Two classes of short interfering RNA in RNA silencing

EMBO Journal

Volumn 21, Issue 17, 2002, Pages 4671-4679

  Hamilton, Andrew ^b   Voinnet, Olivier ^b   Chappell, Louise ^a   Baulcombe, David ^a  

^a SAINSBURY LABORATORY   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

DNA methylation; Double stranded RNA; Retroelements; RNA silencing; Silencing suppressor; Systemic signalling

Indexed keywords

DOUBLE STRANDED RNA; GREEN FLUORESCENT PROTEIN;

ARABIDOPSIS; ARTICLE; CONTROLLED STUDY; GENE MUTATION; GENE SILENCING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RETROPOSON; RNA ANALYSIS; RNA DEGRADATION; RNA METHYLATION; RNA SEQUENCE; SIGNAL TRANSDUCTION; TRANSGENE;

ANIMALIA; ARABIDOPSIS; EUKARYOTA;

EID: 0037009520     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdf464     Document Type: Article

References (66)

1. A viral suppressor of gene silencing in plants
2. A calmodulin-related protein that suppresses posttranscriptional gene silencing in plants
3. Double-stranded RNA-mediated silencing of genomic tandem repeats and transposable elements in the D. melanogaster germline
4. Agrobacterium transient expression system as a tool for isolation of disease resistance genes: Application to the Rx2 locus in potato
5. Role for a bidentate ribonuclease in the initiation step of RNA interference
6. Viral pathogenicity determinants are suppressors of transgene silencing in Nicotiana benthamiana
7. An RNA-dependent RNA polymerase gene in Arabidopsis is required for posttranscriptional gene silencing mediated by a transgene but not by a virus
8. SDE3 encodes an RNA helicase required for post-transcriptional gene silencing in Arabidopsis
9. Identification, subcellular localization and some properties of a cysteine-rich suppressor of gene silencing encoded by peanut clump virus
10. RNA interference is mediated by 21- and 22-nucleotide RNAs
11. Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate
12. Arabidopsis mutants impaired in cosuppression
13. Suppression of virus accumulation in transgenic plants exhibiting silencing of nuclear genes
14. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
15. Inactivation of gene expression in plants as a consequence of specific sequence duplication
16. TNT1, a mobile retroviral-like transposable element of tobacco isolated by plant-cell genetics
17. Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing
18. A viral protein inhibits the long range signaling activity of the gene silencing signal
19. A novel species of small antisense RNA in post-transcriptional gene silencing
20. Stable transfer of intact high molecular weight DNA into plant chromosomes
21. An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cell extracts
22. Argonaute2, a link between genetic and biochemical analyses of RNAi
23. Post-transcriptional gene silencing by double-stranded RNA
24. pGreen: A versatile and flexible binary Ti vector for Agrobacteruim-mediated plant transformation
25. Silencing of retrotransposons in arabidopsis and reactivation by the ddm1 mutation
26. A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA
27. Posttranscriptional silencing of reporter transgenes in tobacco correlates with DNA methylation
28. Silencing on the spot. Induction and suppression of RNA silencing in the Agrobacterium-mediated transient expression system
29. RNA-DNA interactions and DNA methylation in post-transcriptional gene silencing
30. RNA-directed transcriptional gene silencing in plants can be inherited independently of the RNA trigger and requires Met1 for maintenance
31. A counterdefensive strategy of plant viruses: Suppression of post-transcriptional gene silencing
32. mut-7 of C. elegans, required for transposon silencing and RNA interference, is a homolog of Werner syndrome helicase and RNaseD
33. Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans
34. Virus-encoded suppressor of posttranscriptional gene silencing targets a maintenance step in the silencing pathway
35. HC-Pro suppression of transgene silencing eliminates the small RNAs but not transgene methylation or the mobile signal
36. Pathogen-derived resistance targeted against the negative-strand RNA of tobacco mosaic virus: RNA strand-specific gene silencing?
37. Transcriptional silencing and promoter methylation triggered by double-stranded RNA
38. Resistance of RNA-mediated TGS to HC-Pro, a viral suppressor of PTGS, suggests alternative pathways for dsRNA processing
39. Post-transcriptional silencing of pectin methylesterase gene in transgenic tomato fruits results from impaired pre-mRNA processing
40. Mobilization of transposons by a mutation abolishing full DNA methylation in Arabidopsis
41. DNA methylation and chromatin structure affect transcriptional and post-transcriptional transgene silencing in Arabidopsis
42. Arabidopsis SGS2 and SGS3 genes are required for posttranscriptional gene silencing and natural virus resistance
43. Identification and structural analysis of SINE elements in the Arabidopsis thaliana genome
44. Introduction of a chimeric chalcone synthase gene into Petunia results in reversible co-suppression of homologous genes in trans
45. ATP requirements and small interfering RNA structure in the RNA interference pathway
46. Systemic acquired silencing: Transgene-specific post-transcriptional silencing is transmitted by grafting from silenced stocks to nonsilenced scions
47. The silence of the genes
48. Tobacco rattle virus as a vector for analysis of gene function by silencing
49. Initiation and maintenance of virus-induced gene silencing
50. RNA interference
51. On the role of RNA amplification in dsRNA-triggered gene silencing
52. Transcriptional and posttranscriptional gene silencing are mechanistically related
53. The rde-1 gene, RNA interference and transposon silencing in C. elegans
54. Spreading of RNA targeting and DNA methylation in RNA silencing requires transcription of the target gene and a putative RNA-dependent RNA polymerase
55. Post-transcriptional silencing of a neomycin phosphotransferase II transgene correlates with the accumulation of unproductive RNAs and with increased cytosine methylation of 3′ flanking regions
56. RNA silencing as a plant immune system against viruses
57. Systemic signalling in gene silencing
58. Systemic spread of sequence-specific transgene RNA degradation is initiated by localised introduction of ectopic promoterless DNA
59. Suppression of gene silencing: A general strategy used by diverse DNA and RNA viruses
60. A viral movement protein prevents systemic spread of the gene silencing signal in Nicotiana benthamiana
61. A model for RNA-mediated gene silencing in higher plants
62. Systemic RNA in C. elegans requires the putative transmembrane protein SID-1
63. Transgene and transposon silencing in Chlamydomonas reinhardtii by a DEAH-Box RNA helicase
64. Molecular characterisation of a short interspersed repetitive element from tobacco that exhibits sequence homology to specific transfer-RNAS
65. RNAi: Double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals