Transgenic mice with human mutant genes causing Parkinson's disease and amyotrophic lateral sclerosis provide common insight into mechanisms of motor neuron selective vulnerability to degeneration

Reviews in the Neurosciences

Volumn 18, Issue 2, 2007, Pages 115-136

  Martin, Lee J ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; DNA damage; iNOS; Mitochondria; p53; Peroxynitrite; synuclein

Indexed keywords

ALANINE; ALPHA SYNUCLEIN; COPPER ZINC SUPEROXIDE DISMUTASE; CYTOCHROME C OXIDASE; GLYCINE; INDUCIBLE NITRIC OXIDE SYNTHASE; MANGANESE SUPEROXIDE DISMUTASE; PROTEIN P53; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE; THREONINE; SUPEROXIDE DISMUTASE;

AMYOTROPHIC LATERAL SCLEROSIS; CELL MIGRATION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA STRAND BREAKAGE; DOUBLE STRANDED DNA BREAK; ENZYME ACTIVITY; GENE DELETION; HUMAN; IMMUNOREACTIVITY; KNOCKOUT MOUSE; LIFESPAN; MITOCHONDRION; MOTONEURON; MOTOR DYSFUNCTION; MUTANT; MUTATION; NERVE CELL DEGENERATION; NERVE CELL NECROSIS; NERVE DEGENERATION; NERVE ENDING; NEUROLOGIC DISEASE; NITRATION; NITRATIVE STRESS; NONHUMAN; OUTER MEMBRANE; PARALYSIS; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN TARGETING; REGULATORY MECHANISM; REVIEW; SINGLE STRANDED DNA BREAK; SPINAL CORD; SPINAL CORD MOTONEURON; TRANSGENIC MOUSE; ANIMAL; CELL DEATH; GENETICS; MOUSE; PATHOLOGY; PHYSIOLOGY;

ALPHA-SYNUCLEIN; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; CELL DEATH; HUMANS; MICE; MICE, TRANSGENIC; MITOCHONDRIA; MOTOR NEURONS; MUTATION; NERVE DEGENERATION; PARKINSON DISEASE; SUPEROXIDE DISMUTASE;

EID: 34447506680     PISSN: 03341763     EISSN: None     Source Type: Journal    
DOI: 10.1515/REVNEURO.2007.18.2.115     Document Type: Review

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