Mutational analysis of oncogenic AKT E17K mutation in common solid cancers and acute leukaemias

British Journal of Cancer

Volumn 98, Issue 9, 2008, Pages 1533-1535

  Kim, M S ^a   Jeong, E G ^a   Yoo, N J ^a   Lee, S H ^a  

^a The Catholic University of Korea   (South Korea)

Author keywords

AKT1 E17K; Mutation; Oncogene

Indexed keywords

PROTEIN KINASE B; PROTEIN KINASE B BETA;

ACUTE LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; BREAST CARCINOMA; CANCER TISSUE; COLORECTAL CARCINOMA; CONTROLLED STUDY; GENE MUTATION; GENE SEQUENCE; HUMAN; HUMAN TISSUE; LIVER CELL CARCINOMA; LUNG CARCINOMA; MUTATIONAL ANALYSIS; ONCOGENE; ONCOGENE AKT1 E17K; ONCOGENE AKT3; OVARY CARCINOMA; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM; SOLID TUMOR; STOMACH CARCINOMA;

ACUTE DISEASE; ADENOCARCINOMA; ADULT; AGED; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CARCINOMA, HEPATOCELLULAR; CARCINOMA, NON-SMALL-CELL LUNG; COLORECTAL NEOPLASMS; DNA MUTATIONAL ANALYSIS; FEMALE; GLUTAMIC ACID; HUMANS; LEUKEMIA; LIVER NEOPLASMS; LUNG NEOPLASMS; LYSINE; MALE; MIDDLE AGED; MUTATION; NEOPLASMS; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PROTO-ONCOGENE PROTEINS C-AKT; STOMACH NEOPLASMS;

EID: 43249115083     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6604212     Document Type: Article

References (14)

1. Carpten JD, Faber AL, Horn C, Donoho GP, Briggs SL, Robbins CM, Hostetter G, Boguslawski S, Moses TY, Savage S, Uhlik M, Lin A, Du J, Qian YW, Zeckner DJ, Tucker-Kellogg G, Touchman J, Patel K, Mousses S, Bittner M, Schevitz R, Lai MH, Blanchard KL, Thomas JE (2007) A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Nature 448: 439-444
2. Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher AM (1999) Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 399: 601-605
3. Druker BJ, Sawyers CL, Kantarjian H, Resta DJ, Reese SF, Ford JM, Capdeville R, Talpaz M (2001) Activity of a specific inhibitor of the BCRABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N Engl J Med 344: 1038-1042
4. Fukuoka M, Yano S, Giaccone G, Tamura T, Nakagawa K, Douillard JY, Nishiwaki Y, Vansteenkiste J, Kudoh S, Rischin D, Eek R, Horai T, Noda K, Takata I, Smit E, Averbuch S, Macleod A, Feyereislova A, Dong RP, Baselga J (2003) Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer. J Clin Oncol 21: 2237-2246
5. Gschwind A, Fischer OM, Ullrich A (2004) The discovery of receptor tyrosine kinases: targets for cancer therapy. Nat Rev Cancer 4: 361-370
6. Khwaja A (1999) Akt is more than just a Bad kinase. Nature 401: 33-34
7. Lee SH, Shin MS, Park WS, Kim SY, Kim HS, Han JY, Park GS, Dong SM, Pi JH, Kim CS, Kim SH, Lee JY, Yoo NJ (1999) Alterations of Fas (Apo-1/CD95) gene in non-small cell lung cancer. Oncogene 18: 3754-3760
8. Mende I, Malstrom S, Tsichlis PN, Vogt PK, Aoki M (2001) Oncogenic transformation induced by membrane-targeted Akt2 and Akt3. Oncogene 20: 4419-4423
9. Muise-Helmericks RC, Grimes HL, Bellacosa A, Malstrom SE, Tsichlis PN, Rosen N (1998) Cyclin D expression is controlled post-transcriptionally via a phosphatidylinositol 3-kinase/Akt-dependent pathway. J Biol Chem 273: 29864-29872
10. Ozes ON, Mayo LD, Gustin JA, Pfeffer SR, Pfeffer LM, Donner DB (1999) NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature 401: 82-85
11. Paez JG, Janne PA, Lee JC, Tracy S, Greulich H, Gabriel S, Herman P, Kaye FJ, Lindeman N, Boggon TJ, Naoki K, Sasaki H, Fujii Y, Eck MJ, Sellers WR, Johnson BE, Meyerson M (2004) EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 304: 1497-1500
12. Samuels Y, Wang Z, Bardelli A, Silliman N, Ptak J, Szabo S, Yan H, Gazdar A, Powell SM, Riggins GJ, Willson JK, Markowitz S, Kinzler KW, Vogelstein B, Velculescu VE (2004) High frequency of mutations of the PIK3CA gene in human cancers. Science 304: 554
13. Testa JR, Bellacosa A (2001) AKT plays a central role in tumorigenesis. Proc Natl Acad Sci USA 98: 10983-10985
14. Wei L, Yang Y, Yu Q (2001) Tyrosine kinase-dependent, phosphatidylinositol 3′-kinase, and mitogen-activated protein kinase-independent signaling pathways prevent lung adenocarcinoma cells from anoikis. Cancer Res 61: 2439-2444