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Volumn 22, Issue , 1999, Pages 123-144

Etiology and pathogenesis of Parkinson's disease

Author keywords

Apoptosis; Dopamine neurons; Neuroprotection; Oxidant stress; Substantia nigra

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; ALPHA SYNUCLEIN; ALPHA TOCOPHEROL; ANTIOXIDANT; ANTIPARKINSON AGENT; CYTOKINE; DOPAMINE RECEPTOR STIMULATING AGENT; DRUG METABOLITE; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GLUTAMATE RECEPTOR ANTAGONIST; GLUTATHIONE; LEVODOPA; MONOAMINE OXIDASE INHIBITOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NEUROTROPHIC FACTOR; REMACEMIDE; RILUZOLE; SELEGILINE; UBIQUINONE;

EID: 0032936755     PISSN: 0147006X     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.neuro.22.1.123     Document Type: Review
Times cited : (1206)

References (128)
  • 1
    • 0029312921 scopus 로고
    • Aging, disease and nerve cell death
    • Agid Y. 1995. Aging, disease and nerve cell death. Bull. Acad. Natl. Med. 179:1193-203
    • (1995) Bull. Acad. Natl. Med. , vol.179 , pp. 1193-1203
    • Agid, Y.1
  • 3
    • 0030805622 scopus 로고    scopus 로고
    • A generalized increase in protein carbonyls in the brain in Parkinson's but not Incidental Lewy Body disease
    • Alam ZI, Daniel SE, Lees AJ, Marsden CD, Jenner P, Halliwell B. 1997a. A generalized increase in protein carbonyls in the brain in Parkinson's but not Incidental Lewy Body disease. J. Neurochem. 69:1326-29
    • (1997) J. Neurochem. , vol.69 , pp. 1326-1329
    • Alam, Z.I.1    Daniel, S.E.2    Lees, A.J.3    Marsden, C.D.4    Jenner, P.5    Halliwell, B.6
  • 4
    • 0030878073 scopus 로고    scopus 로고
    • Oxidative DNA damage in the parkinsonian brain; a selective increase in 8-hydroxyguanine in substantia nigra?
    • Alam ZI, Jenner A, Daniel SE, Lees AJ, Cairns N, et al. 1997b. Oxidative DNA damage in the parkinsonian brain; a selective increase in 8-hydroxyguanine in substantia nigra? J. Neurochem. 69:1196-203
    • (1997) J. Neurochem. , vol.69 , pp. 1196-1203
    • Alam, Z.I.1    Jenner, A.2    Daniel, S.E.3    Lees, A.J.4    Cairns, N.5
  • 6
    • 0028872501 scopus 로고
    • Time course of ciliary neurotrophic factor mRNA expression is coincident with the presence of protoplasmic astrocytes in traumatized rat striatum
    • Asada H, Ip NY, Pan L, Razack N, Parfitt MM, Plunkett RJ. 1995. Time course of ciliary neurotrophic factor mRNA expression is coincident with the presence of protoplasmic astrocytes in traumatized rat striatum. J. Neurosci. Res. 40:22-30
    • (1995) J. Neurosci. Res. , vol.40 , pp. 22-30
    • Asada, H.1    Ip, N.Y.2    Pan, L.3    Razack, N.4    Parfitt, M.M.5    Plunkett, R.J.6
  • 7
    • 0030692086 scopus 로고    scopus 로고
    • Association of slow acetylator genotype for N-acetyltransferase 2 with familial Parkinson's disease
    • Bandmann O, Vaughan J, Holmans P, Marsden CD, Wood NW. 1997. Association of slow acetylator genotype for N-acetyltransferase 2 with familial Parkinson's disease. Lancet 350:1136-39
    • (1997) Lancet , vol.350 , pp. 1136-1139
    • Bandmann, O.1    Vaughan, J.2    Holmans, P.3    Marsden, C.D.4    Wood, N.W.5
  • 8
    • 0026584524 scopus 로고
    • Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?
    • Beal MF. 1992. Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses? Ann. Neurol. 31:119-30
    • (1992) Ann. Neurol. , vol.31 , pp. 119-130
    • Beal, M.F.1
  • 9
    • 0025189864 scopus 로고
    • Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide
    • Beckman JS, Beckman TW, Chen J, et al. 1990. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc. Natl. Acad. Sci. USA 87:1620-24
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 1620-1624
    • Beckman, J.S.1    Beckman, T.W.2    Chen, J.3
  • 10
    • 0029910556 scopus 로고    scopus 로고
    • Nitric oxide-mediated mitochondrial damage: A potential neuroprotective role for glutathione
    • Bolanos JP, Heales SJR, Peuchen S, et al. 1996. Nitric oxide-mediated mitochondrial damage: a potential neuroprotective role for glutathione. Free Radic. Biol. Med. 21:995-1001
    • (1996) Free Radic. Biol. Med. , vol.21 , pp. 995-1001
    • Bolanos, J.P.1    Heales, S.J.R.2    Peuchen, S.3
  • 11
    • 0029614765 scopus 로고
    • Neural apoptosis
    • Bredesen DE. 1995 Neural apoptosis. Ann. Neurol. 38:839-51
    • (1995) Ann. Neurol. , vol.38 , pp. 839-851
    • Bredesen, D.E.1
  • 12
    • 0030938169 scopus 로고    scopus 로고
    • The neural nitric oxide synthase inhibitor 7-nitroindazole also inhibits the monoamine oxidase-B-catalyzed oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
    • Castagnoli K, Palmer S, Anderson A, et al. 1997. The neural nitric oxide synthase inhibitor 7-nitroindazole also inhibits the monoamine oxidase-B-catalyzed oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Chem. Res. Toxicol. 10:364-68
    • (1997) Chem. Res. Toxicol. , vol.10 , pp. 364-368
    • Castagnoli, K.1    Palmer, S.2    Anderson, A.3
  • 13
    • 0028048113 scopus 로고
    • Temporal and spatial increase of astroglial basic fibroblast growth factor synthesis after 6-hydroxydopamine-induced degeneration of the nigrostriatal dopamine neurons
    • Chadi G, Cao Y, Pettersson RF, Fuxe K. 1994. Temporal and spatial increase of astroglial basic fibroblast growth factor synthesis after 6-hydroxydopamine-induced degeneration of the nigrostriatal dopamine neurons. Neuroscience 61:891-910
    • (1994) Neuroscience , vol.61 , pp. 891-910
    • Chadi, G.1    Cao, Y.2    Pettersson, R.F.3    Fuxe, K.4
  • 14
    • 0029092802 scopus 로고
    • Quantitative analysis of isoferritins in select regions of aged, Parkinsonian, and Alzheimer diseased brains
    • Connor JR, Snyder BS, Arosio P, et al. 1995. Quantitative analysis of isoferritins in select regions of aged, Parkinsonian, and Alzheimer diseased brains. J. Neurochem. 65:717-24
    • (1995) J. Neurochem. , vol.65 , pp. 717-724
    • Connor, J.R.1    Snyder, B.S.2    Arosio, P.3
  • 15
    • 0026781572 scopus 로고
    • A novel N18TG2 x mesencephalon cell hybrid expresses properties that suggest a dopaminergic cell line of substantia nigra origin
    • Crawford GD, Le WD, Smith RG, Xie WJ, Stefani E, Appel SH. 1992. A novel N18TG2 x mesencephalon cell hybrid expresses properties that suggest a dopaminergic cell line of substantia nigra origin. J. Neurosci. 12:3392-98
    • (1992) J. Neurosci. , vol.12 , pp. 3392-3398
    • Crawford, G.D.1    Le, W.D.2    Smith, R.G.3    Xie, W.J.4    Stefani, E.5    Appel, S.H.6
  • 16
    • 0029873904 scopus 로고    scopus 로고
    • Threshold effects and control of oxidative phosphorylation in non-synaptic rat brain mitochondria
    • Davey GP, Clark JB. 1996. Threshold effects and control of oxidative phosphorylation in non-synaptic rat brain mitochondria. J. Neurochem. 66:1617-24
    • (1996) J. Neurochem. , vol.66 , pp. 1617-1624
    • Davey, G.P.1    Clark, J.B.2
  • 18
    • 0025298139 scopus 로고
    • Primate models of movement disorders of basal ganglia origin
    • DeLong MR. 1990. Primate models of movement disorders of basal ganglia origin. Trends Neurosci. 13:281-89
    • (1990) Trends Neurosci. , vol.13 , pp. 281-289
    • DeLong, M.R.1
  • 19
    • 0029990439 scopus 로고    scopus 로고
    • Astrocytes protect neurons from hydrogen peroxide toxicity
    • Desagher S, Glowinski J, Premont J. 1996. Astrocytes protect neurons from hydrogen peroxide toxicity. J. Neurosci. 16:2553-62
    • (1996) J. Neurosci. , vol.16 , pp. 2553-2562
    • Desagher, S.1    Glowinski, J.2    Premont, J.3
  • 20
    • 0024585155 scopus 로고
    • Basal lipid peroxidation in substantia nigra is increased in Parkinson's disease
    • Dexter DT, Carter CJ, Wells FR, et al. 1989b. Basal lipid peroxidation in substantia nigra is increased in Parkinson's disease. J. Neurochem. 52:381-89
    • (1989) J. Neurochem. , vol.52 , pp. 381-389
    • Dexter, D.T.1    Carter, C.J.2    Wells, F.R.3
  • 21
    • 0027952849 scopus 로고
    • Increased levels of lipid hydroperoxides in the parkinsonian substantia nigra: An HPLC and ESR study
    • Dexter DT, Holley AE, Flitter WD, et al. 1994b. Increased levels of lipid hydroperoxides in the parkinsonian substantia nigra: an HPLC and ESR study. Mov. Disord. 9:92-97
    • (1994) Mov. Disord. , vol.9 , pp. 92-97
    • Dexter, D.T.1    Holley, A.E.2    Flitter, W.D.3
  • 22
    • 0028091176 scopus 로고
    • Indices of oxidative stress and mitochondrial function in individuals with incidental Lewy body disease
    • Dexter DT, Sian J, Rose S, et al. 1994a. Indices of oxidative stress and mitochondrial function in individuals with incidental Lewy body disease. Ann. Neurol. 35:38-44
    • (1994) Ann. Neurol. , vol.35 , pp. 38-44
    • Dexter, D.T.1    Sian, J.2    Rose, S.3
  • 23
    • 0024356620 scopus 로고
    • Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease
    • Dexter DT, Wells FR, Lees AJ, et al. 1989a. Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease. J. Neurochem. 52:1830-36
    • (1989) J. Neurochem. , vol.52 , pp. 1830-1836
    • Dexter, D.T.1    Wells, F.R.2    Lees, A.J.3
  • 24
    • 0027379322 scopus 로고
    • Mitochondrial involvement in Parkinson's disease: The controversy continues
    • DiMauro S. 1993. Mitochondrial involvement in Parkinson's disease: the controversy continues. Neurology 43:2170-72
    • (1993) Neurology , vol.43 , pp. 2170-2172
    • DiMauro, S.1
  • 25
    • 0028786932 scopus 로고
    • Expression of lactoferrin receptors is increased in the mesencephalon of patients with Parkinson's disease
    • Faucheux B, Nillesse N, Damier P, et al. 1995. Expression of lactoferrin receptors is increased in the mesencephalon of patients with Parkinson's disease. Proc. Natl. Acad. Sci. USA 92:9603-7
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 9603-9607
    • Faucheux, B.1    Nillesse, N.2    Damier, P.3
  • 26
    • 0029614333 scopus 로고
    • Morphological and functional effects of intranigrally administered GDNF in normal rhesus monkeys
    • Gash DM, Zhang ZM, Cass WA, Ovadia A, Simmerman L, et al. 1995. Morphological and functional effects of intranigrally administered GDNF in normal rhesus monkeys. J. Comp. Neurol. 363:345-58
    • (1995) J. Comp. Neurol. , vol.363 , pp. 345-358
    • Gash, D.M.1    Zhang, Z.M.2    Cass, W.A.3    Ovadia, A.4    Simmerman, L.5
  • 27
    • 0031662603 scopus 로고    scopus 로고
    • Neuroprotective and neurorestorative properties of GDNF
    • In press
    • Gash DM, Zhang Z, Gerhardt G. 1998. Neuroprotective and neurorestorative properties of GDNF. Ann. Neurol. In press
    • (1998) Ann. Neurol.
    • Gash, D.M.1    Zhang, Z.2    Gerhardt, G.3
  • 28
    • 0028124654 scopus 로고
    • Genetic studies in autosomal dominant parkinsonism: Evaluation of seven candidate genes
    • Gasser T, Wszolek ZK, Trofatter J, et al. 1994. Genetic studies in autosomal dominant parkinsonism: evaluation of seven candidate genes. Ann. Neurol. 36:387-96
    • (1994) Ann. Neurol. , vol.36 , pp. 387-396
    • Gasser, T.1    Wszolek, Z.K.2    Trofatter, J.3
  • 29
    • 0029127954 scopus 로고
    • Characterization of a novel protein regulated during the critical period for song learning in the zebra finch
    • George JM, Jin H, Woods WS, Clayton DP. 1995. Characterization of a novel protein regulated during the critical period for song learning in the zebra finch. Neuron 15:361-72
    • (1995) Neuron , vol.15 , pp. 361-372
    • George, J.M.1    Jin, H.2    Woods, W.S.3    Clayton, D.P.4
  • 30
    • 0025244959 scopus 로고
    • The genetics of Parkinson's disease: A reconsideration
    • Golbe L. 1990. The genetics of Parkinson's disease: a reconsideration. Neurology 40:7-14
    • (1990) Neurology , vol.40 , pp. 7-14
    • Golbe, L.1
  • 31
    • 0026746512 scopus 로고
    • Neuromelanin-containing neurons of the substantia nigra accumulate iron and aluminum in Parkinson's disease: A LAMMA study
    • Good P, Olanow CW, Perl DP. 1992. Neuromelanin-containing neurons of the substantia nigra accumulate iron and aluminum in Parkinson's disease: A LAMMA study. Brain Res. 593:343-46
    • (1992) Brain Res. , vol.593 , pp. 343-346
    • Good, P.1    Olanow, C.W.2    Perl, D.P.3
  • 33
    • 0000775028 scopus 로고    scopus 로고
    • SOD-1 G86R transgenic mice have decreased striatal dopamine and a greater sensitivity to MPTP than control mice
    • Abstr.
    • Good PF, Olanow CW, Hsu A, Gordon J. 1997. SOD-1 G86R transgenic mice have decreased striatal dopamine and a greater sensitivity to MPTP than control mice. Soc. Neurosci. 23:1877 (Abstr.)
    • (1997) Soc. Neurosci. , vol.23 , pp. 1877
    • Good, P.F.1    Olanow, C.W.2    Hsu, A.3    Gordon, J.4
  • 34
    • 0028232327 scopus 로고
    • Antiparkinsonian effects of ramacemide hydrochloride, a glutamate antagonist, in rodent and primate models of Parkinson's disease
    • Greenmayre TE, Eller RV, Zhang Z, et al. 1994. Antiparkinsonian effects of ramacemide hydrochloride, a glutamate antagonist, in rodent and primate models of Parkinson's disease. Ann. Neurol. 35:655-61
    • (1994) Ann. Neurol. , vol.35 , pp. 655-661
    • Greenmayre, T.E.1    Eller, R.V.2    Zhang, Z.3
  • 35
    • 0029799831 scopus 로고    scopus 로고
    • Neuroprotection by aspirin and sodium salicylate through blockade of NF-kappaB activation
    • Grilli M, Pizzi M, Mano M, Spano P. 1996. Neuroprotection by aspirin and sodium salicylate through blockade of NF-kappaB activation. Science 22:1383-85
    • (1996) Science , vol.22 , pp. 1383-1385
    • Grilli, M.1    Pizzi, M.2    Mano, M.3    Spano, P.4
  • 36
    • 0026531499 scopus 로고
    • Ciliary neurotrophic factor prevents neuronal degeneration and promotes low affinity NGF receptor expression in the adult rat CNS
    • Hagg T, Quon D, Higaki J, Varon S. 1992. Ciliary neurotrophic factor prevents neuronal degeneration and promotes low affinity NGF receptor expression in the adult rat CNS. Neuron 8:145-48
    • (1992) Neuron , vol.8 , pp. 145-148
    • Hagg, T.1    Quon, D.2    Higaki, J.3    Varon, S.4
  • 37
    • 0027276870 scopus 로고
    • Ciliary neurotrophic factor prevents degeneration of adult rat substantia nigra dopaminergic neurons in vivo
    • Hagg T, Varon S. 1993. Ciliary neurotrophic factor prevents degeneration of adult rat substantia nigra dopaminergic neurons in vivo. Proc. Natl. Acad. Sci. USA 90:6315-19
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 6315-6319
    • Hagg, T.1    Varon, S.2
  • 38
  • 39
    • 0029012476 scopus 로고
    • A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death
    • Ham J, Babij C, Whitfield J, Pfarr CM, Lallemand D, et al. 1995. A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death. Neuron 14:927-39
    • (1995) Neuron , vol.14 , pp. 927-939
    • Ham, J.1    Babij, C.2    Whitfield, J.3    Pfarr, C.M.4    Lallemand, D.5
  • 40
    • 0029844003 scopus 로고    scopus 로고
    • Inhibition of neuronal nitric oxide synthase prevents MPTP-induced parkinsonism in baboons
    • Hantrave P, Brouillet E, Ferrante R, et al. 1996. Inhibition of neuronal nitric oxide synthase prevents MPTP-induced parkinsonism in baboons. Nat. Med. 2:1017-21
    • (1996) Nat. Med. , vol.2 , pp. 1017-1021
    • Hantrave, P.1    Brouillet, E.2    Ferrante, R.3
  • 41
    • 0031715925 scopus 로고    scopus 로고
    • Glial cells and inflammation in Parkinson's disease: A role in neurodegeneration?
    • In press
    • Hirsch EC, Hunot S, Damier P, Faucheux B. 1998. Glial cells and inflammation in Parkinson's disease: a role in neurodegeneration? Ann. Neurol. In press
    • (1998) Ann. Neurol.
    • Hirsch, E.C.1    Hunot, S.2    Damier, P.3    Faucheux, B.4
  • 42
    • 10544242965 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor (GDNF) gene expression in the human brain: A post mortem in situ hybridization study with special reference to Parkinson's disease
    • Hunot S, Bernard V, Faucheux B, Boissiere F, Leguern E, et al. 1996. Glial cell line-derived neurotrophic factor (GDNF) gene expression in the human brain: a post mortem in situ hybridization study with special reference to Parkinson's disease. J. Neural Transm. 103:1043-52
    • (1996) J. Neural Transm. , vol.103 , pp. 1043-1052
    • Hunot, S.1    Bernard, V.2    Faucheux, B.3    Boissiere, F.4    Leguern, E.5
  • 43
    • 0030842085 scopus 로고    scopus 로고
    • Nuclear translocation of NF-κB is increased in dopaminergic neurons of patients with Parkinson disease
    • Hunot S, Brugg B, Ricard D, et al. 1997. Nuclear translocation of NF-κB is increased in dopaminergic neurons of patients with Parkinson disease. Proc. Natl. Acad. Sci. USA 94:7531-36
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 7531-7536
    • Hunot, S.1    Brugg, B.2    Ricard, D.3
  • 44
    • 0025876757 scopus 로고
    • BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra
    • Hyman C, Hofer M, Barde Y-A, Juhasz M, Yancopoulos GD, et al. 1991. BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra. Nature 350:230-32
    • (1991) Nature , vol.350 , pp. 230-232
    • Hyman, C.1    Hofer, M.2    Barde, Y.-A.3    Juhasz, M.4    Yancopoulos, G.D.5
  • 45
    • 0028854722 scopus 로고
    • Point mutations of mitochondrial genome in Parkinson's disease
    • Ikebe S, Tanaka M, Ozawa T. 1995. Point mutations of mitochondrial genome in Parkinson's disease. Mol. Brain Res. 28:281-95
    • (1995) Mol. Brain Res. , vol.28 , pp. 281-295
    • Ikebe, S.1    Tanaka, M.2    Ozawa, T.3
  • 46
    • 0026485192 scopus 로고
    • Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase
    • Ischiropoulos H, Zhu L, Chen J, et al. 1992. Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase. Arch. Biochem. Biophys. 298:431-37
    • (1992) Arch. Biochem. Biophys. , vol.298 , pp. 431-437
    • Ischiropoulos, H.1    Zhu, L.2    Chen, J.3
  • 47
    • 0030426279 scopus 로고    scopus 로고
    • An antisense oligonucleotide to glyderaldehyde-3-phosphate dehydrogenase blocks age-induced apoptosis of mature cerebro-cortical neurons in culture
    • Ishitani R, Kimura M, Sunaga K, Katsube N, Tanaka M, Chuang DM. 1996. An antisense oligonucleotide to glyderaldehyde-3-phosphate dehydrogenase blocks age-induced apoptosis of mature cerebro-cortical neurons in culture. J. Pharm. Exp. Ther. 278:447-54
    • (1996) J. Pharm. Exp. Ther. , vol.278 , pp. 447-454
    • Ishitani, R.1    Kimura, M.2    Sunaga, K.3    Katsube, N.4    Tanaka, M.5    Chuang, D.M.6
  • 48
    • 0029751104 scopus 로고    scopus 로고
    • Oxidative stress and the pathogenesis of Parkinson's disease
    • Jenner P, Olanow CW. 1996. Oxidative stress and the pathogenesis of Parkinson's disease. Neurology 47:161-70
    • (1996) Neurology , vol.47 , pp. 161-170
    • Jenner, P.1    Olanow, C.W.2
  • 49
    • 0031687793 scopus 로고    scopus 로고
    • Understanding cell death in Parkinson's disease
    • In press
    • Jenner P, Olanow CW. 1998. Understanding cell death in Parkinson's disease. Ann. Neurol. In press
    • (1998) Ann. Neurol.
    • Jenner, P.1    Olanow, C.W.2
  • 50
    • 0026460114 scopus 로고
    • Burst firing in dopamine neurons induced by N-methyl-D-aspartate: Role of electrogenic sodium pump
    • Johnson SW, Seutin V, North A. 1992. Burst firing in dopamine neurons induced by N-methyl-D-aspartate: role of electrogenic sodium pump. Science 258:665-67
    • (1992) Science , vol.258 , pp. 665-667
    • Johnson, S.W.1    Seutin, V.2    North, A.3
  • 51
    • 0013494590 scopus 로고    scopus 로고
    • mRNAs overexpressed during induced apoptosis in substantia nigra identified by RNA differential display
    • Abstr.
    • Kholodilov NG, Neystat M, Burke RE. 1997. mRNAs overexpressed during induced apoptosis in substantia nigra identified by RNA differential display. Soc. Neurosci. 23:631 (Abstr.)
    • (1997) Soc. Neurosci. , vol.23 , pp. 631
    • Kholodilov, N.G.1    Neystat, M.2    Burke, R.E.3
  • 53
  • 54
    • 0020680904 scopus 로고
    • Chronic parkinsonism in humans due to a product of meperidine analog synthesis
    • Langston JW, Ballard PA, Tetrud JW, Irwin I. 1983. Chronic parkinsonism in humans due to a product of meperidine analog synthesis. Science 219:979-80
    • (1983) Science , vol.219 , pp. 979-980
    • Langston, J.W.1    Ballard, P.A.2    Tetrud, J.W.3    Irwin, I.4
  • 55
    • 0030950227 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor attenuates behavioural deficits and regulates nigrostriatal dopaminergic and peptidergic markers in 6-hydroxydopamine-lesioned adult rats: Comparison of intraventricular and intranigral delivery
    • Lapchak PA, Miller PJ, Collins F, Jiao S. 1997. Glial cell line-derived neurotrophic factor attenuates behavioural deficits and regulates nigrostriatal dopaminergic and peptidergic markers in 6-hydroxydopamine-lesioned adult rats: comparison of intraventricular and intranigral delivery. Neuroscience 78:61-72
    • (1997) Neuroscience , vol.78 , pp. 61-72
    • Lapchak, P.A.1    Miller, P.J.2    Collins, F.3    Jiao, S.4
  • 56
    • 0025047351 scopus 로고
    • Normal mitochondrial genome in brain from patients with Parkinson's disease and complex I defect
    • Lestienne P, Nelson J, Riederer P, Jellinger K, Reichmann H. 1990. Normal mitochondrial genome in brain from patients with Parkinson's disease and complex I defect. J. Neurochem. 55:1810-12
    • (1990) J. Neurochem. , vol.55 , pp. 1810-1812
    • Lestienne, P.1    Nelson, J.2    Riederer, P.3    Jellinger, K.4    Reichmann, H.5
  • 57
    • 84981835993 scopus 로고
    • A diffusible agent of mouse sarcoma producing hyperplasia of sympathetic ganglia and hyperneurotization of the chick embryo
    • Levi-Montalcini R, Hamburger V. 1953. A diffusible agent of mouse sarcoma producing hyperplasia of sympathetic ganglia and hyperneurotization of the chick embryo. J. Exp. Zool. 123:233-88
    • (1953) J. Exp. Zool. , vol.123 , pp. 233-288
    • Levi-Montalcini, R.1    Hamburger, V.2
  • 58
    • 0027285510 scopus 로고
    • GDNF: A glial cell-line derived neurotrophic factor for midbrain dopaminergic neurons
    • Lin WW, Doherty DH, Lile JD, Bektesh S, Collins F. 1993. GDNF: a glial cell-line derived neurotrophic factor for midbrain dopaminergic neurons. Science 260:1130-32
    • (1993) Science , vol.260 , pp. 1130-1132
    • Lin, W.W.1    Doherty, D.H.2    Lile, J.D.3    Bektesh, S.4    Collins, F.5
  • 59
    • 0030581151 scopus 로고    scopus 로고
    • Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
    • Liu XS, Kim CN, Yang J, Jemmerson R, Wang XD. 1996. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell 86:147-57
    • (1996) Cell , vol.86 , pp. 147-157
    • Liu, X.S.1    Kim, C.N.2    Yang, J.3    Jemmerson, R.4    Wang, X.D.5
  • 60
    • 0023722437 scopus 로고
    • Synuclein: A neuron-specific protein localized to the nucleus and presynaptic nerve terminal
    • Maroteaux L, Campanelli JT, Scheller RH. 1988. Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal. J. Neurosci. 8:2804-15
    • (1988) J. Neurosci. , vol.8 , pp. 2804-2815
    • Maroteaux, L.1    Campanelli, J.T.2    Scheller, R.H.3
  • 61
    • 0023782375 scopus 로고
    • Expression of the histocompatibility glycoprotein HLA-DR in neurological disease
    • McGeer PL, Itagaki S, McGeer EG. 1988. Expression of the histocompatibility glycoprotein HLA-DR in neurological disease. Acta Neuropathol. 76:550-57
    • (1988) Acta Neuropathol. , vol.76 , pp. 550-557
    • McGeer, P.L.1    Itagaki, S.2    McGeer, E.G.3
  • 62
    • 0029811901 scopus 로고    scopus 로고
    • Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: A review of 17 epidemiologic studies
    • McGeer PL, Schulzer M, McGeer EG. 1996. Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies. Neurology 47:425-32
    • (1996) Neurology , vol.47 , pp. 425-432
    • McGeer, P.L.1    Schulzer, M.2    McGeer, E.G.3
  • 63
    • 0028176592 scopus 로고
    • An immunohistochemical study on α-ketoglutarate dehydrogenase complex in Parkinson's disease
    • Mizuno Y, Matuda S, Yoshino H, et al. 1994. An immunohistochemical study on α-ketoglutarate dehydrogenase complex in Parkinson's disease. Ann. Neurol. 35:204-10
    • (1994) Ann. Neurol. , vol.35 , pp. 204-210
    • Mizuno, Y.1    Matuda, S.2    Yoshino, H.3
  • 64
    • 0029942337 scopus 로고    scopus 로고
    • Histochemical detection of apoptosis in Parkinson's disease
    • Mochizuki H, Goto K, Mori H, Mizuno Y. 1996. Histochemical detection of apoptosis in Parkinson's disease. J. Neurol. Sci. 131:120-23
    • (1996) J. Neurol. Sci. , vol.131 , pp. 120-123
    • Mochizuki, H.1    Goto, K.2    Mori, H.3    Mizuno, Y.4
  • 66
    • 0027362832 scopus 로고
    • Toxic and protective effects of L-DOPA on mesencephalic cell cultures
    • Mytilineou C, Han S-K, Cohen G. 1993. Toxic and protective effects of L-DOPA on mesencephalic cell cultures. J. Neurochem. 61:1470-78
    • (1993) J. Neurochem. , vol.61 , pp. 1470-1478
    • Mytilineou, C.1    Han, S.-K.2    Cohen, G.3
  • 67
    • 0031886449 scopus 로고    scopus 로고
    • Deprenyl and desmethylselegiline protect mesencephalic neurons from toxicity induced by glutathione depletion
    • Mytilineou C, Leonardi EK, Radcliffe P, Heinonen EH, Han SK, et al. 1998. Deprenyl and desmethylselegiline protect mesencephalic neurons from toxicity induced by glutathione depletion. J. Pharm. Exp. Ther. 284:700-6
    • (1998) J. Pharm. Exp. Ther. , vol.284 , pp. 700-706
    • Mytilineou, C.1    Leonardi, E.K.2    Radcliffe, P.3    Heinonen, E.H.4    Han, S.K.5
  • 68
    • 0031020650 scopus 로고    scopus 로고
    • L-Deprenyl protects mesencephalic dopamine neurons from glutamate receptor-mediated toxicity in vitro
    • Mytilineou C, Radcliffe P, Leonardi EK, Werner P, Olanow CW. 1997a. L-Deprenyl protects mesencephalic dopamine neurons from glutamate receptor-mediated toxicity in vitro. J. Neurochem. 68:33-39
    • (1997) J. Neurochem. , vol.68 , pp. 33-39
    • Mytilineou, C.1    Radcliffe, P.2    Leonardi, E.K.3    Werner, P.4    Olanow, C.W.5
  • 69
    • 0031037786 scopus 로고    scopus 로고
    • L-(-)-desmethylselegiline, a metabolite of selegiline [L-(-)-deprenyl], protects mesencephalic dopamine neurons from excitotoxicity in vitro
    • Mytilineou C, Radcliffe PM, Olanow CW. 1997b. L-(-)-desmethylselegiline, a metabolite of selegiline [L-(-)-deprenyl], protects mesencephalic dopamine neurons from excitotoxicity in vitro. J. Neurochem. 68:434-36
    • (1997) J. Neurochem. , vol.68 , pp. 434-436
    • Mytilineou, C.1    Radcliffe, P.M.2    Olanow, C.W.3
  • 70
    • 0028019746 scopus 로고
    • Cell-free apoptosis in Xenopus egg extracts: Inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria
    • Newmeyer DD, Farschon DM, Reed JC. 1994. Cell-free apoptosis in Xenopus egg extracts: inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria. Cell 79:353-64
    • (1994) Cell , vol.79 , pp. 353-364
    • Newmeyer, D.D.1    Farschon, D.M.2    Reed, J.C.3
  • 71
    • 0021810979 scopus 로고
    • Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine
    • Nicklas WJ, Vyas I, Heikkila RE. 1985. Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine. Life Sci. 36:2503-8
    • (1985) Life Sci. , vol.36 , pp. 2503-2508
    • Nicklas, W.J.1    Vyas, I.2    Heikkila, R.E.3
  • 72
    • 0027991538 scopus 로고
    • Degeneration of nigrostriatal dopaminergic neurons increases iron within the substantia nigra: A histochemical and neurochemical study
    • Oestreicher E, Sengstock GJ, Riederer P, Olanow CW, Dunn AJ, Arendash G. 1994. Degeneration of nigrostriatal dopaminergic neurons increases iron within the substantia nigra: a histochemical and neurochemical study. Brain Res. 660:8-18
    • (1994) Brain Res. , vol.660 , pp. 8-18
    • Oestreicher, E.1    Sengstock, G.J.2    Riederer, P.3    Olanow, C.W.4    Dunn, A.J.5    Arendash, G.6
  • 73
    • 0028343897 scopus 로고
    • Differential effects of chronic L-DOPA treatment on lipid peroxidation in the mouse brain with or without pretreatment with 6-hydro-xydopamine
    • Ogawa N, Asanuma M, Kondo Y, et al. 1994. Differential effects of chronic L-DOPA treatment on lipid peroxidation in the mouse brain with or without pretreatment with 6-hydro-xydopamine. Neurosci. Lett. 171:55-58
    • (1994) Neurosci. Lett. , vol.171 , pp. 55-58
    • Ogawa, N.1    Asanuma, M.2    Kondo, Y.3
  • 74
    • 0030298571 scopus 로고    scopus 로고
    • Pentoxyfylline delays the onset of experimental allergic encephalomyelitis in mice by modulating cytokine production in peripheral blood mononuclear cells
    • Okuda Y, Sakoda S, Fujimara H, Yamagihara T. 1997. Pentoxyfylline delays the onset of experimental allergic encephalomyelitis in mice by modulating cytokine production in peripheral blood mononuclear cells. Immunopharmacology 35:141-48
    • (1997) Immunopharmacology , vol.35 , pp. 141-148
    • Okuda, Y.1    Sakoda, S.2    Fujimara, H.3    Yamagihara, T.4
  • 75
    • 0025242960 scopus 로고
    • Oxidation reactions in Parkinson's disease
    • Olanow CW. 1990. Oxidation reactions in Parkinson's disease. Neurology 40:32-37
    • (1990) Neurology , vol.40 , pp. 32-37
    • Olanow, C.W.1
  • 76
    • 0027496238 scopus 로고
    • A radical hypothesis for neurodegeneration
    • Olanow CW. 1993. A radical hypothesis for neurodegeneration. Trends Neurosci. 16:439-44
    • (1993) Trends Neurosci. , vol.16 , pp. 439-444
    • Olanow, C.W.1
  • 77
    • 0028858370 scopus 로고
    • The effect of deprenyl and levodopa on the progression of Parkinson's disease
    • Olanow CW, Hauser RA, Gauger L, Malapira T, Koller W, et al. 1995. The effect of deprenyl and levodopa on the progression of Parkinson's disease. Ann. Neurol. 38:771-77
    • (1995) Ann. Neurol. , vol.38 , pp. 771-777
    • Olanow, C.W.1    Hauser, R.A.2    Gauger, L.3    Malapira, T.4    Koller, W.5
  • 78
    • 0002762598 scopus 로고    scopus 로고
    • Neurodegeneration in Parkinson's disease
    • ed. J Jankovic, E Tolosa. Baltimore, MD: Williams & Wilkins. 3rd ed.
    • Olanow CW, Jenner P, Tatton N, Tatton WG. 1998. Neurodegeneration in Parkinson's disease. In Parkinson's Disease and Movement Disorders, ed. J Jankovic, E Tolosa, pp. 67-103. Baltimore, MD: Williams & Wilkins. 3rd ed.
    • (1998) Parkinson's Disease and Movement Disorders , pp. 67-103
    • Olanow, C.W.1    Jenner, P.2    Tatton, N.3    Tatton, W.G.4
  • 79
    • 0002563935 scopus 로고    scopus 로고
    • Iron and neurodegeneration: Prospects for neuroprotection
    • ed. CW Olanow, P Jenner, MHB Youdim. London: Academic
    • Olanow CW, Youdim MHB. 1996. Iron and neurodegeneration: prospects for neuroprotection. In Neurodegeneration and Neuroprotection in Parkinson's Disease, ed. CW Olanow, P Jenner, MHB Youdim, pp. 55-67. London: Academic
    • (1996) Neurodegeneration and Neuroprotection in Parkinson's Disease , pp. 55-67
    • Olanow, C.W.1    Youdim, M.H.B.2
  • 80
    • 0027530638 scopus 로고
    • Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease
    • Parkinson's Study Group. 1993. Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease. N. Engl. J. Med. 328:176-83
    • (1993) N. Engl. J. Med. , vol.328 , pp. 176-183
  • 81
    • 0029897501 scopus 로고    scopus 로고
    • Subthalamic nucleus lesion in rat prevents dopaminergic nigral neuron degeneration after striatal 6-OHDA injection
    • Piallat B, Bennazouz A, Bressand L, et al. 1996. Subthalamic nucleus lesion in rat prevents dopaminergic nigral neuron degeneration after striatal 6-OHDA injection. Eur. J. Neurosci. 8:1408-14
    • (1996) Eur. J. Neurosci. , vol.8 , pp. 1408-1414
    • Piallat, B.1    Bennazouz, A.2    Bressand, L.3
  • 82
    • 0024537271 scopus 로고
    • Reduction of brain glutathione by L-buthionine sulfoximine potentiates the dopamine-depleting action of 6-hydroxydopamine in rat striatum
    • Pileblad E, Magnusson T, Fornstedt B. 1989. Reduction of brain glutathione by L-buthionine sulfoximine potentiates the dopamine-depleting action of 6-hydroxydopamine in rat striatum. J. Neurochem. 52:978-80
    • (1989) J. Neurochem. , vol.52 , pp. 978-980
    • Pileblad, E.1    Magnusson, T.2    Fornstedt, B.3
  • 84
    • 0030744876 scopus 로고    scopus 로고
    • Mutation in the α-synuclein gene identified in families with Parkinson's disease
    • Polymeropoulos MH, Lavedan C, Leroy E, Ide SE, Dehejia A, et al. 1997. Mutation in the α-synuclein gene identified in families with Parkinson's disease. Science 276:2045-47
    • (1997) Science , vol.276 , pp. 2045-2047
    • Polymeropoulos, M.H.1    Lavedan, C.2    Leroy, E.3    Ide, S.E.4    Dehejia, A.5
  • 85
    • 0031719120 scopus 로고    scopus 로고
    • Autosomal dominant Parkinson's disease and alpha synuclein
    • In press
    • Polymeropoulos MH. 1998. Autosomal dominant Parkinson's disease and alpha synuclein. Ann. Neurol. In press
    • (1998) Ann. Neurol.
    • Polymeropoulos, M.H.1
  • 87
    • 0031696407 scopus 로고    scopus 로고
    • Subthalamic nucleus-mediated excitotoxicity in Parkinson's disease: A possible target for neuroprotection
    • In press
    • Rodriguez MC, Obeso JA, Olanow CW. 1998. Subthalamic nucleus-mediated excitotoxicity in Parkinson's disease: a possible target for neuroprotection. Ann. Neurol. In press
    • (1998) Ann. Neurol.
    • Rodriguez, M.C.1    Obeso, J.A.2    Olanow, C.W.3
  • 89
    • 0000232034 scopus 로고
    • A marker of oxyradical-mediated DNA damage (8-hydroxy-2′deoxyguanosine) is increased in nigro-striatum of Parkinson's disease brain
    • Sanchez-Ramos J, Overvik E, Ames BN. 1994. A marker of oxyradical-mediated DNA damage (8-hydroxy-2′deoxyguanosine) is increased in nigro-striatum of Parkinson's disease brain. Neurodegeneration 3:197-204
    • (1994) Neurodegeneration , vol.3 , pp. 197-204
    • Sanchez-Ramos, J.1    Overvik, E.2    Ames, B.N.3
  • 90
    • 0030868934 scopus 로고    scopus 로고
    • Glyderaldehyde-3-phosphate dehydrogenase: Nuclear translocation participates in neuronal and non-neuronal cell death
    • Sawa A, Khan AA, Hester LD, Snyder SH. 1997. Glyderaldehyde-3-phosphate dehydrogenase: nuclear translocation participates in neuronal and non-neuronal cell death. Proc. Natl. Acad. Sci. USA 94:11669-74
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 11669-11674
    • Sawa, A.1    Khan, A.A.2    Hester, L.D.3    Snyder, S.H.4
  • 91
    • 0025254401 scopus 로고
    • Mitochondrial complex I deficiency in Parkinson's disease
    • Schapira AHV, Cooper JM, Dexter D, et al. 1990. Mitochondrial complex I deficiency in Parkinson's disease. J. Neurochem. 54:823-27
    • (1990) J. Neurochem. , vol.54 , pp. 823-827
    • Schapira, A.H.V.1    Cooper, J.M.2    Dexter, D.3
  • 92
    • 0028631458 scopus 로고
    • The role of Jun transcription factor expression and phosphorylation in neuronal differentiation, neuronal cell death, and plastic adaptations in vivo
    • Schlingensiepen KH, Wollnik F, Kunst M, Schlingensiepen R, Herdegen T, Brysch W. 1994. The role of Jun transcription factor expression and phosphorylation in neuronal differentiation, neuronal cell death, and plastic adaptations in vivo. Cell Mol. Neurobiol. 14:487-505
    • (1994) Cell Mol. Neurobiol. , vol.14 , pp. 487-505
    • Schlingensiepen, K.H.1    Wollnik, F.2    Kunst, M.3    Schlingensiepen, R.4    Herdegen, T.5    Brysch, W.6
  • 93
    • 0028978106 scopus 로고
    • Coenzyme Q10 and nicotinamide and a free radical spin trap protect against MPTP toxicity
    • Schulz JB, Henshaw DR, Matthews RT, Beal MF. 1995a. Coenzyme Q10 and nicotinamide and a free radical spin trap protect against MPTP toxicity. Exp. Neurol. 132:279-83
    • (1995) Exp. Neurol. , vol.132 , pp. 279-283
    • Schulz, J.B.1    Henshaw, D.R.2    Matthews, R.T.3    Beal, M.F.4
  • 94
    • 0028796770 scopus 로고
    • Inhibition of neuronal nitric oxide synthase by 7-nitroindazole protects against MPTP-induced neurotoxicity in mice
    • Schulz JB, Matthews RT, Muqit MMK, Browne SE, Beal MF. 1995b. Inhibition of neuronal nitric oxide synthase by 7-nitroindazole protects against MPTP-induced neurotoxicity in mice. J. Neurochem. 64:936-39
    • (1995) J. Neurochem. , vol.64 , pp. 936-939
    • Schulz, J.B.1    Matthews, R.T.2    Muqit, M.M.K.3    Browne, S.E.4    Beal, M.F.5
  • 95
    • 0025329856 scopus 로고
    • Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 1-methyl-4-phenyl-pyridinium ion on ATP levels of mouse synaptosomes
    • Scotcher KP, Irwin I, DeLanney LE, et al. 1990. Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 1-methyl-4-phenyl-pyridinium ion on ATP levels of mouse synaptosomes. J. Neurochem. 54:1295-301
    • (1990) J. Neurochem. , vol.54 , pp. 1295-1301
    • Scotcher, K.P.1    Irwin, I.2    DeLanney, L.E.3
  • 96
    • 0027221546 scopus 로고
    • Infusion of iron into the rat substantia nigra: Nigral pathology and dose-dependent loss of striatal dopaminergic markers
    • Sengstock GJ, Olanow CW, Dunn AJ, Arendash GW. 1993. Infusion of iron into the rat substantia nigra: nigral pathology and dose-dependent loss of striatal dopaminergic markers. J. Neurosci. Res. 35:67-82
    • (1993) J. Neurosci. Res. , vol.35 , pp. 67-82
    • Sengstock, G.J.1    Olanow, C.W.2    Dunn, A.J.3    Arendash, G.W.4
  • 97
    • 0028556407 scopus 로고
    • Progressive changes in striatal dopaminergic markers, nigral volume, and rotational behavior following iron infusion into the rat substantia nigra
    • Sengstock G, Olanow CW, Dunn AJ, Barone S, Arendash G. 1994. Progressive changes in striatal dopaminergic markers, nigral volume, and rotational behavior following iron infusion into the rat substantia nigra. Exp. Neurol. 130:82-94
    • (1994) Exp. Neurol. , vol.130 , pp. 82-94
    • Sengstock, G.1    Olanow, C.W.2    Dunn, A.J.3    Barone, S.4    Arendash, G.5
  • 98
    • 0028075410 scopus 로고
    • Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia
    • Sian J, Dexter DT, Lees AJ, et al. 1994a. Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia. Ann. Neurol. 36:348-55
    • (1994) Ann. Neurol. , vol.36 , pp. 348-355
    • Sian, J.1    Dexter, D.T.2    Lees, A.J.3
  • 100
    • 0023224837 scopus 로고
    • Biochemical events in the development of parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
    • Singer TP, Castagnoli N Jr, Ramsay RR, Trevor AJ. 1987. Biochemical events in the development of parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. J. Neurochem. 49:1-8
    • (1987) J. Neurochem. , vol.49 , pp. 1-8
    • Singer, T.P.1    Castagnoli N., Jr.2    Ramsay, R.R.3    Trevor, A.J.4
  • 101
    • 0026644192 scopus 로고
    • Reduced and oxidized glutathione in the substantia nigra of patients with Parkinson's disease
    • Sofic E, Lange KW, Jellinger K, Riederer P. 1992. Reduced and oxidized glutathione in the substantia nigra of patients with Parkinson's disease. Neurosci. Lett. 142:128-30
    • (1992) Neurosci. Lett. , vol.142 , pp. 128-130
    • Sofic, E.1    Lange, K.W.2    Jellinger, K.3    Riederer, P.4
  • 103
    • 12644257556 scopus 로고    scopus 로고
    • Neurotrophic immunophilin ligands stimulate structural and functional recovery in neurodegenerative animal models
    • Steiner JP, Hamilton GS, Ross DT, Valentine HL, Guo H, et al. 1997. Neurotrophic immunophilin ligands stimulate structural and functional recovery in neurodegenerative animal models. Proc. Natl. Acad. Sci. USA 94:2019-24
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 2019-2024
    • Steiner, J.P.1    Hamilton, G.S.2    Ross, D.T.3    Valentine, H.L.4    Guo, H.5
  • 104
    • 0029950290 scopus 로고    scopus 로고
    • Bcl-2 inhibits the mitochondrial release of an apoptogenic protease
    • Susin SA, Zamzami N, Castedo M, Hirsch T, Marchetti P, et al. 1996a. Bcl-2 inhibits the mitochondrial release of an apoptogenic protease. J. Exp. Med. 184:1331-41
    • (1996) J. Exp. Med. , vol.184 , pp. 1331-1341
    • Susin, S.A.1    Zamzami, N.2    Castedo, M.3    Hirsch, T.4    Marchetti, P.5
  • 105
    • 0001425438 scopus 로고    scopus 로고
    • The cell biology of apoptosis: Evidence for the implication of mitochondria
    • Susin SA, Zamzami N, Kroemer G. 1996b. The cell biology of apoptosis: evidence for the implication of mitochondria. Apoptosis 1:231-42
    • (1996) Apoptosis , vol.1 , pp. 231-242
    • Susin, S.A.1    Zamzami, N.2    Kroemer, G.3
  • 106
    • 0029908226 scopus 로고    scopus 로고
    • Origin and functional consequences of the complex I defect in Parkinson's disease
    • Swerdlow RH, Parks JK, Miller SW, Tuttle JB, Trimmer PA, et al. 1996. Origin and functional consequences of the complex I defect in Parkinson's disease. Ann. Neurol. 40:663-71
    • (1996) Ann. Neurol. , vol.40 , pp. 663-671
    • Swerdlow, R.H.1    Parks, J.K.2    Miller, S.W.3    Tuttle, J.B.4    Trimmer, P.A.5
  • 107
    • 0025200313 scopus 로고
    • Do environmental toxins cause Parkinson's disease? A critical review
    • Tanner CM, Langston JW. 1990. Do environmental toxins cause Parkinson's disease? A critical review. Neurology 40:17-30
    • (1990) Neurology , vol.40 , pp. 17-30
    • Tanner, C.M.1    Langston, J.W.2
  • 108
    • 0000166310 scopus 로고    scopus 로고
    • Parkinson's disease (PD) concordance in elderly mate monozygotic (MZ) and dizygotic (DZ) twins
    • Tanner CM, Ottman R, Ellenberg JH, et al. 1997. Parkinson's disease (PD) concordance in elderly mate monozygotic (MZ) and dizygotic (DZ) twins. Neurology 48:333
    • (1997) Neurology , vol.48 , pp. 333
    • Tanner, C.M.1    Ottman, R.2    Ellenberg, J.H.3
  • 109
    • 0030888286 scopus 로고    scopus 로고
    • In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice using terminal deoxynucleotidyl transferase labelling and acridine orange staining
    • Tatton NA, Kish SJ. 1997. In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice using terminal deoxynucleotidyl transferase labelling and acridine orange staining. Neuroscience 77:1037-48
    • (1997) Neuroscience , vol.77 , pp. 1037-1048
    • Tatton, N.A.1    Kish, S.J.2
  • 110
    • 0031696403 scopus 로고    scopus 로고
    • A fluorescent double-labeling method to detect and confirm apoptotic nuclei in Parkinson's disease
    • In press
    • Tatton NA, Maclean-Fraser A, Tatton WG, Perl DF, Olanow CW. 1998. A fluorescent double-labeling method to detect and confirm apoptotic nuclei in Parkinson's disease. Ann. Neurol. In press
    • (1998) Ann. Neurol.
    • Tatton, N.A.1    Maclean-Fraser, A.2    Tatton, W.G.3    Perl, D.F.4    Olanow, C.W.5
  • 111
    • 0029731378 scopus 로고    scopus 로고
    • Modulation of gene expression rather than monoamine oxidase inhibition: (-) Deprenyl-related compounds in controlling neuro-degeneration
    • Tatton WG, Chalmers-Redman RME. 1996. Modulation of gene expression rather than monoamine oxidase inhibition: (-) deprenyl-related compounds in controlling neuro-degeneration. Neurology 47:171-83
    • (1996) Neurology , vol.47 , pp. 171-183
    • Tatton, W.G.1    Chalmers-Redman, R.M.E.2
  • 112
  • 113
    • 0027941312 scopus 로고
    • (-)-Deprenyl reduces PC12 cell apoptosis by inducing new protein synthesis
    • Tatton WG, Ju WY, Holland DP, Tai C, Kwan M. 1994. (-)-Deprenyl reduces PC12 cell apoptosis by inducing new protein synthesis. J. Neurochem. 63:1572-75
    • (1994) J. Neurochem. , vol.63 , pp. 1572-1575
    • Tatton, W.G.1    Ju, W.Y.2    Holland, D.P.3    Tai, C.4    Kwan, M.5
  • 114
    • 0000191245 scopus 로고    scopus 로고
    • Reduction of neuronal apoptosis by small molecules: Promise for new approaches to neurological therapy
    • ed. CW Olanow, M Youdim, P Jenner. New York: Academic
    • Tatton WG, Ju WJH, Wadia J, Tatton NA. 1996. Reduction of neuronal apoptosis by small molecules: promise for new approaches to neurological therapy. In Neuroprotection and Neurodegeneration, ed. CW Olanow, M Youdim, P Jenner, pp. 209-29. New York: Academic
    • (1996) Neuroprotection and Neurodegeneration , pp. 209-229
    • Tatton, W.G.1    Ju, W.J.H.2    Wadia, J.3    Tatton, N.A.4
  • 115
    • 4243910796 scopus 로고    scopus 로고
    • Apoptosis in neurodegenerative disease: The role of mitochrondria
    • In press
    • Tatton WG, Olanow CW. 1998. Apoptosis in neurodegenerative disease: the role of mitochrondria. Biochim. Biophys. Acta. In press
    • (1998) Biochim. Biophys. Acta
    • Tatton, W.G.1    Olanow, C.W.2
  • 116
    • 0028045734 scopus 로고
    • Increased iron in the substantia nigra compacta of the MPTP-lesioned hemiparkinsonian African green monkey: Evidence from proton microprobe elemental microanalysis
    • Temlett JA, Landsberg JP, Watt F, Grime GW. 1994. Increased iron in the substantia nigra compacta of the MPTP-lesioned hemiparkinsonian African green monkey: evidence from proton microprobe elemental microanalysis. J. Neurochem. 62:134-46
    • (1994) J. Neurochem. , vol.62 , pp. 134-146
    • Temlett, J.A.1    Landsberg, J.P.2    Watt, F.3    Grime, G.W.4
  • 117
    • 0031025924 scopus 로고    scopus 로고
    • Chronic glutathione depletion in rat brain does not cause nigrostriatal pathway degeneration
    • Toffa S, Kunikowska GM, Zeng B-Y, Jenner P, Marsden CD. 1997. Chronic glutathione depletion in rat brain does not cause nigrostriatal pathway degeneration. J. Neural Transm. 104:67-75
    • (1997) J. Neural Transm. , vol.104 , pp. 67-75
    • Toffa, S.1    Kunikowska, G.M.2    Zeng, B.-Y.3    Jenner, P.4    Marsden, C.D.5
  • 118
    • 0028834063 scopus 로고
    • Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo
    • Tomac A, Lindqvist E, Lin LFH, Ogren SO, Young D, et al. 1995. Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo. Nature 373:335-39
    • (1995) Nature , vol.373 , pp. 335-339
    • Tomac, A.1    Lindqvist, E.2    Lin, L.F.H.3    Ogren, S.O.4    Young, D.5
  • 119
    • 0028221169 scopus 로고
    • Down-regulation of copper/zinc superoxide dismutase causes apoptotic death in PC12 neuronal cells
    • Troy CM, Shelanski ML. 1994. Down-regulation of copper/zinc superoxide dismutase causes apoptotic death in PC12 neuronal cells. Proc. Natl. Acad. Sci. USA 91:6384-87
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 6384-6387
    • Troy, C.M.1    Shelanski, M.L.2
  • 121
    • 0027489773 scopus 로고
    • Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease
    • Ueda K, Fukushima H, Masliah E, Xia Y, Iwai A, et al. 1993. Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. Proc. Natl. Acad. Sci. USA 90:11282-86
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 11282-11286
    • Ueda, K.1    Fukushima, H.2    Masliah, E.3    Xia, Y.4    Iwai, A.5
  • 122
    • 0031890109 scopus 로고    scopus 로고
    • Mitochondrial membrane potential and nuclear changes in apoptosis caused by trophic withdrawal: Time course and modification by (-) deprenyl
    • Wadia JS, Chalmers-Redman RME, Ju WJH, Carlile GW, Phillips JL, Tatton WG. 1998. Mitochondrial membrane potential and nuclear changes in apoptosis caused by trophic withdrawal: time course and modification by (-) deprenyl. J. Neurosci. 18:932-47
    • (1998) J. Neurosci. , vol.18 , pp. 932-947
    • Wadia, J.S.1    Chalmers-Redman, R.M.E.2    Ju, W.J.H.3    Carlile, G.W.4    Phillips, J.L.5    Tatton, W.G.6
  • 123
    • 0029051317 scopus 로고
    • Induction of apoptosis in catecholaminergic PC12 cells by L-DOPA. Implications for the treatment of Parkinson's disease
    • Walkinshaw G, Waters CM. 1995. Induction of apoptosis in catecholaminergic PC12 cells by L-DOPA. Implications for the treatment of Parkinson's disease. J. Clin. Invest. 95:2458-64
    • (1995) J. Clin. Invest. , vol.95 , pp. 2458-2464
    • Walkinshaw, G.1    Waters, C.M.2
  • 124
    • 0029904487 scopus 로고    scopus 로고
    • NACP, a protein implicated in Alzheimer's disease and learning, is naturally unfolded
    • Weinreb PH, Zhen W, Poon AW, Conway KA, Lansbury PT. 1996. NACP, a protein implicated in Alzheimer's disease and learning, is naturally unfolded. Biochemistry 35:13709-15
    • (1996) Biochemistry , vol.35 , pp. 13709-13715
    • Weinreb, P.H.1    Zhen, W.2    Poon, A.W.3    Conway, K.A.4    Lansbury, P.T.5
  • 125
    • 0031696267 scopus 로고    scopus 로고
    • Genetic risk factors in Parkinson's disease
    • In press
    • Wood N. 1998. Genetic risk factors in Parkinson's disease. Ann. Neurol. In press
    • (1998) Ann. Neurol.
    • Wood, N.1
  • 128
    • 0029116916 scopus 로고
    • The mitochondrial permeability transition
    • Zoratti M, Szabo I. 1995. The mitochondrial permeability transition. Biochim. Biophys. Acta 1241:139-76
    • (1995) Biochim. Biophys. Acta , vol.1241 , pp. 139-176
    • Zoratti, M.1    Szabo, I.2


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