TLR8-driven IL-12-dependent reciprocal and synergistic activation of NK cells and monocytes by immunostimulatory RNA

Journal of Immunotherapy

Volumn 32, Issue 3, 2009, Pages 262-271

  Berger, Michael ^a,b   Ablasser, Andrea ^c   Kim, Sarah ^a   Bekeredjian Ding, Isabelle ^d   Giese, Thomas ^d   Endres, Stefan ^a   Hornung, Veit ^c   Hartmann, Gunther ^c  

^a Division of Clinical Pharmacology

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c UNIVERSITY HOSPITAL BONN   (Germany)

^d UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Anticancer therapy; IsRNA; Monocytes, TLRs; NK cells

Indexed keywords

GAMMA INTERFERON; IMMUNOSTIMULATORY RNA; INTERLEUKIN 12; NUCLEIC ACID; RNA; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; UNCLASSIFIED DRUG; LIGAND; TLR7 PROTEIN, HUMAN; TLR8 PROTEIN, HUMAN;

ACCESSORY CELL; ANIMAL CELL; ANTIGEN SPECIFICITY; ARTICLE; CELL ACTIVATION; CELL FUNCTION; CELL INTERACTION; CELL MEDIATED CYTOTOXICITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOLYSIS; DAUDI CELL; HUMAN; HUMAN CELL; INTERFERON PRODUCTION; MOLECULAR LIBRARY; MONOCYTE; MOUSE; NATURAL KILLER T CELL; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; ANIMAL; BIOSYNTHESIS; CELL COMMUNICATION; CELL CULTURE; COCULTURE; CYTOTOXICITY; DRUG EFFECT; DRUG POTENTIATION; GENETICS; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MOUSE MUTANT; NATURAL KILLER CELL; TUMOR CELL LINE;

ANIMALS; CELL COMMUNICATION; CELL LINE, TUMOR; CELLS, CULTURED; COCULTURE TECHNIQUES; CYTOTOXICITY, IMMUNOLOGIC; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-12; KILLER CELLS, NATURAL; LIGANDS; LYMPHOCYTE ACTIVATION; MICE; MICE, KNOCKOUT; MONOCYTES; RNA; TOLL-LIKE RECEPTOR 7; TOLL-LIKE RECEPTOR 8;

EID: 67449108173     PISSN: 15249557     EISSN: None     Source Type: Journal    
DOI: 10.1097/CJI.0b013e318198bd2a     Document Type: Article

References (30)

1. Hornung V, Guenthner-Biller M, Bourquin C, et al. Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7. Nat Med. 2005;11:263-270.
2. Bourquin C, Schmidt L, Hornung V, et al. Immunostimulatory RNA oligonucleotides trigger an antigen-specific cytotoxic T-cell and IgG2a response. Blood. 2007;109:2953-2960.
3. Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell. 2006; 124:783-801.
4. Alexopoulou L, Holt AC, Medzhitov R, et al. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature. 2001;413:732-738.
5. Diebold SS, Kaisho T, Hemmi H, et al. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science. 2004;303:1529-1531.
6. Heil F, Hemmi H, Hochrein H, et al. Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science. 2004;303:1526-1529.
7. Hemmi H, Takeuchi O, Kawai T, et al. A Toll-like receptor recognizes bacterial DNA. Nature. 2000;408:740-745.
8. Bauer S, Kirschning CJ, Hacker H, et al. Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition. Proc Natl Acad Sci USA. 2001;98: 9237-9242.
9. Biron CA, Nguyen KB, Pien GC, et al. Natural killer cells in antiviral defense: function and regulation by innate cytokines. Annu Rev Immunol. 1999;17:189-220.
10. Raulet DH. Missing self recognition and self tolerance of natural killer (NK) cells. Semin Immunol. 2006; 18:145-150.
11. Cerwenka A, Lanier LL. Natural killer cells, viruses and cancer. Nat Rev Immunol. 2001;1:41-49.
12. Lanier LL. On guard - activating NK cell receptors. Nat Immunol. 2001;2:23-27.
13. Moretta A, Bottino C, Vitale M, et al. Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis. Annu Rev Immunol. 2001;19:197-223.
14. + CD25hi T regulatory cells. Eur J Immunol. 2005;35:2452-2458.
15. Gerosa F, Baldani-Guerra B, Nisii C, et al. Reciprocal activating interaction between natural killer cells and dendritic cells. J Exp Med. 2002;195:327-333.
16. Sivori S, Falco M, Della Chiesa M, et al. CpG and double-stranded RNA trigger human NK cells by Toll-like receptors: induction of cytokine release and cytotoxicity against tumors and dendritic cells. Proc Natl Acad Sci USA. 2004;101: 10116-10121.
17. Hart OM, Athie-Morales V, O'Connor GM, et al. TLR7/8-mediated activation of human NK cells results in accessory cell-dependent IFN-gamma production. J Immunol. 2005;175: 1636-1642.
18. Gorski KS, Waller EL, Bjornton-Severson J, et al. Distinct indirect pathways govern human NK-cell activation by TLR-7 and TLR-8 agonists. Int Immunol. 2006;18:1115-1126.
19. Lauzon NM, Mian F, Mackenzie R, et al. The direct effects of Toll-like receptor ligands on human NK cell cytokine production and cytotoxicity. Cell Immunol. 2006;241:102-112.
20. Sivori S, Carlomagno S, Moretta L, et al. Comparison of different CpG oligodeoxynucleotide classes for their capability to stimulate human NK cells. Eur J Immunol. 2006;36:961-967.
21. Alter G, Suscovich TJ, Teigen N, et al. Single-stranded RNA derived from HIV-1 serves as a potent activator of NK cells. J Immunol. 2007; 178:7658-7666.
22. Gordon S, Taylor PR. Monocyte and macrophage heterogeneity. Nat Rev Immunol. 2005;5:953-964.
23. + monocytes. J Immunol. 2005;174: 2273-2279.
24. Bekeredjian-Ding I, Roth SI, Gilles S, et al. T cell-independent, TLR-induced IL-12p70 production in primary human monocytes. J Immunol. 2006;176:7438-7446.
25. Hornung V, Rothenfusser S, Britsch S, et al. Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J Immunol. 2002;168:4531-4537.
26. Della Chiesa M, Romagnani C, Thiel A, et al. Multidirectional interactions are bridging human NK cells with plasmacytoid and monocyte-derived dendritic cells during innate immune responses. Blood. 2006;108:3851-3858.
27. Kanneganti TD, Ozoren N, Body-Malapel M, et al. Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. Nature. 2006;40:233-236.
28. Gitlin L, Barchet W, Gilfillan S, et al. Essential role of MDA-5 in type I IFN responses to polyriboinosinic: polyribocytidylic acid and encephalomyocarditis picornavirus. Proc Natl Acad Sci USA. 2006;103:8459-8464.
29. Kato H, Takeuchi O, Sato S, et al. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature. 2006;441:101-105.
30. Moretta L, Bottino C, Pende D, et al. Human natural killer cells: their origin, receptors and function. Eur J Immunol. 2002; 32:1205-1211.