Amplification of AKT2 in human pancreatic cancer cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 8, 1996, Pages 3636-3641

  Cheng, Jin Quan ^a   Ruggeri, Bruce ^b   Klein, Walter M ^a   Sonoda, Gonosuke ^a   Altomare, Deborah A ^a   Watson, Dennis K ^c   Testa, Joseph R ^a  

^a FOX CHASE CANCER CENTER   (United States)

^b DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY RNA;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CANCER INHIBITION; CARCINOGENICITY; DNA TRANSFECTION; FEMALE; GENE AMPLIFICATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUDE MOUSE; ONCOGENE; ONCOGENE AKT 2; PANCREAS CARCINOMA; PRIORITY JOURNAL; TRACHEA; TUMOR GROWTH; XENOGRAFT;

ANIMALS; BASE SEQUENCE; CELL DIVISION; DNA PRIMERS; GENE AMPLIFICATION; GENE EXPRESSION; GENE THERAPY; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MICE; MICE, NUDE; MOLECULAR SEQUENCE DATA; ONCOGENE PROTEINS; ONCOGENES; PANCREATIC NEOPLASMS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RNA, ANTISENSE; TUMOR CELLS, CULTURED;

ANIMALIA; MUS MUSCULUS;

EID: 0001457668     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.8.3636     Document Type: Article

References (32)

1. Cheng, J. Q., Godwin, A. K., Bellacosa, A., Taguchi, T., Franke, T. F., Hamilton, T. C., Tsichlis, P. N. & Testa, J. R. (1992) Proc. Natl. Acad. Sci. USA 89, 9267-9271.
2. Bellacosa, A., Testa, J. R., Staal, S. P. & Tsichlis, P. N. (1991) Science 254, 274-277.
3. Mayer, B. J., Ren, R., Clark, K. L. & Baltimore, D. (1993) Cell 73, 629-630.
4. Musacchio, A., Gibson, T., Rice, P., Thompson, J. & Saraste, M. (1993) Trends Biochem. Sci. 18, 343-348.
5. Franke, T. F., Yang, S.-I., Chan, T. O., Datta, K., Kazlauskas, A., Morrison, D. K., Kaplan, D. R. & Tsichlis, P. N. (1995) Cell 81, 727-736.
6. Burgering, B. M. T. & Coffer, P. J. (1995) Nature (London) 376, 599-602.
7. Downward, J. (1995) Nature (London) 376, 553-554.
8. Bellacosa, A., de Feo, D., Godwin, A. K., Bell, D. W., Cheng, J. Q., Altomare, D. A., Wan, M., Dubeau, L., Scambia, G., Masciullo, V., Ferrandina, G., Panici, P. B., Mancuso, S., Neri, G. & Testa, J. R. (1995) Int. J. Cancer 64, 280-285.
9. Kasid, U., Pfeifer, A., Brennan, T., Beckett, M., Weichselbaum, R. R., Dritschilo, A. & Mark, G. E. (1989) Science 243, 1354-1356.
10. Szczylik, C., Skorski, T., Nicolaides, N. C., Manzella, L., Malaguarnera, L., Venturelli, D., Gewirtz, A. M. & Calabretta, B. (1991) Science 253, 562-565.
11. Stein, C. A. & Cheng, Y.-C. (1993) Science 261, 1004-1011.
12. Gray, G. D., Hernandez, O. M., Hebel, D., Root, M., Pow-Sang, J. M. & Wickstrom, E. (1993) Cancer Res. 53, 577-580.
13. Schmidt, M. L., Salwen, H. R., Manohar, C. F., Ikegaki, N. & Cohn, S. L. (1994) Cell Growth Differ. 5, 171-178.
14. Francastel, C., Groisman, R., Pfarr, C. M. & Robert-Lezenes, J. (1994) Oncogene 9, 1957-1964.
15. Georges, R. N., Mukhopadhyay, T., Zhang, Y., Yen, N. & Roth, J. A. (1993) Cancer Res. Cell 53, 1743-1746.
16. Colomer, R., Lupu, R., Bacus, S. S. & Gelmann, E. P. (1994) Br. J. Cancer 70, 819-825.
17. Chomczynski, P. & Sacchi, N. (1987) Anal. Biochem. 162, 156-159.
18. Cheng, J. Q., Jhanwar, S. C, Klein, W. M., Bell, D.W., Lee, W.-C, Altomare, D. A., Nobori, T., Olopade, O. I., Buckler, A. J. & Testa, J. R. (1994) Cancer Res. 54, 5547-5551.
19. Miller, A. D. & Rosman, G. J. (1989) BioTechniques 7, 980-990.
20. Fan, Y.-S., Davis, L. M. & Shows, T. B. (1990) Proc. Natl. Acad. Sci. USA 87, 6223-6227.
21. Testa, J. R., Taguchi, T., Knudson, A.C. & Hino, O. (1992) Cylogenet. Cell Genet. 60, 247-249.
22. Momiki, S., Baba, M., Caamano, J., lizasa, T., Nakajima, M., Yamaguchi, Y. & Klein-Szanto, A. (1991) Invasion Metastasis 11, 66-75.
23. Boring, C. C., Squires, T. S. & Tong, T. (1993) Ca Cancer J. Clin. 43, 7-26.
24. Ruggeri, B., Zhang, S.-Y., Caamano, J., DiRado, M., Flynn, S. D. & Klein-Szanto, A. J. P. (1992) Oncogens 7, 1503-1511.
25. Almoguera, C., Shibata, D., Forrester, K., Martin, J., Arnheim, N. & Perucho, M. (1988) Cell 53, 549-554.
26. Pellegata, N. S., Sessa, F., Renault, B., Bonato, M., Leone, B. E., Solcia, E. & Ranzani, G. N. (1994) Cancer Res. 54, 1556-1560.
27. Caldas, C. Hahn, S. A., da Costa, L. T., Redston, M. S., Schutte, M., Seymour, A. B., Weinstein, C. L., Hruban, R. H., Yeo, C. J. & Kern, S. E. (1994) Nat. Genet. 8, 27-32.
28. Brodeur, G. M., Seeger, R. C., Schwab, M., Varmus, H. E. & Bishop, J. M. (1984) Science 224, 1121-1124.
29. Yokota, J., Tsunetsugu-Yokota, Y., Battifora, H., Le Fevre, C. & Cline, M. J. (1986) Science 231, 261-265.
30. Slamon, D. J., Clark, G. M., Wong, S. G., Levin, W. J., Ullrich, A. & McGuire, W. L. (1987) Science 235, 177-182.
31. Baba, M., Klein-Szanto, A. J. P., Trono, D., Obara, T., Yoakum, G. H., Masui, T. & Harris, C. C. (1987) Cancer Res. 47, 573-578.
32. Berrozpe, G., Schaeffer, J., Peinado, M. A., Real, F. X. & Perucho, M. (1994) Int. J. Cancer 58, 185-191.