메뉴 건너뛰기




Volumn 181, Issue 4, 2008, Pages 2694-2704

Double-stranded RNA induces an antiviral defense status in epidermal keratinocytes through TLR3-, PKR-, and MDA5/RIG-I-mediated differential signaling

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED RNA; IMIDAZOQUINOLINE DERIVATIVE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 3; PROTEIN KINASE R; RETINOIC ACID INDUCIBLE PROTEIN I; RNA HELICASE; SINGLE STRANDED RNA; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 7; VIRUS RECEPTOR; ANTIVIRUS AGENT; DEAD BOX PROTEIN; IFIH1 PROTEIN, HUMAN; IRF3 PROTEIN, HUMAN; PATTERN RECOGNITION RECEPTOR; POLYINOSINIC POLYCYTIDYLIC ACID; RARRES3 PROTEIN, HUMAN; RETINOIC ACID RECEPTOR; TLR3 PROTEIN, HUMAN;

EID: 53149143179     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.181.4.2694     Document Type: Article
Times cited : (155)

References (59)
  • 2
    • 33748094122 scopus 로고    scopus 로고
    • Antimicrobial peptides: An essential component of the skin defensive barrier
    • Braff, M. H., and R. L. Gallo. 2006. Antimicrobial peptides: an essential component of the skin defensive barrier. Curr. Top. Microbiol. Immunol. 306: 91-110.
    • (2006) Curr. Top. Microbiol. Immunol , vol.306 , pp. 91-110
    • Braff, M.H.1    Gallo, R.L.2
  • 4
    • 10744222928 scopus 로고    scopus 로고
    • Toll-like receptor expression in human keratinocytes: Nuclear factor κB controlled gene activation by Staphylococcus aureus is Toll-like receptor 2 but not Toll-like receptor 4 or platelet activating factor receptor dependent
    • Mempel, M., V. Voelcker, G. Kollisch, C. Plank, R. Rad, M. Gerhard, C. Schnopp, P. Fraunberger, A. K. Walli, J. Ring, et al. 2003. Toll-like receptor expression in human keratinocytes: nuclear factor κB controlled gene activation by Staphylococcus aureus is Toll-like receptor 2 but not Toll-like receptor 4 or platelet activating factor receptor dependent. J. Invest. Dermatol. 121: 1389-1396.
    • (2003) J. Invest. Dermatol , vol.121 , pp. 1389-1396
    • Mempel, M.1    Voelcker, V.2    Kollisch, G.3    Plank, C.4    Rad, R.5    Gerhard, M.6    Schnopp, C.7    Fraunberger, P.8    Walli, A.K.9    Ring, J.10
  • 6
    • 0037791839 scopus 로고    scopus 로고
    • Double-stranded RNA-exposed human keratinocytes promote Th1 responses by inducing a type-1 polarized phenotype in dendritic cells: Role of keratinocyte-derived tumor necrosis factor α, type I interferons, and interleukin-18
    • Lebre, M. C., J. C. Antons, P. Kalinski, J. H. Schuitemaker, T. M. van Capel, M. L. Kapsenberg, and E. C. De Jong. 2003. Double-stranded RNA-exposed human keratinocytes promote Th1 responses by inducing a type-1 polarized phenotype in dendritic cells: role of keratinocyte-derived tumor necrosis factor α, type I interferons, and interleukin-18. J. Invest. Dermatol. 120: 990-997.
    • (2003) J. Invest. Dermatol , vol.120 , pp. 990-997
    • Lebre, M.C.1    Antons, J.C.2    Kalinski, P.3    Schuitemaker, J.H.4    van Capel, T.M.5    Kapsenberg, M.L.6    De Jong, E.C.7
  • 8
    • 33645108946 scopus 로고    scopus 로고
    • IKK-i signals through IRF3 and NFκB to mediate the production of inflammatory cytokines
    • Sankar, S., H. Chan, W. J. Romanow, J. Li, and R. J. Bates. 2006. IKK-i signals through IRF3 and NFκB to mediate the production of inflammatory cytokines. Cell. Signal. 18: 982-993.
    • (2006) Cell. Signal , vol.18 , pp. 982-993
    • Sankar, S.1    Chan, H.2    Romanow, W.J.3    Li, J.4    Bates, R.J.5
  • 9
    • 1542723466 scopus 로고    scopus 로고
    • Toll-like receptor 3-mediated activation of NF-κB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-β
    • Jiang, Z., T. W. Mak, G. Sen, and X. Li. 2004. Toll-like receptor 3-mediated activation of NF-κB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-β. Proc. Natl. Acad. Sci. USA 101: 3533-3538.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 3533-3538
    • Jiang, Z.1    Mak, T.W.2    Sen, G.3    Li, X.4
  • 10
    • 4344566281 scopus 로고    scopus 로고
    • The roles of two IκB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection
    • Hemmi, H., O. Takeuchi, S. Sato, M. Yamamoto, T. Kaisho, H. Sanjo, T. Kawai, K. Hoshino, K. Takeda, and S. Akira. 2004. The roles of two IκB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection. J. Exp. Med. 199: 1641-1650.
    • (2004) J. Exp. Med , vol.199 , pp. 1641-1650
    • Hemmi, H.1    Takeuchi, O.2    Sato, S.3    Yamamoto, M.4    Kaisho, T.5    Sanjo, H.6    Kawai, T.7    Hoshino, K.8    Takeda, K.9    Akira, S.10
  • 11
    • 33750984771 scopus 로고    scopus 로고
    • Pichlmair, A., O. Schulz, C. P. Tan, T. I. Naslund, P. Liljestrom, F. Weber, and C. Reis e Sousa. 2006. RIG-I-mediated antiviral responses to single-stranded RNA bearing 5′-phosphates. Science 314: 997-1001.
    • Pichlmair, A., O. Schulz, C. P. Tan, T. I. Naslund, P. Liljestrom, F. Weber, and C. Reis e Sousa. 2006. RIG-I-mediated antiviral responses to single-stranded RNA bearing 5′-phosphates. Science 314: 997-1001.
  • 13
    • 27144440476 scopus 로고    scopus 로고
    • Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
    • Meylan, E., J. Curran, K. Hofmann, D. Moradpour, M. Binder, R. Bartenschlager, and J. Tschopp. 2005. Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature 437: 1167-1172.
    • (2005) Nature , vol.437 , pp. 1167-1172
    • Meylan, E.1    Curran, J.2    Hofmann, K.3    Moradpour, D.4    Binder, M.5    Bartenschlager, R.6    Tschopp, J.7
  • 16
    • 9644266744 scopus 로고    scopus 로고
    • Mechanism of PKR activation: Dimerization and kinase activation in the absence of double-stranded RNA
    • Lemaire, P. A., J. Lary, and J. L. Cole. 2005. Mechanism of PKR activation: dimerization and kinase activation in the absence of double-stranded RNA. J. Mol. Biol. 345: 81-90.
    • (2005) J. Mol. Biol , vol.345 , pp. 81-90
    • Lemaire, P.A.1    Lary, J.2    Cole, J.L.3
  • 18
    • 0030725442 scopus 로고    scopus 로고
    • The double-stranded RNA-dependent protein kinase PKR: Structure and function
    • Clemens, M. J., and A. Elia. 1997. The double-stranded RNA-dependent protein kinase PKR: structure and function. J. Interferon Cytokine Res. 17: 503-524.
    • (1997) J. Interferon Cytokine Res , vol.17 , pp. 503-524
    • Clemens, M.J.1    Elia, A.2
  • 19
    • 0034663942 scopus 로고    scopus 로고
    • The protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxin
    • Goh, K. C., M. J. deVeer, and B. R. Williams. 2000. The protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxin. EMBO J. 19: 4292-4297.
    • (2000) EMBO J , vol.19 , pp. 4292-4297
    • Goh, K.C.1    deVeer, M.J.2    Williams, B.R.3
  • 20
    • 17444449609 scopus 로고    scopus 로고
    • Kumar, A., Y. L. Yang, V. Flati, S. Der, S. Kadereit, A. Deb, J. Haque, L. Reis, C. Weissmann, and B. R. Williams. 1997. Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF-1 and NF-κB. EMBO J. 16: 406-416.
    • Kumar, A., Y. L. Yang, V. Flati, S. Der, S. Kadereit, A. Deb, J. Haque, L. Reis, C. Weissmann, and B. R. Williams. 1997. Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF-1 and NF-κB. EMBO J. 16: 406-416.
  • 22
    • 4344560477 scopus 로고    scopus 로고
    • Topical immunomodulation in dermatology: Potential of Toll-like receptor agonists
    • Hengge, U. R., and T. Ruzicka. 2004. Topical immunomodulation in dermatology: potential of Toll-like receptor agonists. Dermatol. Surg. 30: 1101-1112.
    • (2004) Dermatol. Surg , vol.30 , pp. 1101-1112
    • Hengge, U.R.1    Ruzicka, T.2
  • 23
    • 0037316303 scopus 로고    scopus 로고
    • A comparison of normalization methods for high density oligonucleotide array data based on variance and bias
    • Bolstad, B. M., R. A. Irizarry, M. Astrand, and T. P. Speed. 2003. A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics 19: 185-193.
    • (2003) Bioinformatics , vol.19 , pp. 185-193
    • Bolstad, B.M.1    Irizarry, R.A.2    Astrand, M.3    Speed, T.P.4
  • 24
    • 33644872577 scopus 로고    scopus 로고
    • Limma: Linear models for microarray data
    • R. Gentleman, V. Carey, S. Dudoit, R. Irizarry, and W. Huber, eds. Springer, New York, pp
    • Smyth, G. K. 2005. Limma: linear models for microarray data. In Bioinformatics and Computational Biology Solutions Using R and Bioconductor. R. Gentleman, V. Carey, S. Dudoit, R. Irizarry, and W. Huber, eds. Springer, New York, pp. 397-420.
    • (2005) Bioinformatics and Computational Biology Solutions Using R and Bioconductor , pp. 397-420
    • Smyth, G.K.1
  • 25
    • 0001677717 scopus 로고
    • Controlling the false discovery rate: A practical and powerful approach to multiple testing
    • Benjamini, Y., and Y. Hochberg. 1995. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Stat. Soc. B 57: 289-300.
    • (1995) J. R. Stat. Soc. B , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 27
    • 0021840830 scopus 로고
    • Cross-linked collagen surface for cell culture that is stable, uniform, and optically superior to conventional surfaces
    • Macklis, J. D., R. L. Sidman, and H. D. Shine. 1985. Cross-linked collagen surface for cell culture that is stable, uniform, and optically superior to conventional surfaces. In Vitro Cell. Dev. Biol. 21: 189-194.
    • (1985) In Vitro Cell. Dev. Biol , vol.21 , pp. 189-194
    • Macklis, J.D.1    Sidman, R.L.2    Shine, H.D.3
  • 28
    • 0037080024 scopus 로고    scopus 로고
    • Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines
    • Zarember, K. A., and P. J. Godowski. 2002. Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines. J. Immunol. 168: 554-561.
    • (2002) J. Immunol , vol.168 , pp. 554-561
    • Zarember, K.A.1    Godowski, P.J.2
  • 29
    • 2142660709 scopus 로고    scopus 로고
    • Reduction of double-stranded RNA-activated protein kinase in hepatocellular carcinoma associated with hepatitis B virus
    • Chen, G. G., P. B. Lai, R. L. Ho, P. K. Chan, H. Xu, J. Wong, and W. Y. Lau. 2004. Reduction of double-stranded RNA-activated protein kinase in hepatocellular carcinoma associated with hepatitis B virus. J. Med. Virol. 73: 187-194.
    • (2004) J. Med. Virol , vol.73 , pp. 187-194
    • Chen, G.G.1    Lai, P.B.2    Ho, R.L.3    Chan, P.K.4    Xu, H.5    Wong, J.6    Lau, W.Y.7
  • 30
    • 20444442721 scopus 로고    scopus 로고
    • Distinct poly(I-C) and virus-activated signaling pathways leading to interferon-β production in hepatocytes
    • Li, K., Z. Chen, N. Kato, M. Gale, Jr., and S. M. Lemon. 2005. Distinct poly(I-C) and virus-activated signaling pathways leading to interferon-β production in hepatocytes. J. Biol. Chem. 280: 16739-16747.
    • (2005) J. Biol. Chem , vol.280 , pp. 16739-16747
    • Li, K.1    Chen, Z.2    Kato, N.3    Gale Jr., M.4    Lemon, S.M.5
  • 31
    • 1642348822 scopus 로고    scopus 로고
    • Expression analysis and genomic characterization of human melanoma differentiation associated gene-5, mda-5: A novel type I interferon-responsive apoptosis-inducing gene
    • Kang, D. C., R. V. Gopalkrishnan, L. Lin, A. Randolph, K. Valerie, S. Pestka, and P. B. Fisher. 2004. Expression analysis and genomic characterization of human melanoma differentiation associated gene-5, mda-5: a novel type I interferon-responsive apoptosis-inducing gene. Oncogene 23: 1789-1800.
    • (2004) Oncogene , vol.23 , pp. 1789-1800
    • Kang, D.C.1    Gopalkrishnan, R.V.2    Lin, L.3    Randolph, A.4    Valerie, K.5    Pestka, S.6    Fisher, P.B.7
  • 32
    • 33847781107 scopus 로고    scopus 로고
    • Monocyte-derived dendritic cells from highly atopic individuals are not impaired in their pro-inflammatory response to Toll-like receptor ligands
    • Terhorst, D., B. N. Kalali, S. Weidinger, T. Illig, N. Novak, J. Ring, M. Ollert, and M. Mempel. 2007. Monocyte-derived dendritic cells from highly atopic individuals are not impaired in their pro-inflammatory response to Toll-like receptor ligands. Clin. Exp. Allergy 37: 381-390.
    • (2007) Clin. Exp. Allergy , vol.37 , pp. 381-390
    • Terhorst, D.1    Kalali, B.N.2    Weidinger, S.3    Illig, T.4    Novak, N.5    Ring, J.6    Ollert, M.7    Mempel, M.8
  • 33
    • 0036076593 scopus 로고    scopus 로고
    • Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling
    • Matsumoto, M., S. Kikkawa, M. Kohase, K. Miyake, and T. Seya. 2002. Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling. Biochem. Biophys. Res. Commun. 293: 1364-1369.
    • (2002) Biochem. Biophys. Res. Commun , vol.293 , pp. 1364-1369
    • Matsumoto, M.1    Kikkawa, S.2    Kohase, M.3    Miyake, K.4    Seya, T.5
  • 35
    • 14044260466 scopus 로고    scopus 로고
    • Transcriptional signaling by double-stranded RNA: Role of TLR3
    • Sen, G. C., and S. N. Sarkar. 2005. Transcriptional signaling by double-stranded RNA: role of TLR3. Cytokine Growth Factor Rev. 16: 1-14.
    • (2005) Cytokine Growth Factor Rev , vol.16 , pp. 1-14
    • Sen, G.C.1    Sarkar, S.N.2
  • 36
    • 0035800333 scopus 로고    scopus 로고
    • Signal integration via PKR
    • Williams, B. R. 2001. Signal integration via PKR. Sci. STKE 2001: RE2.
    • (2001) Sci. STKE , vol.2001
    • Williams, B.R.1
  • 38
    • 33750314767 scopus 로고    scopus 로고
    • Cutting edge: Role of TANK-binding kinase 1 and inducible IκB kinase in IFN responses against viruses in innate immune cells
    • Matsui, K., Y. Kumagai, H. Kato, S. Sato, T. Kawagoe, S. Uematsu, O. Takeuchi, and S. Akira. 2006. Cutting edge: Role of TANK-binding kinase 1 and inducible IκB kinase in IFN responses against viruses in innate immune cells. J. Immunol. 177: 5785-5789.
    • (2006) J. Immunol , vol.177 , pp. 5785-5789
    • Matsui, K.1    Kumagai, Y.2    Kato, H.3    Sato, S.4    Kawagoe, T.5    Uematsu, S.6    Takeuchi, O.7    Akira, S.8
  • 39
    • 0027787072 scopus 로고
    • 2-Aminopurine inhibits the double-stranded RNA-dependent protein kinase both in vitro and in vivo
    • Hu, Y., and T. W. Conway. 1993. 2-Aminopurine inhibits the double-stranded RNA-dependent protein kinase both in vitro and in vivo. J. Interferon Res. 13: 323-328.
    • (1993) J. Interferon Res , vol.13 , pp. 323-328
    • Hu, Y.1    Conway, T.W.2
  • 40
    • 31344476404 scopus 로고    scopus 로고
    • Recognition of double-stranded RNA by human Toll-like receptor 3 and downstream receptor signaling requires multimerization and an acidic pH
    • de Bouteiller, O., E. Merck, U. A. Hasan, S. Hubac, B. Benguigui, G. Trinchieri, E. E. Bates, and C. Caux. 2005. Recognition of double-stranded RNA by human Toll-like receptor 3 and downstream receptor signaling requires multimerization and an acidic pH. J. Biol. Chem. 280: 38133-38145.
    • (2005) J. Biol. Chem , vol.280 , pp. 38133-38145
    • de Bouteiller, O.1    Merck, E.2    Hasan, U.A.3    Hubac, S.4    Benguigui, B.5    Trinchieri, G.6    Bates, E.E.7    Caux, C.8
  • 41
  • 46
    • 15444380849 scopus 로고    scopus 로고
    • IFN-α enhances TLR3-mediated antiviral cytokine expression in human endothelial and epithelial cells by up-regulating TLR3 expression
    • Tissari, J., J. Siren, S. Meri, I. Julkunen, and S. Matikainen. 2005. IFN-α enhances TLR3-mediated antiviral cytokine expression in human endothelial and epithelial cells by up-regulating TLR3 expression. J. Immunol. 174: 4289-4294.
    • (2005) J. Immunol , vol.174 , pp. 4289-4294
    • Tissari, J.1    Siren, J.2    Meri, S.3    Julkunen, I.4    Matikainen, S.5
  • 47
    • 14744274494 scopus 로고    scopus 로고
    • Differential role for TLR3 in respiratory syncytial virus-induced chemokine expression
    • Rudd, B. D., E. Burstein, C. S. Duckett, X. Li, and N. W. Lukacs. 2005. Differential role for TLR3 in respiratory syncytial virus-induced chemokine expression. J. Virol. 79: 3350-3357.
    • (2005) J. Virol , vol.79 , pp. 3350-3357
    • Rudd, B.D.1    Burstein, E.2    Duckett, C.S.3    Li, X.4    Lukacs, N.W.5
  • 48
    • 14044267522 scopus 로고    scopus 로고
    • Involvement of Toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus
    • Guillot, L., R. Le Goffic, S. Bloch, N. Escriou, S. Akira, M. Chignard, and M. Si-Tahar. 2005. Involvement of Toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus. J. Biol. Chem. 280: 5571-5580.
    • (2005) J. Biol. Chem , vol.280 , pp. 5571-5580
    • Guillot, L.1    Le Goffic, R.2    Bloch, S.3    Escriou, N.4    Akira, S.5    Chignard, M.6    Si-Tahar, M.7
  • 49
    • 33947206046 scopus 로고    scopus 로고
    • Cutting edge: Influenza A virus activates TLR3-dependent inflammatory and RIG-I-dependent antiviral responses in human lung epithelial cells
    • Le Goffic, R., J. Pothlichet, D. Vitour, T. Fujita, E. Meurs, M. Chignard, and M. Si-Tahar. 2007. Cutting edge: Influenza A virus activates TLR3-dependent inflammatory and RIG-I-dependent antiviral responses in human lung epithelial cells. J. Immunol. 178: 3368-3372.
    • (2007) J. Immunol , vol.178 , pp. 3368-3372
    • Le Goffic, R.1    Pothlichet, J.2    Vitour, D.3    Fujita, T.4    Meurs, E.5    Chignard, M.6    Si-Tahar, M.7
  • 50
    • 11844289006 scopus 로고    scopus 로고
    • Innate immunity in the human female reproductive tract: Antiviral response of uterine epithelial cells to the TLR3 agonist poly(I:C)
    • Schaefer, T. M., J. V. Fahey, J. A. Wright, and C. R. Wira. 2005. Innate immunity in the human female reproductive tract: antiviral response of uterine epithelial cells to the TLR3 agonist poly(I:C). J. Immunol. 174: 992-1002.
    • (2005) J. Immunol , vol.174 , pp. 992-1002
    • Schaefer, T.M.1    Fahey, J.V.2    Wright, J.A.3    Wira, C.R.4
  • 51
    • 3042789092 scopus 로고    scopus 로고
    • Toll-like receptor (TLR) expression and TLR-mediated cytokine/chemokine production by human uterine epithelial cells
    • Schaefer, T. M., K. Desouza, J. V. Fahey, K. W. Beagley, and C. R. Wira. 2004. Toll-like receptor (TLR) expression and TLR-mediated cytokine/chemokine production by human uterine epithelial cells. Immunology 112: 428-436.
    • (2004) Immunology , vol.112 , pp. 428-436
    • Schaefer, T.M.1    Desouza, K.2    Fahey, J.V.3    Beagley, K.W.4    Wira, C.R.5
  • 52
    • 0034445697 scopus 로고    scopus 로고
    • Differential alteration in intestinal epithelial cell expression of Toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease
    • Cario, E., and D. K. Podolsky. 2000. Differential alteration in intestinal epithelial cell expression of Toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease. Infect. Immun. 68: 7010-7017.
    • (2000) Infect. Immun , vol.68 , pp. 7010-7017
    • Cario, E.1    Podolsky, D.K.2
  • 53
    • 18644365496 scopus 로고    scopus 로고
    • Protein kinase R mediates intestinal epithelial gene remodeling in response to double-stranded RNA and live rotavirus
    • Vijay-Kumar, M., J. R. Gentsch, W. J. Kaiser, N. Borregaard, M. K. Offermann, A. S. Neish, and A. T. Gewirtz. 2005. Protein kinase R mediates intestinal epithelial gene remodeling in response to double-stranded RNA and live rotavirus. J. Immunol. 174: 6322-6331.
    • (2005) J. Immunol , vol.174 , pp. 6322-6331
    • Vijay-Kumar, M.1    Gentsch, J.R.2    Kaiser, W.J.3    Borregaard, N.4    Offermann, M.K.5    Neish, A.S.6    Gewirtz, A.T.7
  • 54
    • 34547578038 scopus 로고    scopus 로고
    • Retinoic acid-inducible gene-I and interferon-β promoter stimulator-1 augment proapoptotic responses following mammalian reovirus infection via interferon regulatory factor-3
    • Holm, G. H., J. Zurney, V. Tumilasci, S. Leveille, P. Danthi, J. Hiscott, B. Sherry, and T. S. Dermody. 2007. Retinoic acid-inducible gene-I and interferon-β promoter stimulator-1 augment proapoptotic responses following mammalian reovirus infection via interferon regulatory factor-3. J. Biol. Chem. 282: 21953-21961.
    • (2007) J. Biol. Chem , vol.282 , pp. 21953-21961
    • Holm, G.H.1    Zurney, J.2    Tumilasci, V.3    Leveille, S.4    Danthi, P.5    Hiscott, J.6    Sherry, B.7    Dermody, T.S.8
  • 57
    • 0141923690 scopus 로고    scopus 로고
    • Toll/IL-1 receptor domain-containing adaptor inducing IFN-β (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-κB and IFN-regulatory factor-3, in the Toll-like receptor signaling
    • Sato, S., M. Sugiyama, M. Yamamoto, Y. Watanabe, T. Kawai, K. Takeda, and S. Akira. 2003. Toll/IL-1 receptor domain-containing adaptor inducing IFN-β (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-κB and IFN-regulatory factor-3, in the Toll-like receptor signaling. J. Immunol. 171: 4304-4310.
    • (2003) J. Immunol , vol.171 , pp. 4304-4310
    • Sato, S.1    Sugiyama, M.2    Yamamoto, M.3    Watanabe, Y.4    Kawai, T.5    Takeda, K.6    Akira, S.7
  • 58
    • 33847066747 scopus 로고    scopus 로고
    • Expanding the roles of antimicrobial peptides in skin: Alarming and arming keratinocytes
    • Schauber, J., and R. L. Gallo. 2007. Expanding the roles of antimicrobial peptides in skin: alarming and arming keratinocytes. J. Invest. Dermatol. 127: 510-512.
    • (2007) J. Invest. Dermatol , vol.127 , pp. 510-512
    • Schauber, J.1    Gallo, R.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.