메뉴 건너뛰기




Volumn 10, Issue 3, 2002, Pages 537-548

Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYL GROUP; PHOSPHATE; RNA;

EID: 0036752955     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(02)00651-2     Document Type: Article
Times cited : (395)

References (47)
  • 1
    • 0035905766 scopus 로고    scopus 로고
    • Role for a bidentate ribonuclease in the initiation step of RNA interference
    • Bernstein E., Caudy A.A., Hammond S.M., Hannon G.J. Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature. 409:2001;363-366.
    • (2001) Nature , vol.409 , pp. 363-366
    • Bernstein, E.1    Caudy, A.A.2    Hammond, S.M.3    Hannon, G.J.4
  • 2
    • 0035807818 scopus 로고    scopus 로고
    • Specific interference with gene expression induced by long, double-stranded RNA in mouse embryonal teratocarcinoma cell lines
    • Billy E., Brondani V., Zhang H., Muller U., Filipowicz W. Specific interference with gene expression induced by long, double-stranded RNA in mouse embryonal teratocarcinoma cell lines. Proc. Natl. Acad. Sci. USA. 98:2001;14428-14433.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 14428-14433
    • Billy, E.1    Brondani, V.2    Zhang, H.3    Muller, U.4    Filipowicz, W.5
  • 3
    • 0035856381 scopus 로고    scopus 로고
    • Short 5′-phosphorylated double-stranded RNAs induce RNA interference in Drosophila
    • Boutla A., Delidakis C., Livadaras I., Tsagris M., Tabler M. Short 5′-phosphorylated double-stranded RNAs induce RNA interference in Drosophila. Curr. Biol. 11:2001;1776-1780.
    • (2001) Curr. Biol. , vol.11 , pp. 1776-1780
    • Boutla, A.1    Delidakis, C.2    Livadaras, I.3    Tsagris, M.4    Tabler, M.5
  • 4
    • 0036276110 scopus 로고    scopus 로고
    • Exon-specific RNAi: A tool for dissecting the functional relevance of alternative splicing
    • Celotto A.M., Graveley B.R. Exon-specific RNAi. a tool for dissecting the functional relevance of alternative splicing RNA. 8:2002;718-724.
    • (2002) RNA , vol.8 , pp. 718-724
    • Celotto, A.M.1    Graveley, B.R.2
  • 5
    • 0033551328 scopus 로고    scopus 로고
    • Gene silencing in Neurospora crassa requires a protein homologous to RNA-dependent RNA polymerase
    • Cogoni C., Macino G. Gene silencing in Neurospora crassa requires a protein homologous to RNA-dependent RNA polymerase. Nature. 399:1999;166-169.
    • (1999) Nature , vol.399 , pp. 166-169
    • Cogoni, C.1    Macino, G.2
  • 6
    • 0034716924 scopus 로고    scopus 로고
    • An RNA-dependent RNA polymerase gene in Arabidopsis is required for posttranscriptional gene silencing mediated by a transgene but not by a virus
    • Dalmay T., Hamilton A., Rudd S., Angell S., Baulcombe D.C. An RNA-dependent RNA polymerase gene in Arabidopsis is required for posttranscriptional gene silencing mediated by a transgene but not by a virus. Cell. 101:2000;543-553.
    • (2000) Cell , vol.101 , pp. 543-553
    • Dalmay, T.1    Hamilton, A.2    Rudd, S.3    Angell, S.4    Baulcombe, D.C.5
  • 7
    • 0021100690 scopus 로고
    • Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
    • Dignam J.D., Lebovitz R.M., Roeder R.G. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1983;1475-1489.
    • (1983) Nucleic Acids Res. , vol.11 , pp. 1475-1489
    • Dignam, J.D.1    Lebovitz, R.M.2    Roeder, R.G.3
  • 8
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in mammalian cell culture
    • Elbashir S.M., Harborth J., Lendeckel W., Yalcin A., Weber K., Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in mammalian cell culture. Nature. 411:2001;494-498. a.
    • (2001) Nature , vol.411 , pp. 494-498
    • Elbashir, S.M.1    Harborth, J.2    Lendeckel, W.3    Yalcin, A.4    Weber, K.5    Tuschl, T.6
  • 9
    • 0035863097 scopus 로고    scopus 로고
    • RNA interference is mediated by 21- and 22-nucleotide RNAs
    • Elbashir S.M., Lendeckel W., Tuschl T. RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev. 15:2001;188-200. b.
    • (2001) Genes Dev. , vol.15 , pp. 188-200
    • Elbashir, S.M.1    Lendeckel, W.2    Tuschl, T.3
  • 10
    • 0035803583 scopus 로고    scopus 로고
    • Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate
    • Elbashir S.M., Martinez J., Patkaniowska A., Lendeckel W., Tuschl T. Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate. EMBO J. 20:2001;6877-6888. c.
    • (2001) EMBO J. , vol.20 , pp. 6877-6888
    • Elbashir, S.M.1    Martinez, J.2    Patkaniowska, A.3    Lendeckel, W.4    Tuschl, T.5
  • 12
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    • Fire A., Xu S., Montgomery M.K., Kostas S.A., Driver S.E., Mello C.C. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature. 391:1998;806-811.
    • (1998) Nature , vol.391 , pp. 806-811
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3    Kostas, S.A.4    Driver, S.E.5    Mello, C.C.6
  • 13
    • 17844364875 scopus 로고    scopus 로고
    • Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing
    • Grishok A., Pasquinelli A.E., Conte D., Li N., Parrish S., Ha I., Baillie D.L., Fire A., Ruvkun G., Mello C.C. Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell. 106:2001;23-34.
    • (2001) Cell , vol.106 , pp. 23-34
    • Grishok, A.1    Pasquinelli, A.E.2    Conte, D.3    Li, N.4    Parrish, S.5    Ha, I.6    Baillie, D.L.7    Fire, A.8    Ruvkun, G.9    Mello, C.C.10
  • 14
    • 0029801668 scopus 로고    scopus 로고
    • A bulged lin-4/lin-14 RNA duplex is sufficient for Caenorhabditis elegans lin-14 temporal gradient formation
    • Ha I., Wightman B., Ruvkun G. A bulged lin-4/lin-14 RNA duplex is sufficient for Caenorhabditis elegans lin-14 temporal gradient formation. Genes Dev. 10:1996;3041-3050.
    • (1996) Genes Dev. , vol.10 , pp. 3041-3050
    • Ha, I.1    Wightman, B.2    Ruvkun, G.3
  • 15
    • 0034673638 scopus 로고    scopus 로고
    • An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells
    • Hammond S.M., Bernstein E., Beach D., Hannon G.J. An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature. 404:2000;293-296.
    • (2000) Nature , vol.404 , pp. 293-296
    • Hammond, S.M.1    Bernstein, E.2    Beach, D.3    Hannon, G.J.4
  • 16
    • 0035839109 scopus 로고    scopus 로고
    • Argonaute2, a link between genetic and biochemical analyses of RNAi
    • Hammond S.M., Boettcher S., Caudy A.A., Kobayashi R., Hannon G.J. Argonaute2, a link between genetic and biochemical analyses of RNAi. Science. 293:2001;1146-1150.
    • (2001) Science , vol.293 , pp. 1146-1150
    • Hammond, S.M.1    Boettcher, S.2    Caudy, A.A.3    Kobayashi, R.4    Hannon, G.J.5
  • 17
    • 0037062951 scopus 로고    scopus 로고
    • RNA interference
    • Hannon G.J. RNA interference. Nature. 418:2002;244-251.
    • (2002) Nature , vol.418 , pp. 244-251
    • Hannon, G.J.1
  • 18
    • 0037134623 scopus 로고    scopus 로고
    • RNA interference (RNAi) induction with various types of synthetic oligonucleotide duplexes in cultured human cells
    • Hohjoh H. RNA interference (RNAi) induction with various types of synthetic oligonucleotide duplexes in cultured human cells. FEBS Lett. 521:2002;195-199.
    • (2002) FEBS Lett. , vol.521 , pp. 195-199
    • Hohjoh, H.1
  • 19
    • 0037089135 scopus 로고    scopus 로고
    • Positional effects of short interfering RNAs targeting the human coagulation trigger Tissue Factor
    • Holen T., Amarzguioui M., Wiiger M.T., Babaie E., Prydz H. Positional effects of short interfering RNAs targeting the human coagulation trigger Tissue Factor. Nucleic Acids Res. 30:2002;1757-1766.
    • (2002) Nucleic Acids Res. , vol.30 , pp. 1757-1766
    • Holen, T.1    Amarzguioui, M.2    Wiiger, M.T.3    Babaie, E.4    Prydz, H.5
  • 20
    • 0035800521 scopus 로고    scopus 로고
    • A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA
    • Hutvágner G., McLachlan J., Pasquinelli A.E., Balint É., Tuschl T., Zamore P.D. A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science. 293:2001;834-838.
    • (2001) Science , vol.293 , pp. 834-838
    • Hutvágner, G.1    McLachlan, J.2    Pasquinelli, A.E.3    Balint, É.4    Tuschl, T.5    Zamore, P.D.6
  • 21
    • 0037144546 scopus 로고    scopus 로고
    • A microRNA in a multiple-turnover RNAi enzyme complex
    • in press. Published online August 1, 2002. 10.1126/science.1073827
    • Hutvágner G., Zamore P.D. A microRNA in a multiple-turnover RNAi enzyme complex. Science. in press. 2002;. a Published online August 1, 2002. 10.1126/science.1073827.
    • (2002) Science
    • Hutvágner, G.1    Zamore, P.D.2
  • 23
    • 0035887005 scopus 로고    scopus 로고
    • Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans
    • Ketting R.F., Fischer S.E., Bernstein E., Sijen T., Hannon G.J., Plasterk R.H. Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans. Genes Dev. 15:2001;2654-2659.
    • (2001) Genes Dev. , vol.15 , pp. 2654-2659
    • Ketting, R.F.1    Fischer, S.E.2    Bernstein, E.3    Sijen, T.4    Hannon, G.J.5    Plasterk, R.H.6
  • 24
    • 0037015015 scopus 로고    scopus 로고
    • High molecular weight RNAs and small interfering RNAs induce systemic posttranscriptional gene silencing in plants
    • Klahre U., Crete P., Leuenberger S.A., Iglesias V.A., Meins F. Jr. High molecular weight RNAs and small interfering RNAs induce systemic posttranscriptional gene silencing in plants. Proc. Natl. Acad. Sci. USA. 99:2002;11981-11986.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 11981-11986
    • Klahre, U.1    Crete, P.2    Leuenberger, S.A.3    Iglesias, V.A.4    Meins F., Jr.5
  • 25
    • 0035929322 scopus 로고    scopus 로고
    • A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegans
    • Knight S.W., Bass B.L. A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegans. Science. 293:2001;2269-2271.
    • (2001) Science , vol.293 , pp. 2269-2271
    • Knight, S.W.1    Bass, B.L.2
  • 26
    • 0027751663 scopus 로고
    • The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
    • Lee R.C., Feinbaum R.L., Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell. 75:1993;843-854.
    • (1993) Cell , vol.75 , pp. 843-854
    • Lee, R.C.1    Feinbaum, R.L.2    Ambros, V.3
  • 27
    • 0036727416 scopus 로고    scopus 로고
    • Efficient delivery of siRNA for inhibition of gene expression in postnatal mice
    • Lewis D.L., Hagstrom J.E., Loomis A.G., Wolff J.A., Herweijer H. Efficient delivery of siRNA for inhibition of gene expression in postnatal mice. Nat. Genet. 33:2002;107-108.
    • (2002) Nat. Genet. , vol.33 , pp. 107-108
    • Lewis, D.L.1    Hagstrom, J.E.2    Loomis, A.G.3    Wolff, J.A.4    Herweijer, H.5
  • 28
    • 0035798399 scopus 로고    scopus 로고
    • RNAi as random degradative PCR. siRNA primers convert mRNA into dsRNAs that are degraded to generate new siRNAs
    • Lipardi C., Wei Q., Paterson B.M. RNAi as random degradative PCR. siRNA primers convert mRNA into dsRNAs that are degraded to generate new siRNAs. Cell. 107:2001;297-307.
    • (2001) Cell , vol.107 , pp. 297-307
    • Lipardi, C.1    Wei, Q.2    Paterson, B.M.3
  • 30
    • 0037031576 scopus 로고    scopus 로고
    • Single-stranded antisense siRNAs guide target RNA cleavage in RNAi
    • Martinez J., Patkaniowska A., Urlaub H., Lührmann R., Tuschl T. Single-stranded antisense siRNAs guide target RNA cleavage in RNAi. Cell. 110:2002;563-574.
    • (2002) Cell , vol.110 , pp. 563-574
    • Martinez, J.1    Patkaniowska, A.2    Urlaub, H.3    Lührmann, R.4    Tuschl, T.5
  • 32
    • 0030970775 scopus 로고    scopus 로고
    • The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA
    • Moss E.G., Lee R.C., Ambros V. The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA. Cell. 88:1997;637-646.
    • (1997) Cell , vol.88 , pp. 637-646
    • Moss, E.G.1    Lee, R.C.2    Ambros, V.3
  • 34
    • 0035900635 scopus 로고    scopus 로고
    • A short primer on RNAi: RNA-directed RNA polymerase acts as a key catalyst
    • Nishikura K. A short primer on RNAi. RNA-directed RNA polymerase acts as a key catalyst Cell. 107:2001;415-418.
    • (2001) Cell , vol.107 , pp. 415-418
    • Nishikura, K.1
  • 35
    • 0035798415 scopus 로고    scopus 로고
    • ATP requirements and small interfering RNA structure in the RNA interference pathway
    • Nykänen A., Haley B., Zamore P.D. ATP requirements and small interfering RNA structure in the RNA interference pathway. Cell. 107:2001;309-321.
    • (2001) Cell , vol.107 , pp. 309-321
    • Nykänen, A.1    Haley, B.2    Zamore, P.D.3
  • 36
    • 0033572284 scopus 로고    scopus 로고
    • The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation
    • Olsen P.H., Ambros V. The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation. Dev. Biol. 216:1999;671-680.
    • (1999) Dev. Biol. , vol.216 , pp. 671-680
    • Olsen, P.H.1    Ambros, V.2
  • 39
    • 0037085968 scopus 로고    scopus 로고
    • Two genetic circuits repress the Caenorhabditis elegans heterochronic gene lin-28 after translation initiation
    • Seggerson K., Tang L., Moss E.G. Two genetic circuits repress the Caenorhabditis elegans heterochronic gene lin-28 after translation initiation. Dev. Biol. 243:2002;215-225.
    • (2002) Dev. Biol. , vol.243 , pp. 215-225
    • Seggerson, K.1    Tang, L.2    Moss, E.G.3
  • 41
    • 0034708215 scopus 로고    scopus 로고
    • EGO-1 is related to RNA-directed RNA polymerase and functions in germ-line development and RNA interference in C. elegans
    • Smardon A., Spoerke J., Stacey S., Klein M., Mackin N., Maine E. EGO-1 is related to RNA-directed RNA polymerase and functions in germ-line development and RNA interference in C. elegans. Curr. Biol. 10:2000;169-178.
    • (2000) Curr. Biol. , vol.10 , pp. 169-178
    • Smardon, A.1    Spoerke, J.2    Stacey, S.3    Klein, M.4    Mackin, N.5    Maine, E.6
  • 43
    • 0037188904 scopus 로고    scopus 로고
    • The dsRNA binding protein RDE-4 interacts with RDE-1, DCR-1, and a DexH-Box helicase to direct RNAi in C. elegans
    • Tabara H., Yigit E., Siomi H., Mello C.C. The dsRNA binding protein RDE-4 interacts with RDE-1, DCR-1, and a DexH-Box helicase to direct RNAi in C. elegans. Cell. 109:2002;861-871.
    • (2002) Cell , vol.109 , pp. 861-871
    • Tabara, H.1    Yigit, E.2    Siomi, H.3    Mello, C.C.4
  • 44
    • 0037169034 scopus 로고    scopus 로고
    • RNA helicase MUT-14-dependent gene silencing triggered in C. elegans by short antisense RNAs
    • Tijsterman M., Ketting R.F., Okihara K.L., Sijen T., Plasterk R.H. RNA helicase MUT-14-dependent gene silencing triggered in C. elegans by short antisense RNAs. Science. 295:2002;694-697.
    • (2002) Science , vol.295 , pp. 694-697
    • Tijsterman, M.1    Ketting, R.F.2    Okihara, K.L.3    Sijen, T.4    Plasterk, R.H.5
  • 45
    • 0027730383 scopus 로고
    • Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans
    • Wightman B., Ha I., Ruvkun G. Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell. 75:1993;855-862.
    • (1993) Cell , vol.75 , pp. 855-862
    • Wightman, B.1    Ha, I.2    Ruvkun, G.3
  • 46
    • 0034737298 scopus 로고    scopus 로고
    • Rnai: Double-stranded rna directs the atp-dependent cleavage of mRNA at 21 to 23 nucleotide intervals
    • Zamore P., Tuschl T., Sharp P., Bartel D. Rnai. double-stranded rna directs the atp-dependent cleavage of mRNA at 21 to 23 nucleotide intervals Cell. 101:2000;25-33.
    • (2000) Cell , vol.101 , pp. 25-33
    • Zamore, P.1    Tuschl, T.2    Sharp, P.3    Bartel, D.4
  • 47
    • 0036294527 scopus 로고    scopus 로고
    • Technique: Both natural and designed microRNAs can inhibit the expression of cognate mRNAs when expressed in human cells
    • Zeng Y., Wagner E.J., Cullen B.R. Technique. both natural and designed microRNAs can inhibit the expression of cognate mRNAs when expressed in human cells Mol. Cell. 9:2002;1327-1333.
    • (2002) Mol. Cell , vol.9 , pp. 1327-1333
    • Zeng, Y.1    Wagner, E.J.2    Cullen, B.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.