Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)

Molecular and Cellular Biology

Volumn 21, Issue 3, 2001, Pages 952-965

  Brunet, A ^a   Park, J ^a   Tran, H ^a   Hu, L S ^a   Hemmings, B A ^a   Greenberg, M E ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE; PROTEIN SERINE KINASE; PROTEIN SGK; SERINE PROTEINASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FKHRL1; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL SURVIVAL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MITOSIS INHIBITION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOPTOSIS; BASE SEQUENCE; BINDING SITES; CELL CYCLE; CELL LINE; CELL SURVIVAL; CRICETINAE; DNA PRIMERS; DNA-BINDING PROTEINS; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; IMMEDIATE-EARLY PROTEINS; MUTATION; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; SERINE; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 0035135841     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.3.952-965.2001     Document Type: Article

References (53)

1. Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase
2. 3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro
3. Follicle stimulating hormone-regulated expression of serum/glucocorticoid-inducible kinase in rat ovarian granulosa cells: A functional role for the Sp1 family in promoter activity
4. The serum and glucocorticoid kinase sgk increases the abundance of epithelial sodium channels in the plasma membrane of Xenopus oocytes
5. A retroviral oncogene, akt, encoding a serine threonine kinase containing a SH2-like region
6. Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1
7. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
8. Cell cycle and hormonal control of nuclear-cytoplasmic localization of the serum- and glucocorticoid-inducible protein kinase, Sgk, in mammary tumor cells. A novel convergence point of anti-proliferative and proliferative cell signaling pathways
9. Regulation of cell death protease caspase-9 by phosphorylation
10. Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast
11. Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase
12. Epithelial sodium channel regulated by aldosterone-induced protein sgk
13. Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase
14. Regulation of protein kinase C zeta by PI 3-kinase and PDK-1
15. Expression of serum- and glucocorticoid-regulated kinase (sgk) mRNA is up-regulated by GM-CSF and other proinflammatory mediators in human granulocytes
16. Cellular survival: A play in three Akts
17. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
18. 14-3-3 Proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation
19. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
20. Mechanisms and consequences of activation of protein kinase B/Akt
21. Regulation of neuronal survival by the serine-threonine protein kinase Akt
22. Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK1)
23. Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on IGF binding protein-1 promoter activity through a conserved insulin response sequence
24. Differential expression of sgk mRNA, a member of the Ser/Thr protein kinase gene family, in rat brain after CNS injury
25. 90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1
26. Unified nomenclature for the winged helix/forkhead transcription factors
27. Phosphorylation regulates association of the transcription factor Pho4 with its import receptor Pse1/Kap121
28. Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2
29. Roles of phosphorylation sites in regulating activity of the transcription factor Pho4
30. Forkhead transcription factors: New insights into protein kinase B (c-akt) signaling
31. Direct control of the Forkhead transcription factor AFX by protein kinase B
32. Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1
33. Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein
34. Both isoforms of the cAMP-dependent protein kinase catalytic subunit can activate transcription of the prolactin gene
35. AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1
36. Differential regulation of gene expression by insulin and IGF-1 receptors correlates with phosphorylation of a single amino acid residue in the forkhead transcription factor FKHR
37. Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a wortmannin-sensitive pathway
38. The Forkhead transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
39. Regulation of PHO4 nuclear localization by the PHO80-PHO85 cyclin-CDK complex
40. Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway
41. Phosphorylation and activation of p70s6k by PDK1
42. Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B
43. Ribosomal S6 kinase 1 (RSK1) activation requires signals dependent on and independent of the MAP kinase ERK
44. Regulation of nuclear translocation of forkhead transcription factor AFX by protein kinase B
45. Negative regulation of the Forkhead transcription factor FKHR by Akt
46. Evidence that atypical protein kinase C-lambda and atypical protein kinase C-zeta participate in Ras-mediated reorganization of the F-actin cytoskeleton
47. The PI3K-PDK1 connection: More than just a road to PKB
48. Cloning and characterization of a putative human serine/threonine protein kinase transcriptionally modified during anisotonic and isotonic alterations of cell volume
49. h-sgk serine-threonine protein kinase gene as transcriptional target of transforming growth factor beta in human intestine
50. Immediate-early transcriptional regulation and rapid mRNA turnover of a putative serine/threonine protein kinase
51. Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum
52. Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase