A gain-of-function of an amyotrophic lateral sclerosis-associated Cu,Zn- superoxide dismutase mutant: An enhancement of free radical formation due to a decrease in K(m) for hydrogen peroxide

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 12, 1996, Pages 5709-5714

  Moon Bin Yim, ^a   Kang, J H ^a   Yim, H S ^a   Kwak, H S ^a   Chock, P B ^a   Stadtman, E R ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

electron paramagnetic resonance; recombinant enzyme; site directed mutagenesis; spin trapping

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; FREE RADICAL; HYDROGEN PEROXIDE; SUPEROXIDE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ARTICLE; CONFORMATIONAL TRANSITION; ENZYME ACTIVITY; ENZYME KINETICS; GENE EXPRESSION; GENE LOCUS; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; TRANSGENIC MOUSE; X RAY CRYSTALLOGRAPHY;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; BASE SEQUENCE; CLONING, MOLECULAR; DNA, COMPLEMENTARY; FREE RADICALS; HUMANS; HYDROGEN PEROXIDE; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; MUTATION; SPODOPTERA; SUPEROXIDE DISMUTASE;

EID: 0029939471     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.12.5709     Document Type: Article

References (0)