Adult motor neuron apoptosis is mediated by nitric oxide and Fas death receptor linked by DNA damage and p53 activation

Journal of Neuroscience

Volumn 25, Issue 27, 2005, Pages 6449-6459

  Martin, Lee J ^a   Chen, Kevin ^a   Liu, Zhiping ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Amyotrophic lateral sclerosis; Axotomy; Cell death; DNA damage; Mutant SOD1; Spinal cord injury

Indexed keywords

ANTIOXIDANT; ASCORBIC ACID; COPPER ZINC SUPEROXIDE DISMUTASE; DNA; DNA GLYCOSYLTRANSFERASE; FAS LIGAND; INDUCIBLE NITRIC OXIDE SYNTHASE; MUTANT PROTEIN; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; PEROXYNITRITE; PROTEIN P53; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE; RNA; SINGLE STRANDED DNA; TROLOX C;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; IMMUNOHISTOCHEMISTRY; MOTONEURON; MOTOR NEURON DISEASE; MOUSE; NERVE CELL; NERVE FIBER TRANSECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SPINAL CORD INJURY;

AMINO ACID SUBSTITUTION; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; ANTERIOR HORN CELLS; ANTIGENS, CD95; ANTIOXIDANTS; APOPTOSIS; CASPASE 8; CASPASES; CHROMANS; DISEASE MODELS, ANIMAL; DNA DAMAGE; DNA GLYCOSYLASES; DNA REPAIR; ENZYME INDUCTION; FAS LIGAND PROTEIN; HUMANS; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NADPH DEHYDROGENASE; NECROSIS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE II; OXIDATIVE STRESS; PEROXYNITROUS ACID; POINT MUTATION; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT FUSION PROTEINS; SCIATIC NERVE; SUPEROXIDE DISMUTASE; SUPEROXIDES; TUMOR NECROSIS FACTORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 21844470751     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0911-05.2005     Document Type: Article

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