Akt enhances Mdm2-mediated ubiquitination and degradation of p53

Journal of Biological Chemistry

Volumn 277, Issue 24, 2002, Pages 21843-21850

  Ogawara, Yoko ^a,b,c,d   Kishishita, Shohei ^a,b,c,d   Obata, Toshiyuki ^a,b,c,d   Isazawa, Yuko ^a,b,c,d   Suzuki, Toshiaki ^a,b,c,d   Tanaka, Keiji ^a,b,c,d   Masuyama, Norihisa ^a,b,c,d   Gotoh, Yukiko ^a,b,c,d  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

^c TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIODEGRADATION; DNA; ENZYME INHIBITION;

APOPTOSIS; SERUM TREATMENT;

PROTEINS;

2 MORPHOLINO 8 PHENYLCHROMONE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN MDM2; PROTEIN P53; UBIQUITIN;

AMINO ACID SUBSTITUTION; APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL PROLIFERATION; CELL SURVIVAL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DNA DAMAGE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; REDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; APOPTOSIS; BLOTTING, WESTERN; CELL SURVIVAL; CHROMONES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; MICROSCOPY, FLUORESCENCE; MORPHOLINES; NUCLEAR PROTEINS; ONCOGENE PROTEIN V-AKT; PHOSPHORYLATION; PLASMIDS; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-MDM2; RECOMBINANT PROTEINS; RETROVIRIDAE PROTEINS, ONCOGENIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SERINE; SUBCELLULAR FRACTIONS; TIME FACTORS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN;

EID: 0037077230     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M109745200     Document Type: Article

References (60)