturated fatty acids into cells of the immune system in healthy volunteers. Eur J Clin Nutr 1993;47:255-9.
22. Yaqoob P, Pala HS, Cortina-Borja M, Newsholme EA, Calder PC. Encapsulated fish oil enriched in α-tocopherol alters plasma phospholipid and mononuclear cell fatty acid compositions but not mononuclear cell functions. Eur J Clin Invest 2000;30:260-74.
23. Healy DA, Wallace FA, Miles EA, Calder PC, Newsholme P. Effect of low to moderate amounts of dietary fish oil on neutrophil lipid composition and function. Lipids 2000;35:763-8.
24. Hartwell DL, Henry CJ. Comparison of a self-administered quantitative food amount frequency questionnaire with 4-d estimated food records. Int J Food Sci Nutr 2001;52:151-9.
25. Calder PC, Kew S. The immune system - a target for functional foods? Br J Nutr 2002;88:S165-75.
26. Lesourd B, Mazari L. Nutrition and immunity in the elderly. Proc Nutr Soc 1999;58:685-95.
27. Department of Health Report of the Panel on Dietary Reference Values of the Committee on Medical Aspects of Food Policy. Dietary reference values for food energy and nutrients for the United Kingdom. London: HMSO, 1994.
28. Alam R, Yatsu RM, Tsui L, Alam S. Receptor-mediated uptake and "retroendocytosis" of high-density lipoproteins by cholesterol-loaded human monocyte-derived macrophages; a possible role in enhancing reverse cholesterol transport. Biochim Biophys Acta 1989;1004:292-9.
29. Takahashi S, Kawarabayasi Y, Nakai T, Sakai J, Yamamoto T. Rabbit very low density lipoprotein receptor: a low-density lipoprotein receptor-like protein with distinct ligand specificity. Proc Natl Acad Sci U S A 1992;89:9252-6.
30. Krieger M, Hertz J. Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor related protein (LRP). Annu Rev Biochem 1994;63:601-37.
31. Endemann G, Stanton LW, Madden KS, Bryant CM, White RT, Potter AA. CD36 is a receptor for oxidized low-density lipoprotein. J Biol Chem 1993;268:1811-6.
32. Suzuki K, Hara M, Kitani A. Augmentation of LDL receptor activities on lymphocytes by interleukin-2 and anti CD3 antibody: a flow cytometric analysis. Biochim Biophys Acta 1990;1042:352-63.
33. De Sanctis JB, Blanca I, Adzioch D, Bianco NE. Lipoprotein lipase expression in natural killer cells and its role in their cytotoxic activity. Immunology 1994;83:232-9.
34. Nishiyama-Naruke A, Curi R. Phosphatidylcholine participates in the interaction between macrophages and lymphocytes. Am J Physiol 2000;278:C554-60.
35. Chapkin RS, Coble KJ, Utilization of gamma-linolenic acid by mouse peritoneal macrophages. Biochim Biophys Acta 1991;1085:365-70.
36. Chapkin RS, Miller CC, Somers SD, Erickson KL. Utilization of dihomo-γ-linolenic acid (8,11,14-eicosatrienoic acid) by murine peritoneal macrophages. Biochim Biophys Acta 1988;959:322-31.
37. Ferber E, De Pasquale GG, Resch K. Phospholipid metabolism of stimulated lymphocytes. Biochim Biophys Acta 1975;398:364-76.
38. Curtain CC, Looney FD, Marchalonis JJ, Raison JK. Changes in lipid ordering and state of aggregation in lymphocyte plasma membranes after exposure to mitogens. J Membr Biol 1978;44:211-32.
39. Anel A, Naval J, Gonzalez B, et al. Fatty acid metabolism in human lymphocytes. I. Time course changes in fatty acid composition and membrane fluidity during blastic transformation of peripheral blood lymphocytes. Biochim Biophys Acta 1990;1044:323-31.
40. Chandra RK. 1990 McCollum Award Lecture. Nutrition and immunity: lessons from the past and new insights into the future. Am J Clin Nutr 1991;53:1087-101.
41. Mahoney EM, Hamill AL, Scott WA, Cohn ZA. Response of endocytosis to altered fatty acyl composition of macrophage phospholipids. Proc Natl Acad Sci U S A 1977;74:4895-9.
42. Calder PC, Bond JA, Harvey DJ, Gordon S, Newsholme EA. Uptake and incorporation of saturated and unsaturated fatty acids into macrophage lipids and their effect upon macrophage adhesion and phagocytosis. Biochem J 1990;269:807-14.
43. Calder PC, Yaqoob P, Harvey DJ, Watts A, Newsholme EA. Incorporation of fatty acids by concanavalin A-stimulated lymphocytes and the effect on fatty acid composition and membrane fluidity. Biochem J 1994;300:509-18.
44. Miles EA, Calder PC. Modulation of immune function by dietary fatty acids. Proc Nutr Soc 1998;57:277-92.
45. Denys A, Hichami A, Khan NA. Eicosapentaenoic acid and docosahexaenoic acid modulate MAP kinase (ERK1/ERK2) signaling in human T cells. J Lipid Res 2001;42:2015-20.
46. Meydani M, Natiello F, Goldin B, et al. Effect of long-term fish oil supplementation on vitamin E status and lipid peroxidation in women. J Nutr 1991;121:484-91.