Structural basis of double-stranded RNA recognition by the RIG-I like receptor MDA5

Archives of Biochemistry and Biophysics

Volumn 488, Issue 1, 2009, Pages 23-33

  Li, Xiaojun ^a   Lu, Cheng ^a   Stewart, Mikaela ^a   Xu, Hengyu ^b   Strong, Roland K ^b   Igumenova, Tatyana ^a   Li, Pingwei ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

^b Fred Hutchinson Cancer Research Center   (United States)

Author keywords

Crystal structure; Innate immunity; MDA5 CTD; Nucleic acid receptor

Indexed keywords

DOUBLE STRANDED RNA; MELANOMA DIFFERENTIATION ASSOCIATED PROTEIN 5; RECEPTOR PROTEIN; RETINOIC ACID INDUCIBLE PROTEIN I; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; MOLECULAR MODEL; MOLECULAR RECOGNITION; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN RNA BINDING; PROTEIN STRUCTURE; RNA ANALYSIS; RNA STRUCTURE;

AMINO ACID SEQUENCE; BASE SEQUENCE; CRYSTALLOGRAPHY, X-RAY; DEAD-BOX RNA HELICASES; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RNA HELICASES; RNA, DOUBLE-STRANDED; SEQUENCE HOMOLOGY, AMINO ACID; STATIC ELECTRICITY; SURFACE PROPERTIES;

EID: 67651232539     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2009.06.008     Document Type: Article

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