PKB/Akt mediates cell-cycle progression by phosphorylation of p27Kip1 at threonine 157 and modulation of its cellular localization

Nature Medicine

Volumn 8, Issue 10, 2002, Pages 1145-1152

  Shin, Incheol ^a   Yakes, F Michael ^a   Rojo, Federico ^c   Shin, Nah young ^a   Bakin, Andrei V ^a   Baselga, Jose ^c   Arteaga, Carlos L ^a,b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT INGRAM CANCER CENTER   (United States)

^c HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN KINASE B; PROTEIN P27; SERINE; THREONINE;

ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; CELL CYCLE; CELL LINE; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; MITOSIS INHIBITION; ONCOGENE NEU; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION;

BREAST NEOPLASMS; CARCINOMA; CDC2-CDC28 KINASES; CELL CYCLE; CELL CYCLE PROTEINS; CELL FRACTIONATION; CELL LINE; CELL NUCLEUS; CYCLIN E; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; ENZYME INHIBITORS; FEMALE; HUMANS; MAP KINASE KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECOMBINANT FUSION PROTEINS; THREONINE; TUMOR SUPPRESSOR PROTEINS;

EID: 0036799377     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm759     Document Type: Article

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