Crystal structure of an activated Akt/Protein Kinase B ternary complex with GSK3-peptide and AMP-PNP

Nature Structural Biology

Volumn 9, Issue 12, 2002, Pages 940-944

  Yang, Jing ^a   Cron, Peter ^b   Good, Valerie M ^a   Thompson, Vivienne ^a   Hemmings, Brian A ^b   Barford, David ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE PHOSPHATE; GLYCOGEN SYNTHASE KINASE 3BETA; PROTEIN KINASE B; SERINE; THREONINE;

ALPHA HELIX; ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; ENZYME CONFORMATION; ENZYME REGULATION; ENZYME SUBSTRATE; HYDROPHOBICITY; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN TERTIARY STRUCTURE; STRUCTURE ANALYSIS;

ADENYLYL IMIDODIPHOSPHATE; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; GLYCOGEN SYNTHASE KINASE 3; HYDROPHOBICITY; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; PEPTIDES; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECOMBINANT FUSION PROTEINS; SUBSTRATE SPECIFICITY;

EID: 18744373865     PISSN: 10728368     EISSN: None     Source Type: Journal    
DOI: 10.1038/nsb870     Document Type: Article

References (25)

1. Brazil, D.P. & Hemmings, B.A. Trends Biochem. Sci. 26, 657-664 (2001).
2. Alessi, D.R. et al. EMBO J. 15, 6541-6551 (1996).
3. Alessi, D.R. et al. Curr. Biol. 7, 261-269 (1997).
4. Stokoe, D. et al. Science 277, 567-570 (1997).
5. Testa, R. & Bellacosa, A. Proc. Natl. Acad. Sci. USA 98, 10983-10985 (2001).
6. Parekh, D.B., Ziegler, W. & Parker, P.J. EMBO J. 19, 496-503 (2000).
7. Lang, F. & Cohen, P. Sci. STKE 108, RE17 (2001).
8. Yang, J. et al. Mol. Cell 9, 1227-1240 (2002).
9. Balendran, A. et al. Curr. Biol. 9, 393-404 (1999).
10. Cross, D.A., Alessi, D.R., Cohen, P., Andjelkovich, M. & Hemmings, B.A. Nature 378, 785-789 (1995).
11. Knighton, D.R. et al. Science 253, 407-414 (1991).
12. Knighton, D.R. et al. Science 253, 414-420 (1991).
13. Bossemeyer, D., Engh, R.A., Kinzel, V., Ponstingl, H. & Huber, R. EMBO J. 12, 849-859 (1993).
14. Johnson, L.N., Noble, M.E. & Owen, D.J. Cell 85, 149-158 (1996).
15. Etchebehere, L.C. et al. Eur. J. Biochem. 248, 820-826 (1997).
16. Alessi, D.R., Caudwell, F.B., Andjelkovic, M., Hemmings, B.A. & Cohen, P. FEBS Lett. 399, 333-338 (1996).
17. Obata, T. et al. J. Biol. Chem. 275, 36108-36115 (2000).
18. Kennelly, P.J. & Krebs, E.G. J. Biol. Chem. 266, 15555-15558 (1991).
19. Lowe, E.D. et al. EMBO J. 16, 6646-6658 (1997).
20. Biondi, R.M. et al. EMBO J. 21, 4219-4228 (2002).
21. Biondi, R.M. et al. EMBO J. 19, 979-988 (2000).
22. Collaborative Computational Project, Number 4. Acta Crystallogr. D 50, 760-763 (1994).
23. Brünger, A.T. et al. Acta Crystallogr. D 54, 905-921 (1998).
24. Jones, T.A., Zou, J.Y., Cowan, S.W. & Kjeldgaard, M. Acta Ctystallogr. A 50, 157-160 (1991).
25. Nicholls, A., Sharp, K.A. & Honig, B. Proteins 11, 281-296 (1991).