Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA

Nature

Volumn 454, Issue 7203, 2008, Pages 523-527

  Saito, Takeshi ^a   Owen, David M ^a,b   Jiang, Fuguo ^c   Marcotrigiano, Joseph ^c   Gale Jr , Michael ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; CYTIDINE; HEPATITIS C VACCINE; IMMUNOLOGICAL ADJUVANT; INTERFERON; INTERFERON STIMULATED GENE FACTOR; PATHOGEN ASSOCIATED MOLECULAR PATTERN RNA; PHOSPHATE; PLASMID VECTOR; POLY U UC RNA; POLYADENYLATED RNA; POLYCYTIDYLIC ACID; POLYGUANYLIC ACID; RETINOIC ACID INDUCIBLE PROTEIN I; RIBONUCLEOTIDE; TRANSCRIPTION FACTOR; VIRUS RNA;

DISEASE CONTROL; ENZYME ACTIVITY; GENE EXPRESSION; GENOME; HEPATITIS; IMMUNITY; POLYMER; RNA; VACCINE; VIRUS;

3' UNTRANSLATED REGION; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; CYTOKINE RELEASE; EMBRYO; GENE REPLICATION; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; IMMUNOGENICITY; IMMUNOSTIMULATION; IMMUNOTHERAPY; IN VITRO STUDY; IN VIVO STUDY; INNATE IMMUNITY; LIVER FUNCTION; MACROMOLECULE; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN MOTIF; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; VIRUS GENOME; VIRUS INHIBITION;

ADENINE; ANIMALS; CELL LINE; DEAD-BOX RNA HELICASES; GENOME, VIRAL; HEPACIVIRUS; HUMANS; IMMUNITY, NATURAL; INTERFERON-BETA; LIGANDS; LIVER; MICE; RNA, VIRAL; URIDINE; VIRUS REPLICATION;

HEPATITIS C VIRUS; MURINAE; RNA VIRUSES;

EID: 47949092573     PISSN: 00280836     EISSN: 14764679     Source Type: Journal    
DOI: 10.1038/nature07106     Document Type: Article

References (30)

1. Saito, T. & Gale, M. Principles of intracellular viral recognition. Curr. Opin. Immunol. 19, 17-23 (2007).
2. Lauer, G. M. & Walker, B. D. Medical progress: Hepatitis C virus infection. N. Engl. J. Med. 345, 41-52 (2001).
3. Gale, M. & Foy, E. M. Evasion of intracellular host defence by hepatitis C virus. Nature 436, 939-945 (2005).
4. Sumpter, R. et al. Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I. J. Virol. 79, 2689-2699 (2005).
5. Hornung, V. et al. 5′-triphosphate RNA is the ligand for RIG-I. Science 314, 994-997 (2006).
6. Pichlmair, A. et al. RIG-I-mediated antiviral responses to single-stranded RNA bearing 5′-phosphates. Science 314, 997-1001 (2006).
7. Yoneyama, M. et al. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nature Immunol. 5, 730-737 (2004).
8. Loo, Y. M. et al. Distinct RIG-I and MDA5 signaling regulation by RNA viruses in innate immunity. J. Virol. 27, 697 (2007).
9. Lau, D. T. et al. Interferon regulatory factor-3 activation, hepatic interferon-stimulated gene expression, and immune cell infiltration in hepatitis C virus patients. Hepatology 47, 799-809 (2008).
10. Smith, M. W. et al. Gene expression patterns that correlate with hepatitis C and early progression to fibrosis in liver transplant recipients. Gastroenterology 130, 179-187 (2006).
11. Simmonds, P. Genetic diversity and evolution of hepatitis C virus - 15 years on. J. Gen. Virol. 85, 3173-3188 (2004).
12. Kolykhalov, A. A., Mihalik, K., Feinstone, S. M. & Rice, C. M. Hepatitis C virus-encoded enzymatic activities and conserved RNA elements in the 3′ nontranslated region are essential for virus replication in vivo. J. Virol. 74, 2046-2051 (2000).
13. Yi, M. K. & Lemon, S. M. 3′ Nontranslated RNA signals required for replication of hepatitis C virus RNA. J. Virol. 77, 3557-3568 (2003).
14. Honda, M. et al. Structural requirements for initiation of translation by internal ribosome entry within genome-length hepatitis C virus RNA. Virology 222, 31-42 (1996).
15. Kato, H. et al. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 441, 101-105 (2006).
16. Heil, F. et al. Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science 303, 1526-1529 (2004).
17. Saito, T. et al. Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2. Proc. Natl Acad. Sci. USA 104, 582-587 (2007).
18. Takahasi, K. et al. Nonself RNA-sensing mechanism of RIG-I helicase and activation of antiviral immune responses. Mol. Cell 29, 428-440 (2008).
19. Cui, S. et al. The C-terminal regulatory domain is the RNA 5′-triphosphate sensor of RIG-I. Mol. Cell 29, 169-179 (2008).
20. Marques, J. T. et al. A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells. Nature Biotechnol. 24, 559-565 (2006).
21. You, S. & Rice, C. M. 3′ RNA elements in hepatitis C virus replication: kissing partners and long poly(U). J. Virol. 82, 184-195 (2008).
22. Ito, T. & Lai, M. M. C. An internal polypyrimidine-tract-binding protein-binding site in the hepatitis C virus RNA attenuates translation, which is relieved by the 3′-untranslated sequence. Virology 254, 288-296 (1999).
23. Kim, D. H. et al. Interferon induction by siRNAs and ssRNAs synthesized by phage polymerase. Nature Biotechnol. 22, 321-325 (2004).
24. Afonina, E., Stauber, R. & Pavlakis, G. N. The human Poly(A)-binding protein 1 shuttles between the nucleus and the cytoplasm. J. Biol. Chem. 273, 13015-13021 (1998).
25. Yusupov, M. M. et al. Crystal structure of the ribosome at 5.5Å resolution. Science 292, 883-896 (2001).
26. Meylan, E. et al. Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature 437, 1167-1172 (2005).
27. Loo, Y. M. et al. Viral and therapeutic control of IFN-β promoter stimulator 1 during hepatitis C virus infection. Proc. Natl Acad. Sci. USA 103, 6001-6006 (2006).
28. Tse, K. & Horner, A. A. Update on toll-like receptor-directed therapies for human disease. Ann. Rheum. Dis. 66 (suppl. 3), 77-80 (2007).
29. Beard, M. R. et al. An infectious molecular clone of a Japanese genotype 1b hepatitis C virus. Hepatology 30, 316-324 (1999).
30. Takaoka, A. et al. DAI (DLM-1/ZBP1) is a cytosolic DNAsensor and an activator of innate immune response. Nature 448, 501-505 (2007).