Cytosolic viral sensor RIG-I is a 5′-triphosphate-dependent translocase on double-stranded RNA

Science

Volumn 323, Issue 5917, 2009, Pages 1070-1074

  Myong, Sua ^a   Cui, Sheng ^b   Cornish, Peter V ^c,d   Kirchhofer, Axel ^b   Gack, Michaela U ^e,f,g   Jung, Jae U ^e,f   Hopfner, Karl Peter ^b   Ha, Taekjip ^a,c,d  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF MUNICH   (Germany)

^c University of Illinois at Urbana Champaign   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^e UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^f HARVARD MEDICAL SCHOOL   (United States)

^g UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CASPASE RECRUITMENT DOMAIN SIGNALING PROTEIN; DOUBLE STRANDED RNA; RETINOIC ACID INDUCIBLE PROTEIN I;

ENZYME ACTIVITY; FLUORESCENCE; GENE EXPRESSION; IMMUNE RESPONSE; MOLECULAR ANALYSIS; PHOSPHATE; PROTEIN; RNA; TRANSLOCATION; VIRUS;

ARTICLE; CONTROLLED STUDY; CYTOSOL; ENZYME BINDING; PRIORITY JOURNAL; RNA TRANSPORT;

ADENOSINE TRIPHOSPHATE; ANIMALS; CELL LINE; CYTOSOL; DEAD-BOX RNA HELICASES; KINETICS; NUCLEIC ACID HETERODUPLEXES; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, PATTERN RECOGNITION; RNA; RNA, DOUBLE-STRANDED; RNA, VIRAL; SIGNAL TRANSDUCTION; TEMPERATURE;

EID: 60749124538     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1168352     Document Type: Article

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31. We thank C. Joo and K. Ragunathan for careful review of the manuscript. This work was supported by NIH grant R01-GM065367 and NSF Physics Frontiers Center grant 0822613 to T.H., NIH grant CA82057 to J.U.J., and a Human Frontiers of Science grant to T.H. and K.-P.H. K.-P.H. acknowledges support from the German Excellence Initiative. S.C. is supported by Deutsche Forschungsgemeinschaft (DFG) program project 455 to K.-P.H. A.K. acknowledges support from the DFG graduate school 1202. T.H. is an investigator with the Howard Hughes Medical Institute. S.M. is a fellow at the Institute for Genomic Biology.