Akt-dependent phosphorylation of p21Cip1 regulates PCNA binding and proliferation of endothelial cells

Molecular and Cellular Biology

Volumn 21, Issue 16, 2001, Pages 5644-5657

  Rossig L ^a   Jadidi, A S ^a   Urbich, C ^a   Badorff, C ^a   Zeiher, A M ^a   Dimmeler, S ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN KINASE B; PROTEIN P21;

ARTICLE; CELL CYCLE; CELL CYCLE G0 PHASE; CELL FRACTIONATION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DNA REPLICATION; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MITOSIS INHIBITION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SITE DIRECTED MUTAGENESIS;

CELL DIVISION; CELL LINE; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; ENDOTHELIUM, VASCULAR; HUMANS; PHOSPHORYLATION; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 0034941567     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.16.5644-5657.2001     Document Type: Article

References (49)

1. Mechanism of activation of protein kinase B by insulin and IGF-1
2. Role of translocation in the activation and function of protein kinase B
3. Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization
4. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
5. Regulation of cell death by protease caspase-9 by phosphorylation
6. Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA
7. Cyclin-binding motifs are essential for the function of p21CIP1
8. The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts
9. Hematopoietic stem cell quiescence maintained by p21cip1/waf1
10. PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase
11. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
12. Cellular survival: A play in three Akts
13. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
14. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
15. Glycogen synthase kinase-3â regulates cyclin D1 proteolysis and subcellular localization
16. Activation of nitric oxide synthase in endothelial cells via Akt-dependent phosphorylation
17. Akt takes centre stage in angiogenesis signaling
18. WAF1, a potential mediator of p53 tumor suppression
19. Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase delta holoenzyme
20. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
21. Phosphatidylinositol 3-kinase inhibitors, wortmannin or LY294002, inhibited accumulation of p21 protein after gamma-irradiation by stabilization of the protein
22. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt
23. Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein
24. Multiple ras effector pathways contribute to G(1) cell cycle progression
25. Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA
26. Inhibition of cyclin-dependent kinases by p21
27. Angiopoietin-1 regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway
28. Direct control of the Forkhead transcription factor AFX by protein kinase B
29. The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals
30. New functional activities for the p21 family of CDK inhibitors
31. Involvement of p21cip-1 and p27kip-1 in the molecular mechanisms of steel factor-induced proliferative synergy in vitro and of p21cip-1 in the maintenance of stem/progenitor cells in vivo
32. PKB/Akt: Connecting phosphoinositide 3-kinase to cell survival and beyond
33. AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kipl
34. Cyclin D expression is controlled post-transcriptionally via a phosphatidylinositol 3-kinase/Akt-dependent pathway
35. Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway
36. The role of phosphoinositide 3-kinase lipid products in cell function
37. NF-êB is a target of AKT in anti-apoptotic PDGF signalling
38. Growth inhibition by CDK-cyclin and PCNA binding domains of p21 occurs by distinct mechanisms and is regulated by ubiquitin-proteasome pathway
39. The Ki-67 protein: From the known and the unknown
40. Reversible phosphorylation at the C-terminal regulatory, domain of p21(Waf1/Cip1) modulates proliferating cell nuclear antigen binding
41. Cyclin E-CDK2 is a regulator of p27Kip1
42. Proteasomal turnover of p21Cip1 does not require p21Cip1 ubiquitination
43. CDK inhibitors: Positive and negative regulators of G1-phase progression
44. PCNA, a multifunctional ring on DNA
45. The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA
46. A small peptide inhibitor of DNA replication defines the site of interaction between the cyclin-dependent kinase inhibitor p21WAF1 and proliferating cell nuclear antigen
47. p21(Waf1/Cip1) is an assembly factor required for platelet-derived growth factor-induced vascular smooth muscle cell proliferation
48. Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells
49. Phosphorylation and regulation of Raf by Akt (protein kinase B)