Transcriptional signaling by double-stranded RNA: Role of TLR3

Cytokine and Growth Factor Reviews

Volumn 16, Issue 1, 2005, Pages 1-14

  Sen, Ganes C ^a   Sarkar, Saumendra N ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Double stranded RNA; PI3 kinase; Receptor tyrosine phosphorylation; Toll like receptor 3; Viral stress inducible genes

Indexed keywords

ADAPTOR PROTEIN; CYTOKINE; DOUBLE STRANDED RNA; INTERFERON; INTERFERON REGULATORY FACTOR 3; ISOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN TRIF; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 3; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

CYTOKINE RELEASE; GENE EXPRESSION REGULATION; GENE INDUCTION; GENETIC CODE; GENETIC TRANSCRIPTION; HUMAN; INNATE IMMUNITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REVIEW; RNA TRANSCRIPTION; SIGNAL TRANSDUCTION; VIRUS INFECTION; VIRUS REPLICATION;

EID: 14044260466     PISSN: 13596101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cytogfr.2005.01.006     Document Type: Review

References (84)

1. S. Akira, and K. Takeda Toll-like receptor signalling Nat Rev Immunol 4 2004 499 511
2. B. Beutler Inferences, questions and possibilities in Toll-like receptor signalling Nature 430 2004 257 263
3. C.A. Janeway Jr., and R. Medzhitov Innate immune recognition Annu Rev Immunol 20 2002 197 216
4. S.N. Vogel, K.A. Fitzgerald, and M.J. Fenton TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression Mol Interv 3 2003 466 477
5. L. Alexopoulou, A.C. Holt, R. Medzhitov, and R.A. Flavell Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3 Nature 413 2001 732 738
6. K. Crozat, and B. Beutler TLR7: a new sensor of viral infection Proc Natl Acad Sci USA 101 2004 6835 6836
7. H. Hemmi, O. Takeuchi, T. Kawai, T. Kaisho, S. Sato, and H. Sanjo A Toll-like receptor recognizes bacterial DNA Nature 408 2000 740 745
8. O. Adachi, T. Kawai, K. Takeda, M. Matsumoto, H. Tsutsui, and M. Sakagami Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function Immunity 9 1998 143 150
9. K. Takeda, T. Kaisho, and S. Akira Toll-like receptors Annu Rev Immunol 21 2003 335 376
10. M. Rehli Of mice and men: species variations of Toll-like receptor expression Trends Immunol 23 2002 375 378
11. S. Heinz, V. Haehnel, M. Karaghiosoff, L. Schwarzfischer, M. Muller, and S.W. Krause Species-specific regulation of Toll-like receptor 3 genes in men and mice J Biol Chem 278 2003 21502 21509
12. M. Matsumoto, K. Funami, M. Tanabe, H. Oshiumi, M. Shingai, and Y. Seto Subcellular localization of Toll-like receptor 3 in human dendritic cells J Immunol 171 2003 3154 3162
13. B. Lemaitre The road to toll Nat Rev Immunol 4 2004 521 527
14. J.K. Bell, G.E. Mullen, C.A. Leifer, A. Mazzoni, D.R. Davies, and D.M. Segal Leucine-rich repeats and pathogen recognition in Toll-like receptors Trends Immunol 24 2003 528 533
15. D.S. Schneider, K.L. Hudson, T.Y. Lin, and K.V. Anderson Dominant and recessive mutations define functional domains of toll, a transmembrane protein required for dorsal-ventral polarity in the Drosophila embryo Genes Dev 5 1991 797 807
16. M. Yamamoto, S. Sato, K. Mori, K. Hoshino, O. Takeuchi, and K. Takeda Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling J Immunol 169 2002 6668 6672
17. K.W. Boehme, and T. Compton Innate sensing of viruses by toll-like receptors J Virol 78 2004 7867 7873
18. G.C. Sen Viruses and interferons Annu Rev Microbiol 55 2001 255 281
19. J.M. Lund, L. Alexopoulou, A. Sato, M. Karow, N.C. Adams, and N.W. Gale Recognition of single-stranded RNA viruses by Toll-like receptor 7 Proc Natl Acad Sci USA 101 2004 5598 5603
20. S.S. Diebold, T. Kaisho, H. Hemmi, S. Akira, and C. Reis e Sousa Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA Science 303 2004 1529 1531
21. K. Hoebe, X. Du, P. Georgel, E. Janssen, K. Tabeta, and S.O. Kim Identification of Lps2 as a key transducer of MyD88-independent TIR signalling Nature 424 2003 743 748
22. Guillot L, Le Goffic R, Bloch S, Escriou N, Akira S, Chignard M, et al. Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus. J Biol Chem, doi:10.1074/jbc.M410592200.
23. K. Tabeta, P. Georgel, E. Janssen, X. Du, K. Hoebe, and K. Crozat Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection Proc Natl Acad Sci USA 101 2004 3516 3521
24. A. Krug, G.D. Luker, W. Barchet, D.A. Leib, S. Akira, and M. Colonna Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9 Blood 103 2004 1433 1437
25. J.C. Rassa, J.L. Meyers, Y. Zhang, R. Kudaravalli, and S.R. Ross Murine retroviruses activate B cells via interaction with toll-like receptor 4 Proc Natl Acad Sci USA 99 2002 2281 2286
26. L.M. Haynes, D.D. Moore, E.A. Kurt-Jones, R.W. Finberg, L.J. Anderson, and R.A. Tripp Involvement of toll-like receptor 4 in innate immunity to respiratory syncytial virus J Virol 75 2001 10730 10737
27. K. Bieback, E. Lien, I.M. Klagge, E. Avota, J. Schneider-Schaulies, and W.P. Duprex Hemagglutinin protein of wild-type measles virus activates toll-like receptor 2 signaling J Virol 76 2002 8729 8736
28. T. Compton, E.A. Kurt-Jones, K.W. Boehme, J. Belko, E. Latz, and D.T. Golenbock Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2 J Virol 77 2003 4588 4596
29. A. Sato, and A. Iwasaki Induction of antiviral immunity requires Toll-like receptor signaling in both stromal and dendritic cell compartments Proc Natl Acad Sci USA 101 2004 16274 16279
30. A. Krug, A.R. French, W. Barchet, J.A. Fischer, A. Dzionek, and J.T. Pingel TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function Immunity 21 2004 107 119
31. J. Lund, A. Sato, S. Akira, R. Medzhitov, and A. Iwasaki Toll-like receptor 9-mediated recognition of herpes simplex virus-2 by plasmacytoid dendritic cells J Exp Med 198 2003 513 520
32. D. Burzyn, J.C. Rassa, D. Kim, I. Nepomnaschy, S.R. Ross, and I. Piazzon Toll-like receptor 4-dependent activation of dendritic cells by a retrovirus J Virol 78 2004 576 584
33. E.A. Kurt-Jones, L. Popova, L. Kwinn, L.M. Haynes, L.P. Jones, and R.A. Tripp Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus Nat Immunol 1 2000 398 401
34. K.H. Edelmann, S. Richardson-Burns, L. Alexopoulou, K.L. Tyler, R.A. Flavell, and M.B. Oldstone Does Toll-like receptor 3 play a biological role in virus infections? Virology 322 2004 231 238
35. T. Wang, T. Town, L. Alexopoulou, J.F. Anderson, E. Fikrig, and R.A. Flavell Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis Nat Med 10 2004 1366 1373
36. K. Kariko, H. Ni, J. Capodici, M. Lamphier, and D. Weissman mRNA is an endogenous ligand for Toll-like receptor 3 J Biol Chem 279 2004 12542 12550
37. B. Tian, P.C. Bevilacqua, A. Diegelman-Parente, and M.B. Mathews The double-stranded-RNA-binding motif: interference and much more Nat Rev Mol Cell Biol 5 2004 1013 1023
38. G. Geiss, G. Jin, J. Guo, R. Bumgarner, M.G. Katze, and G.C. Sen A comprehensive view of regulation of gene expression by double-stranded RNA-mediated cell signaling J Biol Chem 276 2001 30178 30182
39. H. Oshiumi, M. Matsumoto, K. Funami, T. Akazawa, and T. Seya TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction Nat Immunol 4 2003 161 167
40. M. Yamamoto, S. Sato, H. Hemmi, K. Hoshino, T. Kaisho, and H. Sanjo Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway Science 301 2003 640 643
41. Z. Jiang, T.W. Mak, G. Sen, and X. Li Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta Proc Natl Acad Sci USA 101 2004 3533 3538
42. Z. Jiang, M. Zamanian-Daryoush, H. Nie, A.M. Silva, B.R. Williams, and X. Li Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR J Biol Chem 278 2003 16713 16719
43. E. Meylan, K. Burns, K. Hofmann, V. Blancheteau, F. Martinon, and M. Kelliher RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation Nat Immunol 5 2004 503 507
44. K.L. Peters, H.L. Smith, G.R. Stark, and G.C. Sen IRF-3-dependent, NFkappa B- and JNK-independent activation of the 561 and IFN-beta genes in response to double-stranded RNA Proc Natl Acad Sci USA 99 2002 6322 6327
45. M.J. Servant, B. Tenoever, and R. Lin Overlapping and distinct mechanisms regulating IRF-3 and IRF-7 function J Interferon Cytokine Res 22 2002 49 58
46. M. Yoneyama, W. Suhara, and T. Fujita Control of IRF-3 activation by phosphorylation J Interferon Cytokine Res 22 2002 73 76
47. K.A. Fitzgerald, S.M. McWhirter, K.L. Faia, D.C. Rowe, E. Latz, and D.T. Golenbock IKK epsilon and TBK1 are essential components of the IRF3 signaling pathway Nat Immunol 4 2003 491 496
48. S. Sharma, B.R. tenOever, N. Grandvaux, G.P. Zhou, R. Lin, and J. Hiscott Triggering the interferon antiviral response through an IKK-related pathway Science 300 2003 1148 1151
49. M.S. Hayden, and S. Ghosh Signaling to NF-kappaB Genes Dev 18 2004 2195 2224
50. S.M. McWhirter, K.A. Fitzgerald, J. Rosains, D.C. Rowe, D.T. Golenbock, and T. Maniatis IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts Proc Natl Acad Sci USA 101 2004 233 238
51. B.K. Weaver, K.P. Kumar, and N.C. Reich Interferon regulatory factor 3 and CREB-binding protein/p300 are subunits of double-stranded RNA-activated transcription factor DRAF1 Mol Cell Biol 18 1998 1359 1368
52. S.N. Sarkar, H.L. Smith, T.M. Rowe, and G.C. Sen Double-stranded RNA signaling by Toll-like receptor 3 requires specific tyrosine residues in its cytoplasmic domain J Biol Chem 278 2003 4393 4396
53. C. Daly, and N. Reich Double-stranded RNA activates novel factors that bind to the interferon-stimulated response element Mol Cell Biol 13 1993 3756 3764
54. S.N. Sarkar, K.L. Peters, C.P. Elco, S. Sakamoto, S. Pal, and G.C. Sen Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling Nat Struct Mol Biol 11 2004 1060 1067
55. M.J. Servant, N. Grandvaux, B.R. tenOever, D. Duguay, R. Lin, and J. Hiscott Identification of the minimal phosphoacceptor site required for in vivo activation of interferon regulatory factor 3 in response to virus and double-stranded RNA J Biol Chem 278 2003 9441 9447
56. M. Mori, M. Yoneyama, T. Ito, K. Takahashi, F. Inagaki, and T. Fujita Identification of Ser-386 of interferon regulatory factor 3 as critical target for inducible phosphorylation that determines activation J Biol Chem 279 2004 9698 9702
57. B.Y. Qin, C. Liu, S.S. Lam, H. Srinath, R. Delston, and J.J. Correia Crystal structure of IRF-3 reveals mechanism of autoinhibition and virus-induced phosphoactivation Nat Struct Biol 10 2003 913 921
58. H. Nguyen, C.V. Ramana, J. Bayes, and G.R. Stark Roles of phosphatidylinositol 3-kinase in interferon-gamma-dependent phosphorylation of STAT1 on serine 727 and activation of gene expression J Biol Chem 276 2001 33361 33368
59. H. Zhong, M.J. May, E. Jimi, and S. Ghosh The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1 Mol Cell 9 2002 625 636
60. N. Sizemore, N. Lerner, N. Dombrowski, H. Sakurai, and G.R. Stark Distinct roles of the Ikappa B kinase alpha and beta subunits in liberating nuclear factor kappa B (NF-kappa B) from Ikappa B and in phosphorylating the p65 subunit of NF-kappa B J Biol Chem 277 2002 3863 3869
61. M. Yoneyama, M. Kikuchi, T. Natsukawa, N. Shinobu, T. Imaizumi, and M. Miyagishi The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses Nat Immunol 5 2004 730 737
62. T. Horng, G.M. Barton, and R. Medzhitov TIRAP: an adapter molecule in the toll signaling pathway Nat Immunol 2 2001 835 841
63. K.A. Fitzgerald, E.M. Palsson-McDermott, A.G. Bowie, C.A. Jefferies, A.S. Mansell, and G. Brady Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction Nature 413 2001 78 83
64. M. Yamamoto, S. Sato, H. Hemmi, S. Uematsu, K. Hoshino, and T. Kaisho TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway Nat Immunol 4 2003 1144 1150
65. H. Oshiumi, M. Sasai, K. Shida, T. Fujita, M. Matsumoto, and T. Seya TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta J Biol Chem 278 2003 49751 49762
66. L.H. Bin, L.G. Xu, and H.B. Shu TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling J Biol Chem 278 2003 24526 24532
67. T. Fukao, M. Tanabe, Y. Terauchi, T. Ota, S. Matsuda, and T. Asano PI3K-mediated negative feedback regulation of IL-12 production in DCs Nat Immunol 3 2002 875 881
68. M. Guha, and N. Mackman The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells J Biol Chem 277 2002 32124 32132
69. J.Y. Lee, J. Ye, Z. Gao, H.S. Youn, W.H. Lee, and L. Zhao Reciprocal modulation of Toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated fatty acids J Biol Chem 278 2003 37041 37051
70. M. Ojaniemi, V. Glumoff, K. Harju, M. Liljeroos, K. Vuori, and M. Hallman Phosphatidylinositol 3-kinase is involved in Toll-like receptor 4-mediated cytokine expression in mouse macrophages Eur J Immunol 33 2003 597 605
71. P.G. Arndt, N. Suzuki, N.J. Avdi, K.C. Malcolm, and G.S. Worthen Lipopolysaccharide-induced c-Jun NH2-terminal kinase activation in human neutrophils: role of phosphatidylinositol 3-Kinase and Syk-mediated pathways J Biol Chem 279 2004 10883 10891
72. L. Arbibe, J.P. Mira, N. Teusch, L. Kline, M. Guha, and N. Mackman Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway Nat Immunol 1 2000 533 540
73. M. Martin, R.E. Schifferle, N. Cuesta, S.N. Vogel, J. Katz, and S.M. Michalek Role of the phosphatidylinositol 3 kinase-Akt pathway in the regulation of IL-10 and IL-12 by porphyromonas gingivalis lipopolysaccharide J Immunol 171 2003 717 725
74. D. Strassheim, K. Asehnoune, J.S. Park, J.Y. Kim, Q. He, and D. Richter Phosphoinositide 3-kinase and Akt occupy central roles in inflammatory responses of Toll-like receptor 2-stimulated neutrophils J Immunol 172 2004 5727 5733
75. K.J. Ishii, F. Takeshita, I. Gursel, M. Gursel, J. Conover, and A. Nussenzweig Potential role of phosphatidylinositol 3 kinase, rather than DNA-dependent protein kinase, in CpG DNA-induced immune activation J Exp Med 196 2002 269 274
76. S.S. Diebold, M. Montoya, H. Unger, L. Alexopoulou, P. Roy, and L.E. Haswell Viral infection switches non-plasmacytoid dendritic cells into high interferon producers Nature 424 2003 324 328
77. A.M. Silva, M. Whitmore, Z. Xu, Z. Jiang, X. Li, and B.R. Williams Protein kinase R (PKR) interacts with and activates mitogen-activated protein kinase kinase 6 (MKK6) in response to double-stranded RNA stimulation J Biol Chem 279 2004 37670 37676
78. J. Gil, M.A. Garcia, P. Gomez-Puertas, S. Guerra, J. Rullas, and H. Nakano TRAF family proteins link PKR with NF-kappa B activation Mol Cell Biol 24 2004 4502 4512
79. K. Kobayashi, N. Inohara, L.D. Hernandez, J.E. Galan, G. Nunez, and C.A. Janeway RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems Nature 416 2002 194 199
80. D.E. Levy, and I.J. Marie RIGging an antiviral defense - it's in the CARDs Nat Immunol 5 2004 699 701
81. S. Balachandran, E. Thomas, and G.N. Barber A FADD-dependent innate immune mechanism in mammalian cells Nature 432 2004 401 405
82. J. Andrejeva, K.S. Childs, D.F. Young, T.S. Carlos, N. Stock, and S. Goodbourn The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter Proc Natl Acad Sci USA 101 2004 17264 17269
83. E. Aksoy, C.S. Zouain, F. Vanhoutte, J. Fontaine, N. Pavelka, and N. Thieblemont Double-stranded RNAs from the helminth parasite schistosoma activate TLR3 in dendritic cells J Biol Chem 280 2005 277 283
84. Elco CP, Guenther JM, Williams BRG, Sen GC. Analysis of genes induced by Sendai virus infection of mutant cell lines reveals essential roles of IRF-3, NF-κB and interferon, but not TLR3. J. Virol, in press.