-
1
-
-
60049097909
-
The ribonome: a dominant force in co-ordinating gene expression
-
Mansfield, K.D. and Keene, J.D. (2009) The ribonome: a dominant force in co-ordinating gene expression. Biol. Cell, 101, 169-178.
-
(2009)
Biol. Cell.
, vol.101
, pp. 169-178
-
-
Mansfield, K.D.1
Keene, J.D.2
-
2
-
-
41349116135
-
The eukaryotic genome as an RNA machine
-
Amaral, P.P., Dinger, M.E., Mercer, T.R. and Mattick, J.S. (2008) The eukaryotic genome as an RNA machine. Science, 319, 1787-1789.
-
(2008)
Science
, vol.319
, pp. 1787-1789
-
-
Amaral, P.P.1
Dinger, M.E.2
Mercer, T.R.3
Mattick, J.S.4
-
3
-
-
37648999313
-
Distinguishing protein-coding and noncoding genes in the human genome
-
Clamp, M., Fry, B., Kamal, M., Xie, X., Cuff, J., Lin, M.F., Kellis, M., Lindblad-Toh, K. and Lander, E.S. (2007) Distinguishing protein-coding and noncoding genes in the human genome. Proc. Natl Acad. Sci. USA, 104, 19428-19433.
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 19428-19433
-
-
Clamp, M.1
Fry, B.2
Kamal, M.3
Xie, X.4
Cuff, J.5
Lin, M.F.6
Kellis, M.7
Lindblad-Toh, K.8
Lander, E.S.9
-
4
-
-
60349120914
-
Long non-coding RNAs: insights into functions
-
Mercer, T.R., Dinger, M.E. and Mattick, J.S. (2009) Long non-coding RNAs: insights into functions. Nat. Rev. Genet., 10, 155-159.
-
(2009)
Nat. Rev. Genet.
, vol.10
, pp. 155-159
-
-
Mercer, T.R.1
Dinger, M.E.2
Mattick, J.S.3
-
5
-
-
58449134534
-
Small silencing RNAs: an expanding universe
-
Ghildiyal, M. and Zamore, P.D. (2009) Small silencing RNAs: an expanding universe. Nat. Rev. Genet., 10, 94-108.
-
(2009)
Nat. Rev. Genet.
, vol.10
, pp. 94-108
-
-
Ghildiyal, M.1
Zamore, P.D.2
-
6
-
-
33747602081
-
RNA structural motifs: building blocks of a modular biomolecule
-
Hendrix, D.K., Brenner, S.E. and Holbrook, S.R. (2005) RNA structural motifs: building blocks of a modular biomolecule. Q. Rev. Biophys., 38, 221-243.
-
(2005)
Q. Rev. Biophys.
, vol.38
, pp. 221-243
-
-
Hendrix, D.K.1
Brenner, S.E.2
Holbrook, S.R.3
-
7
-
-
0033757940
-
Structural genomics of RNA
-
Doudna, J.A. (2000) Structural genomics of RNA. Nat. Struct. Biol., 7, 954-956.
-
(2000)
Nat. Struct. Biol.
, vol.7
, pp. 954-956
-
-
Doudna, J.A.1
-
8
-
-
33646580027
-
Hairpin RNA: a secondary structure of primary importance
-
Svoboda, P. and Di Cara, A. (2006) Hairpin RNA: a secondary structure of primary importance. Cell Mol. Life Sci., 63, 901-908.
-
(2006)
Cell Mol. Life Sci.
, vol.63
, pp. 901-908
-
-
Svoboda, P.1
Di Cara, A.2
-
9
-
-
59749098821
-
Frameshifting RNA pseudoknots: structure and mechanism
-
Giedroc, D.P. and Cornish, P.V. (2009) Frameshifting RNA pseudoknots: structure and mechanism. Virus Res., 139, 193-208.
-
(2009)
Virus Res
, vol.139
, pp. 193-208
-
-
Giedroc, D.P.1
Cornish, P.V.2
-
10
-
-
47649101029
-
Hunting G-quadruplexes
-
Huppert, J.L. (2008) Hunting G-quadruplexes. Biochimie., 90, 1140-1148.
-
(2008)
Biochimie
, vol.90
, pp. 1140-1148
-
-
Huppert, J.L.1
-
11
-
-
44449166478
-
RNA-binding proteins and post-transcriptional gene regulation
-
Glisovic, T., Bachorik, J.L., Yong, J. and Dreyfuss, G. (2008) RNA-binding proteins and post-transcriptional gene regulation. FEBS Lett., 582, 1977-1986.
-
(2008)
FEBS Lett
, vol.582
, pp. 1977-1986
-
-
Glisovic, T.1
Bachorik, J.L.2
Yong, J.3
Dreyfuss, G.4
-
12
-
-
34249316905
-
RNA-binding proteins: modular design for efficient function
-
Lunde, B.M., Moore, C. and Varani, G. (2007) RNA-binding proteins: modular design for efficient function. Nat. Rev. Mol. Cell Biol., 8, 479-490.
-
(2007)
Nat. Rev. Mol. Cell Biol.
, vol.8
, pp. 479-490
-
-
Lunde, B.M.1
Moore, C.2
Varani, G.3
-
13
-
-
18444383371
-
Protein families and RNA recognition
-
Chen, Y. and Varani, G. (2005) Protein families and RNA recognition. FEBS J., 272, 2088-2097.
-
(2005)
FEBS J
, vol.272
, pp. 2088-2097
-
-
Chen, Y.1
Varani, G.2
-
14
-
-
34250735674
-
RNA regulons: coordination of post-transcriptional events
-
Keene, J.D. (2007) RNA regulons: coordination of post-transcriptional events. Nat. Rev. Genet., 8, 533-543.
-
(2007)
Nat. Rev. Genet.
, vol.8
, pp. 533-543
-
-
Keene, J.D.1
-
15
-
-
60149086205
-
mRNA localization: gene expression in the spatial dimension
-
Martin, K.C. and Ephrussi, A. (2009) mRNA localization: gene expression in the spatial dimension. Cell, 136, 719-730.
-
(2009)
Cell
, vol.136
, pp. 719-730
-
-
Martin, K.C.1
Ephrussi, A.2
-
16
-
-
56749096054
-
Translational control of localized mRNAs: restricting protein synthesis in space and time
-
Besse, F. and Ephrussi, A. (2008) Translational control of localized mRNAs: restricting protein synthesis in space and time. Nat. Rev. Mol. Cell Biol., 9, 971-980.
-
(2008)
Nat. Rev. Mol. Cell Biol.
, vol.9
, pp. 971-980
-
-
Besse, F.1
Ephrussi, A.2
-
17
-
-
60149090021
-
The many pathways of RNA degradation
-
Houseley, J. and Tollervey, D. (2009) The many pathways of RNA degradation. Cell, 20, 763-776.
-
(2009)
Cell
, vol.20
, pp. 763-776
-
-
Houseley, J.1
Tollervey, D.2
-
18
-
-
0035955374
-
Identification of novel genes coding for small expressed RNAs
-
Lagos-Quintana, M., Rauhut, R., Lendeckel, W. and Tuschl, T. (2001) Identification of novel genes coding for small expressed RNAs. Science, 294, 853-858.
-
(2001)
Science
, vol.294
, pp. 853-858
-
-
Lagos-Quintana, M.1
Rauhut, R.2
Lendeckel, W.3
Tuschl, T.4
-
19
-
-
0035955361
-
An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans
-
Lau, N.C., Lim, L.P., Weinstein, E.G. and Bartel, D.P. (2001) An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science, 294, 858-862.
-
(2001)
Science
, vol.294
, pp. 858-862
-
-
Lau, N.C.1
Lim, L.P.2
Weinstein, E.G.3
Bartel, D.P.4
-
20
-
-
0035955366
-
An extensive class of small RNAs in Caenorhabditis elegans
-
Lee, R.C. and Ambros, V. (2001) An extensive class of small RNAs in Caenorhabditis elegans. Science, 294, 862-864.
-
(2001)
Science
, vol.294
, pp. 862-864
-
-
Lee, R.C.1
Ambros, V.2
-
21
-
-
38549150275
-
miRBase: tools for microRNA genomics
-
Griffiths-Jones, S., Saini, H.K., van Dongen, S. and Enright, A.J. (2008) miRBase: tools for microRNA genomics. Nucleic Acids Res., 36, D154-D158.
-
(2008)
Nucleic Acids Res
, vol.36
-
-
Griffiths-Jones, S.1
Saini, H.K.2
van Dongen, S.3
Enright, A.J.4
-
22
-
-
60149095444
-
Most mammalian mRNAs are conserved targets of microRNAs
-
Friedman, R.C., Farh, K.K., Burge, C.B. and Bartel, D.P. (2009) Most mammalian mRNAs are conserved targets of microRNAs. Genome Res., 19, 92-105.
-
(2009)
Genome Res
, vol.19
, pp. 92-105
-
-
Friedman, R.C.1
Farh, K.K.2
Burge, C.B.3
Bartel, D.P.4
-
23
-
-
8144225486
-
MicroRNA genes are transcribed by RNA polymerase II
-
Lee, Y., Kim, M., Han, J., Yeom, K.H., Lee, S., Baek, S.H. and Kim, V.N. (2004) MicroRNA genes are transcribed by RNA polymerase II. EMBO J., 23, 4051-4060.
-
(2004)
EMBO J
, vol.23
, pp. 4051-4060
-
-
Lee, Y.1
Kim, M.2
Han, J.3
Yeom, K.H.4
Lee, S.5
Baek, S.H.6
Kim, V.N.7
-
24
-
-
0141843656
-
The nuclear RNase III Drosha initiates microRNA processing
-
Lee, Y., Ahn, C., Han, J., Choi, H., Kim, J., Yim, J., Lee, J., Provost, P., Rådmark, O. and Kim, S. (2003) The nuclear RNase III Drosha initiates microRNA processing. Nature, 425, 415-419.
-
(2003)
Nature
, vol.425
, pp. 415-419
-
-
Lee, Y.1
Ahn, C.2
Han, J.3
Choi, H.4
Kim, J.5
Yim, J.6
Lee, J.7
Provost, P.8
Rådmark, O.9
Kim, S.10
-
25
-
-
10344248903
-
The human DiGeorge syndrome critical region gene 8 and Its D. melanogaster homolog are required for miRNA biogenesis
-
Landthaler, M., Yalcin, A. and Tuschl, T. (2004) The human DiGeorge syndrome critical region gene 8 and Its D. melanogaster homolog are required for miRNA biogenesis. Curr. Biol., 14, 2162-2167.
-
(2004)
Curr. Biol.
, vol.14
, pp. 2162-2167
-
-
Landthaler, M.1
Yalcin, A.2
Tuschl, T.3
-
26
-
-
9144224451
-
Processing of primary microRNAs by the Microprocessor complex
-
Denli, A.M., Tops, B.B., Plasterk, R.H., Ketting, R.F. and Hannon, G.J. (2004) Processing of primary microRNAs by the Microprocessor complex. Nature, 432, 231-235.
-
(2004)
Nature
, vol.432
, pp. 231-235
-
-
Denli, A.M.1
Tops, B.B.2
Plasterk, R.H.3
Ketting, R.F.4
Hannon, G.J.5
-
27
-
-
9144225636
-
The Microprocessor complex mediates the genesis of microRNAs
-
Gregory, R.I., Yan, K.P., Amuthan, G., Chendrimada, T., Doratotaj, B., Cooch, N. and Shiekhattar, R. (2004) The Microprocessor complex mediates the genesis of microRNAs. Nature, 432, 235-240.
-
(2004)
Nature
, vol.432
, pp. 235-240
-
-
Gregory, R.I.1
Yan, K.P.2
Amuthan, G.3
Chendrimada, T.4
Doratotaj, B.5
Cooch, N.6
Shiekhattar, R.7
-
28
-
-
0347988235
-
Nuclear export of microRNA precursors
-
Lund, E., Güttinger, S., Calado, A., Dahlberg, J.E. and Kutay, U. (2004) Nuclear export of microRNA precursors. Science, 303, 95-98.
-
(2004)
Science
, vol.303
, pp. 95-98
-
-
Lund, E.1
Güttinger, S.2
Calado, A.3
Dahlberg, J.E.4
Kutay, U.5
-
29
-
-
27744537851
-
Human RISC couples microRNA biogenesis and posttranscriptional gene silencing
-
Gregory, R.I., Chendrimada, T.P., Cooch, N. and Shiekhattar, R. (2005) Human RISC couples microRNA biogenesis and posttranscriptional gene silencing. Cell, 123, 631-640.
-
(2005)
Cell
, vol.123
, pp. 631-640
-
-
Gregory, R.I.1
Chendrimada, T.P.2
Cooch, N.3
Shiekhattar, R.4
-
30
-
-
11844278458
-
Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
-
Lewis, B.P., Burge, C.B. and Bartel, D.P. (2005) Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell, 120, 15-20.
-
(2005)
Cell
, vol.120
, pp. 15-20
-
-
Lewis, B.P.1
Burge, C.B.2
Bartel, D.P.3
-
31
-
-
0037031576
-
Single-stranded antisense siRNAs guide target RNA cleavage in RNAi
-
Martinez, J., Patkaniowska, A., Urlaub, H., Lührmann, R. and Tuschl, T. (2002) Single-stranded antisense siRNAs guide target RNA cleavage in RNAi. Cell, 110, 563-574.
-
(2002)
Cell
, vol.110
, pp. 563-574
-
-
Martinez, J.1
Patkaniowska, A.2
Urlaub, H.3
Lührmann, R.4
Tuschl, T.5
-
32
-
-
0036752955
-
Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways
-
Schwarz, D.S., Hutvágner, G., Haley, B. and Zamore, P.D. (2002) Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways. Mol. Cell, 10, 537-548.
-
(2002)
Mol. Cell.
, vol.10
, pp. 537-548
-
-
Schwarz, D.S.1
Hutvágner, G.2
Haley, B.3
Zamore, P.D.4
-
33
-
-
0038074374
-
Similar behaviour of single-strand and double-strand siRNAs suggests they act through a common RNAi pathway
-
Holen, T., Amarzguioui, M., Babaie, E. and Prydz, H. (2003) Similar behaviour of single-strand and double-strand siRNAs suggests they act through a common RNAi pathway. Nucleic Acids Res., 31, 2401-2407.
-
(2003)
Nucleic Acids Res
, vol.31
, pp. 2401-2407
-
-
Holen, T.1
Amarzguioui, M.2
Babaie, E.3
Prydz, H.4
-
34
-
-
4344705410
-
Small interfering RNA-induced transcriptional gene silencing in human cells
-
Morris, K.V., Chan, S.W., Jacobsen, S.E. and Looney, D.J. (2004) Small interfering RNA-induced transcriptional gene silencing in human cells. Science, 30, 1289-1292.
-
(2004)
Science
, vol.30
, pp. 1289-1292
-
-
Morris, K.V.1
Chan, S.W.2
Jacobsen, S.E.3
Looney, D.J.4
-
35
-
-
66249108936
-
Promoter targeted small RNAs induce long-term transcriptional gene silencing in human cells
-
Hawkins, P.G., Santoso, S., Adams, C., Anest, V. and Morris, K.V. (2009) Promoter targeted small RNAs induce long-term transcriptional gene silencing in human cells. Nucleic Acids Res., 37, 2984-2995.
-
(2009)
Nucleic Acids Res
, vol.37
, pp. 2984-2995
-
-
Hawkins, P.G.1
Santoso, S.2
Adams, C.3
Anest, V.4
Morris, K.V.5
-
36
-
-
31044433795
-
The antisense strand of small interfering RNAs directs histone methylation and transcriptional gene silencing in human cells
-
Weinberg, M.S., Villeneuve, L.M., Ehsani, A., Amarzguioui, M., Aagaard, L., Chen, Z.X., Riggs, A.D., Rossi, J.J. and Morris, K.V. (2006) The antisense strand of small interfering RNAs directs histone methylation and transcriptional gene silencing in human cells. RNA, 12, 256-262.
-
(2006)
RNA
, vol.12
, pp. 256-262
-
-
Weinberg, M.S.1
Villeneuve, L.M.2
Ehsani, A.3
Amarzguioui, M.4
Aagaard, L.5
Chen, Z.X.6
Riggs, A.D.7
Rossi, J.J.8
Morris, K.V.9
-
37
-
-
22844448088
-
Functional polarity is introduced by Dicer processing of short substrate RNAs
-
Rose, S.D., Kim, D.H., Amarzguioui, M., Heidel, J.D., Collingwood, M.A., Davis, M.E., Rossi, J.J. and Behlke, M.A. (2005) Functional polarity is introduced by Dicer processing of short substrate RNAs. Nucleic Acids Res., 33, 4140-4156.
-
(2005)
Nucleic Acids Res
, vol.33
, pp. 4140-4156
-
-
Rose, S.D.1
Kim, D.H.2
Amarzguioui, M.3
Heidel, J.D.4
Collingwood, M.A.5
Davis, M.E.6
Rossi, J.J.7
Behlke, M.A.8
-
38
-
-
33747748975
-
Rational design and in vitro and in vivo delivery of Dicer substrate siRNA
-
Amarzguioui, M., Lundberg, P., Cantin, E., Hagstrom, J., Behlke, M.A. and Rossi, J.J. (2006) Rational design and in vitro and in vivo delivery of Dicer substrate siRNA. Nat. Protoc., 1, 508-517.
-
(2006)
Nat. Protoc.
, vol.1
, pp. 508-517
-
-
Amarzguioui, M.1
Lundberg, P.2
Cantin, E.3
Hagstrom, J.4
Behlke, M.A.5
Rossi, J.J.6
-
39
-
-
13844281898
-
Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy
-
Kim, D.H., Behlke, M.A., Rose, S.D., Chang, M.S., Choi, S. and Rossi, J.J. (2005) Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy. Nat. Biotechnol., 23, 222-226.
-
(2005)
Nat. Biotechnol.
, vol.23
, pp. 222-226
-
-
Kim, D.H.1
Behlke, M.A.2
Rose, S.D.3
Chang, M.S.4
Choi, S.5
Rossi, J.J.6
-
40
-
-
0036273940
-
Gene silencing using micro-RNA designed hairpins
-
McManus, M.T., Petersen, C.P., Haines, B.B., Chen, J. and Sharp, P.A. (2002) Gene silencing using micro-RNA designed hairpins. RNA, 8, 842-850.
-
(2002)
RNA
, vol.8
, pp. 842-850
-
-
McManus, M.T.1
Petersen, C.P.2
Haines, B.B.3
Chen, J.4
Sharp, P.A.5
-
41
-
-
0037009520
-
Two classes of short interfering RNA in RNA silencing
-
Hamilton, A., Voinnet, O., Chappell, L. and Baulcombe, D. (2002) Two classes of short interfering RNA in RNA silencing. EMBO J., 21, 4671-4679.
-
(2002)
EMBO J
, vol.21
, pp. 4671-4679
-
-
Hamilton, A.1
Voinnet, O.2
Chappell, L.3
Baulcombe, D.4
-
42
-
-
0037089589
-
Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells
-
Paddison, P.J., Caudy, A.A., Bernstein, E., Hannon, G.J. and Conklin, D.S. (2002) Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells. Genes Dev., 16, 948-958.
-
(2002)
Genes Dev
, vol.16
, pp. 948-958
-
-
Paddison, P.J.1
Caudy, A.A.2
Bernstein, E.3
Hannon, G.J.4
Conklin, D.S.5
-
43
-
-
34548442961
-
Nuclear transcription of long hairpin RNA triggers innate immune responses
-
Gantier, M.P., Baugh, J.A. and Donnelly, S.C. (2007) Nuclear transcription of long hairpin RNA triggers innate immune responses. J. Interferon Cytokine Res., 27, 789-797.
-
(2007)
J. Interferon Cytokine Res.
, vol.27
, pp. 789-797
-
-
Gantier, M.P.1
Baugh, J.A.2
Donnelly, S.C.3
-
44
-
-
33747754760
-
Lessons from Nature: microRNA-based shRNA libraries
-
Chang, K., Elledge, S.J. and Hannon, G.J. (2006) Lessons from Nature: microRNA-based shRNA libraries. Nat. Methods, 3, 707-714.
-
(2006)
Nat. Methods
, vol.3
, pp. 707-714
-
-
Chang, K.1
Elledge, S.J.2
Hannon, G.J.3
-
45
-
-
38949133928
-
MicroRNAs as targets for antisense-based therapeutics
-
Stenvang, J. and Kauppinen, S. (2008) MicroRNAs as targets for antisense-based therapeutics. Expert Opin. Biol. Ther., 8, 59-81.
-
(2008)
Expert Opin. Biol. Ther.
, vol.8
, pp. 59-81
-
-
Stenvang, J.1
Kauppinen, S.2
-
46
-
-
38049066025
-
Lentivirus-mediated antagomir expression for specific inhibition of miRNA function
-
Scherr, M., Venturini, L., Battmer, K., Schaller-Schoenitz, M., Schaefer, D., Dallmann, I., Ganser, A. and Eder, M. (2007) Lentivirus-mediated antagomir expression for specific inhibition of miRNA function. Nucleic Acids Res., 35, e149.
-
(2007)
Nucleic Acids Res
, vol.35
-
-
Scherr, M.1
Venturini, L.2
Battmer, K.3
Schaller-Schoenitz, M.4
Schaefer, D.5
Dallmann, I.6
Ganser, A.7
Eder, M.8
-
47
-
-
28444469246
-
Silencing of microRNAs in vivo with 'antagomirs'
-
Krützfeldt, J., Rajewsky, N., Braich, R., Rajeev, K.G., Tuschl, T., Manoharan, M. and Stoffel, M. (2005) Silencing of microRNAs in vivo with 'antagomirs'. Nature, 438, 685-689.
-
(2005)
Nature
, vol.438
, pp. 685-689
-
-
Krützfeldt, J.1
Rajewsky, N.2
Braich, R.3
Rajeev, K.G.4
Tuschl, T.5
Manoharan, M.6
Stoffel, M.7
-
48
-
-
34548316982
-
MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells
-
Ebert, M.S., Neilson, J.R. and Sharp, P.A. (2007) MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells. Nat. Methods, 4, 721-726.
-
(2007)
Nat. Methods
, vol.4
, pp. 721-726
-
-
Ebert, M.S.1
Neilson, J.R.2
Sharp, P.A.3
-
49
-
-
64549109671
-
Vectors expressing efficient RNA decoys achieve the long-term suppression of specific microRNA activity in mammalian cells
-
Haraguchi, T., Ozaki, Y. and Iba, H. (2009) Vectors expressing efficient RNA decoys achieve the long-term suppression of specific microRNA activity in mammalian cells. Nucleic Acids Res., 37, e43.
-
(2009)
Nucleic Acids Res
, vol.37
-
-
Haraguchi, T.1
Ozaki, Y.2
Iba, H.3
-
50
-
-
34547497309
-
Target mimicry provides a new mechanism for regulation of microRNA activity
-
Franco-Zorrilla, J.M., Valli, A., Todesco, M., Mateos, I., Puga, M.I., Rubio-Somoza, I., Leyva, A., Weigel, D., García, J.A. and Paz-Ares, J. (2007) Target mimicry provides a new mechanism for regulation of microRNA activity. Nat. Genet., 39, 1033-1037.
-
(2007)
Nat. Genet.
, vol.39
, pp. 1033-1037
-
-
Franco-Zorrilla, J.M.1
Valli, A.2
Todesco, M.3
Mateos, I.4
Puga, M.I.5
Rubio-Somoza, I.6
Leyva, A.7
Weigel, D.8
García, J.A.9
Paz-Ares, J.10
-
51
-
-
35348914716
-
Target protectors reveal dampening and balancing of Nodal agonist and antagonist by miR-430
-
Choi, W.Y., Giraldez, A.J. and Schier, A.F. (2007) Target protectors reveal dampening and balancing of Nodal agonist and antagonist by miR-430. Science, 318, 271-274.
-
(2007)
Science
, vol.318
, pp. 271-274
-
-
Choi, W.Y.1
Giraldez, A.J.2
Schier, A.F.3
-
52
-
-
33751264968
-
Synthetic microRNA designed to target glioma-associated antigen 1 transcription factor inhibits division and induces late apoptosis in pancreatic tumor cells
-
Tsuda, N., Ishiyama, S., Li, Y., Ioannides, C.G., Abbruzzese, J.L. and Chang, D.Z. (2006) Synthetic microRNA designed to target glioma-associated antigen 1 transcription factor inhibits division and induces late apoptosis in pancreatic tumor cells. Clin. Cancer Res., 12, 6557-6564.
-
(2006)
Clin. Cancer Res.
, vol.12
, pp. 6557-6564
-
-
Tsuda, N.1
Ishiyama, S.2
Li, Y.3
Ioannides, C.G.4
Abbruzzese, J.L.5
Chang, D.Z.6
-
53
-
-
34249817549
-
Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis
-
Chang, T.C., Wentzel, E.A., Kent, O.A., Ramachandran, K., Mullendore, M., Lee, K.H., Feldmann, G., Yamakuchi, M., Ferlito, M., Lowenstein, C.J. et al. (2007) Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. Mol. Cell, 26, 745-752.
-
(2007)
Mol. Cell.
, vol.26
, pp. 745-752
-
-
Chang, T.C.1
Wentzel, E.A.2
Kent, O.A.3
Ramachandran, K.4
Mullendore, M.5
Lee, K.H.6
Feldmann, G.7
Yamakuchi, M.8
Ferlito, M.9
Lowenstein, C.J.10
-
54
-
-
33947224690
-
Transcripts targeted by the microRNA-16 family cooperatively regulate cell cycle progression
-
Linsley, P.S., Schelter, J., Burchard, J., Kibukawa, M., Martin, M.M., Bartz, S.R., Johnson, J.M., Cummins, J.M., Raymond, C.K., Dai, H. et al. (2007) Transcripts targeted by the microRNA-16 family cooperatively regulate cell cycle progression. Mol. Cell Biol., 27, 2240-2252.
-
(2007)
Mol. Cell Biol.
, vol.27
, pp. 2240-2252
-
-
Linsley, P.S.1
Schelter, J.2
Burchard, J.3
Kibukawa, M.4
Martin, M.M.5
Bartz, S.R.6
Johnson, J.M.7
Cummins, J.M.8
Raymond, C.K.9
Dai, H.10
-
55
-
-
67349215495
-
Lipid-based systemic delivery of siRNA
-
Tseng, Y.C., Mozumdar, S. and Huang, L. (2009) Lipid-based systemic delivery of siRNA. Adv. Drug Deliv. Rev., 61, 721-731.
-
(2009)
Adv. Drug Deliv. Rev.
, vol.61
, pp. 721-731
-
-
Tseng, Y.C.1
Mozumdar, S.2
Huang, L.3
-
56
-
-
65449128109
-
The potential of modulating small RNA activity in vivo
-
van Mil, A., Doevendans, P.A. and Sluijter, J.P. (2009) The potential of modulating small RNA activity in vivo. Mini Rev. Med. Chem., 9, 235-248.
-
(2009)
Mini Rev. Med. Chem.
, vol.9
, pp. 235-248
-
-
van Mil, A.1
Doevendans, P.A.2
Sluijter, J.P.3
-
57
-
-
0037422066
-
Regulated portals of entry into the cell
-
Conner, S.D. and Schmid, S.L. (2003) Regulated portals of entry into the cell. Nature, 422, 37-44.
-
(2003)
Nature
, vol.422
, pp. 37-44
-
-
Conner, S.D.1
Schmid, S.L.2
-
59
-
-
35348861314
-
Cellular uptake and intracellular release are major obstacles to the therapeutic application of siRNA: novel options by phosphorothioate-stimulated delivery
-
Mescalchin, A., Detzer, A., Wecke, M., Overhoff, M., Wünsche, W. and Sczakiel, G. (2007) Cellular uptake and intracellular release are major obstacles to the therapeutic application of siRNA: novel options by phosphorothioate-stimulated delivery. Expert Opin. Biol. Ther., 7, 1531-1538.
-
(2007)
Expert Opin. Biol. Ther.
, vol.7
, pp. 1531-1538
-
-
Mescalchin, A.1
Detzer, A.2
Wecke, M.3
Overhoff, M.4
Wünsche, W.5
Sczakiel, G.6
-
60
-
-
59849103061
-
Drug delivery of siRNA therapeutics: potentials and limits of nanosystems
-
Reischl, D. and Zimmer, A. (2009) Drug delivery of siRNA therapeutics: potentials and limits of nanosystems. Nanomedicine, 5, 8-20.
-
(2009)
Nanomedicine
, vol.5
, pp. 8-20
-
-
Reischl, D.1
Zimmer, A.2
-
61
-
-
0037124051
-
Lipoplex-mediated transfection of mammalian cells occurs through the cholesterol-dependent clathrin-mediated pathway of endocytosis
-
Zuhorn, I.S., Kalicharan, R. and Hoekstra, D. (2002) Lipoplex-mediated transfection of mammalian cells occurs through the cholesterol-dependent clathrin-mediated pathway of endocytosis. J. Biol. Chem., 277, 18021-18028.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 18021-18028
-
-
Zuhorn, I.S.1
Kalicharan, R.2
Hoekstra, D.3
-
62
-
-
37549032712
-
Breaking the bonds: non-viral vectors become chemically dynamic
-
Wolff, J.A. and Rozema, D.B. (2008) Breaking the bonds: non-viral vectors become chemically dynamic. Mol. Ther., 16, 8-15.
-
(2008)
Mol. Ther.
, vol.16
, pp. 8-15
-
-
Wolff, J.A.1
Rozema, D.B.2
-
63
-
-
47249138782
-
Mechanisms and strategies for effective delivery of antisense and siRNA oligonucleotides
-
Juliano, R., Alam, M.R., Dixit, V. and Kang, H. (2008) Mechanisms and strategies for effective delivery of antisense and siRNA oligonucleotides. Nucleic Acids Res., 36, 4158-4171.
-
(2008)
Nucleic Acids Res
, vol.36
, pp. 4158-4171
-
-
Juliano, R.1
Alam, M.R.2
Dixit, V.3
Kang, H.4
-
64
-
-
33847036990
-
Strategies for silencing human disease using RNA interference
-
Kim, D.H. and Rossi, J.J. (2007) Strategies for silencing human disease using RNA interference. Nat. Rev. Genet., 8, 173-184.
-
(2007)
Nat. Rev. Genet.
, vol.8
, pp. 173-184
-
-
Kim, D.H.1
Rossi, J.J.2
-
65
-
-
59349116903
-
Knocking down barriers: advances in siRNA delivery
-
Whitehead, K.A., Langer, R. and Anderson, D.G. (2009) Knocking down barriers: advances in siRNA delivery. Nat. Rev. Drug Discov., 8, 129-138.
-
(2009)
Nat. Rev. Drug Discov.
, vol.8
, pp. 129-138
-
-
Whitehead, K.A.1
Langer, R.2
Anderson, D.G.3
-
66
-
-
58749104364
-
The promises and pitfalls of RNA-interference-based therapeutics
-
Castanotto, D. and Rossi, J.J. (2009) The promises and pitfalls of RNA-interference-based therapeutics. Nature, 457, 426-433.
-
(2009)
Nature
, vol.457
, pp. 426-433
-
-
Castanotto, D.1
Rossi, J.J.2
-
67
-
-
66249105368
-
siRNA and innate immunity
-
Robbins, M., Judge, A. and MacLachlan, I. (2009) siRNA and innate immunity. Oligonucleotides, 19, 89-102.
-
(2009)
Oligonucleotides
, vol.19
, pp. 89-102
-
-
Robbins, M.1
Judge, A.2
MacLachlan, I.3
-
68
-
-
42649103333
-
Does the understanding of immune activation by RNA predict the design of safe siRNAs?
-
Sioud, M. (2008) Does the understanding of immune activation by RNA predict the design of safe siRNAs? Front Biosci., 13, 4379-4392.
-
(2008)
Front Biosci
, vol.13
, pp. 4379-4392
-
-
Sioud, M.1
-
69
-
-
20444395838
-
Immune responses to dsRNA: implications for gene silencing technologies
-
Karpala, A.J., Doran, T.J. and Bean, A.G. (2005) Immune responses to dsRNA: implications for gene silencing technologies. Immunol. Cell Biol., 83, 211-216.
-
(2005)
Immunol. Cell Biol.
, vol.83
, pp. 211-216
-
-
Karpala, A.J.1
Doran, T.J.2
Bean, A.G.3
-
70
-
-
33745299723
-
Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways
-
Grimm, D., Streetz, K.L., Jopling, C.L., Storm, T.A., Pandey, K., Davis, C.R., Marion, P., Salazar, F. and Kay, M.A. (2006) Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways. Nature, 441, 537-541.
-
(2006)
Nature
, vol.441
, pp. 537-541
-
-
Grimm, D.1
Streetz, K.L.2
Jopling, C.L.3
Storm, T.A.4
Pandey, K.5
Davis, C.R.6
Marion, P.7
Salazar, F.8
Kay, M.A.9
-
71
-
-
12844285548
-
Overexpression of exportin 5 enhances RNA interference mediated by short hairpin RNAs and microRNAs
-
Yi, R., Doehle, B.P., Qin, Y., Macara, I.G. and Cullen, B.R. (2005) Overexpression of exportin 5 enhances RNA interference mediated by short hairpin RNAs and microRNAs. RNA, 11, 220-226.
-
(2005)
RNA
, vol.11
, pp. 220-226
-
-
Yi, R.1
Doehle, B.P.2
Qin, Y.3
Macara, I.G.4
Cullen, B.R.5
-
72
-
-
0037685280
-
Expression profiling reveals off-target gene regulation by RNAi
-
Jackson, A.L., Bartz, S.R., Schelter, J., Kobayashi, S.V., Burchard, J., Mao, M., Li, B., Cavet, G. and Linsley, P.S. (2003) Expression profiling reveals off-target gene regulation by RNAi. Nat. Biotechnol., 21, 635-637.
-
(2003)
Nat. Biotechnol.
, vol.21
, pp. 635-637
-
-
Jackson, A.L.1
Bartz, S.R.2
Schelter, J.3
Kobayashi, S.V.4
Burchard, J.5
Mao, M.6
Li, B.7
Cavet, G.8
Linsley, P.S.9
-
73
-
-
33745608078
-
Off-target effects by siRNA can induce toxic phenotype
-
Fedorov, Y., Anderson, E.M., Birmingham, A., Reynolds, A., Karpilow, J., Robinson, K., Leake, D., Marshall, W.S. and Khvorova, A. (2006) Off-target effects by siRNA can induce toxic phenotype. RNA, 12, 118811-118896.
-
(2006)
RNA
, vol.12
, pp. 118811-118896
-
-
Fedorov, Y.1
Anderson, E.M.2
Birmingham, A.3
Reynolds, A.4
Karpilow, J.5
Robinson, K.6
Leake, D.7
Marshall, W.S.8
Khvorova, A.9
-
74
-
-
27944459341
-
Activation of the mammalian immune system by siRNAs
-
Marques, J.T. and Williams, B.R. (2005) Activation of the mammalian immune system by siRNAs. Nat. Biotechnol., 23, 1399-1405.
-
(2005)
Nat. Biotechnol.
, vol.23
, pp. 1399-1405
-
-
Marques, J.T.1
Williams, B.R.2
-
75
-
-
0017180822
-
Interferon-induced inhibition of protein synthesis in L-cell extracts: an ATP-dependent step in the activation of an inhibitor by double-stranded RNA
-
Roberts, W.K., Clemens, M.J. and Kerr, I.M. (1976) Interferon-induced inhibition of protein synthesis in L-cell extracts: an ATP-dependent step in the activation of an inhibitor by double-stranded RNA. Proc. Natl Acad. Sci. USA, 73, 3136-3140.
-
(1976)
Proc. Natl Acad. Sci. USA
, vol.73
, pp. 3136-3140
-
-
Roberts, W.K.1
Clemens, M.J.2
Kerr, I.M.3
-
76
-
-
0002864972
-
Interferon action: two distinct pathways for inhibition of protein synthesis by double-stranded RNA
-
Farrell, P.J., Sen, G.C., Dubois, M.F., Ratner, L., Slattery, E. and Lengyel, P. (1978) Interferon action: two distinct pathways for inhibition of protein synthesis by double-stranded RNA. Proc. Natl Acad. Sci. USA, 75, 5893-5897.
-
(1978)
Proc. Natl Acad. Sci. USA
, vol.75
, pp. 5893-5897
-
-
Farrell, P.J.1
Sen, G.C.2
Dubois, M.F.3
Ratner, L.4
Slattery, E.5
Lengyel, P.6
-
77
-
-
0035909372
-
Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
-
Alexopoulou, L., Holt, A.C., Medzhitov, R. and Flavell, R.A. (2001) Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature, 413, 732-738.
-
(2001)
Nature
, vol.413
, pp. 732-738
-
-
Alexopoulou, L.1
Holt, A.C.2
Medzhitov, R.3
Flavell, R.A.4
-
78
-
-
0035971150
-
Functional characterization of and cooperation between the double-stranded RNA-binding motifs of the protein kinase PKR
-
Tian, B. and Mathews, M.B. (2001) Functional characterization of and cooperation between the double-stranded RNA-binding motifs of the protein kinase PKR. J. Biol. Chem., 276, 9936-9944.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 9936-9944
-
-
Tian, B.1
Mathews, M.B.2
-
79
-
-
25144477805
-
Mechanistic link between PKR dimerization, autophosphorylation, and eIF2alpha substrate recognition
-
Dey, M., Cao, C., Dar, A.C., Tamura, T., Ozato, K., Sicheri, F. and Dever, T.E. (2005) Mechanistic link between PKR dimerization, autophosphorylation, and eIF2alpha substrate recognition. Cell, 122, 901-913.
-
(2005)
Cell
, vol.122
, pp. 901-913
-
-
Dey, M.1
Cao, C.2
Dar, A.C.3
Tamura, T.4
Ozato, K.5
Sicheri, F.6
Dever, T.E.7
-
80
-
-
0027105279
-
Two RNA-binding motifs in the double-stranded RNA-activated protein kinase
-
Green, S.R. and Mathews, M.B. (1992) Two RNA-binding motifs in the double-stranded RNA-activated protein kinase, DAI. Genes Dev., 6, 2478-2490.
-
(1992)
DAI. Genes Dev.
, vol.6
, pp. 2478-2490
-
-
Green, S.R.1
Mathews, M.B.2
-
81
-
-
0026713151
-
Interactions between double-stranded RNA regulators and the protein kinase DAI
-
Manche, L., Green, S.R., Schmedt, C. and Mathews, M.B. (1992) Interactions between double-stranded RNA regulators and the protein kinase DAI. Mol. Cell Biol., 12, 5238-5248.
-
(1992)
Mol. Cell Biol.
, vol.12
, pp. 5238-5248
-
-
Manche, L.1
Green, S.R.2
Schmedt, C.3
Mathews, M.B.4
-
82
-
-
0026716253
-
Mechanism of interferon action: cDNA structure, expression, and regulation of the interferon-induced, RNA-dependent P1/eIF-2 alpha protein kinase from human cells
-
Thomis, D.C., Doohan, J.P. and Samuel, C.E. (1992) Mechanism of interferon action: cDNA structure, expression, and regulation of the interferon-induced, RNA-dependent P1/eIF-2 alpha protein kinase from human cells. Virology, 188, 33-46.
-
(1992)
Virology
, vol.188
, pp. 33-46
-
-
Thomis, D.C.1
Doohan, J.P.2
Samuel, C.E.3
-
83
-
-
0027421163
-
Organization of the double-stranded RNA-activated protein kinase DAI and virus-associated VA RNAI in adenovirus-2-infected HeLa cells
-
Jiménez-García, L.F., Green, S.R., Mathews, M.B. and Spector, D.L. (1993) Organization of the double-stranded RNA-activated protein kinase DAI and virus-associated VA RNAI in adenovirus-2-infected HeLa cells. J. Cell Sci., 106, 11-22.
-
(1993)
J. Cell Sci.
, vol.106
, pp. 11-22
-
-
Jiménez-García, L.F.1
Green, S.R.2
Mathews, M.B.3
Spector, D.L.4
-
84
-
-
30444452652
-
Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the elF2a RNA-dependent protein kinase
-
Su, Q., Wang, S., Baltzis, D., Qu, L., Wong, A.H. and Koromilas, A.E. (2006) Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the elF2a RNA-dependent protein kinase. Proc. Natl Acad. Sci. USA, 103, 63-68.
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 63-68
-
-
Su, Q.1
Wang, S.2
Baltzis, D.3
Qu, L.4
Wong, A.H.5
Koromilas, A.E.6
-
85
-
-
0034739919
-
Activation of NF-kappaB by double-stranded RNA (dsRNA) in the absence of protein kinase R and RNase L demonstrates the existence of two separate dsRNA-triggered antiviral programs
-
Iordanov, M.S., Wong, J., Bell, J.C. and Magun, B.E. (2001) Activation of NF-kappaB by double-stranded RNA (dsRNA) in the absence of protein kinase R and RNase L demonstrates the existence of two separate dsRNA-triggered antiviral programs. Mol. Cell Biol., 21, 61-72.
-
(2001)
Mol. Cell Biol.
, vol.21
, pp. 61-72
-
-
Iordanov, M.S.1
Wong, J.2
Bell, J.C.3
Magun, B.E.4
-
86
-
-
61449174865
-
An antiviral response directed by PKR phosphorylation of the RNA helicase A
-
Sadler, A.J., Latchoumanin, O., Hawkes, D., Mak, J. and Williams, B.R. (2009) An antiviral response directed by PKR phosphorylation of the RNA helicase A. PLoS Pathog., 5, e1000311.
-
(2009)
PLoS Pathog
, vol.5
-
-
Sadler, A.J.1
Latchoumanin, O.2
Hawkes, D.3
Mak, J.4
Williams, B.R.5
-
87
-
-
47049113097
-
Mechanism of PKR Activation by dsRNA
-
Lemaire, P.A., Anderson, E., Lary, J. and Cole, J.L. (2008) Mechanism of PKR Activation by dsRNA. J. Mol. Biol., 381, 351-360.
-
(2008)
J. Mol. Biol.
, vol.381
, pp. 351-360
-
-
Lemaire, P.A.1
Anderson, E.2
Lary, J.3
Cole, J.L.4
-
88
-
-
33845627785
-
Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative action
-
García, M.A., Gil, J., Ventoso, I., Guerra, S., Domingo, E., Rivas, C. and Esteban, M. (2006) Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative action. Microbiol. Mol. Biol. Rev., 70, 1032-1060.
-
(2006)
Microbiol. Mol. Biol. Rev.
, vol.70
, pp. 1032-1060
-
-
García, M.A.1
Gil, J.2
Ventoso, I.3
Guerra, S.4
Domingo, E.5
Rivas, C.6
Esteban, M.7
-
89
-
-
0032485912
-
Binding of the protein kinase PKR to RNAs with secondary structure defects: role of the tandem A-G mismatch and noncontiguous helixes
-
Bevilacqua, P.C., George, C.X., Samuel, C.E. and Cech, T.R. (1998) Binding of the protein kinase PKR to RNAs with secondary structure defects: role of the tandem A-G mismatch and noncontiguous helixes. Biochemistry, 37, 6303-1636.
-
(1998)
Biochemistry
, vol.37
, pp. 6303-1636
-
-
Bevilacqua, P.C.1
George, C.X.2
Samuel, C.E.3
Cech, T.R.4
-
90
-
-
0030033398
-
In vitro activation of the interferon-induced, double-stranded RNA-dependent protein kinase PKR by RNA from the 3' untranslated regions of human alpha-tropomyosin
-
Davis, S. and Watson, J.C. (1996) In vitro activation of the interferon-induced, double-stranded RNA-dependent protein kinase PKR by RNA from the 3' untranslated regions of human alpha-tropomyosin. Proc. Natl Acad. Sci. USA, 93, 508-513.
-
(1996)
Proc. Natl Acad. Sci. USA
, vol.93
, pp. 508-513
-
-
Davis, S.1
Watson, J.C.2
-
91
-
-
9344221643
-
Activation of the protein kinase PKR by short double-stranded RNAs with single-stranded tails
-
Zheng, X. and Bevilacqua, P.C. (2004) Activation of the protein kinase PKR by short double-stranded RNAs with single-stranded tails. RNA, 10, 1934-1945.
-
(2004)
RNA
, vol.10
, pp. 1934-1945
-
-
Zheng, X.1
Bevilacqua, P.C.2
-
92
-
-
36749086446
-
5'-triphosphate-dependent activation of PKR by RNAs with short stem-loops
-
Nallagatla, S.R., Hwang, J., Toroney, R., Zheng, X., Cameron, C.E. and Bevilacqua, P.C. (2007) 5'-triphosphate-dependent activation of PKR by RNAs with short stem-loops. Science, 318, 1455-1458.
-
(2007)
Science
, vol.318
, pp. 1455-1458
-
-
Nallagatla, S.R.1
Hwang, J.2
Toroney, R.3
Zheng, X.4
Cameron, C.E.5
Bevilacqua, P.C.6
-
93
-
-
0042972933
-
Activation of the interferon system by short-interfering RNAs
-
Sledz, C.A., Holko, M., de Veer, M.J., Silverman, R.H. and Williams, B.R. (2003) Activation of the interferon system by short-interfering RNAs. Nat. Cell Biol., 5, 834-839.
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 834-839
-
-
Sledz, C.A.1
Holko, M.2
de Veer, M.J.3
Silverman, R.H.4
Williams, B.R.5
-
94
-
-
33646891110
-
Induction of the interferon response by siRNA is cell type- and duplex length-dependent
-
Reynolds, A., Anderson, E.M., Vermeulen, A., Fedorov, Y., Robinson, K., Leake, D., Karpilow, J., Marshall, W.S. and Khvorova, A. (2006) Induction of the interferon response by siRNA is cell type- and duplex length-dependent. RNA, 12, 988-993.
-
(2006)
RNA
, vol.12
, pp. 988-993
-
-
Reynolds, A.1
Anderson, E.M.2
Vermeulen, A.3
Fedorov, Y.4
Robinson, K.5
Leake, D.6
Karpilow, J.7
Marshall, W.S.8
Khvorova, A.9
-
95
-
-
0023902022
-
Characterization of 69- and 100-kDa forms of 2-5A-synthetase from interferon-treated human cells
-
Hovanessian, A.G., Svab, J., Marié, I., Robert, N., Chamaret, S. and Laurent, A.G. (1988) Characterization of 69- and 100-kDa forms of 2-5A-synthetase from interferon-treated human cells. J. Biol. Chem., 263, 4945-4949.
-
(1988)
J. Biol. Chem.
, vol.263
, pp. 4945-4949
-
-
Hovanessian, A.G.1
Svab, J.2
Marié, I.3
Robert, N.4
Chamaret, S.5
Laurent, A.G.6
-
96
-
-
0032531248
-
The human 2', 5'-oligoadenylate synthetase locus is composed of three distinct genes clustered on chromosome 12q24.2 encoding the 100-, 69-, and 40-kDa forms
-
Hovnanian, A., Rebouillat, D., Mattei, M.G., Levy, E.R., Marié, I., Monaco, A.P. and Hovanessian, A.G. (1998) The human 2', 5'-oligoadenylate synthetase locus is composed of three distinct genes clustered on chromosome 12q24.2 encoding the 100-, 69-, and 40-kDa forms. Genomics, 52, 267-277.
-
(1998)
Genomics
, vol.52
, pp. 267-277
-
-
Hovnanian, A.1
Rebouillat, D.2
Mattei, M.G.3
Levy, E.R.4
Marié, I.5
Monaco, A.P.6
Hovanessian, A.G.7
-
97
-
-
0032951754
-
The human 2', 5'-oligoadenylate synthetase family: interferon-induced proteins with unique enzymatic properties
-
Rebouillat, D. and Hovanessian, A.G. (1999) The human 2', 5'-oligoadenylate synthetase family: interferon-induced proteins with unique enzymatic properties. J. Interferon Cytokine Res., 19, 295-308.
-
(1999)
J. Interferon Cytokine Res.
, vol.19
, pp. 295-308
-
-
Rebouillat, D.1
Hovanessian, A.G.2
-
98
-
-
26844496280
-
A transcriptional signaling pathway in the IFN system mediated by 2'-5'-oligoadenylate activation of RNase L
-
Malathi, K., Paranjape, J.M., Bulanova, E., Shim, M., Guenther-Johnson, J.M., Faber, P.W., Eling, T.E., Williams, B.R. and Silverman, R.H. (2005) A transcriptional signaling pathway in the IFN system mediated by 2'-5'-oligoadenylate activation of RNase L. Proc. Natl Acad. Sci. USA, 102, 14533-14538.
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 14533-14538
-
-
Malathi, K.1
Paranjape, J.M.2
Bulanova, E.3
Shim, M.4
Guenther-Johnson, J.M.5
Faber, P.W.6
Eling, T.E.7
Williams, B.R.8
Silverman, R.H.9
-
99
-
-
0347093362
-
An apoptotic signaling pathway in the interferon antiviral response mediated by RNase L and c-Jun NH2-terminal kinase
-
Li, G., Xiang, Y., Sabapathy, K. and Silverman, R.H. (2004) An apoptotic signaling pathway in the interferon antiviral response mediated by RNase L and c-Jun NH2-terminal kinase. J. Biol. Chem., 279, 1123-1131.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 1123-1131
-
-
Li, G.1
Xiang, Y.2
Sabapathy, K.3
Silverman, R.H.4
-
100
-
-
0028042337
-
HIV-1 TAR RNA has an intrinsic ability to activate interferon-inducible enzymes
-
Maitra, R.K., McMillan, N.A., Desai, S., McSwiggen, J., Hovanessian, A.G., Sen, G., Williams, B.R. and Silverman, R.H. (1994) HIV-1 TAR RNA has an intrinsic ability to activate interferon-inducible enzymes. Virology, 204, 823-827.
-
(1994)
Virology
, vol.204
, pp. 823-827
-
-
Maitra, R.K.1
McMillan, N.A.2
Desai, S.3
McSwiggen, J.4
Hovanessian, A.G.5
Sen, G.6
Williams, B.R.7
Silverman, R.H.8
-
101
-
-
0028857491
-
Activation of interferon-inducible 2'-5' oligoadenylate synthetase by adenoviral VAI RNA
-
Desai, S.Y., Patel, R.C., Sen, G.C., Malhotra, P., Ghadge, G.D. and Thimmapaya, B. (1995) Activation of interferon-inducible 2'-5' oligoadenylate synthetase by adenoviral VAI RNA. J. Biol. Chem., 270, 3454-3461.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 3454-3461
-
-
Desai, S.Y.1
Patel, R.C.2
Sen, G.C.3
Malhotra, P.4
Ghadge, G.D.5
Thimmapaya, B.6
-
102
-
-
0018801485
-
Structural requirements of double-stranded RNA for the activation of 2', 5'-oligo(A) polymerase and protein kinase of interferon-treated HeLa cells
-
Minks, M.A., West, D.K., Benvin, S. and Baglioni, C. (1979) Structural requirements of double-stranded RNA for the activation of 2', 5'-oligo(A) polymerase and protein kinase of interferon-treated HeLa cells. J. Biol. Chem., 254, 10180-10183.
-
(1979)
J. Biol. Chem.
, vol.254
, pp. 10180-10183
-
-
Minks, M.A.1
West, D.K.2
Benvin, S.3
Baglioni, C.4
-
103
-
-
0033556388
-
Enzymatic characteristics of recombinant medium isozyme of 2'-5' oligoadenylate synthetase
-
Sarkar, S.N., Bandyopadhyay, S., Ghosh, A. and Sen, G.C. (1999) Enzymatic characteristics of recombinant medium isozyme of 2'-5' oligoadenylate synthetase. J. Biol. Chem., 274, 1848-1855.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 1848-1855
-
-
Sarkar, S.N.1
Bandyopadhyay, S.2
Ghosh, A.3
Sen, G.C.4
-
104
-
-
16844371515
-
Reading the viral signature by Toll-like receptors and other pattern recognition receptors
-
Mogensen, T.H. and Paludan, S.R. (2005) Reading the viral signature by Toll-like receptors and other pattern recognition receptors. J. Mol. Med., 83, 180-192.
-
(2005)
J. Mol. Med.
, vol.83
, pp. 180-192
-
-
Mogensen, T.H.1
Paludan, S.R.2
-
105
-
-
23744483354
-
TLR3 in antiviral immunity: key player or bystander?
-
Schröder, M. and Bowie, A.G. (2005) TLR3 in antiviral immunity: key player or bystander? Trends Immunol., 26, 462-468.
-
(2005)
Trends Immunol
, vol.26
, pp. 462-468
-
-
Schröder, M.1
Bowie, A.G.2
-
106
-
-
0037320451
-
TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction
-
Oshiumi, H., Matsumoto, M., Funami, K., Akazawa, T. and Seya, T. (2003) TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction. Nat. Immunol., 4, 161-167.
-
(2003)
Nat. Immunol.
, vol.4
, pp. 161-167
-
-
Oshiumi, H.1
Matsumoto, M.2
Funami, K.3
Akazawa, T.4
Seya, T.5
-
107
-
-
14044260466
-
Transcriptional signaling by double-stranded RNA: role of TLR3
-
Sen, G.C. and Sarkar, S.N. (2005) Transcriptional signaling by double-stranded RNA: role of TLR3. Cytokine Growth Factor Rev., 16, 1-14.
-
(2005)
Cytokine Growth Factor Rev
, vol.16
, pp. 1-14
-
-
Sen, G.C.1
Sarkar, S.N.2
-
108
-
-
41649115210
-
Sequence- and target-independent angiogenesis suppression by siRNA via TLR3
-
Kleinman, M.E., Yamada, K., Takeda, A., Chandrasekaran, V., Nozaki, M., Baffi, J.Z., Albuquerque, R.J., Yamasaki, S., Itaya, M., Pan, Y. et al. (2008) Sequence- and target-independent angiogenesis suppression by siRNA via TLR3. Nature, 452, 591-597.
-
(2008)
Nature
, vol.452
, pp. 591-597
-
-
Kleinman, M.E.1
Yamada, K.2
Takeda, A.3
Chandrasekaran, V.4
Nozaki, M.5
Baffi, J.Z.6
Albuquerque, R.J.7
Yamasaki, S.8
Itaya, M.9
Pan, Y.10
-
109
-
-
1542317578
-
Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8
-
Heil, F., Hemmi, H., Hochrein, H., Ampenberger, F., Kirschning, C., Akira, S., Lipford, G., Wagner, H. and Bauer, S. (2004) Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science, 305, 1526-1529.
-
(2004)
Science
, vol.305
, pp. 1526-1529
-
-
Heil, F.1
Hemmi, H.2
Hochrein, H.3
Ampenberger, F.4
Kirschning, C.5
Akira, S.6
Lipford, G.7
Wagner, H.8
Bauer, S.9
-
110
-
-
20144389695
-
Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7
-
Hornung, V., Guenthner-Biller, M., Bourquin, C., Ablasser, A., Schlee, M., Uematsu, S., Noronha, A., Manoharan, M., Akira, S., de Fougerolles, A. et al. (2005) Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7. Nat. Med., 11, 263-270.
-
(2005)
Nat. Med.
, vol.11
, pp. 263-270
-
-
Hornung, V.1
Guenthner-Biller, M.2
Bourquin, C.3
Ablasser, A.4
Schlee, M.5
Uematsu, S.6
Noronha, A.7
Manoharan, M.8
Akira, S.9
de Fougerolles, A.10
-
111
-
-
22344454846
-
Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA
-
Judge, A.D., Sood, V., Shaw, J.R., Fang, D., McClintock, K. and MacLachlan, I. (2005) Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA. Nat. Biotechnol., 23, 457-462.
-
(2005)
Nat. Biotechnol.
, vol.23
, pp. 457-462
-
-
Judge, A.D.1
Sood, V.2
Shaw, J.R.3
Fang, D.4
McClintock, K.5
MacLachlan, I.6
-
112
-
-
33646544416
-
Single-stranded small interfering RNA are more immunostimulatory than their double-stranded counterparts: a central role for 2'-hydroxyl uridines in immune responses
-
Sioud, M. (2006) Single-stranded small interfering RNA are more immunostimulatory than their double-stranded counterparts: a central role for 2'-hydroxyl uridines in immune responses. Eur. J. Immunol., 36, 1222-1230.
-
(2006)
Eur. J. Immunol.
, vol.36
, pp. 1222-1230
-
-
Sioud, M.1
-
113
-
-
33845579097
-
Nucleic acid agonists for Toll-like receptor 7 are defined by the presence of uridine ribonucleotides
-
Diebold, S.S., Massacrier, C., Akira, S., Paturel, C., Morel, Y. and Reis e Sousa, C. (2006) Nucleic acid agonists for Toll-like receptor 7 are defined by the presence of uridine ribonucleotides. Eur. J. Immunol., 36, 3256-3267.
-
(2006)
Eur. J. Immunol.
, vol.36
, pp. 3256-3267
-
-
Diebold, S.S.1
Massacrier, C.2
Akira, S.3
Paturel, C.4
Morel, Y.5
Reis e Sousa, C.6
-
114
-
-
18044365415
-
Induction of inflammatory cytokines and interferon responses by double-stranded and single-stranded siRNAs is sequence-dependent and requires endosomal localization
-
Sioud, M. (2005) Induction of inflammatory cytokines and interferon responses by double-stranded and single-stranded siRNAs is sequence-dependent and requires endosomal localization. J. Mol. Biol., 348, 1079-1090.
-
(2005)
J. Mol. Biol.
, vol.348
, pp. 1079-1090
-
-
Sioud, M.1
-
115
-
-
42149167357
-
TLR7 is involved in sequence-specific sensing of single-stranded RNAs in human macrophages
-
Gantier, M.P., Tong, S., Behlke, M.A., Xu, D., Phipps, S., Foster, P.S. and Williams, B.R. (2008) TLR7 is involved in sequence-specific sensing of single-stranded RNAs in human macrophages. J. Immunol., 180, 2117-2124.
-
(2008)
J. Immunol.
, vol.180
, pp. 2117-2124
-
-
Gantier, M.P.1
Tong, S.2
Behlke, M.A.3
Xu, D.4
Phipps, S.5
Foster, P.S.6
Williams, B.R.7
-
116
-
-
3242813113
-
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses
-
Yoneyama, M., Kikuchi, M., Natsukawa, T., Shinobu, N., Imaizumi, T., Miyagishi, M., Taira, K., Akira, S. and Fujita, T. (2004) The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat. Immunol., 5, 730-737.
-
(2004)
Nat. Immunol.
, vol.5
, pp. 730-737
-
-
Yoneyama, M.1
Kikuchi, M.2
Natsukawa, T.3
Shinobu, N.4
Imaizumi, T.5
Miyagishi, M.6
Taira, K.7
Akira, S.8
Fujita, T.9
-
117
-
-
64549126847
-
The regulatory domain of the RIG-I family ATPase LGP2 senses double-stranded RNA
-
Pippig, D.A., Hellmuth, J.C., Cui, S., Kirchhofer, A., Lammens, K., Lammens, A., Schmidt, A., Rothenfusser, S. and Hopfner, K.P. (2009) The regulatory domain of the RIG-I family ATPase LGP2 senses double-stranded RNA. Nucleic Acids Res., 37, 2014-2025.
-
(2009)
Nucleic Acids Res
, vol.37
, pp. 2014-2025
-
-
Pippig, D.A.1
Hellmuth, J.C.2
Cui, S.3
Kirchhofer, A.4
Lammens, K.5
Lammens, A.6
Schmidt, A.7
Rothenfusser, S.8
Hopfner, K.P.9
-
118
-
-
0037154176
-
mda-5: an interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties
-
Kang, D.C., Gopalkrishnan, R.V., Wu, Q., Jankowsky, E., Pyle, A.M. and Fisher, P.B. (2002) mda-5: an interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties. Proc. Natl Acad. Sci. USA, 99, 637-642.
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 637-642
-
-
Kang, D.C.1
Gopalkrishnan, R.V.2
Wu, Q.3
Jankowsky, E.4
Pyle, A.M.5
Fisher, P.B.6
-
119
-
-
67650510680
-
Solution structures of cytosolic RNA sensor MDA5 and LGP2 C-terminal domains: identification of the RNA recognition loop in RIG-I-like receptors
-
Takahasi, K., Kumeta, H., Tsuduki, N., Narita, R., Shigemoto, T., Hirai, R., Yoneyama, M., Horiuchi, M., Ogura, K., Fujita, T. et al. (2009) Solution structures of cytosolic RNA sensor MDA5 and LGP2 C-terminal domains: identification of the RNA recognition loop in RIG-I-like receptors. J. Biol. Chem., 284, 17465-17474.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 17465-17474
-
-
Takahasi, K.1
Kumeta, H.2
Tsuduki, N.3
Narita, R.4
Shigemoto, T.5
Hirai, R.6
Yoneyama, M.7
Horiuchi, M.8
Ogura, K.9
Fujita, T.10
-
120
-
-
38649089789
-
The C-terminal regulatory domain is the RNA 5'-triphosphate sensor of RIG-I
-
Cui, S., Eisenächer, K., Kirchhofer, A., Brzózka, K., Lammens, A., Lammens, K., Fujita, T., Conzelmann, K.K., Krug, A. and Hopfner, K.P. (2008) The C-terminal regulatory domain is the RNA 5'-triphosphate sensor of RIG-I. Mol. Cell, 29, 169-179.
-
(2008)
Mol. Cell.
, vol.29
, pp. 169-179
-
-
Cui, S.1
Eisenächer, K.2
Kirchhofer, A.3
Brzózka, K.4
Lammens, A.5
Lammens, K.6
Fujita, T.7
Conzelmann, K.K.8
Krug, A.9
Hopfner, K.P.10
-
121
-
-
67651232539
-
Structural basis of double-stranded RNA recognition by the RIG-I like receptor MDA5
-
[Epub ahead of print, June 14]
-
Li, X., Lu, C., Stewart, M., Xu, H., Strong, R.K., Igumenova, T. and ana Li, P. (2009) Structural basis of double-stranded RNA recognition by the RIG-I like receptor MDA5. Arch. Biochem. Biophys., [Epub ahead of print, June 14].
-
(2009)
Arch. Biochem. Biophys.
-
-
Li, X.1
Lu, C.2
Stewart, M.3
Xu, H.4
Strong, R.K.5
Igumenova, T.6
ana Li, P.7
-
122
-
-
26844503987
-
The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I
-
Rothenfusser, S., Goutagny, N., DiPerna, G., Gong, M., Monks, B.G., Schoenemeyer, A., Yamamoto, M., Akira, S. and Fitzgerald, K.A. (2005) The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I. J. Immunol., 175, 5260-5268.
-
(2005)
J. Immunol.
, vol.175
, pp. 5260-5268
-
-
Rothenfusser, S.1
Goutagny, N.2
DiPerna, G.3
Gong, M.4
Monks, B.G.5
Schoenemeyer, A.6
Yamamoto, M.7
Akira, S.8
Fitzgerald, K.A.9
-
123
-
-
23844438864
-
Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity
-
Yoneyama, M., Kikuchi, M., Matsumoto, K., Imaizumi, T., Miyagishi, M., Taira, K., Foy, E., Loo, Y.M., Gale, M. Jr, Akira, S. et al. (2005) Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. J. Immunol., 175, 2851-2858.
-
(2005)
J. Immunol.
, vol.175
, pp. 2851-2858
-
-
Yoneyama, M.1
Kikuchi, M.2
Matsumoto, K.3
Imaizumi, T.4
Miyagishi, M.5
Taira, K.6
Foy, E.7
Loo, Y.M.8
Gale M., Jr.9
Akira, S.10
-
124
-
-
27144440523
-
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
-
Kawai, T., Takahashi, K., Sato, S., Coban, C., Kumar, H., Kato, H., Ishii, K.J., Takeuchi, O. and Akira, S. (2005) IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat. Immunol., 6, 981-988.
-
(2005)
Nat. Immunol.
, vol.6
, pp. 981-988
-
-
Kawai, T.1
Takahashi, K.2
Sato, S.3
Coban, C.4
Kumar, H.5
Kato, H.6
Ishii, K.J.7
Takeuchi, O.8
Akira, S.9
-
125
-
-
24144461689
-
Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3
-
Seth, R.B., Sun, L., Ea, C.K. and Chen, Z.J. Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. Cell, 122, 669-682.
-
Cell
, vol.122
, pp. 669-682
-
-
Seth, R.B.1
Sun, L.2
Ea, C.K.3
Chen, Z.J.4
-
126
-
-
24944538819
-
VISA is an adapter protein required for virus-triggered IFN-beta signaling
-
Xu, L.G., Wang, Y.Y., Han, K.J., Li, L.Y., Zhai, Z. and Shu, H.B. (2005) VISA is an adapter protein required for virus-triggered IFN-beta signaling. Mol. Cell, 19, 727-740.
-
(2005)
Mol. Cell.
, vol.19
, pp. 727-740
-
-
Xu, L.G.1
Wang, Y.Y.2
Han, K.J.3
Li, L.Y.4
Zhai, Z.5
Shu, H.B.6
-
127
-
-
27144440476
-
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
-
Meylan, E., Curran, J., Hofmann, K., Moradpour, D., Binder, M., Bartenschlager, R. and Tschopp, J. (2005) Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature, 437, 1167-1172.
-
(2005)
Nature
, vol.437
, pp. 1167-1172
-
-
Meylan, E.1
Curran, J.2
Hofmann, K.3
Moradpour, D.4
Binder, M.5
Bartenschlager, R.6
Tschopp, J.7
-
128
-
-
22544455673
-
Cell type-specific involvement of RIG-I in antiviral response
-
Kato, H., Sato, S., Yoneyama, M., Yamamoto, M., Uematsu, S., Matsui, K., Tsujimura, T., Takeda, K., Fujita, T. and Takeuchi, O. (2005) Cell type-specific involvement of RIG-I in antiviral response. Immunity, 23, 19-28.
-
(2005)
Immunity
, vol.23
, pp. 19-28
-
-
Kato, H.1
Sato, S.2
Yoneyama, M.3
Yamamoto, M.4
Uematsu, S.5
Matsui, K.6
Tsujimura, T.7
Takeda, K.8
Fujita, T.9
Takeuchi, O.10
-
129
-
-
53149143179
-
Double-stranded RNA induces an antiviral defense status in epidermal keratinocytes through TLR3-, PKR-, and MDA5/RIG-I-mediated differential signaling
-
Kalali, B.N., Köllisch, G., Mages, J., Müller, T., Bauer, S., Wagner, H., Ring, J., Lang, R., Mempel, M. and Ollert, M. (2008) Double-stranded RNA induces an antiviral defense status in epidermal keratinocytes through TLR3-, PKR-, and MDA5/RIG-I-mediated differential signaling. J. Immunol., 181, 2694-2704.
-
(2008)
J. Immunol.
, vol.181
, pp. 2694-2704
-
-
Kalali, B.N.1
Köllisch, G.2
Mages, J.3
Müller, T.4
Bauer, S.5
Wagner, H.6
Ring, J.7
Lang, R.8
Mempel, M.9
Ollert, M.10
-
130
-
-
46949097299
-
Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5
-
Kato, H., Takeuchi, O., Mikamo-Satoh, E., Hirai, R., Kawai, T., Matsushita, K., Hiiragi, A., Dermody, T.S., Fujita, T. and Akira, S. (2008) Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5. J. Exp. Med., 205, 1601-1610.
-
(2008)
J. Exp. Med.
, vol.205
, pp. 1601-1610
-
-
Kato, H.1
Takeuchi, O.2
Mikamo-Satoh, E.3
Hirai, R.4
Kawai, T.5
Matsushita, K.6
Hiiragi, A.7
Dermody, T.S.8
Fujita, T.9
Akira, S.10
-
131
-
-
68049089651
-
Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus
-
Schlee, M., Roth, A., Hornung, V., Hagmann, C.A., Wimmenauer, V., Barchet, W., Coch, C., Janke, M., Mihailovic, A., Wardle, G. et al. (2009) Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus. Immunity, 31, 25-34.
-
(2009)
Immunity
, vol.31
, pp. 25-34
-
-
Schlee, M.1
Roth, A.2
Hornung, V.3
Hagmann, C.A.4
Wimmenauer, V.5
Barchet, W.6
Coch, C.7
Janke, M.8
Mihailovic, A.9
Wardle, G.10
-
132
-
-
68249146531
-
A nonself RNA pattern: tri-p to panhandle
-
Fujita, T. (2009) A nonself RNA pattern: tri-p to panhandle. Immunity, 31, 4-5.
-
(2009)
Immunity
, vol.31
, pp. 4-5
-
-
Fujita, T.1
-
133
-
-
67749133995
-
5'-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I
-
Schmidt, A., Schwerd, T., Hamm, W., Hellmuth, J.C., Cui, S., Wenzel, M., Hoffmann, F.S., Michallet, M.C., Besch, R., Hopfner, K.P. et al. (2009) 5'-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I. Proc. Natl Acad. Sci. USA, 106, 12067-12072.
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 12067-12072
-
-
Schmidt, A.1
Schwerd, T.2
Hamm, W.3
Hellmuth, J.C.4
Cui, S.5
Wenzel, M.6
Hoffmann, F.S.7
Michallet, M.C.8
Besch, R.9
Hopfner, K.P.10
-
134
-
-
33646561864
-
A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells
-
Marques, J.T., Devosse, T., Wang, D., Zamanian-Daryoush, M., Serbinowski, P., Hartmann, R., Fujita, T., Behlke, M.A. and Williams, B.R. (2006) A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells. Nat. Biotechnol., 24, 559-565.
-
(2006)
Nat. Biotechnol.
, vol.24
, pp. 559-565
-
-
Marques, J.T.1
Devosse, T.2
Wang, D.3
Zamanian-Daryoush, M.4
Serbinowski, P.5
Hartmann, R.6
Fujita, T.7
Behlke, M.A.8
Williams, B.R.9
-
135
-
-
33750976374
-
5'-Triphosphate RNA is the ligand for RIG-I
-
Hornung, V., Ellegast, J., Kim, S., Brzózka, K., Jung, A., Kato, H., Poeck, H., Akira, S., Conzelmann, K.K., Schlee, M. et al. (2006) 5'-Triphosphate RNA is the ligand for RIG-I. Science, 314, 994-997.
-
(2006)
Science
, vol.314
, pp. 994-997
-
-
Hornung, V.1
Ellegast, J.2
Kim, S.3
Brzózka, K.4
Jung, A.5
Kato, H.6
Poeck, H.7
Akira, S.8
Conzelmann, K.K.9
Schlee, M.10
-
136
-
-
33750984771
-
RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates
-
Pichlmair, A., Schulz, O., Tan, C.P., Näslund, T.I., Liljeström, P., Weber, F. and Reis e Sousa, C. (2006) RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates. Science, 314, 997-1001.
-
(2006)
Science
, vol.314
, pp. 997-1001
-
-
Pichlmair, A.1
Schulz, O.2
Tan, C.P.3
Näslund, T.I.4
Liljeström, P.5
Weber, F.6
Reis e Sousa, C.7
-
137
-
-
47949092573
-
Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA
-
Saito, T., Owen, D.M., Jiang, F., Marcotrigiano, J. and Gale, M. Jr. (2008) Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA. Nature, 454, 523-527.
-
(2008)
Nature
, vol.454
, pp. 523-527
-
-
Saito, T.1
Owen, D.M.2
Jiang, F.3
Marcotrigiano, J.4
Gale M., Jr.5
-
138
-
-
39649092731
-
Nonself RNA-sensing mechanism of RIG-I helicase and activation of antiviral immune responses
-
Takahasi, K., Yoneyama, M., Nishihori, T., Hirai, R., Kumeta, H., Narita, R., Gale, M. Jr, Inagaki, F. and Fujita, T. (2008) Nonself RNA-sensing mechanism of RIG-I helicase and activation of antiviral immune responses. Mol. Cell, 29, 428-440.
-
(2008)
Mol. Cell.
, vol.29
, pp. 428-440
-
-
Takahasi, K.1
Yoneyama, M.2
Nishihori, T.3
Hirai, R.4
Kumeta, H.5
Narita, R.6
Gale M., Jr.7
Inagaki, F.8
Fujita, T.9
-
139
-
-
60749124538
-
Cytosolic viral sensor RIG-I is a 5'-triphosphate-dependent translocase on double-stranded RNA
-
Myong, S., Cui, S., Cornish, P.V., Kirchhofer, A., Gack, M.U., Jung, J.U., Hopfner, K.P. and Ha, T. (2009) Cytosolic viral sensor RIG-I is a 5'-triphosphate-dependent translocase on double-stranded RNA. Science, 323, 1070-1074.
-
(2009)
Science
, vol.323
, pp. 1070-1074
-
-
Myong, S.1
Cui, S.2
Cornish, P.V.3
Kirchhofer, A.4
Gack, M.U.5
Jung, J.U.6
Hopfner, K.P.7
Ha, T.8
-
140
-
-
0035859929
-
Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems
-
Caplen, N.J., Parrish, S., Imani, F., Fire, A. and Morgan, R.A. (2001) Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems. Proc. Natl Acad. Sci. USA, 98, 9742-9747.
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 9742-9747
-
-
Caplen, N.J.1
Parrish, S.2
Imani, F.3
Fire, A.4
Morgan, R.A.5
-
141
-
-
0034775750
-
Specific double-stranded RNA interference in undifferentiated mouse embryonic stem cells
-
Yang, S., Tutton, S., Pierce, E. and Yoon, K. (2001) Specific double-stranded RNA interference in undifferentiated mouse embryonic stem cells. Mol. Cell Biol., 21, 7807-7816.
-
(2001)
Mol. Cell Biol.
, vol.21
, pp. 7807-7816
-
-
Yang, S.1
Tutton, S.2
Pierce, E.3
Yoon, K.4
-
142
-
-
0035942736
-
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
-
Elbashir, S.M., Harborth, J., Lendeckel, W., Yalcin, A., Weber, K. and Tuschl, T. (2001) Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature, 411, 494-498.
-
(2001)
Nature
, vol.411
, pp. 494-498
-
-
Elbashir, S.M.1
Harborth, J.2
Lendeckel, W.3
Yalcin, A.4
Weber, K.5
Tuschl, T.6
-
143
-
-
33747761923
-
On the art of identifying effective and specific siRNAs
-
Pei, Y. and Tuschl, T. (2006) On the art of identifying effective and specific siRNAs. Nat. Methods, 3, 670-676.
-
(2006)
Nat. Methods
, vol.3
, pp. 670-676
-
-
Pei, Y.1
Tuschl, T.2
-
144
-
-
38449100230
-
A protocol for designing siRNAs with high functionality and specificity
-
Birmingham, A., Anderson, E., Sullivan, K., Reynolds, A., Boese, Q., Leake, D., Karpilow, J. and Khvorova, A. (2007) A protocol for designing siRNAs with high functionality and specificity. Nat. Protoc., 2, 2068-2078.
-
(2007)
Nat. Protoc.
, vol.2
, pp. 2068-2078
-
-
Birmingham, A.1
Anderson, E.2
Sullivan, K.3
Reynolds, A.4
Boese, Q.5
Leake, D.6
Karpilow, J.7
Khvorova, A.8
-
145
-
-
66349108231
-
A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity
-
Bramsen, J.B., Laursen, M.B., Nielsen, A.F., Hansen, T.B., Bus, C., Langkjær, N., Babu, B.R., Højland, T., Abramov, M., Van Aerschot, A. et al. (2009) A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity. Nucleic Acids Res., 37, 2867-2881.
-
(2009)
Nucleic Acids Res
, vol.37
, pp. 2867-2881
-
-
Bramsen, J.B.1
Laursen, M.B.2
Nielsen, A.F.3
Hansen, T.B.4
Bus, C.5
Langkjær, N.6
Babu, B.R.7
Højland, T.8
Abramov, M.9
Van Aerschot, A.10
-
146
-
-
33744793237
-
High potency silencing by single-stranded boranophosphate siRNA
-
Hall, A.H., Wan, J., Spesock, A., Sergueeva, Z., Shaw, B.R. and Alexander, K.A. (2006) High potency silencing by single-stranded boranophosphate siRNA. Nucleic Acids Res., 34, 2773-2781.
-
(2006)
Nucleic Acids Res
, vol.34
, pp. 2773-2781
-
-
Hall, A.H.1
Wan, J.2
Spesock, A.3
Sergueeva, Z.4
Shaw, B.R.5
Alexander, K.A.6
-
147
-
-
33644620908
-
Chemical modification of siRNAs to improve serum stability without loss of efficacy
-
Choung, S., Kim, Y.J., Kim, S., Park, H.O. and Choi, Y.C. (2006) Chemical modification of siRNAs to improve serum stability without loss of efficacy. Biochem. Biophys. Res. Commun., 342, 919-927.
-
(2006)
Biochem. Biophys. Res. Commun.
, vol.342
, pp. 919-927
-
-
Choung, S.1
Kim, Y.J.2
Kim, S.3
Park, H.O.4
Choi, Y.C.5
-
148
-
-
57349134691
-
Chemical modification of siRNAs for in vivo use
-
Behlke, M.A. (2008) Chemical modification of siRNAs for in vivo use. Oligonucleotides, 18, 305-319.
-
(2008)
Oligonucleotides
, vol.18
, pp. 305-319
-
-
Behlke, M.A.1
-
149
-
-
33645763485
-
Cleavage of the siRNA passenger strand during RISC assembly in human cells
-
Leuschner, P.J., Ameres, S.L., Kueng, S. and Martinez, J. (2006) Cleavage of the siRNA passenger strand during RISC assembly in human cells. EMBO Rep., 7, 314-320.
-
(2006)
EMBO Rep
, vol.7
, pp. 314-320
-
-
Leuschner, P.J.1
Ameres, S.L.2
Kueng, S.3
Martinez, J.4
-
150
-
-
32944454941
-
Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo
-
Judge, A.D., Bola, G., Lee, A.C. and MacLachlan, I. (2006) Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo. Mol Ther., 13, 494-505.
-
(2006)
Mol Ther
, vol.13
, pp. 494-505
-
-
Judge, A.D.1
Bola, G.2
Lee, A.C.3
MacLachlan, I.4
-
151
-
-
23844464444
-
Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA
-
Karikó, K., Buckstein, M., Ni, H. and Weissman, D. (2005) Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA. Immunity, 23, 165-175.
-
(2005)
Immunity
, vol.23
, pp. 165-175
-
-
Karikó, K.1
Buckstein, M.2
Ni, H.3
Weissman, D.4
-
152
-
-
33751511117
-
Gene expression analysis in blood cells in response to unmodified and 2'-modified siRNAs reveals TLR-dependent and independent effects
-
Cekaite, L., Furset, G., Hovig, E. and Sioud, M. (2007) Gene expression analysis in blood cells in response to unmodified and 2'-modified siRNAs reveals TLR-dependent and independent effects. J. Mol. Biol., 365, 90-108.
-
(2007)
J. Mol. Biol.
, vol.365
, pp. 90-108
-
-
Cekaite, L.1
Furset, G.2
Hovig, E.3
Sioud, M.4
-
153
-
-
11144347529
-
Lack of interferon response in animals to naked siRNAs
-
Heidel, J.D., Hu, S., Liu, X.F., Triche, T.J. and Davis, M.E. (2004) Lack of interferon response in animals to naked siRNAs. Nat. Biotechnol., 22, 1579-1582.
-
(2004)
Nat. Biotechnol.
, vol.22
, pp. 1579-1582
-
-
Heidel, J.D.1
Hu, S.2
Liu, X.F.3
Triche, T.J.4
Davis, M.E.5
-
154
-
-
13744250159
-
Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality
-
Elmén, J., Thonberg, H., Ljungberg, K., Frieden, M., Westergaard, M., Xu, Y., Wahren, B., Liang, Z., Ørum, H., Koch, T. et al. (2005) Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality. Nucleic Acids Res., 33, 439-447.
-
(2005)
Nucleic Acids Res
, vol.33
, pp. 439-447
-
-
Elmén, J.1
Thonberg, H.2
Ljungberg, K.3
Frieden, M.4
Westergaard, M.5
Xu, Y.6
Wahren, B.7
Liang, Z.8
Ørum, H.9
Koch, T.10
-
155
-
-
34848926634
-
Improved silencing properties using small internally segmented interfering RNAs
-
Bramsen, J.B., Laursen, M.B., Damgaard, C.K., Lena, S.W., Babu, B.R., Wengel, J. and Kjems, J. (2007) Improved silencing properties using small internally segmented interfering RNAs. Nucleic Acids Res., 35, 5886-5897.
-
(2007)
Nucleic Acids Res
, vol.35
, pp. 5886-5897
-
-
Bramsen, J.B.1
Laursen, M.B.2
Damgaard, C.K.3
Lena, S.W.4
Babu, B.R.5
Wengel, J.6
Kjems, J.7
-
156
-
-
36049042009
-
Sticky overhangs enhance siRNA-mediated gene silencing
-
Bolcato-Bellemin, A.L., Bonnet, M.E., Creusat, G., Erbacher, P. and Behr, J.P. (2007) Sticky overhangs enhance siRNA-mediated gene silencing. Proc. Natl Acad. Sci. USA, 104, 16050-16055.
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 16050-16055
-
-
Bolcato-Bellemin, A.L.1
Bonnet, M.E.2
Creusat, G.3
Erbacher, P.4
Behr, J.P.5
-
157
-
-
0037197969
-
IRF-3-dependent, NFkappa B- and JNK-independent activation of the 561 and IFN-beta genes in response to double-stranded RNA
-
Peters, K.L., Smith, H.L., Stark, G.R. and Sen, G.C. (2002) IRF-3-dependent, NFkappa B- and JNK-independent activation of the 561 and IFN-beta genes in response to double-stranded RNA. Proc. Natl Acad. Sci. USA, 99, 6322-6327.
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 6322-6327
-
-
Peters, K.L.1
Smith, H.L.2
Stark, G.R.3
Sen, G.C.4
-
158
-
-
33747777302
-
Gene silencing with siRNA duplexes composed of target-mRNA-complementary and partially palindromic or partially complementary single-stranded siRNAs
-
Hossbach, M., Gruber, J., Osborn, M., Weber, K. and Tuschl, T. (2006) Gene silencing with siRNA duplexes composed of target-mRNA-complementary and partially palindromic or partially complementary single-stranded siRNAs. RNA Biol., 3, 82-89.
-
(2006)
RNA Biol
, vol.3
, pp. 82-89
-
-
Hossbach, M.1
Gruber, J.2
Osborn, M.3
Weber, K.4
Tuschl, T.5
-
159
-
-
13844280638
-
Synthetic shRNAs as potent RNAi triggers
-
Siolas, D., Lerner, C., Burchard, J., Ge, W., Linsley, P.S., Paddison, P.J., Hannon, G.J. and Cleary, M.A. (2005) Synthetic shRNAs as potent RNAi triggers. Nat. Biotechnol., 23, 227-231.
-
(2005)
Nat. Biotechnol.
, vol.23
, pp. 227-231
-
-
Siolas, D.1
Lerner, C.2
Burchard, J.3
Ge, W.4
Linsley, P.S.5
Paddison, P.J.6
Hannon, G.J.7
Cleary, M.A.8
-
160
-
-
64549150593
-
Inducible transgenic rat model for diabetes mellitus based on shRNA-mediated gene knockdown
-
Kotnik, K., Popova, E., Todiras, M., Mori, M.A., Alenina, N., Seibler, J. and Bader, M. (2009) Inducible transgenic rat model for diabetes mellitus based on shRNA-mediated gene knockdown. PLoS ONE, 4, e5124.
-
(2009)
PLoS ONE
, vol.4
-
-
Kotnik, K.1
Popova, E.2
Todiras, M.3
Mori, M.A.4
Alenina, N.5
Seibler, J.6
Bader, M.7
-
161
-
-
44449121785
-
Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: implications for the therapeutic development of RNAi
-
McBride, J.L., Boudreau, R.L., Harper, S.Q., Staber, P.D., Monteys, A.M., Martins, I., Gilmore, B.L., Burstein, H., Peluso, R.W., Polisky, B. et al. (2008) Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: implications for the therapeutic development of RNAi. Proc. Natl Acad. Sci. USA, 105, 5868-5873.
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 5868-5873
-
-
McBride, J.L.1
Boudreau, R.L.2
Harper, S.Q.3
Staber, P.D.4
Monteys, A.M.5
Martins, I.6
Gilmore, B.L.7
Burstein, H.8
Peluso, R.W.9
Polisky, B.10
-
162
-
-
26944498261
-
Approaches for chemically synthesized siRNA and vector-mediated RNAi
-
Amarzguioui, M., Rossi, J.J. and Kim, D. (2005) Approaches for chemically synthesized siRNA and vector-mediated RNAi. FEBS Lett., 579, 5974-5981.
-
(2005)
FEBS Lett
, vol.579
, pp. 5974-5981
-
-
Amarzguioui, M.1
Rossi, J.J.2
Kim, D.3
-
163
-
-
41449111098
-
Construction of simple and efficient DNA vector-based short hairpin RNA expression systems for specific gene silencing in mammalian cells
-
Cheng, T.L. and Chang, W.T. (2007) Construction of simple and efficient DNA vector-based short hairpin RNA expression systems for specific gene silencing in mammalian cells. Methods Mol. Biol., 408, 223-241.
-
(2007)
Methods Mol. Biol.
, vol.408
, pp. 223-241
-
-
Cheng, T.L.1
Chang, W.T.2
-
164
-
-
21244449939
-
Sequence context effects on oligo(dT) termination signal recognition by Saccharomyces cerevisiae RNA polymerase III
-
Braglia, P., Percudani, R. and Dieci, G. (2005) Sequence context effects on oligo(dT) termination signal recognition by Saccharomyces cerevisiae RNA polymerase III. J. Biol. Chem., 280, 19551-19562.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 19551-19562
-
-
Braglia, P.1
Percudani, R.2
Dieci, G.3
-
165
-
-
1542306855
-
Interferon induction by siRNAs and ssRNAs synthesized by phage polymerase
-
Kim, D.H., Longo, M., Han, Y., Lundberg, P., Cantin, E. and Rossi, J.J. (2004) Interferon induction by siRNAs and ssRNAs synthesized by phage polymerase. Nat. Biotechnol., 22, 321-325.
-
(2004)
Nat. Biotechnol.
, vol.22
, pp. 321-325
-
-
Kim, D.H.1
Longo, M.2
Han, Y.3
Lundberg, P.4
Cantin, E.5
Rossi, J.J.6
-
166
-
-
39449128863
-
Short-hairpin RNAs synthesized by T7 phage polymerase do not induce interferon
-
Gondai, T., Yamaguchi, K., Miyano-Kurosaki, N., Habu, Y. and Takaku, H. (2008) Short-hairpin RNAs synthesized by T7 phage polymerase do not induce interferon. Nucleic Acids Res., 36, e18.
-
(2008)
Nucleic Acids Res
, vol.36
-
-
Gondai, T.1
Yamaguchi, K.2
Miyano-Kurosaki, N.3
Habu, Y.4
Takaku, H.5
-
167
-
-
0642277951
-
Interferon-alpha/beta receptor-mediated selective induction of a gene cluster by CpG oligodeoxynucleotide
-
Kato, A., Homma, T., Batchelor, J., Hashimoto, N., Imai, S., Wakiguchi, H., Saito, H. and Matsumoto, K. (2003) Interferon-alpha/beta receptor-mediated selective induction of a gene cluster by CpG oligodeoxynucleotide. BMC Immunol., 4, 4-8.
-
(2003)
BMC Immunol
, vol.4
, pp. 4-8
-
-
Kato, A.1
Homma, T.2
Batchelor, J.3
Hashimoto, N.4
Imai, S.5
Wakiguchi, H.6
Saito, H.7
Matsumoto, K.8
-
168
-
-
33745946911
-
Therapeutic potential of Toll-like receptor 9 activation
-
Krieg, A.M. (2006) Therapeutic potential of Toll-like receptor 9 activation. Nat. Rev. Drug Discov., 5, 471-484.
-
(2006)
Nat. Rev. Drug Discov.
, vol.5
, pp. 471-484
-
-
Krieg, A.M.1
-
169
-
-
34547143110
-
DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response
-
Takaoka, A., Wang, Z., Choi, M.K., Yanai, H., Negishi, H., Ban, T., Lu, Y., Miyagishi, M., Kodama, T., Honda, K. et al. (2007) DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response. Nature, 448, 501-505.
-
(2007)
Nature
, vol.448
, pp. 501-505
-
-
Takaoka, A.1
Wang, Z.2
Choi, M.K.3
Yanai, H.4
Negishi, H.5
Ban, T.6
Lu, Y.7
Miyagishi, M.8
Kodama, T.9
Honda, K.10
-
170
-
-
4544277478
-
Determinants of interferon-stimulated gene induction by RNAi vectors
-
Pebernard, S. and Iggo, R.D. (2004) Determinants of interferon-stimulated gene induction by RNAi vectors. Differentiation, 72, 103-111.
-
(2004)
Differentiation
, vol.72
, pp. 103-111
-
-
Pebernard, S.1
Iggo, R.D.2
-
171
-
-
0037134020
-
A system for stable expression of short interfering RNAs in mammalian cells
-
Brummelkamp, T.R., Bernards, R. and Agami, R. (2002) A system for stable expression of short interfering RNAs in mammalian cells. Science, 296, 550-553.
-
(2002)
Science
, vol.296
, pp. 550-553
-
-
Brummelkamp, T.R.1
Bernards, R.2
Agami, R.3
-
172
-
-
24344500241
-
Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing
-
Harborth, J., Elbashir, S.M., Vandenburgh, K., Manninga, H., Scaringe, S.A., Weber, K. and Tuschl, T. (2003) Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing. Antisense Nucleic Acid Drug Dev., 13, 83-105.
-
(2003)
Antisense Nucleic Acid Drug Dev
, vol.13
, pp. 83-105
-
-
Harborth, J.1
Elbashir, S.M.2
Vandenburgh, K.3
Manninga, H.4
Scaringe, S.A.5
Weber, K.6
Tuschl, T.7
-
173
-
-
41849144420
-
Adverse effects induced by short hairpin RNA expression in porcine fetal fibroblasts
-
Stewart, C.K., Li, J. and Golovan, S.P. (2008) Adverse effects induced by short hairpin RNA expression in porcine fetal fibroblasts. Biochem. Biophys. Res. Commun., 370, 113-117.
-
(2008)
Biochem. Biophys. Res. Commun.
, vol.370
, pp. 113-117
-
-
Stewart, C.K.1
Li, J.2
Golovan, S.P.3
-
174
-
-
38349149279
-
Helper-dependent adenovirus-mediated short hairpin RNA expression in the liver activates the interferon response
-
Witting, S.R., Brown, M., Saxena, R., Nabinger, S. and Morral, N. (2008) Helper-dependent adenovirus-mediated short hairpin RNA expression in the liver activates the interferon response. J. Biol. Chem., 283, 2120-2128.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 2120-2128
-
-
Witting, S.R.1
Brown, M.2
Saxena, R.3
Nabinger, S.4
Morral, N.5
-
175
-
-
0347361541
-
Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs
-
Yi, R., Qin, Y., Macara, I.G. and Cullen, B.R. (2003) Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev., 17, 3011-3016.
-
(2003)
Genes Dev
, vol.17
, pp. 3011-3016
-
-
Yi, R.1
Qin, Y.2
Macara, I.G.3
Cullen, B.R.4
-
176
-
-
34250618419
-
Off-targeting and other non-specific effects of RNAi experiments in mammalian cells
-
Svoboda, P. (2007) Off-targeting and other non-specific effects of RNAi experiments in mammalian cells. Curr. Opin. Mol. Ther., 9, 248-257.
-
(2007)
Curr. Opin. Mol. Ther.
, vol.9
, pp. 248-257
-
-
Svoboda, P.1
-
177
-
-
50549092566
-
Expression of shRNA from a tissue-specific pol II promoter is an effective and safe RNAi therapeutic
-
Giering, J.C., Grimm, D., Storm, T.A. and Kay, M.A. (2008) Expression of shRNA from a tissue-specific pol II promoter is an effective and safe RNAi therapeutic. Mol. Ther., 16, 1630-1636.
-
(2008)
Mol. Ther.
, vol.16
, pp. 1630-1636
-
-
Giering, J.C.1
Grimm, D.2
Storm, T.A.3
Kay, M.A.4
-
178
-
-
33747799289
-
Enhancing and confirming the specificity of RNAi experiments
-
Cullen, B.R. (2006) Enhancing and confirming the specificity of RNAi experiments. Nat. Methods, 3, 677-681.
-
(2006)
Nat. Methods
, vol.3
, pp. 677-681
-
-
Cullen, B.R.1
-
179
-
-
27644436787
-
Second-generation shRNA libraries covering the mouse and human genomes
-
Silva, J.M., Li, M.Z., Chang, K., Ge, W., Golding, M.C., Rickles, R.J., Siolas, D., Hu, G., Paddison, P.J., Schlabach, M.R. et al. (2005) Second-generation shRNA libraries covering the mouse and human genomes. Nat. Genet., 37, 1281-1288.
-
(2005)
Nat. Genet.
, vol.37
, pp. 1281-1288
-
-
Silva, J.M.1
Li, M.Z.2
Chang, K.3
Ge, W.4
Golding, M.C.5
Rickles, R.J.6
Siolas, D.7
Hu, G.8
Paddison, P.J.9
Schlabach, M.R.10
-
180
-
-
2342471249
-
Enhanced gene silencing of HIV-1 specific siRNA using microRNA designed hairpins
-
Boden, D., Pusch, O., Silbermann, R., Lee, F., Tucker, L. and Ramratnam, B. (2004) Enhanced gene silencing of HIV-1 specific siRNA using microRNA designed hairpins. Nucleic Acids Res., 32, 1154-1158.
-
(2004)
Nucleic Acids Res
, vol.32
, pp. 1154-1158
-
-
Boden, D.1
Pusch, O.2
Silbermann, R.3
Lee, F.4
Tucker, L.5
Ramratnam, B.6
-
181
-
-
58149232358
-
Artificial microRNAs as siRNA shuttles: improved safety as compared to shRNAs in vitro and in vivo
-
Boudreau, R.L., Martins, I. and Davidson, B.L. (2009) Artificial microRNAs as siRNA shuttles: improved safety as compared to shRNAs in vitro and in vivo. Mol. Ther., 17, 169-175.
-
(2009)
Mol. Ther.
, vol.17
, pp. 169-175
-
-
Boudreau, R.L.1
Martins, I.2
Davidson, B.L.3
-
182
-
-
58149456661
-
Prevention of interferon-stimulated gene expression using microRNA-designed hairpins
-
Bauer, M., Kinkl, N., Meixner, A., Kremmer, E., Riemenschneider, M., Förstl, H., Gasser, T. and Ueffing, M. (2009) Prevention of interferon-stimulated gene expression using microRNA-designed hairpins. Gene Ther., 16, 142-147.
-
(2009)
Gene Ther
, vol.16
, pp. 142-147
-
-
Bauer, M.1
Kinkl, N.2
Meixner, A.3
Kremmer, E.4
Riemenschneider, M.5
Förstl, H.6
Gasser, T.7
Ueffing, M.8
-
183
-
-
52749083438
-
Design and delivery of antisense oligonucleotides to block microRNA function in cultured Drosophila and human cells
-
Horwich, M.D. and Zamore, P.D. (2008) Design and delivery of antisense oligonucleotides to block microRNA function in cultured Drosophila and human cells. Nat. Protoc., 3, 1537-1549.
-
(2008)
Nat. Protoc.
, vol.3
, pp. 1537-1549
-
-
Horwich, M.D.1
Zamore, P.D.2
-
184
-
-
58149252151
-
Stable knockdown of microRNA in vivo by lentiviral vectors
-
Gentner, B., Schira, G., Giustacchini, A., Amendola, M., Brown, B.D., Ponzoni, M. and Naldini, L. (2009) Stable knockdown of microRNA in vivo by lentiviral vectors. Nat. Methods., 6, 63-66.
-
(2009)
Nat. Methods.
, vol.6
, pp. 63-66
-
-
Gentner, B.1
Schira, G.2
Giustacchini, A.3
Amendola, M.4
Brown, B.D.5
Ponzoni, M.6
Naldini, L.7
-
185
-
-
38649105459
-
miR-122 targeting with LNA/2'-O-methyl oligonucleotide mixmers, peptide nucleic acids (PNA), and PNA-peptide conjugates
-
Fabani, M.M. and Gait, M.J. (2008) miR-122 targeting with LNA/2'-O-methyl oligonucleotide mixmers, peptide nucleic acids (PNA), and PNA-peptide conjugates. RNA, 14, 336-346.
-
(2008)
RNA
, vol.14
, pp. 336-346
-
-
Fabani, M.M.1
Gait, M.J.2
-
186
-
-
42249093319
-
LNA-mediated microRNA silencing in non-human primates
-
Elmén, J., Lindow, M., Schütz, S., Lawrence, M., Petri, A., Obad, S., Lindholm, M., Hedtjärn, M., Hansen, H.F., Berger, U. et al. (2008) LNA-mediated microRNA silencing in non-human primates. Nature, 452, 896-899.
-
(2008)
Nature
, vol.452
, pp. 896-899
-
-
Elmén, J.1
Lindow, M.2
Schütz, S.3
Lawrence, M.4
Petri, A.5
Obad, S.6
Lindholm, M.7
Hedtjärn, M.8
Hansen, H.F.9
Berger, U.10
-
187
-
-
19344378192
-
Sequence-specific inhibition of small RNA function
-
Hutvágner, G., Simard, M.J., Mello, C.C. and Zamore, P.D. (2004) Sequence-specific inhibition of small RNA function. PLoS Biol., 2, e98.
-
(2004)
PLoS Biol
, vol.2
-
-
Hutvágner, G.1
Simard, M.J.2
Mello, C.C.3
Zamore, P.D.4
-
188
-
-
33646715590
-
Improved targeting of miRNA with antisense oligonucleotides
-
Davis, S., Lollo, B., Freier, S. and Esau, C. (2006) Improved targeting of miRNA with antisense oligonucleotides. Nucleic Acids Res., 34, 2294-2304.
-
(2006)
Nucleic Acids Res
, vol.34
, pp. 2294-2304
-
-
Davis, S.1
Lollo, B.2
Freier, S.3
Esau, C.4
-
189
-
-
40249104566
-
The utility of LNA in microRNA-based cancer diagnostics and therapeutics
-
Stenvang, J., Silahtaroglu, A.N., Lindow, M., Elmen, J. and Kauppinen, S. (2008) The utility of LNA in microRNA-based cancer diagnostics and therapeutics. Semin. Cancer Biol., 18, 89-102.
-
(2008)
Semin. Cancer Biol.
, vol.18
, pp. 89-102
-
-
Stenvang, J.1
Silahtaroglu, A.N.2
Lindow, M.3
Elmen, J.4
Kauppinen, S.5
-
190
-
-
34247382522
-
Double-stranded regions are essential design components of potent inhibitors of RISC function
-
Vermeulen, A., Robertson, B., Dalby, A.B., Marshall, W.S., Karpilow, J., Leake, D., Khvorova, A. and Baskerville, S. (2007) Double-stranded regions are essential design components of potent inhibitors of RISC function. RNA, 13, 723-730.
-
(2007)
RNA
, vol.13
, pp. 723-730
-
-
Vermeulen, A.1
Robertson, B.2
Dalby, A.B.3
Marshall, W.S.4
Karpilow, J.5
Leake, D.6
Khvorova, A.7
Baskerville, S.8
-
191
-
-
34250679405
-
Specificity, duplex degradation and subcellular localization of antagomirs
-
Krützfeldt, J., Kuwajima, S., Braich, R., Rajeev, K.G., Pena, J., Tuschl, T., Manoharan, M. and Stoffel, M. (2007) Specificity, duplex degradation and subcellular localization of antagomirs. Nucleic Acids Res., 35, 2885-2892.
-
(2007)
Nucleic Acids Res
, vol.35
, pp. 2885-2892
-
-
Krützfeldt, J.1
Kuwajima, S.2
Braich, R.3
Rajeev, K.G.4
Pena, J.5
Tuschl, T.6
Manoharan, M.7
Stoffel, M.8
-
192
-
-
20444389056
-
Detection of foreign RNA: implications for RNAi
-
de Veer, M.J., Sledz, C.A. and Williams, B.R. (2005) Detection of foreign RNA: implications for RNAi. Immunol. Cell Biol., 83, 224-228.
-
(2005)
Immunol. Cell Biol.
, vol.83
, pp. 224-228
-
-
de Veer, M.J.1
Sledz, C.A.2
Williams, B.R.3
-
193
-
-
54949095836
-
Misinterpreting the therapeutic effects of small interfering RNA caused by immune stimulation
-
Robbins, M., Judge, A., Ambegia, E., Choi, C., Yaworski, E., Palmer, L., McClintock, K. and MacLachlan, I. (2008) Misinterpreting the therapeutic effects of small interfering RNA caused by immune stimulation. Hum. Gene Ther., 19, 991-999.
-
(2008)
Hum. Gene Ther.
, vol.19
, pp. 991-999
-
-
Robbins, M.1
Judge, A.2
Ambegia, E.3
Choi, C.4
Yaworski, E.5
Palmer, L.6
McClintock, K.7
MacLachlan, I.8
-
194
-
-
39449097277
-
Overcoming the innate immune response to small interfering RNA
-
Judge, A. and MacLachlan, I. (2008) Overcoming the innate immune response to small interfering RNA. Hum. Gene Ther., 19, 111-124.
-
(2008)
Hum. Gene Ther.
, vol.19
, pp. 111-124
-
-
Judge, A.1
MacLachlan, I.2
-
195
-
-
0347756922
-
Toxicogenomics of non-viral vectors for gene therapy: a microarray study of lipofectin- and oligofectamine-induced gene expression changes in human epithelial cells
-
Omidi, Y., Hollins, A.J., Benboubetra, M., Drayton, R., Benter, I.F. and Akhtar, S. (2003) Toxicogenomics of non-viral vectors for gene therapy: a microarray study of lipofectin- and oligofectamine-induced gene expression changes in human epithelial cells. J. Drug Target, 11, 311-323.
-
(2003)
J. Drug Target
, vol.11
, pp. 311-323
-
-
Omidi, Y.1
Hollins, A.J.2
Benboubetra, M.3
Drayton, R.4
Benter, I.F.5
Akhtar, S.6
-
196
-
-
6344291687
-
Lipidic carriers of siRNA: differences in the formulation, cellular uptake, and delivery with plasmid DNA
-
Spagnou, S., Miller, A.D. and Keller, M. (2004) Lipidic carriers of siRNA: differences in the formulation, cellular uptake, and delivery with plasmid DNA. Biochemistry, 43, 13348-13356.
-
(2004)
Biochemistry
, vol.43
, pp. 13348-13356
-
-
Spagnou, S.1
Miller, A.D.2
Keller, M.3
-
197
-
-
13944282215
-
Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
-
Lim, L.P., Lau, N.C., Garrett-Engele, P., Grimson, A., Schelter, J.M., Castle, J., Bartel, D.P., Linsley, P.S. and Johnson, J.M. (2005) Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature, 443, 769-773.
-
(2005)
Nature
, vol.443
, pp. 769-773
-
-
Lim, L.P.1
Lau, N.C.2
Garrett-Engele, P.3
Grimson, A.4
Schelter, J.M.5
Castle, J.6
Bartel, D.P.7
Linsley, P.S.8
Johnson, J.M.9
-
198
-
-
0038419800
-
Induction of an interferon response by RNAi vectors in mammalian cells
-
Bridge, A.J., Pebernard, S., Ducraux, A., Nicoulaz, A.L. and Iggo, R. (2003) Induction of an interferon response by RNAi vectors in mammalian cells. Nat. Genet., 34, 263-264.
-
(2003)
Nat. Genet.
, vol.34
, pp. 263-264
-
-
Bridge, A.J.1
Pebernard, S.2
Ducraux, A.3
Nicoulaz, A.L.4
Iggo, R.5
-
199
-
-
33750000660
-
Identification of miRNA targets with stable isotope labeling by amino acids in cell culture
-
Vinther, J., Hedegaard, M.M., Gardner, P.P., Andersen, J.S. and Arctander, P. (2006) Identification of miRNA targets with stable isotope labeling by amino acids in cell culture. Nucleic Acids Res., 34, e107.
-
(2006)
Nucleic Acids Res
, vol.34
-
-
Vinther, J.1
Hedegaard, M.M.2
Gardner, P.P.3
Andersen, J.S.4
Arctander, P.5
-
200
-
-
0036583926
-
Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics
-
Ong, S.E., Blagoev, B., Kratchmarova, I., Kristensen, D.B., Steen, H., Pandey, A. and Mann, M. (2002) Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics. Mol. Cell Proteomics, 1, 376-386.
-
(2002)
Mol. Cell Proteomics
, vol.1
, pp. 376-386
-
-
Ong, S.E.1
Blagoev, B.2
Kratchmarova, I.3
Kristensen, D.B.4
Steen, H.5
Pandey, A.6
Mann, M.7
-
201
-
-
49949116902
-
The impact of microRNAs on protein output
-
Baek, D., Villén, J., Shin, C., Camargo, F.D., Gygi, S.P. and Bartel, D.P. (2008) The impact of microRNAs on protein output. Nature, 455, 64-71.
-
(2008)
Nature
, vol.455
, pp. 64-71
-
-
Baek, D.1
Villén, J.2
Shin, C.3
Camargo, F.D.4
Gygi, S.P.5
Bartel, D.P.6
-
202
-
-
49949117302
-
Widespread changes in protein synthesis induced by microRNAs
-
Selbach, M., Schwanhäusser, B., Thierfelder, N., Fang, Z., Khanin, R. and Rajewsky, N. (2008) Widespread changes in protein synthesis induced by microRNAs. Nature, 455, 58-63.
-
(2008)
Nature
, vol.455
, pp. 58-63
-
-
Selbach, M.1
Schwanhäusser, B.2
Thierfelder, N.3
Fang, Z.4
Khanin, R.5
Rajewsky, N.6
-
203
-
-
49549111852
-
Proteomics joins the search for microRNA targets
-
Grosshans, H. and Filipowicz, W. (2008) Proteomics joins the search for microRNA targets. Cell, 134, 560-562.
-
(2008)
Cell
, vol.134
, pp. 560-562
-
-
Grosshans, H.1
Filipowicz, W.2
-
204
-
-
67149115119
-
Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs
-
Khan, A.A., Betel, D., Miller, M.L., Sander, C., Leslie, C.S. and Marks, D.S. (2009) Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs. Nat. Biotechnol., 27, 549-555.
-
(2009)
Nat. Biotechnol.
, vol.27
, pp. 549-555
-
-
Khan, A.A.1
Betel, D.2
Miller, M.L.3
Sander, C.4
Leslie, C.S.5
Marks, D.S.6
-
205
-
-
67749132423
-
Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps
-
Chi, S.W., Zang, J.B., Mele, A. and Darnell, R.B. (2009) Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps. Nature, 460, 479-486.
-
(2009)
Nature
, vol.460
, pp. 479-486
-
-
Chi, S.W.1
Zang, J.B.2
Mele, A.3
Darnell, R.B.4
-
206
-
-
67650484984
-
Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins
-
Ray, D., Kazan, H., Chan, E.T., Castillo, L.P., Chaudhry, S., Talukder, S., Blencowe, B.J., Morris, Q. and Hughes, T.R. (2009) Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins. Nat. Biotechnol., 27, 667-670.
-
(2009)
Nat. Biotechnol.
, vol.27
, pp. 667-670
-
-
Ray, D.1
Kazan, H.2
Chan, E.T.3
Castillo, L.P.4
Chaudhry, S.5
Talukder, S.6
Blencowe, B.J.7
Morris, Q.8
Hughes, T.R.9
-
207
-
-
0347623204
-
Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs)
-
Persengiev, S.P., Zhu, X. and Green, M.R. (2004) Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs). RNA, 10, 12-18.
-
(2004)
RNA
, vol.10
, pp. 12-18
-
-
Persengiev, S.P.1
Zhu, X.2
Green, M.R.3
-
208
-
-
65949109048
-
Profiling RNA interference (RNAi)-mediated toxicity in neural cultures for effective short interfering RNA design
-
Read, M.L., Mir, S., Spice, R., Seabright, R.J., Suggate, E.L., Ahmed, Z., Berry, M. and Logan, A. (2009) Profiling RNA interference (RNAi)-mediated toxicity in neural cultures for effective short interfering RNA design. J. Gene Med., 11, 523-534.
-
(2009)
J. Gene Med.
, vol.11
, pp. 523-534
-
-
Read, M.L.1
Mir, S.2
Spice, R.3
Seabright, R.J.4
Suggate, E.L.5
Ahmed, Z.6
Berry, M.7
Logan, A.8
-
209
-
-
67149093390
-
Efficient siRNA delivery into primary cells by a peptide transduction domain-dsRNA binding domain fusion protein
-
Eguchi, A., Meade, B.R., Chang, Y.C., Fredrickson, C.T., Willert, K., Puri, N. and Dowdy, S.F. (2009) Efficient siRNA delivery into primary cells by a peptide transduction domain-dsRNA binding domain fusion protein. Nat. Biotechnol., 27, 567-571.
-
(2009)
Nat. Biotechnol.
, vol.27
, pp. 567-571
-
-
Eguchi, A.1
Meade, B.R.2
Chang, Y.C.3
Fredrickson, C.T.4
Willert, K.5
Puri, N.6
Dowdy, S.F.7
-
210
-
-
61449250853
-
Astrocytes are very sensitive to develop innate immune responses to lipid-carried short interfering RNA
-
Gorina, R., Santalucia, T., Petegnief, V., Ejarque-Ortiz, A., Saura, J. and Planas, A.M. (2009) Astrocytes are very sensitive to develop innate immune responses to lipid-carried short interfering RNA. Glia, 57, 93-107.
-
(2009)
Glia
, vol.57
, pp. 93-107
-
-
Gorina, R.1
Santalucia, T.2
Petegnief, V.3
Ejarque-Ortiz, A.4
Saura, J.5
Planas, A.M.6
-
211
-
-
55549114663
-
5'-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma
-
Poeck, H., Besch, R., Maihoefer, C., Renn, M., Tormo, D., Morskaya, S.S., Kirschnek, S., Gaffal, E., Landsberg, J., Hellmuth, J. et al. (2008) 5'-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma. Nat. Med., 14, 1256-1263.
-
(2008)
Nat. Med.
, vol.14
, pp. 1256-1263
-
-
Poeck, H.1
Besch, R.2
Maihoefer, C.3
Renn, M.4
Tormo, D.5
Morskaya, S.S.6
Kirschnek, S.7
Gaffal, E.8
Landsberg, J.9
Hellmuth, J.10
-
212
-
-
65649085603
-
Confirming the RNAi-mediated mechanism of action of siRNA-based cancer therapeutics in mice
-
Judge, A.D., Robbins, M., Tavakoli, I., Levi, J., Hu, L., Fronda, A., Ambegia, E., McClintock, K. and MacLachlan, I. (2009) Confirming the RNAi-mediated mechanism of action of siRNA-based cancer therapeutics in mice. J. Clin. Invest., 119, 661-673.
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 661-673
-
-
Judge, A.D.1
Robbins, M.2
Tavakoli, I.3
Levi, J.4
Hu, L.5
Fronda, A.6
Ambegia, E.7
McClintock, K.8
MacLachlan, I.9
-
213
-
-
68949213101
-
Sequence determinants of innate immune activation by short interfering RNAs
-
Goodchild, A., Nopper, N., King, A., Doan, T., Tanudji, M., Arndt, G.M., Poidinger, M., Rivory, L.P. and Passioura, T. (2009) Sequence determinants of innate immune activation by short interfering RNAs. BMC Immunol., 10, 40.
-
(2009)
BMC Immunol
, vol.10
, pp. 40
-
-
Goodchild, A.1
Nopper, N.2
King, A.3
Doan, T.4
Tanudji, M.5
Arndt, G.M.6
Poidinger, M.7
Rivory, L.P.8
Passioura, T.9
-
214
-
-
47649095102
-
Chemical modification patterns compatible with high potency dicer-substrate small interfering RNAs
-
Collingwood, M.A., Rose, S.D., Huang, L., Hillier, C., Amarzguioui, M., Wiiger, M.T., Soifer, H.S., Rossi, J.J. and Behlke, M.A. (2008) Chemical modification patterns compatible with high potency dicer-substrate small interfering RNAs. Oligonucleotides, 18, 187-200.
-
(2008)
Oligonucleotides
, vol.18
, pp. 187-200
-
-
Collingwood, M.A.1
Rose, S.D.2
Huang, L.3
Hillier, C.4
Amarzguioui, M.5
Wiiger, M.T.6
Soifer, H.S.7
Rossi, J.J.8
Behlke, M.A.9
-
215
-
-
67449108173
-
TLR8-driven IL-12-dependent reciprocal and synergistic activation of NK cells and monocytes by immunostimulatory RNA
-
Berger, M., Ablasser, A., Kim, S., Bekeredjian-Ding, I., Giese, T., Endres, S., Hornung, V. and Hartmann, G. (2009) TLR8-driven IL-12-dependent reciprocal and synergistic activation of NK cells and monocytes by immunostimulatory RNA. J. Immunother., 32, 262-271.
-
(2009)
J. Immunother.
, vol.32
, pp. 262-271
-
-
Berger, M.1
Ablasser, A.2
Kim, S.3
Bekeredjian-Ding, I.4
Giese, T.5
Endres, S.6
Hornung, V.7
Hartmann, G.8
-
216
-
-
26644472182
-
Absence of non-specific effects of RNA interference triggered by long double-stranded RNA in mouse oocytes
-
Stein, P., Zeng, F., Pan, H. and Schultz, R.M. (2005) Absence of non-specific effects of RNA interference triggered by long double-stranded RNA in mouse oocytes. Dev. Biol., 286, 464-471.
-
(2005)
Dev. Biol.
, vol.286
, pp. 464-471
-
-
Stein, P.1
Zeng, F.2
Pan, H.3
Schultz, R.M.4
-
217
-
-
62549091540
-
MicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction
-
Kocerha, J., Faghihi, M.A., Lopez-Toledano, M.A., Huang, J., Ramsey, A.J., Caron, M.G., Sales, N., Willoughby, D., Elmen, J., Hansen, H.F. et al. (2009) MicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction. Proc. Natl Acad. Sci. USA, 106, 3507-3512.
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 3507-3512
-
-
Kocerha, J.1
Faghihi, M.A.2
Lopez-Toledano, M.A.3
Huang, J.4
Ramsey, A.J.5
Caron, M.G.6
Sales, N.7
Willoughby, D.8
Elmen, J.9
Hansen, H.F.10
-
218
-
-
34250851115
-
A microRNA component of the p53 tumour suppressor network
-
He, L., He, X., Lim, L.P., de Stanchina, E., Xuan, Z., Liang, Y., Xue, W., Zender, L., Magnus, J., Ridzon, D. et al. (2007) A microRNA component of the p53 tumour suppressor network. Nature, 447, 1130-1134.
-
(2007)
Nature
, vol.447
, pp. 1130-1134
-
-
He, L.1
He, X.2
Lim, L.P.3
de Stanchina, E.4
Xuan, Z.5
Liang, Y.6
Xue, W.7
Zender, L.8
Magnus, J.9
Ridzon, D.10
-
219
-
-
33645472191
-
Systematic identification of microRNA functions by combining target prediction and expression profiling
-
Wang, X. and Wang, X. (2006) Systematic identification of microRNA functions by combining target prediction and expression profiling. Nucleic Acids Res., 34, 1646-1652.
-
(2006)
Nucleic Acids Res
, vol.34
, pp. 1646-1652
-
-
Wang, X.1
Wang, X.2
-
220
-
-
66449095667
-
A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis
-
Valastyan, S., Reinhardt, F., Benaich, N., Calogrias, D., Szász, A.M., Wang, Z.C., Brock, J.E., Richardson, A.L. and Weinberg, R.A. (2009) A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis. Cell, 137, 1032-1046.
-
(2009)
Cell
, vol.137
, pp. 1032-1046
-
-
Valastyan, S.1
Reinhardt, F.2
Benaich, N.3
Calogrias, D.4
Szász, A.M.5
Wang, Z.C.6
Brock, J.E.7
Richardson, A.L.8
Weinberg, R.A.9
-
221
-
-
48349136544
-
Dispatched Homolog 2 is targeted by miR-214 through a combination of three weak microRNA recognition sites
-
Li, N., Flynt, A.S., Kim, H.R., Solnica-Krezel, L. and Patron, J.G. (2008) Dispatched Homolog 2 is targeted by miR-214 through a combination of three weak microRNA recognition sites. Nucleic Acids Res., 36, 4277-4285.
-
(2008)
Nucleic Acids Res
, vol.36
, pp. 4277-4285
-
-
Li, N.1
Flynt, A.S.2
Kim, H.R.3
Solnica-Krezel, L.4
Patron, J.G.5
-
222
-
-
65649124497
-
Vascular smooth muscle-specific knockdown of the noncardiac form of the L-type calcium channel by microRNA-based short hairpin RNA as a potential antihypertensive therapy
-
Rhee, S.W., Stimers, J.R., Wang, W. and Pang, L. (2009) Vascular smooth muscle-specific knockdown of the noncardiac form of the L-type calcium channel by microRNA-based short hairpin RNA as a potential antihypertensive therapy. J. Pharmacol Exp Ther., 329, 775-782.
-
(2009)
J. Pharmacol Exp Ther.
, vol.329
, pp. 775-782
-
-
Rhee, S.W.1
Stimers, J.R.2
Wang, W.3
Pang, L.4
-
223
-
-
50649121877
-
Minimizing variables among hairpin-based RNAi vectors reveals the potency of shRNAs
-
Boudreau, R.L., Monteys, A.M. and Davidson, B.L. (2008) Minimizing variables among hairpin-based RNAi vectors reveals the potency of shRNAs. RNA, 14, 1834-1844.
-
(2008)
RNA
, vol.14
, pp. 1834-1844
-
-
Boudreau, R.L.1
Monteys, A.M.2
Davidson, B.L.3
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