Nuclear Export of MicroRNA Precursors

Science

Volumn 303, Issue 5654, 2004, Pages 95-98

  Lund, Elsebet ^a   Güttinger, Stephan ^b   Calado, Angelo ^b,c   Dahlberg, James E ^a   Kutay, Ulrike ^b  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b ETH ZURICH   (Switzerland)

^c UNIVERSITY OF LISBON   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

GENES; PHOSPHATES;

GENE EXPRESSION;

RNA;

CARRIER PROTEIN; ENDONUCLEASE; EXPORTIN 5; GUANOSINE TRIPHOSPHATE; MICRORNA; RAN PROTEIN; RIBONUCLEASE III; RNA PRECURSOR; UNCLASSIFIED DRUG;

GENE EXPRESSION; RNA;

ARTICLE; CELL NUCLEUS; CYTOPLASM; EUKARYOTE; GENE EXPRESSION REGULATION; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN RNA BINDING; RNA PROCESSING;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; CARRIER PROTEINS; CELL NUCLEUS; CYTOPLASM; GUANOSINE TRIPHOSPHATE; HELA CELLS; HUMANS; KARYOPHERINS; MICRORNAS; NUCLEOCYTOPLASMIC TRANSPORT PROTEINS; OOCYTES; RAN GTP-BINDING PROTEIN; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECOMBINANT PROTEINS; RIBONUCLEASE III; RNA INTERFERENCE; RNA PRECURSORS; RNA, SMALL INTERFERING; XENOPUS;

EUKARYOTA;

EID: 0347988235     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1090599     Document Type: Article

References (31)

1. M. Lagos-Quintana, R. Rauhut, W. Lendeckel, T. Tuschi, Science 294, 853 (2001).
2. N. Lau, L. Lim, E. Weinstein, D. Bartel, Science 294, 858 (2001).
3. R. Lee, V. Ambros, Science 294, 862 (2001).
4. Z. Mourelatos et al., Genes Dev. 16, 720 (2002).
5. B. Reinhart, E. Weinstein, M. Rhoades, B. Bartel, D. Bartel, Genes Dev. 16, 1616 (2002).
6. M. Carmell, Z. Xuan, M. Zhang, G. Hannon, Genes Dev. 16, 2733 (2002).
7. E. Moss, R. Poethig, Curr. Biol. 12, R688 (2002).
8. D. Dykxhoom, C. Novina, P. Sharp, Nature Rev. Mol. Cell. Biol. 4, 457 (2003).
9. R. Lee, R. Feinbaum, V. Ambros, Cell 75, 843 (1993).
10. D. Banerjee, F. Slack, Bioessays 24, 119 (2002).
11. A. Pasquinelli, G. Ruvkun, Annu. Rev. Cell Dev. Biol. 18, 495 (2002).
12. J. Carrington, V. Ambros, Science 301, 336 (2003).
13. C. Kidner, R. Martienssen, Trends Genet. 19, 13 (2003).
14. Y. Lee, K. Jeon, J. Lee, S. Kim, V. Kim, EMBO J. 21, 4663 (2002).
15. Y. Lee et al., Nature 425, 415 (2003).
16. G. Hutvagner et al., Science 293, 834 (2001).
17. R. Ketting et al., Genes Dev. 15, 2654 (2001).
18. Y. Zeng, B. Cullen, RNA 9, 112 (2003).
19. Materials and Methods are available as supporting material on Science Online.
20. H. Zhang, F. Kolb, V. Brondani, E. Billy, W. Filipowicz, EMBO J. 21, 5875 (2002).
21. H. Fried, U. Kutay, Cell. Mol. Life Sci. 60, 1659 (2003).
22. E. Izaurralde, U. Kutay, C. von Kobbe, I. Mattaj, D. Görlich, EMBO J. 16, 6535 (1997).
23. E. Lund et al., unpublished data.
24. A. Brownawell, I. Macara, J. Cell Biol. 156, 53 (2002).
25. C. Gwizdek et al., J. Biol. Chem. 278, 5505 (2003).
26. A. Calado, N. Treichel, E. Müller, A. Otto, U. Kutay, EMBO J. 21, 6216 (2002).
27. M. Tems, E. Lund, J. Dahlberg, Mol. Cell Biol. 12, 3032 (1992).
28. C. Grimm, E. Lund, J. Dahlberg, EMBO J. 16, 793 (1997).
29. M. Bohnsack et al., EMBO J. 21, 6205 (2002).
30. K. Bollman et al., Development 130, 1493 (2003).
31. We thank E. White and B. Clark for technical assistance; M. Olson, H. Allawi, V. Lyamichev, and S. Olson of Third Wave Technologies Inc. Madison, WI for help with Invader assays; C. B. Jensen for initiating in vitro Dicer experiments; and G. Lipowsky and S. Hasan for critically reading the manuscript. UK is supported by the Swiss National Science Foundation, and J.E.D. and E.L. are supported by NIH grant GM-30220. J.E.D. and E.L. have a financial interest in Third Wave Technologies Inc.