Akt1/PKBα protects PC12 cells against the Parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium and reduces the levels of oxygen-free radicals

Molecular and Cellular Neuroscience

Volumn 17, Issue 1, 2001, Pages 67-77

  Salinas, Marta ^a   Martín, Daniel ^a   Alvarez, Alberto ^b   Cuadrado, Antonio ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; NEUROTOXIN; OXYGEN RADICAL; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; AKT1 PROTEIN, RAT; ONCOPROTEIN; OXIDOREDUCTASE; PHOTOPROTEIN; PROTEIN SERINE THREONINE KINASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE);

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; GENE OVEREXPRESSION; GENETIC TRANSFECTION; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MOUSE; NERVE CELL; NONHUMAN; OXIDATIVE STRESS; PARKINSONISM; PRIORITY JOURNAL; ANIMAL; CELL LINE; CELL MEMBRANE POTENTIAL; CELL STRAIN; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENETICS; METABOLISM; MITOCHONDRION; RAT;

ANIMALIA;

1-METHYL-4-PHENYLPYRIDINIUM; ANIMALS; APOPTOSIS; CELL LINE; ELECTRON TRANSPORT COMPLEX I; GREEN FLUORESCENT PROTEINS; LUMINESCENT PROTEINS; MEMBRANE POTENTIALS; MICE; MITOCHONDRIA; NADH, NADPH OXIDOREDUCTASES; OXIDATIVE STRESS; PC12 CELLS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; REACTIVE OXYGEN SPECIES; RECOMBINANT FUSION PROTEINS; TRANSFECTION;

EID: 0034746573     PISSN: 10447431     EISSN: None     Source Type: Journal    
DOI: 10.1006/mcne.2000.0921     Document Type: Article

References (53)

1. Inactivation of tyrosine hydroxylase by nitration following exposure to peroxynitrite and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
2. Several dinucleoside polyphosphates are acceptor substrates in the T4 RNA ligase catalyzed reaction
3. Changes in mitochondrial function resulting from synaptic activity in the rat hippocampal slice
4. Mitochondrial membrane potential and hydroethidine-monitored superoxide generation in cultured cerebellar granule cells
5. Respiratory chain enzyme activities in lymphocytes from untreated patients with Parkinson disease
6. Pramipexole reduces reactive oxygen species production in vivo and in vitro and inhibits the mitochondrial permeability transition produced by the parkinsonian neurotoxin methylpyridinium ion
7. Neurotrophin receptors: Mediators of life and death
8. Dopaminergic neurons protected from degeneration by GDNF gene therapy
9. The survival of sympathetic neurons promoted by potassium depolarization, but not by cyclic AMP, requires phosphatidylinositol 3-kinase and Akt
10. Cellular survival: A play in three Akts
11. Role of neuronal nitric oxide in 1-methyl-4phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity
12. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
13. A dopaminergic cell line variant resistant to the neurotoxin1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
14. Regulation of neuronal survival by the serine-threonine protein kinase Akt
15. Akt, a target of phosphatidylinositol 3-kinase, inhibits apoptosis in a differentiating neuronal cell line
16. Implanted fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevent 1-methyl-4-phenylpyridinium toxicity to dopaminergic neurons in the rat
17. Oxidative mechanisms in nigral cell death in Parkinson's disease
18. The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB
19. The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal
20. + toxicity and oxidative stress in neonatal animals
21. Protective effects of the antiparkinsonian drugs talipexole and pramipexole against 1-methyl-4-phenylpyridinium-induced apoptotic death in human neuroblastoma SH-SY5Y cells
22. Protective effect of harmalol and harmaline on MPTP neurotoxicity in the mouse and dopamine-induced damage of brain mitochondria and PC12 cells
23. Distinct mechanisms underlie neurotoxin-mediated cell death in cultured dopaminergic neurons
24. The protooncogene bcl-2 inhibits apoptosis in PC12 cells
25. The effect of gila-conditioned medium on dopamine neurons in culture. Modulation of apoptosis, tyrosine hydroxylase expression and 1-methyl-4-phenylpyridinium
26. Metabolic and energetic changes during apoptosis in neural cells
27. +) in mouse brain in vitro and in vivo
28. +) and the use of an ion-selective electrode to measure their accumulation by the mitochondria and electron-transport particles
29. Etiology and pathogenesis of Parkinson's disease
30. Oxidative stress and Parkinson's disease
31. Neuronal cell death
32. Activated phosphatidylinositol 3-kinase and Akt kinase promote survival of superior cervical neurons
33. Detection of apoptosis and changes in mitochondrial membrane potential with chloromethyl-X-rosamine
34. +) analogs and their energized accumulation by mitochondria
35. Adenosine 5′-triphosphate independent secretion from PC12 pheochromocytoma cells
36. Inhibition of PKB/Akt1 by C2-ceramide involves activation of ceramide-activated protein phosphatase in PC12 cells
37. Free radical scavengers protect dopaminergic cell lines from apoptosis induced by complex I inhibitors
38. Cyclosporin inhibition of apoptosis induced by mitochondrial complex I toxins
39. - induced apoptotic cell death in SH-SY5Y neuroblastoma cells: An electron microscope study
40. Mechanism of the neurotoxicity of MPTP. An update
41. Neuroprotection and neuronal differentiation studies using substantia nigra dopaminergic cells derived from transgenic mouse embryos
42. Nerve growth factor protects PC12 cells against peroxynitrite-induced apoptosis via a mechanism dependent on phosphatidylinositol 3-kinase
43. Brain-derived neurotrophic factor protects dopamine neurons against 6-hydroxydopamine and N-methyl-4-phenylpyridinium ion toxicity: Involvement of the glutathione system
44. Citrate synthase
45. Superoxide formation and lipid peroxidation by the mitochondrial electron-transfer chain
46. The PI3K-PDK1 connection: More than just a road to PKB
47. Schwarm cell survival mediated by the signaling phospholipid lysophosphatidic acid
48. Suppression of hydroxyl radical formation and protection of nigral neurons by I-deprenyl (selegiline)
49. + toxicity by deprenyl (selegiline)
50. Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor
51. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyride neurotoxicity is attenuated in mice overexpressing Bcl-2
52. Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis
53. Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress