-
1
-
-
0029804116
-
Mechanism of activation of protein kinase B by insulin and IGF-1
-
Alessi DR, Andjelkovic M, Caudwell B, Cron P, Morrice N, Cohen P et al. (1996a). Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J 15: 6541-6551.
-
(1996)
EMBO J
, vol.15
, pp. 6541-6551
-
-
Alessi, D.R.1
Andjelkovic, M.2
Caudwell, B.3
Cron, P.4
Morrice, N.5
Cohen, P.6
-
2
-
-
0030590875
-
Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase
-
Alessi DR, Caudwell FB, Andjelkovic M, Hemmings BA, Cohen P. (1996b). Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase. FEBS Lett 399: 333-338.
-
(1996)
FEBS Lett
, vol.399
, pp. 333-338
-
-
Alessi, D.R.1
Caudwell, F.B.2
Andjelkovic, M.3
Hemmings, B.A.4
Cohen, P.5
-
3
-
-
0031127305
-
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha
-
Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PR, Reese CB et al. (1997). Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha. Curr Biol 7: 261-269.
-
(1997)
Curr Biol
, vol.7
, pp. 261-269
-
-
Alessi, D.R.1
James, S.R.2
Downes, C.P.3
Holmes, A.B.4
Gaffney, P.R.5
Reese, C.B.6
-
4
-
-
24044521010
-
A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis
-
Anai M, Shojima N, Katagiri H, Ogihara T, Sakoda H, Onishi Y et al. (2005). A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis. J Biol Chem 280: 18525-18535.
-
(2005)
J Biol Chem
, vol.280
, pp. 18525-18535
-
-
Anai, M.1
Shojima, N.2
Katagiri, H.3
Ogihara, T.4
Sakoda, H.5
Onishi, Y.6
-
5
-
-
0032443803
-
The akt kinase: Molecular determinants of oncogenicity
-
Aoki M, Batista O, Bellacosa A, Tsichlis P, Vogt PK. (1998). The akt kinase: molecular determinants of oncogenicity. Proc Natl Acad Sci USA 95: 14950-14955.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 14950-14955
-
-
Aoki, M.1
Batista, O.2
Bellacosa, A.3
Tsichlis, P.4
Vogt, P.K.5
-
6
-
-
0037229714
-
Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells
-
Arboleda MJ, Lyons JF, Kabbinavar FF, Bray MR, Snow BE, Ayala R et al. (2003). Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells. Cancer Res 63: 196-206.
-
(2003)
Cancer Res
, vol.63
, pp. 196-206
-
-
Arboleda, M.J.1
Lyons, J.F.2
Kabbinavar, F.F.3
Bray, M.R.4
Snow, B.E.5
Ayala, R.6
-
7
-
-
9744231378
-
Neurodevelopment, neuroplasticity, and new genes for schizophrenia
-
Arnold SE, Talbot K, Hahn CG. (2005). Neurodevelopment, neuroplasticity, and new genes for schizophrenia. Prog Brain Res 147: 319-345.
-
(2005)
Prog Brain Res
, vol.147
, pp. 319-345
-
-
Arnold, S.E.1
Talbot, K.2
Hahn, C.G.3
-
8
-
-
85047700501
-
Phosphorylation of HDM2 by Akt
-
Ashcroft M, Ludwig RL, Woods DB, Copeland TD, Weber HO, MacRae EJ et al. (2002). Phosphorylation of HDM2 by Akt. Oncogene 21: 1955-1962.
-
(2002)
Oncogene
, vol.21
, pp. 1955-1962
-
-
Ashcroft, M.1
Ludwig, R.L.2
Woods, D.B.3
Copeland, T.D.4
Weber, H.O.5
MacRae, E.J.6
-
9
-
-
0024601010
-
PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells
-
Auger KR, Serunian LA, Soltoff SP, Libby P, Cantley LC. (1989). PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells. Cell 57: 167-175.
-
(1989)
Cell
, vol.57
, pp. 167-175
-
-
Auger, K.R.1
Serunian, L.A.2
Soltoff, S.P.3
Libby, P.4
Cantley, L.C.5
-
10
-
-
16644393213
-
The PIK3CA gene is mutated with high frequency in human breast cancers
-
Bachman KE, Argani P, Samuels Y, Silliman N, Ptak J, Szabo S et al. (2004). The PIK3CA gene is mutated with high frequency in human breast cancers. Cancer Biol Ther 3: 772-775.
-
(2004)
Cancer Biol Ther
, vol.3
, pp. 772-775
-
-
Bachman, K.E.1
Argani, P.2
Samuels, Y.3
Silliman, N.4
Ptak, J.5
Szabo, S.6
-
11
-
-
1542781732
-
Isoform-specific regulation of insulin-dependent glucose uptake by Akt/protein kinase B
-
Bae SS, Cho H, Mu J, Birnbaum MJ. (2003). Isoform-specific regulation of insulin-dependent glucose uptake by Akt/protein kinase B. J Biol Chem 278: 49530-49536.
-
(2003)
J Biol Chem
, vol.278
, pp. 49530-49536
-
-
Bae, S.S.1
Cho, H.2
Mu, J.3
Birnbaum, M.J.4
-
12
-
-
0033594480
-
PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2
-
Balendran A, Casamayor A, Deak M, Paterson A, Gaffney P, Currie R et al. (1999). PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2. Curr Biol 9: 393-404.
-
(1999)
Curr Biol
, vol.9
, pp. 393-404
-
-
Balendran, A.1
Casamayor, A.2
Deak, M.3
Paterson, A.4
Gaffney, P.5
Currie, R.6
-
13
-
-
0033575290
-
Regulation of GLUT1 gene transcription by the serine/threonine kinase Akt1
-
Barthel A, Okino ST, Liao J, Nakatani K, Li J, Whitlock Jr JP et al. (1999). Regulation of GLUT1 gene transcription by the serine/threonine kinase Akt1. J Biol Chem 274: 20281-20286.
-
(1999)
J Biol Chem
, vol.274
, pp. 20281-20286
-
-
Barthel, A.1
Okino, S.T.2
Liao, J.3
Nakatani, K.4
Li, J.5
Whitlock Jr, J.P.6
-
14
-
-
0037423289
-
Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival
-
Barthwal MK, Sathyanarayana P, Kundu CN, Rana B, Pradeep A, Sharma C et al. (2003). Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival. J Biol Chem 278: 3897-3902.
-
(2003)
J Biol Chem
, vol.278
, pp. 3897-3902
-
-
Barthwal, M.K.1
Sathyanarayana, P.2
Kundu, C.N.3
Rana, B.4
Pradeep, A.5
Sharma, C.6
-
15
-
-
0037131187
-
Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function
-
Basso AD, Solit DB, Chiosis G, Giri B, Tsichlis P, Rosen N. (2002). Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function. J Biol Chem 277: 39858-39866.
-
(2002)
J Biol Chem
, vol.277
, pp. 39858-39866
-
-
Basso, A.D.1
Solit, D.B.2
Chiosis, G.3
Giri, B.4
Tsichlis, P.5
Rosen, N.6
-
17
-
-
22744449073
-
An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior
-
Beaulieu JM, Sotnikova TD, Marion S, Lefkowitz RJ, Gainetdinov RR, Caron MG. (2005). An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior. Cell 122: 261-273.
-
(2005)
Cell
, vol.122
, pp. 261-273
-
-
Beaulieu, J.M.1
Sotnikova, T.D.2
Marion, S.3
Lefkowitz, R.J.4
Gainetdinov, R.R.5
Caron, M.G.6
-
18
-
-
1842787936
-
Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade
-
Beaulieu JM, Sotnikova TD, Yao WD, Kockeritz L, Woodgett JR, Gainetdinov RR et al. (2004). Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade. Proc Natl Acad Sci USA 101: 5099-5104.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 5099-5104
-
-
Beaulieu, J.M.1
Sotnikova, T.D.2
Yao, W.D.3
Kockeritz, L.4
Woodgett, J.R.5
Gainetdinov, R.R.6
-
19
-
-
0027470177
-
Structure, expression and chromosomal mapping of c-akt: Relationship to v-akt and its implications
-
Bellacosa A, Franke TF, Gonzalez-Portal ME, Datta K, Taguchi T, Gardner J et al. (1993). Structure, expression and chromosomal mapping of c-akt: relationship to v-akt and its implications. Oncogene 8: 745-754.
-
(1993)
Oncogene
, vol.8
, pp. 745-754
-
-
Bellacosa, A.1
Franke, T.F.2
Gonzalez-Portal, M.E.3
Datta, K.4
Taguchi, T.5
Gardner, J.6
-
20
-
-
0026095665
-
A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region
-
Bellacosa A, Testa JR, Staal SP, Tsichlis PN. (1991). A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region. Science 254: 274-277.
-
(1991)
Science
, vol.254
, pp. 274-277
-
-
Bellacosa, A.1
Testa, J.R.2
Staal, S.P.3
Tsichlis, P.N.4
-
21
-
-
0032562682
-
The activation of p38 and apoptosis by the inhibition of Erk is antagonized by the phosphoinositide 3-kinase/Akt pathway
-
Berra E, Diaz-Meco MT, Moscat J. (1998). The activation of p38 and apoptosis by the inhibition of Erk is antagonized by the phosphoinositide 3-kinase/Akt pathway. J Biol Chem 273: 10792-10797.
-
(1998)
J Biol Chem
, vol.273
, pp. 10792-10797
-
-
Berra, E.1
Diaz-Meco, M.T.2
Moscat, J.3
-
22
-
-
12344290720
-
Protein kinase B phosphorylation of PIKfyve regulates the trafficking of GLUT4 vesicles
-
Berwick DC, Dell GC, Welsh GI, Heesom KJ, Hers I, Fletcher LM et al. (2004). Protein kinase B phosphorylation of PIKfyve regulates the trafficking of GLUT4 vesicles. J Cell Sci 117: 5985-5993.
-
(2004)
J Cell Sci
, vol.117
, pp. 5985-5993
-
-
Berwick, D.C.1
Dell, G.C.2
Welsh, G.I.3
Heesom, K.J.4
Hers, I.5
Fletcher, L.M.6
-
23
-
-
0037072780
-
The identification of ATP-citrate lyase as a protein kinase B (Akt) substrate in primary adipocytes
-
Berwick DC, Hers I, Heesom KJ, Moule SK, Tavare JM. (2002). The identification of ATP-citrate lyase as a protein kinase B (Akt) substrate in primary adipocytes. J Biol Chem 277: 33895-33900.
-
(2002)
J Biol Chem
, vol.277
, pp. 33895-33900
-
-
Berwick, D.C.1
Hers, I.2
Heesom, K.J.3
Moule, S.K.4
Tavare, J.M.5
-
24
-
-
0034161251
-
Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA
-
Biondi RM, Cheung PC, Casamayor A, Deak M, Currie RA, Alessi DR. (2000). Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA. EMBO J 19: 979-988.
-
(2000)
EMBO J
, vol.19
, pp. 979-988
-
-
Biondi, R.M.1
Cheung, P.C.2
Casamayor, A.3
Deak, M.4
Currie, R.A.5
Alessi, D.R.6
-
25
-
-
52149086562
-
AKT1(E17K) in human solid tumours
-
publication, 26 May, doi:10.1038/onc.2008.170
-
Bleeker FE, Felicioni L, Buttitta F, Lamba S, Cardone L, Rodolfo M et al. (2008). AKT1(E17K) in human solid tumours. Oncogene, advance online publication, 26 May 2008; doi:10.1038/onc.2008.170.
-
(2008)
Oncogene, advance online
-
-
Bleeker, F.E.1
Felicioni, L.2
Buttitta, F.3
Lamba, S.4
Cardone, L.5
Rodolfo, M.6
-
26
-
-
42949165854
-
PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival
-
Bozulic L, Surucu B, Hynx D, Hemmings BA. (2008). PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival. Mol Cell 30: 203-213.
-
(2008)
Mol Cell
, vol.30
, pp. 203-213
-
-
Bozulic, L.1
Surucu, B.2
Hynx, D.3
Hemmings, B.A.4
-
27
-
-
0035499454
-
Ten years of protein kinase B signalling: A hard Akt to follow
-
Brazil DP, Hemmings BA. (2001). Ten years of protein kinase B signalling: a hard Akt to follow. Trends Biochem Sci 26: 657-664.
-
(2001)
Trends Biochem Sci
, vol.26
, pp. 657-664
-
-
Brazil, D.P.1
Hemmings, B.A.2
-
28
-
-
0036849331
-
PKB binding proteins. Getting in on the Akt
-
Brazil DP, Park J, Hemmings BA. (2002). PKB binding proteins. Getting in on the Akt. Cell 111: 293-303.
-
(2002)
Cell
, vol.111
, pp. 293-303
-
-
Brazil, D.P.1
Park, J.2
Hemmings, B.A.3
-
29
-
-
33947203621
-
PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms
-
Brognard J, Sierecki E, Gao T, Newton AC. (2007). PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms. Mol Cell 25: 917-931.
-
(2007)
Mol Cell
, vol.25
, pp. 917-931
-
-
Brognard, J.1
Sierecki, E.2
Gao, T.3
Newton, A.C.4
-
30
-
-
34547574720
-
A new mutational AKTivation in the PI3K pathway
-
Brugge J, Hung MC, Mills GB. (2007). A new mutational AKTivation in the PI3K pathway. Cancer Cell 12: 104-107.
-
(2007)
Cancer Cell
, vol.12
, pp. 104-107
-
-
Brugge, J.1
Hung, M.C.2
Mills, G.B.3
-
31
-
-
0033582929
-
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
-
Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS et al. (1999). Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96: 857-868.
-
(1999)
Cell
, vol.96
, pp. 857-868
-
-
Brunet, A.1
Bonni, A.2
Zigmond, M.J.3
Lin, M.Z.4
Juo, P.5
Hu, L.S.6
-
32
-
-
0035135841
-
Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)
-
Brunet A, Park J, Tran H, Hu LS, Hemmings BA, Greenberg ME. (2001). Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a). Mol Cell Biol 21: 952-965.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 952-965
-
-
Brunet, A.1
Park, J.2
Tran, H.3
Hu, L.S.4
Hemmings, B.A.5
Greenberg, M.E.6
-
33
-
-
0029160069
-
Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
-
Burgering BMT, Coffer PJ. (1995). Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature 376: 599-602.
-
(1995)
Nature
, vol.376
, pp. 599-602
-
-
Burgering, B.M.T.1
Coffer, P.J.2
-
34
-
-
20244367771
-
Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations
-
Butler MG, Dasouki MJ, Zhou XP, Talebizadeh Z, Brown M, Takahashi TN et al. (2005). Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations. J Med Genet 42: 318-321.
-
(2005)
J Med Genet
, vol.42
, pp. 318-321
-
-
Butler, M.G.1
Dasouki, M.J.2
Zhou, X.P.3
Talebizadeh, Z.4
Brown, M.5
Takahashi, T.N.6
-
35
-
-
34247391898
-
Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo
-
Calleja V, Alcor D, Laguerre M, Park J, Vojnovic B, Hemmings BA et al. (2007). Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo. PLoS Biol 5: e95.
-
(2007)
PLoS Biol
, vol.5
-
-
Calleja, V.1
Alcor, D.2
Laguerre, M.3
Park, J.4
Vojnovic, B.5
Hemmings, B.A.6
-
36
-
-
7444250290
-
Mutation of the PIK3CA gene in ovarian and breast cancer
-
Campbell IG, Russell SE, Choong DY, Montgomery KG, Ciavarella ML, Hooi CS et al. (2004). Mutation of the PIK3CA gene in ovarian and breast cancer. Cancer Res 64: 7678-7681.
-
(2004)
Cancer Res
, vol.64
, pp. 7678-7681
-
-
Campbell, I.G.1
Russell, S.E.2
Choong, D.Y.3
Montgomery, K.G.4
Ciavarella, M.L.5
Hooi, C.S.6
-
37
-
-
0032515027
-
Regulation of cell death protease caspase-9 by phosphorylation
-
Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke TF, Stanbridge E et al. (1998). Regulation of cell death protease caspase-9 by phosphorylation. Science 282: 1318-1321.
-
(1998)
Science
, vol.282
, pp. 1318-1321
-
-
Cardone, M.H.1
Roy, N.2
Stennicke, H.R.3
Salvesen, G.S.4
Franke, T.F.5
Stanbridge, E.6
-
38
-
-
43749120732
-
The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications
-
Carnero A, Blanco-Aparicio C, Renner O, Link W, Leal JF. (2008). The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications. Curr Cancer Drug Targets 8: 187-198.
-
(2008)
Curr Cancer Drug Targets
, vol.8
, pp. 187-198
-
-
Carnero, A.1
Blanco-Aparicio, C.2
Renner, O.3
Link, W.4
Leal, J.F.5
-
39
-
-
34547172596
-
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
-
Carpten JD, Faber AL, Horn C, Donoho GP, Briggs SL, Robbins CM et al. (2007). A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Nature 448: 439-444.
-
(2007)
Nature
, vol.448
, pp. 439-444
-
-
Carpten, J.D.1
Faber, A.L.2
Horn, C.3
Donoho, G.P.4
Briggs, S.L.5
Robbins, C.M.6
-
40
-
-
0027991781
-
Phosphatidylinositol 3,4,5-trisphosphate is formed from phosphatidylinositol 4,5-bisphosphate in thrombin-stimulated platelets
-
Carter AN, Huang R, Sorisky A, Downes CP, Rittenhouse SE. (1994). Phosphatidylinositol 3,4,5-trisphosphate is formed from phosphatidylinositol 4,5-bisphosphate in thrombin-stimulated platelets. Biochem J 301(Part 2): 415-420.
-
(1994)
Biochem J
, vol.301
, Issue.PART 2
, pp. 415-420
-
-
Carter, A.N.1
Huang, R.2
Sorisky, A.3
Downes, C.P.4
Rittenhouse, S.E.5
-
41
-
-
0031770118
-
Role of Akt and c-Jun N-terminal kinase 2 in apoptosis induced by interleukin-4 deprivation
-
Cerezo A, Martinez AC, Lanzarot D, Fischer S, Franke TF, Rebollo A. (1998). Role of Akt and c-Jun N-terminal kinase 2 in apoptosis induced by interleukin-4 deprivation. Mol Biol Cell 9: 3107-3118.
-
(1998)
Mol Biol Cell
, vol.9
, pp. 3107-3118
-
-
Cerezo, A.1
Martinez, A.C.2
Lanzarot, D.3
Fischer, S.4
Franke, T.F.5
Rebollo, A.6
-
42
-
-
0032881288
-
AKT/PKB and other D3 phosphoinositide-regulated kinases: Kinase activation by phosphoinositide- dependent phosphorylation
-
Chan TO, Rittenhouse SE, Tsichlis PN. (1999). AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide- dependent phosphorylation. Annu Rev Biochem 68: 965-1014.
-
(1999)
Annu Rev Biochem
, vol.68
, pp. 965-1014
-
-
Chan, T.O.1
Rittenhouse, S.E.2
Tsichlis, P.N.3
-
44
-
-
0037726598
-
Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1
-
Chen HK, Fernandez-Funez P, Acevedo SF, Lam YC, Kaytor MD, Fernandez MH et al. (2003). Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1. Cell 113: 457-468.
-
(2003)
Cell
, vol.113
, pp. 457-468
-
-
Chen, H.K.1
Fernandez-Funez, P.2
Acevedo, S.F.3
Lam, Y.C.4
Kaytor, M.D.5
Fernandez, M.H.6
-
45
-
-
0035448879
-
Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene
-
Chen WS, Xu PZ, Gottlob K, Chen ML, Sokol K, Shiyanova T et al. (2001). Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes Dev 15: 2203-2208.
-
(2001)
Genes Dev
, vol.15
, pp. 2203-2208
-
-
Chen, W.S.1
Xu, P.Z.2
Gottlob, K.3
Chen, M.L.4
Sokol, K.5
Shiyanova, T.6
-
46
-
-
0001457668
-
Amplification of AKT2 in human pancreatic cancer cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA
-
Cheng JQ, Ruggeri B, Klein WM, Sonoda G, Altomare DA, Watson DK et al. (1996). Amplification of AKT2 in human pancreatic cancer cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA. PNAS 93: 3636-3641.
-
(1996)
PNAS
, vol.93
, pp. 3636-3641
-
-
Cheng, J.Q.1
Ruggeri, B.2
Klein, W.M.3
Sonoda, G.4
Altomare, D.A.5
Watson, D.K.6
-
47
-
-
0035368548
-
Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)
-
Cho H, Mu J, Kim JK, Thorvaldsen JL, Chu Q, Crenshaw III EB et al. (2001a). Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). Science 292: 1728-1731.
-
(2001)
Science
, vol.292
, pp. 1728-1731
-
-
Cho, H.1
Mu, J.2
Kim, J.K.3
Thorvaldsen, J.L.4
Chu, Q.5
Crenshaw III, E.B.6
-
48
-
-
0035914388
-
Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice
-
Cho H, Thorvaldsen JL, Chu Q, Feng F, Birnbaum MJ. (2001b). Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice. J Biol Chem 276: 38349-38352.
-
(2001)
J Biol Chem
, vol.276
, pp. 38349-38352
-
-
Cho, H.1
Thorvaldsen, J.L.2
Chu, Q.3
Feng, F.4
Birnbaum, M.J.5
-
49
-
-
0026006501
-
Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families
-
Coffer PJ, Woodgett JR. (1991). Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families. Eur J Biochem 201: 475-481.
-
(1991)
Eur J Biochem
, vol.201
, pp. 475-481
-
-
Coffer, P.J.1
Woodgett, J.R.2
-
50
-
-
0029587224
-
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
-
Cross DAE, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA. (1995). Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378: 785-789.
-
(1995)
Nature
, vol.378
, pp. 785-789
-
-
Cross, D.A.E.1
Alessi, D.R.2
Cohen, P.3
Andjelkovich, M.4
Hemmings, B.A.5
-
51
-
-
1242317030
-
Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP)
-
Dan HC, Sun M, Kaneko S, Feldman RI, Nicosia SV, Wang HG et al. (2004). Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP). J Biol Chem 279: 5405-5412.
-
(2004)
J Biol Chem
, vol.279
, pp. 5405-5412
-
-
Dan, H.C.1
Sun, M.2
Kaneko, S.3
Feldman, R.I.4
Nicosia, S.V.5
Wang, H.G.6
-
52
-
-
0041357164
-
BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis
-
Danial NN, Gramm CF, Scorrano L, Zhang CY, Krauss S, Ranger AM et al. (2003). BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis. Nature 424: 952-956.
-
(2003)
Nature
, vol.424
, pp. 952-956
-
-
Danial, N.N.1
Gramm, C.F.2
Scorrano, L.3
Zhang, C.Y.4
Krauss, S.5
Ranger, A.M.6
-
53
-
-
0033635235
-
14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation
-
Datta SR, Katsov A, Hu L, Petros A, Fesik SW, Yaffe MB et al. (2000). 14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation. Mol Cell 6: 41-51.
-
(2000)
Mol Cell
, vol.6
, pp. 41-51
-
-
Datta, S.R.1
Katsov, A.2
Hu, L.3
Petros, A.4
Fesik, S.W.5
Yaffe, M.B.6
-
54
-
-
0030748651
-
Phosphorylation and activation of heart 6-phosphofructo-2-kinase by protein kinase B and other protein kinases of the insulin signaling cascades
-
Deprez J, Vertommen D, Alessi DR, Hue L, Rider MH. (1997). Phosphorylation and activation of heart 6-phosphofructo-2-kinase by protein kinase B and other protein kinases of the insulin signaling cascades. J Biol Chem 272: 17269-17275.
-
(1997)
J Biol Chem
, vol.272
, pp. 17269-17275
-
-
Deprez, J.1
Vertommen, D.2
Alessi, D.R.3
Hue, L.4
Rider, M.H.5
-
55
-
-
34548312363
-
Ca(2+)/calmodulin directly interacts with the pleckstrin homology domain of AKT1
-
Dong B, Valencia CA, Liu R. (2007). Ca(2+)/calmodulin directly interacts with the pleckstrin homology domain of AKT1. J Biol Chem 282: 25131-25140.
-
(2007)
J Biol Chem
, vol.282
, pp. 25131-25140
-
-
Dong, B.1
Valencia, C.A.2
Liu, R.3
-
56
-
-
23044467856
-
PDK2: The missing piece in the receptor tyrosine kinase signaling pathway puzzle
-
Dong LQ, Liu F. (2005). PDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle. Am J Physiol Endocrinol Metab 289: E187-E196.
-
(2005)
Am J Physiol Endocrinol Metab
, vol.289
-
-
Dong, L.Q.1
Liu, F.2
-
57
-
-
0042860122
-
Cell biology: Metabolism meets death
-
Downward J. (2003). Cell biology: metabolism meets death. Nature 424: 896-897.
-
(2003)
Nature
, vol.424
, pp. 896-897
-
-
Downward, J.1
-
58
-
-
15444368319
-
DNA-PKcs, but not TLR9, is required for activation of Akt by CpG-DNA
-
Dragoi AM, Fu X, Ivanov S, Zhang P, Sheng L, Wu D et al. (2005). DNA-PKcs, but not TLR9, is required for activation of Akt by CpG-DNA. EMBO J 24: 779-789.
-
(2005)
EMBO J
, vol.24
, pp. 779-789
-
-
Dragoi, A.M.1
Fu, X.2
Ivanov, S.3
Zhang, P.4
Sheng, L.5
Wu, D.6
-
59
-
-
0038242819
-
TRB3: A tribbles homolog that inhibits Akt/PKB activation by insulin in liver
-
Du K, Herzig S, Kulkarni RN, Montminy M. (2003). TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver. Science 300: 1574-1577.
-
(2003)
Science
, vol.300
, pp. 1574-1577
-
-
Du, K.1
Herzig, S.2
Kulkarni, R.N.3
Montminy, M.4
-
60
-
-
27844601539
-
Regulation of the Akt kinase by interacting proteins
-
Du K, Tsichlis PN. (2005). Regulation of the Akt kinase by interacting proteins. Oncogene 24: 7401-7409.
-
(2005)
Oncogene
, vol.24
, pp. 7401-7409
-
-
Du, K.1
Tsichlis, P.N.2
-
61
-
-
0031053586
-
Regulation of neuronal survival by the serine-threonine protein kinase Akt
-
Dudek H, Datta SR, Franke TF, Birnbaum MJ, Yao R, Cooper GM et al. (1997). Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 275: 661-665.
-
(1997)
Science
, vol.275
, pp. 661-665
-
-
Dudek, H.1
Datta, S.R.2
Franke, T.F.3
Birnbaum, M.J.4
Yao, R.5
Cooper, G.M.6
-
62
-
-
33750380920
-
Life with a single isoform of Akt: Mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies
-
Dummler B, Tschopp O, Hynx D, Yang ZZ, Dirnhofer S, Hemmings BA. (2006). Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies. Mol Cell Biol 26: 8042-8051.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 8042-8051
-
-
Dummler, B.1
Tschopp, O.2
Hynx, D.3
Yang, Z.Z.4
Dirnhofer, S.5
Hemmings, B.A.6
-
64
-
-
20044382806
-
Role for Akt3/protein kinase Bgamma in attainment of normal brain size
-
Easton RM, Cho H, Roovers K, Shineman DW, Mizrahi M, Forman MS et al. (2005). Role for Akt3/protein kinase Bgamma in attainment of normal brain size. Mol Cell Biol 25: 1869-1878.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 1869-1878
-
-
Easton, R.M.1
Cho, H.2
Roovers, K.3
Shineman, D.W.4
Mizrahi, M.5
Forman, M.S.6
-
65
-
-
0842310838
-
Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia
-
Emamian ES, Hall D, Birnbaum MJ, Karayiorgou M, Gogos JA. (2004). Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia. Nat Genet 36: 131-137.
-
(2004)
Nat Genet
, vol.36
, pp. 131-137
-
-
Emamian, E.S.1
Hall, D.2
Birnbaum, M.J.3
Karayiorgou, M.4
Gogos, J.A.5
-
66
-
-
33746257209
-
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
-
Engelman JA, Luo J, Cantley LC. (2006). The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet 7: 606-619.
-
(2006)
Nat Rev Genet
, vol.7
, pp. 606-619
-
-
Engelman, J.A.1
Luo, J.2
Cantley, L.C.3
-
67
-
-
4644359805
-
Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase
-
Feng J, Park J, Cron P, Hess D, Hemmings BA. (2004). Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase. J Biol Chem 279: 41189-41196.
-
(2004)
J Biol Chem
, vol.279
, pp. 41189-41196
-
-
Feng, J.1
Park, J.2
Cron, P.3
Hess, D.4
Hemmings, B.A.5
-
68
-
-
0346220278
-
Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex
-
Figueroa C, Tarras S, Taylor J, Vojtek AB. (2003). Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex. J Biol Chem 278: 47922-47927.
-
(2003)
J Biol Chem
, vol.278
, pp. 47922-47927
-
-
Figueroa, C.1
Tarras, S.2
Taylor, J.3
Vojtek, A.B.4
-
69
-
-
37149037801
-
Akt-interacting proteins: Attractive opposites. focus on 'Carboxy-terminal modulator protein induces Akt phosphorylation and activation, thereby enhancing antiapoptotic, glycogen synthetic, and glucose uptake pathways'
-
Franke TF. (2007). Akt-interacting proteins: attractive opposites. focus on 'Carboxy-terminal modulator protein induces Akt phosphorylation and activation, thereby enhancing antiapoptotic, glycogen synthetic, and glucose uptake pathways'. Am J Physiol Cell Physiol 293: C1768-C1770.
-
(2007)
Am J Physiol Cell Physiol
, vol.293
-
-
Franke, T.F.1
-
70
-
-
48649088560
-
Intracellular signaling by Akt: Bound to be specific
-
pe29
-
Franke TF. (2008). Intracellular signaling by Akt: bound to be specific. Sci Signal 1: pe29.
-
(2008)
Sci Signal
, vol.1
-
-
Franke, T.F.1
-
71
-
-
0031566693
-
Apoptosis. A Bad kinase makes good
-
Franke TF, Cantley LC. (1997). Apoptosis. A Bad kinase makes good. Nature 390: 116-117.
-
(1997)
Nature
, vol.390
, pp. 116-117
-
-
Franke, T.F.1
Cantley, L.C.2
-
72
-
-
1642471831
-
PI3K/Akt and apoptosis: Size matters
-
Franke TF, Hornik CP, Segev L, Shostak GA, Sugimoto C. (2003). PI3K/Akt and apoptosis: size matters. Oncogene 22: 8983-8998.
-
(2003)
Oncogene
, vol.22
, pp. 8983-8998
-
-
Franke, T.F.1
Hornik, C.P.2
Segev, L.3
Shostak, G.A.4
Sugimoto, C.5
-
73
-
-
0031039024
-
Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate
-
Franke TF, Kaplan DR, Cantley LC, Toker A. (1997). Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate. Science 275: 665-668.
-
(1997)
Science
, vol.275
, pp. 665-668
-
-
Franke, T.F.1
Kaplan, D.R.2
Cantley, L.C.3
Toker, A.4
-
74
-
-
0028006155
-
The SH2-like Akt homology (AH) domain of c-akt is present in multiple copies in the genome of vertebrate and invertebrate eucaryotes. Cloning and characterization of the Drosophila melanogaster c-akt homolog Dakt1
-
Franke TF, Tartof KD, Tsichlis PN. (1994). The SH2-like Akt homology (AH) domain of c-akt is present in multiple copies in the genome of vertebrate and invertebrate eucaryotes. Cloning and characterization of the Drosophila melanogaster c-akt homolog Dakt1. Oncogene 9: 141-148.
-
(1994)
Oncogene
, vol.9
, pp. 141-148
-
-
Franke, T.F.1
Tartof, K.D.2
Tsichlis, P.N.3
-
75
-
-
0029079275
-
The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
-
Franke TF, Yang SI, Chan TO, Datta K, Kazlauskas A, Morrison DK et al. (1995). The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 81: 727-736.
-
(1995)
Cell
, vol.81
, pp. 727-736
-
-
Franke, T.F.1
Yang, S.I.2
Chan, T.O.3
Datta, K.4
Kazlauskas, A.5
Morrison, D.K.6
-
76
-
-
0041450058
-
PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms
-
Freeman DJ, Li AG, Wei G, Li HH, Kertesz N, Lesche R et al. (2003). PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms. Cancer Cell 3: 117-130.
-
(2003)
Cancer Cell
, vol.3
, pp. 117-130
-
-
Freeman, D.J.1
Li, A.G.2
Wei, G.3
Li, H.H.4
Kertesz, N.5
Lesche, R.6
-
77
-
-
33748471980
-
mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s
-
Frias MA, Thoreen CC, Jaffe JD, Schroder W, Sculley T, Carr SA et al. (2006). mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s. Curr Biol 16: 1865-1870.
-
(2006)
Curr Biol
, vol.16
, pp. 1865-1870
-
-
Frias, M.A.1
Thoreen, C.C.2
Jaffe, J.D.3
Schroder, W.4
Sculley, T.5
Carr, S.A.6
-
78
-
-
43249095777
-
Akt- and Foxo1-interacting WD-repeat-FYVE protein promotes adipogenesis
-
Fritzius T, Moelling K. (2008). Akt- and Foxo1-interacting WD-repeat-FYVE protein promotes adipogenesis. EMBO J 27: 1399-1410.
-
(2008)
EMBO J
, vol.27
, pp. 1399-1410
-
-
Fritzius, T.1
Moelling, K.2
-
79
-
-
0033595720
-
Akt phosphorylation site found in human caspase-9 is absent in mouse caspase-9
-
Fujita E, Jinbo A, Matuzaki H, Konishi H, Kikkawa U, Momoi T. (1999). Akt phosphorylation site found in human caspase-9 is absent in mouse caspase-9. Biochem Biophys Res Commun 264: 550-555.
-
(1999)
Biochem Biophys Res Commun
, vol.264
, pp. 550-555
-
-
Fujita, E.1
Jinbo, A.2
Matuzaki, H.3
Konishi, H.4
Kikkawa, U.5
Momoi, T.6
-
80
-
-
0030584079
-
Apoptosis meets signal transduction: Elimination of a BAD influence
-
Gajewski TF, Thompson CB. (1996). Apoptosis meets signal transduction: elimination of a BAD influence. Cell 87: 589-592.
-
(1996)
Cell
, vol.87
, pp. 589-592
-
-
Gajewski, T.F.1
Thompson, C.B.2
-
81
-
-
34948866760
-
Akt/PKB interacts with the histone H3 methyltransferase SETDB1 and coordinates to silence gene expression
-
Gao H, Yu Z, Bi D, Jiang L, Cui Y, Sun J et al. (2007). Akt/PKB interacts with the histone H3 methyltransferase SETDB1 and coordinates to silence gene expression. Mol Cell Biochem 305: 35-44.
-
(2007)
Mol Cell Biochem
, vol.305
, pp. 35-44
-
-
Gao, H.1
Yu, Z.2
Bi, D.3
Jiang, L.4
Cui, Y.5
Sun, J.6
-
82
-
-
15944406764
-
PHLPP: A phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth
-
Gao T, Furnari F, Newton AC. (2005). PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol Cell 18: 13-24.
-
(2005)
Mol Cell
, vol.18
, pp. 13-24
-
-
Gao, T.1
Furnari, F.2
Newton, A.C.3
-
83
-
-
22344431879
-
Akt is essential for insulin modulation of amphetamine-induced human dopamine transporter cell-surface redistribution
-
Garcia BG, Wei Y, Moron JA, Lin RZ, Javitch JA, Galli A. (2005). Akt is essential for insulin modulation of amphetamine-induced human dopamine transporter cell-surface redistribution. Mol Pharmacol 68: 102-109.
-
(2005)
Mol Pharmacol
, vol.68
, pp. 102-109
-
-
Garcia, B.G.1
Wei, Y.2
Moron, J.A.3
Lin, R.Z.4
Javitch, J.A.5
Galli, A.6
-
84
-
-
2542528670
-
A family with severe insulin resistance and diabetes due to a mutation in AKT2
-
George S, Rochford JJ, Wolfrum C, Gray SL, Schinner S, Wilson JC et al. (2004). A family with severe insulin resistance and diabetes due to a mutation in AKT2. Science 304: 1325-1328.
-
(2004)
Science
, vol.304
, pp. 1325-1328
-
-
George, S.1
Rochford, J.J.2
Wolfrum, C.3
Gray, S.L.4
Schinner, S.5
Wilson, J.C.6
-
85
-
-
0034983918
-
Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase
-
Gottlob K, Majewski N, Kennedy S, Kandel E, Robey RB, Hay N. (2001). Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase. Genes Dev 15: 1406-1418.
-
(2001)
Genes Dev
, vol.15
, pp. 1406-1418
-
-
Gottlob, K.1
Majewski, N.2
Kennedy, S.3
Kandel, E.4
Robey, R.B.5
Hay, N.6
-
86
-
-
33947101019
-
Patterns of somatic mutation in human cancer genomes
-
Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G et al. (2007). Patterns of somatic mutation in human cancer genomes. Nature 446: 153-158.
-
(2007)
Nature
, vol.446
, pp. 153-158
-
-
Greenman, C.1
Stephens, P.2
Smith, R.3
Dalgliesh, G.L.4
Hunter, C.5
Bignell, G.6
-
87
-
-
34347220473
-
Defining the role of mTOR in cancer
-
Guertin DA, Sabatini DM. (2007). Defining the role of mTOR in cancer. Cancer Cell 12: 9-22.
-
(2007)
Cancer Cell
, vol.12
, pp. 9-22
-
-
Guertin, D.A.1
Sabatini, D.M.2
-
88
-
-
33751348056
-
Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1
-
Guertin DA, Stevens DM, Thoreen CC, Burds AA, Kalaany NY, Moffat J et al. (2006). Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Dev Cell 11: 859-871.
-
(2006)
Dev Cell
, vol.11
, pp. 859-871
-
-
Guertin, D.A.1
Stevens, D.M.2
Thoreen, C.C.3
Burds, A.A.4
Kalaany, N.Y.5
Moffat, J.6
-
89
-
-
42349101312
-
RalGDS couples growth factor signaling to Akt activation
-
Hao Y, Wong R, Feig LA. (2008). RalGDS couples growth factor signaling to Akt activation. Mol Cell Biol 28: 2851-2859.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 2851-2859
-
-
Hao, Y.1
Wong, R.2
Feig, L.A.3
-
91
-
-
2542499831
-
Beta-synuclein regulates Akt activity in neuronal cells. A possible mechanism for neuroprotection in Parkinson's disease
-
Hashimoto M, Bar-On P, Ho G, Takenouchi T, Rockenstein E, Crews L et al. (2004). Beta-synuclein regulates Akt activity in neuronal cells. A possible mechanism for neuroprotection in Parkinson's disease. J Biol Chem 279: 23622-23629.
-
(2004)
J Biol Chem
, vol.279
, pp. 23622-23629
-
-
Hashimoto, M.1
Bar-On, P.2
Ho, G.3
Takenouchi, T.4
Rockenstein, E.5
Crews, L.6
-
93
-
-
0026720350
-
Phosphatidylinositol 3-kinase - structure and expression of the 110 kd catalytic subunit
-
Hiles ID, Otsu M, Volinia S, Fry MJ, Gout I, Dhand R et al. (1992). Phosphatidylinositol 3-kinase - structure and expression of the 110 kd catalytic subunit. Cell 70: 419-429.
-
(1992)
Cell
, vol.70
, pp. 419-429
-
-
Hiles, I.D.1
Otsu, M.2
Volinia, S.3
Fry, M.J.4
Gout, I.5
Dhand, R.6
-
94
-
-
0032695529
-
A role for protein kinase Bbeta/Akt2 in insulin-stimulated GLUT4 translocation in adipocytes
-
Hill MM, Clark SF, Tucker DF, Birnbaum MJ, James DE, Macaulay SL. (1999). A role for protein kinase Bbeta/Akt2 in insulin-stimulated GLUT4 translocation in adipocytes. Mol Cell Biol 19: 7771-7781.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 7771-7781
-
-
Hill, M.M.1
Clark, S.F.2
Tucker, D.F.3
Birnbaum, M.J.4
James, D.E.5
Macaulay, S.L.6
-
95
-
-
0037162291
-
Identification of a plasma membrane Raft-associated PKB Ser473 kinase activity that is distinct from ILK and PDK1
-
Hill MM, Feng J, Hemmings BA. (2002). Identification of a plasma membrane Raft-associated PKB Ser473 kinase activity that is distinct from ILK and PDK1. Curr Biol 12: 1251-1255.
-
(2002)
Curr Biol
, vol.12
, pp. 1251-1255
-
-
Hill, M.M.1
Feng, J.2
Hemmings, B.A.3
-
96
-
-
0037072272
-
Characterization of PDK2 activity against protein kinase B gamma
-
Hodgkinson CP, Sale EM, Sale GJ. (2002). Characterization of PDK2 activity against protein kinase B gamma. Biochemistry 41: 10351-10359.
-
(2002)
Biochemistry
, vol.41
, pp. 10351-10359
-
-
Hodgkinson, C.P.1
Sale, E.M.2
Sale, G.J.3
-
97
-
-
0034020459
-
Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice
-
Holland EC, Celestino J, Dai C, Schaefer L, Sawaya RE, Fuller GN. (2000). Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice. Nat Genet 25: 55-57.
-
(2000)
Nat Genet
, vol.25
, pp. 55-57
-
-
Holland, E.C.1
Celestino, J.2
Dai, C.3
Schaefer, L.4
Sawaya, R.E.5
Fuller, G.N.6
-
98
-
-
48249099306
-
Inhibition of 5-HT(1A) receptor-dependent cell survival by cAMP/protein kinase A: Role of protein phosphatase 2A and Bax
-
Hsiung SC, Tin A, Tamir H, Franke TF, Liu KP. (2008). Inhibition of 5-HT(1A) receptor-dependent cell survival by cAMP/protein kinase A: Role of protein phosphatase 2A and Bax. J Neurosci Res 86: 2326-2338.
-
(2008)
J Neurosci Res
, vol.86
, pp. 2326-2338
-
-
Hsiung, S.C.1
Tin, A.2
Tamir, H.3
Franke, T.F.4
Liu, K.P.5
-
99
-
-
0036083379
-
The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt
-
Humbert S, Bryson EA, Cordelieres FP, Connors NC, Datta SR, Finkbeiner S et al. (2002). The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt. Dev Cell 2: 831-837.
-
(2002)
Dev Cell
, vol.2
, pp. 831-837
-
-
Humbert, S.1
Bryson, E.A.2
Cordelieres, F.P.3
Connors, N.C.4
Datta, S.R.5
Finkbeiner, S.6
-
100
-
-
0035008874
-
-
Hutchinson J, Jin J, Cardiff RD, Woodgett JR, Muller WJ. (2001). Activation of Akt (Protein Kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression. Mol Cell Biol 21: 2203-2212.
-
Hutchinson J, Jin J, Cardiff RD, Woodgett JR, Muller WJ. (2001). Activation of Akt (Protein Kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression. Mol Cell Biol 21: 2203-2212.
-
-
-
-
101
-
-
2342527930
-
-
Hutchinson JN, Jin J, Cardiff RD, Woodgett JR, Muller WJ. (2004). Activation of Akt-1 (PKB-alpha) can accelerate ErbB-2-mediated mammary tumorigenesis but suppresses tumor invasion. Cancer Res 64: 3171-3178.
-
Hutchinson JN, Jin J, Cardiff RD, Woodgett JR, Muller WJ. (2004). Activation of Akt-1 (PKB-alpha) can accelerate ErbB-2-mediated mammary tumorigenesis but suppresses tumor invasion. Cancer Res 64: 3171-3178.
-
-
-
-
102
-
-
0034604624
-
PKB/Akt interacts with inosine-50 monophosphate dehydrogenase through its pleckstrin homology domain
-
Ingley E, Hemmings BA. (2000). PKB/Akt interacts with inosine-50 monophosphate dehydrogenase through its pleckstrin homology domain. FEBS Lett 478: 253-259.
-
(2000)
FEBS Lett
, vol.478
, pp. 253-259
-
-
Ingley, E.1
Hemmings, B.A.2
-
103
-
-
0036713778
-
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
-
Inoki K, Li Y, Zhu T, Wu J, Guan KL. (2002). TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol 4: 648-657.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 648-657
-
-
Inoki, K.1
Li, Y.2
Zhu, T.3
Wu, J.4
Guan, K.L.5
-
104
-
-
0036146082
-
Role for the adaptor protein Grb10 in the activation of Akt
-
Jahn T, Seipel P, Urschel S, Peschel C, Duyster J. (2002). Role for the adaptor protein Grb10 in the activation of Akt. Mol Cell Biol 22: 979-991.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 979-991
-
-
Jahn, T.1
Seipel, P.2
Urschel, S.3
Peschel, C.4
Duyster, J.5
-
105
-
-
34548743454
-
Inositol 1,3,4,5-tetrakisphosphate negatively regulates phosphatidylinositol-3,4,5-trisphosphate signaling in neutrophils
-
Jia Y, Subramanian KK, Erneux C, Pouillon V, Hattori H, Jo H et al. (2007). Inositol 1,3,4,5-tetrakisphosphate negatively regulates phosphatidylinositol-3,4,5-trisphosphate signaling in neutrophils. Immunity 27: 453-467.
-
(2007)
Immunity
, vol.27
, pp. 453-467
-
-
Jia, Y.1
Subramanian, K.K.2
Erneux, C.3
Pouillon, V.4
Hattori, H.5
Jo, H.6
-
106
-
-
0037938847
-
Interaction between Src and a C-terminal proline-rich motif of Akt is required for Akt activation
-
Jiang T, Qiu Y. (2003). Interaction between Src and a C-terminal proline-rich motif of Akt is required for Akt activation. J Biol Chem 278: 15789-15793.
-
(2003)
J Biol Chem
, vol.278
, pp. 15789-15793
-
-
Jiang, T.1
Qiu, Y.2
-
107
-
-
0037934650
-
Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing
-
Jiang ZY, Zhou QL, Coleman KA, Chouinard M, Boese Q, Czech MP. (2003). Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing. Proc Natl Acad Sci USA 100: 7569-7574.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 7569-7574
-
-
Jiang, Z.Y.1
Zhou, Q.L.2
Coleman, K.A.3
Chouinard, M.4
Boese, Q.5
Czech, M.P.6
-
108
-
-
0026270993
-
Molecular cloning of a second form of rac protein kinase
-
Jones PF, Jakubowicz T, Hemmings BA. (1991a). Molecular cloning of a second form of rac protein kinase. Cell Reg. 2: 1001-1009.
-
(1991)
Cell Reg
, vol.2
, pp. 1001-1009
-
-
Jones, P.F.1
Jakubowicz, T.2
Hemmings, B.A.3
-
109
-
-
0025882091
-
Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily
-
Jones PF, Jakubowicz T, Pitossi FJ, Maurer F, Hemmings BA. (1991b). Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily. Proc Natl Acad Sci USA 88: 4171-4175.
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 4171-4175
-
-
Jones, P.F.1
Jakubowicz, T.2
Pitossi, F.J.3
Maurer, F.4
Hemmings, B.A.5
-
110
-
-
0034658320
-
Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo
-
Jones RG, Parsons M, Bonnard M, Chan VS, Yeh WC, Woodgett JR et al. (2000). Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo. J Exp Med 191: 1721-1734.
-
(2000)
J Exp Med
, vol.191
, pp. 1721-1734
-
-
Jones, R.G.1
Parsons, M.2
Bonnard, M.3
Chan, V.S.4
Yeh, W.C.5
Woodgett, J.R.6
-
111
-
-
44149127993
-
The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila
-
Juhasz G, Hill JH, Yan Y, Sass M, Baehrecke EH, Backer JM et al. (2008). The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila. J Cell Biol 181: 655-666.
-
(2008)
J Cell Biol
, vol.181
, pp. 655-666
-
-
Juhasz, G.1
Hill, J.H.2
Yan, Y.3
Sass, M.4
Baehrecke, E.H.5
Backer, J.M.6
-
112
-
-
0032808154
-
Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria
-
Kennedy SG, Kandel ES, Cross TK, Hay N. (1999). Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria. Mol Cell Biol 19: 5800-5810.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 5800-5810
-
-
Kennedy, S.G.1
Kandel, E.S.2
Cross, T.K.3
Hay, N.4
-
113
-
-
0035809160
-
Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae
-
Kihara A, Noda T, Ishihara N, Ohsumi Y. (2001). Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae. J Cell Biol 152: 519-530.
-
(2001)
J Cell Biol
, vol.152
, pp. 519-530
-
-
Kihara, A.1
Noda, T.2
Ishihara, N.3
Ohsumi, Y.4
-
114
-
-
0035133227
-
Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1
-
Kim AH, Khursigara G, Sun X, Franke TF, Chao MV. (2001). Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1. Mol Cell Biol 21: 893-901.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 893-901
-
-
Kim, A.H.1
Khursigara, G.2
Sun, X.3
Franke, T.F.4
Chao, M.V.5
-
115
-
-
0042030924
-
JNK interacting protein 1 promotes Akt1 activation
-
Kim AH, Sasaki T, Chao MV. (2003). JNK interacting protein 1 promotes Akt1 activation. J Biol Chem 278: 29830-29836.
-
(2003)
J Biol Chem
, vol.278
, pp. 29830-29836
-
-
Kim, A.H.1
Sasaki, T.2
Chao, M.V.3
-
116
-
-
0037104660
-
Akt1 regulates a JNK scaffold during excitotoxic apoptosis
-
Kim AH, Yano H, Cho H, Meyer D, Monks B, Margolis B et al. (2002). Akt1 regulates a JNK scaffold during excitotoxic apoptosis. Neuron 35: 697-709.
-
(2002)
Neuron
, vol.35
, pp. 697-709
-
-
Kim, A.H.1
Yano, H.2
Cho, H.3
Meyer, D.4
Monks, B.5
Margolis, B.6
-
117
-
-
43249115083
-
Mutational analysis of oncogenic AKT E17K mutation in common solid cancers and acute leukaemias
-
Kim MS, Jeong EG, Yoo NJ, Lee SH. (2008). Mutational analysis of oncogenic AKT E17K mutation in common solid cancers and acute leukaemias. Br J Cancer 98: 1533-1535.
-
(2008)
Br J Cancer
, vol.98
, pp. 1533-1535
-
-
Kim, M.S.1
Jeong, E.G.2
Yoo, N.J.3
Lee, S.H.4
-
118
-
-
0034457883
-
In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: Overlapping but distinct pathways from insulin
-
Kim YB, Uotani S, Pierroz DD, Flier JS, Kahn BB. (2000). In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: overlapping but distinct pathways from insulin. Endocrinology 141: 2328-2339.
-
(2000)
Endocrinology
, vol.141
, pp. 2328-2339
-
-
Kim, Y.B.1
Uotani, S.2
Pierroz, D.D.3
Flier, J.S.4
Kahn, B.B.5
-
119
-
-
0029143388
-
Insulin stimulates the kinase activity of RAC-PK, a pleckstrin homology domain containing ser/thr kinase
-
Kohn AD, Kovacina KS, Roth RA. (1995). Insulin stimulates the kinase activity of RAC-PK, a pleckstrin homology domain containing ser/thr kinase. EMBO J 14: 4288-4295.
-
(1995)
EMBO J
, vol.14
, pp. 4288-4295
-
-
Kohn, A.D.1
Kovacina, K.S.2
Roth, R.A.3
-
120
-
-
0029908016
-
Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation
-
Kohn AD, Summers SA, Birnbaum MJ, Roth RA. (1996). Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation. J Biol Chem 271: 31372-31378.
-
(1996)
J Biol Chem
, vol.271
, pp. 31372-31378
-
-
Kohn, A.D.1
Summers, S.A.2
Birnbaum, M.J.3
Roth, R.A.4
-
121
-
-
0027985080
-
Molecular cloning of rat RAC protein kinase alpha and beta and their association with protein kinase C zeta
-
Konishi H, Shinomura T, Kuroda S, Ono Y, Kikkawa U. (1994). Molecular cloning of rat RAC protein kinase alpha and beta and their association with protein kinase C zeta. Biochem Biophys Res Commun 205: 817-825.
-
(1994)
Biochem Biophys Res Commun
, vol.205
, pp. 817-825
-
-
Konishi, H.1
Shinomura, T.2
Kuroda, S.3
Ono, Y.4
Kikkawa, U.5
-
122
-
-
33646142995
-
Pten regulates neuronal arborization and social interaction in mice
-
Kwon CH, Luikart BW, Powell CM, Zhou J, Matheny SA, Zhang W et al. (2006). Pten regulates neuronal arborization and social interaction in mice. Neuron 50: 377-388.
-
(2006)
Neuron
, vol.50
, pp. 377-388
-
-
Kwon, C.H.1
Luikart, B.W.2
Powell, C.M.3
Zhou, J.4
Matheny, S.A.5
Zhang, W.6
-
123
-
-
0034614606
-
Akt protein kinase inhibits Rac1-GTP binding through phosphorylation at serine 71 of Rac1
-
Kwon T, Kwon DY, Chun J, Kim JH, Kang SS. (2000). Akt protein kinase inhibits Rac1-GTP binding through phosphorylation at serine 71 of Rac1. J Biol Chem 275: 423-428.
-
(2000)
J Biol Chem
, vol.275
, pp. 423-428
-
-
Kwon, T.1
Kwon, D.Y.2
Chun, J.3
Kim, J.H.4
Kang, S.S.5
-
124
-
-
33750934403
-
Akt1 deficiency affects neuronal morphology and predisposes to abnormalities in prefrontal cortex functioning
-
Lai WS, Xu B, Westphal KG, Paterlini M, Olivier B, Pavlidis P et al. (2006). Akt1 deficiency affects neuronal morphology and predisposes to abnormalities in prefrontal cortex functioning. Proc Natl Acad Sci USA 103: 16906-16911.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 16906-16911
-
-
Lai, W.S.1
Xu, B.2
Westphal, K.G.3
Paterlini, M.4
Olivier, B.5
Pavlidis, P.6
-
125
-
-
0028018858
-
The phosphatidylinositol 3-kinase serine kinase phosphorylates IRS-1. Stimulation by insulin and inhibition by Wortmannin
-
Lam K, Carpenter CL, Ruderman NB, Friel JC, Kelly KL. (1994). The phosphatidylinositol 3-kinase serine kinase phosphorylates IRS-1. Stimulation by insulin and inhibition by Wortmannin. J Biol Chem 269: 20648-20652.
-
(1994)
J Biol Chem
, vol.269
, pp. 20648-20652
-
-
Lam, K.1
Carpenter, C.L.2
Ruderman, N.B.3
Friel, J.C.4
Kelly, K.L.5
-
126
-
-
0028999058
-
Activation of Bruton's tyrosine kinase (BTK) by a point mutation in its pleckstrin homology (PH) domain
-
Li T, Tsukada S, Satterthwaite A, Havlik MH, Park H, Takatsu K et al. (1995). Activation of Bruton's tyrosine kinase (BTK) by a point mutation in its pleckstrin homology (PH) domain. Immunity 2: 451-460.
-
(1995)
Immunity
, vol.2
, pp. 451-460
-
-
Li, T.1
Tsukada, S.2
Satterthwaite, A.3
Havlik, M.H.4
Park, H.5
Takatsu, K.6
-
127
-
-
0037192852
-
AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival
-
Li Y, Dowbenko D, Lasky LA. (2002). AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival. J Biol Chem 277: 11352-11361.
-
(2002)
J Biol Chem
, vol.277
, pp. 11352-11361
-
-
Li, Y.1
Dowbenko, D.2
Lasky, L.A.3
-
128
-
-
18644376449
-
PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest
-
Liang J, Zubovitz J, Petrocelli T, Kotchetkov R, Connor MK, Han K et al. (2002). PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest. Nat Med 8: 1153-1160.
-
(2002)
Nat Med
, vol.8
, pp. 1153-1160
-
-
Liang, J.1
Zubovitz, J.2
Petrocelli, T.3
Kotchetkov, R.4
Connor, M.K.5
Han, K.6
-
129
-
-
0035855710
-
A role for the PI-3 kinase signaling pathway in fear conditioning and synaptic plasticity in the amygdala
-
Lin C, Yeh S, Lu K, Leu T, Chang W, Gean P. (2001). A role for the PI-3 kinase signaling pathway in fear conditioning and synaptic plasticity in the amygdala. Neuron 31: 841-851.
-
(2001)
Neuron
, vol.31
, pp. 841-851
-
-
Lin, C.1
Yeh, S.2
Lu, K.3
Leu, T.4
Chang, W.5
Gean, P.6
-
130
-
-
0034609733
-
Identification of CISK, a new member of the SGK kinase family that promotes IL-3-dependent survival
-
Liu D, Yang X, Songyang Z. (2000). Identification of CISK, a new member of the SGK kinase family that promotes IL-3-dependent survival. Curr Biol 10: 1233-1236.
-
(2000)
Curr Biol
, vol.10
, pp. 1233-1236
-
-
Liu, D.1
Yang, X.2
Songyang, Z.3
-
131
-
-
0031037296
-
Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI3-kinase gamma
-
Lopez-Ilasaca M, Crespo P, Pellici PG, Gutkind JS, Wetzker R. (1997). Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI3-kinase gamma. Science 275: 394-397.
-
(1997)
Science
, vol.275
, pp. 394-397
-
-
Lopez-Ilasaca, M.1
Crespo, P.2
Pellici, P.G.3
Gutkind, J.S.4
Wetzker, R.5
-
132
-
-
43049131769
-
Targeting the PI3K/Akt/mTOR pathway: Effective combinations and clinical considerations
-
LoPiccolo J, Blumenthal GM, Bernstein WB, Dennis PA. (2008). Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations. Drug Resist Updat 11: 32-50.
-
(2008)
Drug Resist Updat
, vol.11
, pp. 32-50
-
-
LoPiccolo, J.1
Blumenthal, G.M.2
Bernstein, W.B.3
Dennis, P.A.4
-
133
-
-
33747356750
-
Protein kinase Cepsilon activates protein kinase B/Akt via DNA-PK to protect against tumor necrosis factor-alpha-induced cell death
-
Lu D, Huang J, Basu A. (2006). Protein kinase Cepsilon activates protein kinase B/Akt via DNA-PK to protect against tumor necrosis factor-alpha-induced cell death. J Biol Chem 281: 22799-22807.
-
(2006)
J Biol Chem
, vol.281
, pp. 22799-22807
-
-
Lu, D.1
Huang, J.2
Basu, A.3
-
134
-
-
0033599029
-
Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism
-
Lynch DK, Ellis CA, Edwards PA, Hiles ID. (1999). Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism. Oncogene 18: 8024-8032.
-
(1999)
Oncogene
, vol.18
, pp. 8024-8032
-
-
Lynch, D.K.1
Ellis, C.A.2
Edwards, P.A.3
Hiles, I.D.4
-
135
-
-
34547567539
-
Regulation of the Pro-apoptotic scaffolding protein POSH by Akt
-
Lyons TR, Thorburn J, Ryan PW, Thorburn A, Anderson SM, Kassenbrock CK. (2007). Regulation of the Pro-apoptotic scaffolding protein POSH by Akt. J Biol Chem 282: 21987-21997.
-
(2007)
J Biol Chem
, vol.282
, pp. 21987-21997
-
-
Lyons, T.R.1
Thorburn, J.2
Ryan, P.W.3
Thorburn, A.4
Anderson, S.M.5
Kassenbrock, C.K.6
-
136
-
-
0347719531
-
Estrogen inhibits paclitaxel-induced apoptosis via the phosphorylation of apoptosis signal-regulating kinase 1 in human ovarian cancer cell lines
-
Mabuchi S, Ohmichi M, Kimura A, Nishio Y, Arimoto-Ishida E, Yada-Hashimoto N et al. (2004). Estrogen inhibits paclitaxel-induced apoptosis via the phosphorylation of apoptosis signal-regulating kinase 1 in human ovarian cancer cell lines. Endocrinology 145: 49-58.
-
(2004)
Endocrinology
, vol.145
, pp. 49-58
-
-
Mabuchi, S.1
Ohmichi, M.2
Kimura, A.3
Nishio, Y.4
Arimoto-Ishida, E.5
Yada-Hashimoto, N.6
-
137
-
-
34548646991
-
PTEN: Its deregulation and tumorigenesis
-
Maehama T. (2007). PTEN: its deregulation and tumorigenesis. Biol Pharm Bull 30: 1624-1627.
-
(2007)
Biol Pharm Bull
, vol.30
, pp. 1624-1627
-
-
Maehama, T.1
-
138
-
-
0032577699
-
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
-
Maehama T, Dixon JE. (1998). The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 273: 13375-13378.
-
(1998)
J Biol Chem
, vol.273
, pp. 13375-13378
-
-
Maehama, T.1
Dixon, J.E.2
-
139
-
-
0035850916
-
Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane
-
Maira SM, Galetic I, Brazil DP, Kaech S, Ingley E, Thelen M et al. (2001). Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane. Science 294: 374-380.
-
(2001)
Science
, vol.294
, pp. 374-380
-
-
Maira, S.M.1
Galetic, I.2
Brazil, D.P.3
Kaech, S.4
Ingley, E.5
Thelen, M.6
-
140
-
-
0038271762
-
Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: The MPAKT model
-
Majumder PK, Yeh JJ, George DJ, Febbo PG, Kum J, Xue Q et al. (2003). Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: The MPAKT model. Proc Natl Acad Sci USA 100: 7841-7846.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 7841-7846
-
-
Majumder, P.K.1
Yeh, J.J.2
George, D.J.3
Febbo, P.G.4
Kum, J.5
Xue, Q.6
-
141
-
-
41849132829
-
Activating E17K mutation in the gene encoding the protein kinase AKT1 in a subset of squamous cell carcinoma of the lung
-
Malanga D, Scrima M, De Marco C, Fabiani F, De Rosa N, De Gisi S et al. (2008). Activating E17K mutation in the gene encoding the protein kinase AKT1 in a subset of squamous cell carcinoma of the lung. Cell Cycle 7: 665-669.
-
(2008)
Cell Cycle
, vol.7
, pp. 665-669
-
-
Malanga, D.1
Scrima, M.2
De Marco, C.3
Fabiani, F.4
De Rosa, N.5
De Gisi, S.6
-
142
-
-
0035909946
-
Tumor induction by an Lck-MyrAkt transgene is delayed by mechanisms controlling the size of the thymus
-
Malstrom S, Tili E, Kappes D, Ceci JD, Tsichlis PN. (2001). Tumor induction by an Lck-MyrAkt transgene is delayed by mechanisms controlling the size of the thymus. Proc Natl Acad Sci USA 98: 14967-14972.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 14967-14972
-
-
Malstrom, S.1
Tili, E.2
Kappes, D.3
Ceci, J.D.4
Tsichlis, P.N.5
-
143
-
-
33750068623
-
mTOR, translation initiation and cancer
-
Mamane Y, Petroulakis E, LeBacquer O, Sonenberg N. (2006). mTOR, translation initiation and cancer. Oncogene 25: 6416-6422.
-
(2006)
Oncogene
, vol.25
, pp. 6416-6422
-
-
Mamane, Y.1
Petroulakis, E.2
LeBacquer, O.3
Sonenberg, N.4
-
144
-
-
8444224619
-
Balancing Akt with S6K: Implications for both metabolic diseases and tumorigenesis
-
Manning BD. (2004). Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis. J Cell Biol 167: 399-403.
-
(2004)
J Cell Biol
, vol.167
, pp. 399-403
-
-
Manning, B.D.1
-
145
-
-
34250788809
-
AKT/PKB signaling: Navigating downstream
-
Manning BD, Cantley LC. (2007). AKT/PKB signaling: navigating downstream. Cell 129: 1261-1274.
-
(2007)
Cell
, vol.129
, pp. 1261-1274
-
-
Manning, B.D.1
Cantley, L.C.2
-
146
-
-
0035949588
-
A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus
-
Mayo LD, Donner DB. (2001). A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus. Proc Natl Acad Sci USA 98: 11598-11603.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 11598-11603
-
-
Mayo, L.D.1
Donner, D.B.2
-
147
-
-
40949083412
-
Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival
-
McDonald PC, Oloumi A, Mills J, Dobreva I, Maidan M, Gray V et al. (2008). Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival. Cancer Res 68: 1618-1624.
-
(2008)
Cancer Res
, vol.68
, pp. 1618-1624
-
-
McDonald, P.C.1
Oloumi, A.2
Mills, J.3
Dobreva, I.4
Maidan, M.5
Gray, V.6
-
148
-
-
0033560747
-
Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium
-
Meili R, Ellsworth C, Lee S, Reddy TB, Ma H, Firtel RA. (1999). Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium. EMBO J 18: 2092-2105.
-
(1999)
EMBO J
, vol.18
, pp. 2092-2105
-
-
Meili, R.1
Ellsworth, C.2
Lee, S.3
Reddy, T.B.4
Ma, H.5
Firtel, R.A.6
-
149
-
-
0033517348
-
Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2
-
Mitsuuchi Y, Johnson SW, Sonoda G, Tanno S, Golemis EA, Testa JR. (1999). Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2. Oncogene 18: 4891-4898.
-
(1999)
Oncogene
, vol.18
, pp. 4891-4898
-
-
Mitsuuchi, Y.1
Johnson, S.W.2
Sonoda, G.3
Tanno, S.4
Golemis, E.A.5
Testa, J.R.6
-
150
-
-
0033591008
-
Identification of a human Akt3 (protein kinase B gamma) which contains the regulatory serine phosphorylation site
-
Nakatani K, Sakaue H, Thompson DA, Weigel RJ, Roth RA. (1999a). Identification of a human Akt3 (protein kinase B gamma) which contains the regulatory serine phosphorylation site. Biochem Biophys Res Commun 257: 906-910.
-
(1999)
Biochem Biophys Res Commun
, vol.257
, pp. 906-910
-
-
Nakatani, K.1
Sakaue, H.2
Thompson, D.A.3
Weigel, R.J.4
Roth, R.A.5
-
151
-
-
0033618371
-
Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines
-
Nakatani K, Thompson DA, Barthel A, Sakaue H, Liu W, Weigel RJ et al. (1999b). Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines. J Biol Chem 274: 21528-21532.
-
(1999)
J Biol Chem
, vol.274
, pp. 21528-21532
-
-
Nakatani, K.1
Thompson, D.A.2
Barthel, A.3
Sakaue, H.4
Liu, W.5
Weigel, R.J.6
-
152
-
-
38349059780
-
A novel Akt/PKB-interacting protein promotes cell adhesion and inhibits familial amyotrophic lateral sclerosis-linked mutant SOD1-induced neuronal death via inhibition of PP2A-mediated dephosphorylation of Akt/PKB
-
Nawa M, Kanekura K, Hashimoto Y, Aiso S, Matsuoka M. (2008). A novel Akt/PKB-interacting protein promotes cell adhesion and inhibits familial amyotrophic lateral sclerosis-linked mutant SOD1-induced neuronal death via inhibition of PP2A-mediated dephosphorylation of Akt/PKB. Cell Signal 20: 493-505.
-
(2008)
Cell Signal
, vol.20
, pp. 493-505
-
-
Nawa, M.1
Kanekura, K.2
Hashimoto, Y.3
Aiso, S.4
Matsuoka, M.5
-
153
-
-
33847743064
-
hvps34, an ancient player, enters a growing game: MTOR Complex1/S6K1 signaling
-
Nobukuni T, Kozma SC, Thomas G. (2007). hvps34, an ancient player, enters a growing game: mTOR Complex1/S6K1 signaling. Curr Opin Cell Biol 19: 135-141.
-
(2007)
Curr Opin Cell Biol
, vol.19
, pp. 135-141
-
-
Nobukuni, T.1
Kozma, S.C.2
Thomas, G.3
-
154
-
-
34547795824
-
Protooncogene TCL1: More than just a coactivator for Akt
-
Noguchi M, Ropars V, Roumestand C, Suizu F. (2007). Protooncogene TCL1: more than just a coactivator for Akt. Faseb J 21: 2273-2284.
-
(2007)
Faseb J
, vol.21
, pp. 2273-2284
-
-
Noguchi, M.1
Ropars, V.2
Roumestand, C.3
Suizu, F.4
-
155
-
-
0036237137
-
Akt phosphorylation and neuronal survival after traumatic brain injury in mice
-
Noshita N, Lewen A, Sugawara T, Chan PH. (2002). Akt phosphorylation and neuronal survival after traumatic brain injury in mice. Neurobiol Dis 9: 294-304.
-
(2002)
Neurobiol Dis
, vol.9
, pp. 294-304
-
-
Noshita, N.1
Lewen, A.2
Sugawara, T.3
Chan, P.H.4
-
156
-
-
0034680838
-
Peptide and protein library screening defines optimal substrate motifs for AKT/PKB
-
Obata T, Yaffe MB, Leparc GG, Piro ET, Maegawa H, Kashiwagi A et al. (2000). Peptide and protein library screening defines optimal substrate motifs for AKT/PKB. J Biol Chem 275: 36108-36115.
-
(2000)
J Biol Chem
, vol.275
, pp. 36108-36115
-
-
Obata, T.1
Yaffe, M.B.2
Leparc, G.G.3
Piro, E.T.4
Maegawa, H.5
Kashiwagi, A.6
-
157
-
-
0037077230
-
Akt enhances Mdm2-mediated ubiquitination and degradation of p53
-
Ogawara Y, Kishishita S, Obata T, Isazawa Y, Suzuki T, Tanaka K et al. (2002). Akt enhances Mdm2-mediated ubiquitination and degradation of p53. J Biol Chem 277: 21843-21850.
-
(2002)
J Biol Chem
, vol.277
, pp. 21843-21850
-
-
Ogawara, Y.1
Kishishita, S.2
Obata, T.3
Isazawa, Y.4
Suzuki, T.5
Tanaka, K.6
-
158
-
-
0032238299
-
The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway
-
Ogg S, Ruvkun G. (1998). The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway. Mol Cell 2: 887-893.
-
(1998)
Mol Cell
, vol.2
, pp. 887-893
-
-
Ogg, S.1
Ruvkun, G.2
-
159
-
-
0032476032
-
Insulin-like growth factor-I inhibits the stress-activated protein kinase/c-Jun N-terminal kinase
-
Okubo Y, Blakesley VA, Stannard B, Gutkind S, Le Roith D. (1998). Insulin-like growth factor-I inhibits the stress-activated protein kinase/c-Jun N-terminal kinase. J Biol Chem 273: 25961-25966.
-
(1998)
J Biol Chem
, vol.273
, pp. 25961-25966
-
-
Okubo, Y.1
Blakesley, V.A.2
Stannard, B.3
Gutkind, S.4
Le Roith, D.5
-
160
-
-
0036463949
-
Induction of ovarian cancer by defined multiple genetic changes in a mouse model system
-
Orsulic S, Li Y, Soslow RA, Vitale-Cross LA, Gutkind JS, Varmus HE. (2002). Induction of ovarian cancer by defined multiple genetic changes in a mouse model system. Cancer Cell 1: 53-62.
-
(2002)
Cancer Cell
, vol.1
, pp. 53-62
-
-
Orsulic, S.1
Li, Y.2
Soslow, R.A.3
Vitale-Cross, L.A.4
Gutkind, J.S.5
Varmus, H.E.6
-
161
-
-
0032493729
-
Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway
-
Pap M, Cooper GM. (1998). Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway. J Biol Chem 273: 19929-19932.
-
(1998)
J Biol Chem
, vol.273
, pp. 19929-19932
-
-
Pap, M.1
Cooper, G.M.2
-
162
-
-
0033151613
-
A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans
-
Paradis S, Ailion M, Toker A, Thomas JH, Ruvkun G. (1999). A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans. Genes Dev 13: 1438-1452.
-
(1999)
Genes Dev
, vol.13
, pp. 1438-1452
-
-
Paradis, S.1
Ailion, M.2
Toker, A.3
Thomas, J.H.4
Ruvkun, G.5
-
163
-
-
0032529189
-
Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor
-
Paradis S, Ruvkun G. (1998). Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. Genes Dev 12: 2488-2498.
-
(1998)
Genes Dev
, vol.12
, pp. 2488-2498
-
-
Paradis, S.1
Ruvkun, G.2
-
164
-
-
0034791125
-
Inhibition of protein kinase B (PKB) and PKCzeta mediates keratin K10-induced cell cycle arrest
-
Paramio JM, Segrelles C, Ruiz S, Jorcano JL. (2001). Inhibition of protein kinase B (PKB) and PKCzeta mediates keratin K10-induced cell cycle arrest. Mol Cell Biol 21: 7449-7459.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 7449-7459
-
-
Paramio, J.M.1
Segrelles, C.2
Ruiz, S.3
Jorcano, J.L.4
-
165
-
-
0037169526
-
Akt (protein kinase B) negatively regulates SEK1 by means of protein phosphorylation
-
Park HS, Kim MS, Huh SH, Park J, Chung J, Kang SS et al. (2002). Akt (protein kinase B) negatively regulates SEK1 by means of protein phosphorylation. J Biol Chem 277: 2573-2578.
-
(2002)
J Biol Chem
, vol.277
, pp. 2573-2578
-
-
Park, H.S.1
Kim, M.S.2
Huh, S.H.3
Park, J.4
Chung, J.5
Kang, S.S.6
-
166
-
-
0038624395
-
Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2
-
Peng XD, Xu PZ, Chen ML, Hahn-Windgassen A, Skeen J, Jacobs J et al. (2003). Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. Genes Dev 17: 1352-1365.
-
(2003)
Genes Dev
, vol.17
, pp. 1352-1365
-
-
Peng, X.D.1
Xu, P.Z.2
Chen, M.L.3
Hahn-Windgassen, A.4
Skeen, J.5
Jacobs, J.6
-
167
-
-
0034724443
-
Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells
-
Persad S, Attwell S, Gray V, Delcommenne M, Troussard A, Sanghera J et al. (2000). Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells. Proc Natl Acad Sci USA 97: 3207-3212.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 3207-3212
-
-
Persad, S.1
Attwell, S.2
Gray, V.3
Delcommenne, M.4
Troussard, A.5
Sanghera, J.6
-
168
-
-
0035868890
-
Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family
-
Pierce SB, Costa M, Wisotzkey R, Devadhar S, Homburger SA, Buchman AR et al. (2001). Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family. Genes Dev 15: 672-686.
-
(2001)
Genes Dev
, vol.15
, pp. 672-686
-
-
Pierce, S.B.1
Costa, M.2
Wisotzkey, R.3
Devadhar, S.4
Homburger, S.A.5
Buchman, A.R.6
-
169
-
-
0036078369
-
Homeostatic control of lymphocyte survival: Potential origins and implications
-
Plas DR, Rathmell JC, Thompson CB. (2002). Homeostatic control of lymphocyte survival: potential origins and implications. Nat Immunol 3: 515-521.
-
(2002)
Nat Immunol
, vol.3
, pp. 515-521
-
-
Plas, D.R.1
Rathmell, J.C.2
Thompson, C.B.3
-
170
-
-
0035853833
-
Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology
-
Plas DR, Talapatra S, Edinger AL, Rathmell JC, Thompson CB. (2001). Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology. J Biol Chem 276: 12041-12048.
-
(2001)
J Biol Chem
, vol.276
, pp. 12041-12048
-
-
Plas, D.R.1
Talapatra, S.2
Edinger, A.L.3
Rathmell, J.C.4
Thompson, C.B.5
-
171
-
-
0035728258
-
Multiplicity of mechanisms of serotonin receptor signal transduction
-
Raymond JR, Mukhin YV, Gelasco A, Turner J, Collinsworth G, Gettys TW et al. (2001). Multiplicity of mechanisms of serotonin receptor signal transduction. Pharmacol Ther 92: 179-212.
-
(2001)
Pharmacol Ther
, vol.92
, pp. 179-212
-
-
Raymond, J.R.1
Mukhin, Y.V.2
Gelasco, A.3
Turner, J.4
Collinsworth, G.5
Gettys, T.W.6
-
172
-
-
33750044112
-
Stress and mTORture signaling
-
Reiling JH, Sabatini DM. (2006). Stress and mTORture signaling. Oncogene 25: 6373-6383.
-
(2006)
Oncogene
, vol.25
, pp. 6373-6383
-
-
Reiling, J.H.1
Sabatini, D.M.2
-
173
-
-
2342558065
-
Akt activity in Alzheimer's disease and other neurodegenerative disorders
-
Rickle A, Bogdanovic N, Volkman I, Winblad B, Ravid R, Cowburn RF. (2004). Akt activity in Alzheimer's disease and other neurodegenerative disorders. Neuroreport 15: 955-959.
-
(2004)
Neuroreport
, vol.15
, pp. 955-959
-
-
Rickle, A.1
Bogdanovic, N.2
Volkman, I.3
Winblad, B.4
Ravid, R.5
Cowburn, R.F.6
-
174
-
-
0037155824
-
Glycogen synthase kinase-3 couples AKT-dependent signaling to the regulation of p21Cip1 degradation
-
Rossig L, Badorff C, Holzmann Y, Zeiher AM, Dimmeler S. (2002). Glycogen synthase kinase-3 couples AKT-dependent signaling to the regulation of p21Cip1 degradation. J Biol Chem 277: 9684-9689.
-
(2002)
J Biol Chem
, vol.277
, pp. 9684-9689
-
-
Rossig, L.1
Badorff, C.2
Holzmann, Y.3
Zeiher, A.M.4
Dimmeler, S.5
-
175
-
-
0034941567
-
Akt-dependent phosphorylation of p21(Cip1) regulates PCNA binding and proliferation of endothelial cells
-
Rossig L, Jadidi AS, Urbich C, Badorff C, Zeiher AM, Dimmeler S. (2001). Akt-dependent phosphorylation of p21(Cip1) regulates PCNA binding and proliferation of endothelial cells. Mol Cell Biol 21: 5644-5657.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 5644-5657
-
-
Rossig, L.1
Jadidi, A.S.2
Urbich, C.3
Badorff, C.4
Zeiher, A.M.5
Dimmeler, S.6
-
176
-
-
33845874096
-
IRS2-Akt pathway in midbrain dopamine neurons regulates behavioral and cellular responses to opiates
-
Russo SJ, Bolanos CA, Theobald DE, DeCarolis NA, Renthal W, Kumar A et al. (2007). IRS2-Akt pathway in midbrain dopamine neurons regulates behavioral and cellular responses to opiates. Nat Neurosci 10: 93-99.
-
(2007)
Nat Neurosci
, vol.10
, pp. 93-99
-
-
Russo, S.J.1
Bolanos, C.A.2
Theobald, D.E.3
DeCarolis, N.A.4
Renthal, W.5
Kumar, A.6
-
177
-
-
0242656408
-
Akt/GSK3beta serine/threonine kinases: Evidence for a signalling pathway mediated by familial Alzheimer's disease mutations
-
Ryder J, Su Y, Ni B. (2004). Akt/GSK3beta serine/threonine kinases: evidence for a signalling pathway mediated by familial Alzheimer's disease mutations. Cell Signal 16: 187-200.
-
(2004)
Cell Signal
, vol.16
, pp. 187-200
-
-
Ryder, J.1
Su, Y.2
Ni, B.3
-
178
-
-
0034746573
-
Akt1/PKBalpha protects PC12 cells against the parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium and reduces the levels of oxygen-free radicals
-
Salinas M, Martin D, Alvarez A, Cuadrado A. (2001). Akt1/PKBalpha protects PC12 cells against the parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium and reduces the levels of oxygen-free radicals. Mol Cell Neurosci 17: 67-77.
-
(2001)
Mol Cell Neurosci
, vol.17
, pp. 67-77
-
-
Salinas, M.1
Martin, D.2
Alvarez, A.3
Cuadrado, A.4
-
180
-
-
11144358645
-
High frequency of mutations of the PIK3CA gene in human cancers
-
Samuels Y, Wang Z, Bardelli A, Silliman N, Ptak J, Szabo S et al. (2004). High frequency of mutations of the PIK3CA gene in human cancers. Science 304: 554.
-
(2004)
Science
, vol.304
, pp. 554
-
-
Samuels, Y.1
Wang, Z.2
Bardelli, A.3
Silliman, N.4
Ptak, J.5
Szabo, S.6
-
181
-
-
33947264077
-
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
-
Sancak Y, Thoreen CC, Peterson TR, Lindquist RA, Kang SA, Spooner E et al. (2007). PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. Mol Cell 25: 903-915.
-
(2007)
Mol Cell
, vol.25
, pp. 903-915
-
-
Sancak, Y.1
Thoreen, C.C.2
Peterson, T.R.3
Lindquist, R.A.4
Kang, S.A.5
Spooner, E.6
-
182
-
-
0037677096
-
Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation
-
Sano H, Kane S, Sano E, Miinea CP, Asara JM, Lane WS et al. (2003). Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation. J Biol Chem 278: 14599-14602.
-
(2003)
J Biol Chem
, vol.278
, pp. 14599-14602
-
-
Sano, H.1
Kane, S.2
Sano, E.3
Miinea, C.P.4
Asara, J.M.5
Lane, W.S.6
-
183
-
-
33646023695
-
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
-
Sarbassov DD, Ali SM, Sengupta S, Sheen JH, Hsu PP, Bagley AF et al. (2006). Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol Cell 22: 159-168.
-
(2006)
Mol Cell
, vol.22
, pp. 159-168
-
-
Sarbassov, D.D.1
Ali, S.M.2
Sengupta, S.3
Sheen, J.H.4
Hsu, P.P.5
Bagley, A.F.6
-
184
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. (2005). Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307: 1098-1101.
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
185
-
-
0034680008
-
The conserved PI30K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila
-
Scanga SE, Ruel L, Binari RC, Snow B, Stambolic V, Bouchard D et al. (2000). The conserved PI30K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila. Oncogene 19: 3971-3977.
-
(2000)
Oncogene
, vol.19
, pp. 3971-3977
-
-
Scanga, S.E.1
Ruel, L.2
Binari, R.C.3
Snow, B.4
Stambolic, V.5
Bouchard, D.6
-
186
-
-
0035489468
-
PKB/AKT: Functional insights from genetic models
-
Scheid MP, Woodgett JR. (2001). PKB/AKT: functional insights from genetic models. Nat Rev Mol Cell Biol 2: 760-768.
-
(2001)
Nat Rev Mol Cell Biol
, vol.2
, pp. 760-768
-
-
Scheid, M.P.1
Woodgett, J.R.2
-
187
-
-
42949092018
-
The endosomal protein Appl1 mediates Akt substrate specificity and cell survival in vertebrate development
-
Schenck A, Goto-Silva L, Collinet C, Rhinn M, Giner A, Habermann B et al. (2008). The endosomal protein Appl1 mediates Akt substrate specificity and cell survival in vertebrate development. Cell 133: 486-497.
-
(2008)
Cell
, vol.133
, pp. 486-497
-
-
Schenck, A.1
Goto-Silva, L.2
Collinet, C.3
Rhinn, M.4
Giner, A.5
Habermann, B.6
-
188
-
-
0027905021
-
Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting
-
Schu PV, Takegawa K, Fry MJ, Stack JH, Waterfield MD, Emr SD. (1993). Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting. Science 260: 88-91.
-
(1993)
Science
, vol.260
, pp. 88-91
-
-
Schu, P.V.1
Takegawa, K.2
Fry, M.J.3
Stack, J.H.4
Waterfield, M.D.5
Emr, S.D.6
-
189
-
-
33745307617
-
Ras, PI(3)K and mTOR signalling controls tumour cell growth
-
Shaw RJ, Cantley LC. (2006). Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature 441: 424-430.
-
(2006)
Nature
, vol.441
, pp. 424-430
-
-
Shaw, R.J.1
Cantley, L.C.2
-
190
-
-
0036799377
-
PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization
-
Shin I, Yakes FM, Rojo F, Shin NY, Bakin AV, Baselga J et al. (2002). PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization. Nat Med 8: 1145-1152.
-
(2002)
Nat Med
, vol.8
, pp. 1145-1152
-
-
Shin, I.1
Yakes, F.M.2
Rojo, F.3
Shin, N.Y.4
Bakin, A.V.5
Baselga, J.6
-
191
-
-
0034213075
-
The conserved phosphoinositide 3-kinase pathway determines heart size in mice
-
Shioi T, Kang PM, Douglas PS, Hampe J, Yballe CM, Lawitts J et al. (2000). The conserved phosphoinositide 3-kinase pathway determines heart size in mice. EMBO J 19: 2537-2548.
-
(2000)
EMBO J
, vol.19
, pp. 2537-2548
-
-
Shioi, T.1
Kang, P.M.2
Douglas, P.S.3
Hampe, J.4
Yballe, C.M.5
Lawitts, J.6
-
192
-
-
0036200937
-
Akt/protein kinase B promotes organ growth in transgenic mice
-
Shioi T, McMullen JR, Kang PM, Douglas PS, Obata T, Franke TF et al. (2002). Akt/protein kinase B promotes organ growth in transgenic mice. Mol Cell Biol 22: 2799-2809.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 2799-2809
-
-
Shioi, T.1
McMullen, J.R.2
Kang, P.M.3
Douglas, P.S.4
Obata, T.5
Franke, T.F.6
-
193
-
-
33749993417
-
The consensus coding sequences of human breast and colorectal cancers
-
Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD et al. (2006). The consensus coding sequences of human breast and colorectal cancers. Science 314: 268-274.
-
(2006)
Science
, vol.314
, pp. 268-274
-
-
Sjoblom, T.1
Jones, S.2
Wood, L.D.3
Parsons, D.W.4
Lin, J.5
Barber, T.D.6
-
194
-
-
0017647580
-
Isolation of transforming murine leukemia viruses from mice with a high incidence of spontaneous lymphoma
-
Staal SP, Hartley JW, Rowe WP. (1977). Isolation of transforming murine leukemia viruses from mice with a high incidence of spontaneous lymphoma. Proc Natl Acad Sci USA 74: 3065-3067.
-
(1977)
Proc Natl Acad Sci USA
, vol.74
, pp. 3065-3067
-
-
Staal, S.P.1
Hartley, J.W.2
Rowe, W.P.3
-
195
-
-
0034854091
-
Regulation of PTEN transcription by p53
-
Stambolic V, MacPherson D, Sas D, Lin Y, Snow B, Jang Y et al. (2001). Regulation of PTEN transcription by p53. Mol Cell 8: 317-325.
-
(2001)
Mol Cell
, vol.8
, pp. 317-325
-
-
Stambolic, V.1
MacPherson, D.2
Sas, D.3
Lin, Y.4
Snow, B.5
Jang, Y.6
-
196
-
-
0032493029
-
Genetic analysis of protein kinase B (AKT) in Drosophila
-
Staveley BE, Ruel L, Jin J, Stambolic V, Mastronardi FG, Heitzler P et al. (1998). Genetic analysis of protein kinase B (AKT) in Drosophila. Curr Biol 8: 599-602.
-
(1998)
Curr Biol
, vol.8
, pp. 599-602
-
-
Staveley, B.E.1
Ruel, L.2
Jin, J.3
Stambolic, V.4
Mastronardi, F.G.5
Heitzler, P.6
-
197
-
-
0032578999
-
Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B
-
Stephens L, Anderson K, Stokoe D, Erdjument-Bromage H, Painter GF, Holmes AB et al. (1998). Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. Science 279: 710-714.
-
(1998)
Science
, vol.279
, pp. 710-714
-
-
Stephens, L.1
Anderson, K.2
Stokoe, D.3
Erdjument-Bromage, H.4
Painter, G.F.5
Holmes, A.B.6
-
198
-
-
0030887632
-
The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101
-
Stephens LR, Eguinoa A, Erdjument-Bromage H, Lui M, Cooke F, Coadwell J et al. (1997). The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101. Cell 89: 105-114.
-
(1997)
Cell
, vol.89
, pp. 105-114
-
-
Stephens, L.R.1
Eguinoa, A.2
Erdjument-Bromage, H.3
Lui, M.4
Cooke, F.5
Coadwell, J.6
-
199
-
-
0025731596
-
Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils
-
Stephens LR, Hughes KT, Irvine RF. (1991). Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils. Nature 351: 33-39.
-
(1991)
Nature
, vol.351
, pp. 33-39
-
-
Stephens, L.R.1
Hughes, K.T.2
Irvine, R.F.3
-
200
-
-
4344575079
-
Akt binds prohibitin 2 and relieves its repression of MyoD and muscle differentiation
-
Sun L, Liu L, Yang XJ, Wu Z. (2004). Akt binds prohibitin 2 and relieves its repression of MyoD and muscle differentiation. J Cell Sci 117: 3021-3029.
-
(2004)
J Cell Sci
, vol.117
, pp. 3021-3029
-
-
Sun, L.1
Liu, L.2
Yang, X.J.3
Wu, Z.4
-
201
-
-
0034091792
-
Selective interaction between leptin and insulin signaling pathways in a hepatic cell line
-
Szanto I, Kahn CR. (2000). Selective interaction between leptin and insulin signaling pathways in a hepatic cell line. Proc Natl Acad Sci USA 97: 2355-2360.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 2355-2360
-
-
Szanto, I.1
Kahn, C.R.2
-
202
-
-
45749149476
-
Genetic variation in AKT1 is linked to dopamine-associated prefrontal cortical structure and function in humans
-
Tan HY, Nicodemus KK, Chen Q, Li Z, Brooke JK, Honea R et al. (2008). Genetic variation in AKT1 is linked to dopamine-associated prefrontal cortical structure and function in humans. J Clin Invest 118: 2200-2208.
-
(2008)
J Clin Invest
, vol.118
, pp. 2200-2208
-
-
Tan, H.Y.1
Nicodemus, K.K.2
Chen, Q.3
Li, Z.4
Brooke, J.K.5
Honea, R.6
-
203
-
-
0037108750
-
Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling
-
Tee AR, Fingar DC, Manning BD, Kwiatkowski DJ, Cantley LC, Blenis J. (2002). Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. Proc Natl Acad Sci USA 99: 13571-13576.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 13571-13576
-
-
Tee, A.R.1
Fingar, D.C.2
Manning, B.D.3
Kwiatkowski, D.J.4
Cantley, L.C.5
Blenis, J.6
-
204
-
-
0042701991
-
Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
-
Tee AR, Manning BD, Roux PP, Cantley LC, Blenis J. (2003). Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Curr Biol 13: 1259-1268.
-
(2003)
Curr Biol
, vol.13
, pp. 1259-1268
-
-
Tee, A.R.1
Manning, B.D.2
Roux, P.P.3
Cantley, L.C.4
Blenis, J.5
-
205
-
-
0034708482
-
Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site
-
Toker A, Newton AC. (2000a). Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site. J Biol Chem 275: 8271-8274.
-
(2000)
J Biol Chem
, vol.275
, pp. 8271-8274
-
-
Toker, A.1
Newton, A.C.2
-
206
-
-
0034644523
-
Cellular signaling: Pivoting around PDK-1
-
Toker A, Newton AC. (2000b). Cellular signaling: pivoting around PDK-1. Cell 103: 185-188.
-
(2000)
Cell
, vol.103
, pp. 185-188
-
-
Toker, A.1
Newton, A.C.2
-
207
-
-
35448935143
-
Casein kinase 2-interacting protein-1, a novel Akt pleckstrin homology domain-interacting protein, down-regulates PI3K/Akt signaling and suppresses tumor growth in vivo
-
Tokuda E, Fujita N, Oh-hara T, Sato S, Kurata A, Katayama R et al. (2007). Casein kinase 2-interacting protein-1, a novel Akt pleckstrin homology domain-interacting protein, down-regulates PI3K/Akt signaling and suppresses tumor growth in vivo. Cancer Res 67: 9666-9676.
-
(2007)
Cancer Res
, vol.67
, pp. 9666-9676
-
-
Tokuda, E.1
Fujita, N.2
Oh-hara, T.3
Sato, S.4
Kurata, A.5
Katayama, R.6
-
208
-
-
23144449547
-
Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis
-
Tschopp O, Yang ZZ, Brodbeck D, Dummler BA, Hemmings-Mieszczak M, Watanabe T et al. (2005). Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis. Development 132: 2943-2954.
-
(2005)
Development
, vol.132
, pp. 2943-2954
-
-
Tschopp, O.1
Yang, Z.Z.2
Brodbeck, D.3
Dummler, B.A.4
Hemmings-Mieszczak, M.5
Watanabe, T.6
-
209
-
-
0035896630
-
Protein kinase B beta/Akt2 plays a specific role in muscle differentiation
-
Vandromme M, Rochat A, Meier R, Carnac G, Besser D, Hemmings BA et al. (2001). Protein kinase B beta/Akt2 plays a specific role in muscle differentiation. J Biol Chem 276: 8173-8179.
-
(2001)
J Biol Chem
, vol.276
, pp. 8173-8179
-
-
Vandromme, M.1
Rochat, A.2
Meier, R.3
Carnac, G.4
Besser, D.5
Hemmings, B.A.6
-
210
-
-
0033258521
-
Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB
-
Verdu J, Buratovich MA, Wilder EL, Birnbaum MJ. (1999). Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB. Nat Cell Biol 1: 500-506.
-
(1999)
Nat Cell Biol
, vol.1
, pp. 500-506
-
-
Verdu, J.1
Buratovich, M.A.2
Wilder, E.L.3
Birnbaum, M.J.4
-
211
-
-
0029884657
-
Mouse p170 is a novel phosphatidylinositol 3-kinase containing a C2 domain
-
Virbasius JV, Guilherme A, Czech MP. (1996). Mouse p170 is a novel phosphatidylinositol 3-kinase containing a C2 domain. J Biol Chem 271: 13304-13307.
-
(1996)
J Biol Chem
, vol.271
, pp. 13304-13307
-
-
Virbasius, J.V.1
Guilherme, A.2
Czech, M.P.3
-
212
-
-
34547099855
-
PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding
-
Wang L, Harris TE, Roth RA, Lawrence Jr JC. (2007). PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding. J Biol Chem 282: 20036-20044.
-
(2007)
J Biol Chem
, vol.282
, pp. 20036-20044
-
-
Wang, L.1
Harris, T.E.2
Roth, R.A.3
Lawrence Jr, J.C.4
-
213
-
-
0035950544
-
-
White DE, Cardiff RD, Dedhar S, Muller WJ. (2001). Mammary epithelial-specific expression of the integrin-linked kinase (ILK) results in the induction of mammary gland hyperplasias and tumors in transgenic mice. Oncogene 20: 7064-7072.
-
White DE, Cardiff RD, Dedhar S, Muller WJ. (2001). Mammary epithelial-specific expression of the integrin-linked kinase (ILK) results in the induction of mammary gland hyperplasias and tumors in transgenic mice. Oncogene 20: 7064-7072.
-
-
-
-
214
-
-
6344271762
-
Autism and tuberous sclerosis
-
Wiznitzer M. (2004). Autism and tuberous sclerosis. J Child Neurol 19: 675-679.
-
(2004)
J Child Neurol
, vol.19
, pp. 675-679
-
-
Wiznitzer, M.1
-
215
-
-
0037135980
-
Novel PtdIns(3)P-binding protein Etf1 functions as an effector of the Vps34 PtdIns 3-kinase in autophagy
-
Wurmser AE, Emr SD. (2002). Novel PtdIns(3)P-binding protein Etf1 functions as an effector of the Vps34 PtdIns 3-kinase in autophagy. J Cell Biol 158: 761-772.
-
(2002)
J Cell Biol
, vol.158
, pp. 761-772
-
-
Wurmser, A.E.1
Emr, S.D.2
-
216
-
-
0034954603
-
The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis
-
Xu Z, Maroney AC, Dobrzanski P, Kukekov NV, Greene LA. (2001). The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis. Mol Cell Biol 21: 4713-4724.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 4713-4724
-
-
Xu, Z.1
Maroney, A.C.2
Dobrzanski, P.3
Kukekov, N.V.4
Greene, L.A.5
-
217
-
-
15444374951
-
Akt2 phosphorylates Synip to regulate docking and fusion of GLUT4-containing vesicles
-
Yamada E, Okada S, Saito T, Ohshima K, Sato M, Tsuchiya T et al. (2005). Akt2 phosphorylates Synip to regulate docking and fusion of GLUT4-containing vesicles. J Cell Biol 168: 921-928.
-
(2005)
J Cell Biol
, vol.168
, pp. 921-928
-
-
Yamada, E.1
Okada, S.2
Saito, T.3
Ohshima, K.4
Sato, M.5
Tsuchiya, T.6
-
218
-
-
18744373865
-
Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP
-
Yang J, Cron P, Good VM, Thompson V, Hemmings BA, Barford D. (2002a). Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP. Nat Struct Biol 9: 940-944.
-
(2002)
Nat Struct Biol
, vol.9
, pp. 940-944
-
-
Yang, J.1
Cron, P.2
Good, V.M.3
Thompson, V.4
Hemmings, B.A.5
Barford, D.6
-
219
-
-
0036295728
-
Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation
-
Yang J, Cron P, Thompson V, Good VM, Hess D, Hemmings BA et al. (2002b). Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation. Mol Cell 9: 1227-1240.
-
(2002)
Mol Cell
, vol.9
, pp. 1227-1240
-
-
Yang, J.1
Cron, P.2
Thompson, V.3
Good, V.M.4
Hess, D.5
Hemmings, B.A.6
-
220
-
-
0032506514
-
Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway
-
Yano S, Tokumitsu H, Soderling TR. (1998). Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway. Nature 396: 584-587.
-
(1998)
Nature
, vol.396
, pp. 584-587
-
-
Yano, S.1
Tokumitsu, H.2
Soderling, T.R.3
-
221
-
-
0038342509
-
AKT2 inhibition of cisplatin-induced JNK/p38 and Bax activation by phosphorylation of ASK1: Implication of AKT2 in chemoresistance
-
Yuan ZQ, Feldman RI, Sussman GE, Coppola D, Nicosia SV, Cheng JQ. (2003). AKT2 inhibition of cisplatin-induced JNK/p38 and Bax activation by phosphorylation of ASK1: implication of AKT2 in chemoresistance. J Biol Chem 278: 23432-23440.
-
(2003)
J Biol Chem
, vol.278
, pp. 23432-23440
-
-
Yuan, Z.Q.1
Feldman, R.I.2
Sussman, G.E.3
Coppola, D.4
Nicosia, S.V.5
Cheng, J.Q.6
-
222
-
-
20444382735
-
ArgBP2gamma interacts with Akt and p21-activated kinase-1 and promotes cell survival
-
Yuan ZQ, Kim D, Kaneko S, Sussman M, Bokoch GM, Kruh GD et al. (2005). ArgBP2gamma interacts with Akt and p21-activated kinase-1 and promotes cell survival. J Biol Chem 280: 21483-21490.
-
(2005)
J Biol Chem
, vol.280
, pp. 21483-21490
-
-
Yuan, Z.Q.1
Kim, D.2
Kaneko, S.3
Sussman, M.4
Bokoch, G.M.5
Kruh, G.D.6
-
223
-
-
1842581856
-
Ras GTPase-activating protein binds to Akt and is required for its activation
-
Yue Y, Lypowy J, Hedhli N, Abdellatif M. (2004). Ras GTPase-activating protein binds to Akt and is required for its activation. J Biol Chem 279: 12883-12889.
-
(2004)
J Biol Chem
, vol.279
, pp. 12883-12889
-
-
Yue, Y.1
Lypowy, J.2
Hedhli, N.3
Abdellatif, M.4
-
224
-
-
46349103337
-
Isoform-specific regulation of adipocyte differentiation by Akt/protein kinase Balpha
-
Yun SJ, Kim EK, Tucker DF, Kim CD, Birnbaum MJ, Bae SS. (2008). Isoform-specific regulation of adipocyte differentiation by Akt/protein kinase Balpha. Biochem Biophys Res Commun 371: 138-143.
-
(2008)
Biochem Biophys Res Commun
, vol.371
, pp. 138-143
-
-
Yun, S.J.1
Kim, E.K.2
Tucker, D.F.3
Kim, C.D.4
Birnbaum, M.J.5
Bae, S.S.6
-
225
-
-
34147146014
-
Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML
-
Zeng Z, Sarbassov dos D, Samudio IJ, Yee KW, Munsell MF, Ellen Jackson C et al (2007). Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML. Blood 109: 3509-3512.
-
(2007)
Blood
, vol.109
, pp. 3509-3512
-
-
Zeng, Z.1
Sarbassov dos, D.2
Samudio, I.J.3
Yee, K.W.4
Munsell, M.F.5
Ellen Jackson, C.6
-
226
-
-
0030584088
-
Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-XL
-
Zha J, Harada H, Yang E, Jockel J, Korsmeyer SJ. (1996). Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-XL. Cell 87: 619-628.
-
(1996)
Cell
, vol.87
, pp. 619-628
-
-
Zha, J.1
Harada, H.2
Yang, E.3
Jockel, J.4
Korsmeyer, S.J.5
-
227
-
-
0034646633
-
Leptin induces insulin-like signaling that antagonizes cAMP elevation by glucagon in hepatocytes
-
Zhao AZ, Shinohara MM, Huang D, Shimizu M, Eldar-Finkelman H, Krebs EG et al. (2000). Leptin induces insulin-like signaling that antagonizes cAMP elevation by glucagon in hepatocytes. J Biol Chem 275: 11348-11354.
-
(2000)
J Biol Chem
, vol.275
, pp. 11348-11354
-
-
Zhao, A.Z.1
Shinohara, M.M.2
Huang, D.3
Shimizu, M.4
Eldar-Finkelman, H.5
Krebs, E.G.6
-
228
-
-
0344784889
-
Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase
-
Zhao JJ, Gjoerup OV, Subramanian RR, Cheng Y, Chen W, Roberts TM et al. (2003). Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase. Cancer Cell 3: 483-495.
-
(2003)
Cancer Cell
, vol.3
, pp. 483-495
-
-
Zhao, J.J.1
Gjoerup, O.V.2
Subramanian, R.R.3
Cheng, Y.4
Chen, W.5
Roberts, T.M.6
-
229
-
-
0034745353
-
Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells
-
Zhou BP, Liao Y, Xia W, Spohn B, Lee MH, Hung MC. (2001). Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells. Nat Cell Biol 3: 245-252.
-
(2001)
Nat Cell Biol
, vol.3
, pp. 245-252
-
-
Zhou, B.P.1
Liao, Y.2
Xia, W.3
Spohn, B.4
Lee, M.H.5
Hung, M.C.6
-
230
-
-
0034735569
-
Akt regulates cell survival and apoptosis at a postmitochondrial level
-
Zhou H, Li XM, Meinkoth J, Pittman RN. (2000). Akt regulates cell survival and apoptosis at a postmitochondrial level. J Cell Biol 151: 483-494.
-
(2000)
J Cell Biol
, vol.151
, pp. 483-494
-
-
Zhou, H.1
Li, X.M.2
Meinkoth, J.3
Pittman, R.N.4
|