Als2-deficient mice exhibit disturbances in endosome trafficking associated with motor behavioral abnormalities

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 25, 2006, Pages 9595-9600

  Devon, R S ^a,f   Orban, P C ^a   Gerrow, K ^b   Barbieri, M A ^c   Schwab, C ^a   Cao, L P ^a   Helm, J R ^a   Bissada, M ^a   Cruz Aguado, R ^a   Davidson, T L ^a   Witmer, J ^a   Metzler, M ^a   Lam, C K ^e   Tetzlaff, W ^e   Simpson, E M ^a   McCaffery, J M ^d   El Husseini, A E ^b   Leavitt, B R ^a   Hayden, M R ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c FLORIDA INTERNATIONAL UNIVERSITY   (United States)

^d JOHNS HOPKINS UNIVERSITY   (United States)

^e UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^f UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

ALS; Alsin; Knockout mouse; Motor neuron; Rab5

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; DEXTRAN; GUANOSINE TRIPHOSPHATASE; PROTEIN ALSIN; RAB PROTEIN; RAC1 PROTEIN; SOMATOMEDIN C; TRANSCRIPTION FACTOR; TRANSFERRIN; UNCLASSIFIED DRUG;

ALS2 GENE; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; AUTOSOMAL RECESSIVE DISORDER; CELL VIABILITY; CONTROLLED STUDY; CYTOSOL; DISEASE COURSE; ENDOCYTOSIS; ENDOSOME; FEMALE; GENE; HISTOPATHOLOGY; LOCOMOTION; MALE; MOTOR CORTEX; MOTOR NEURON DISEASE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SPASTIC PARESIS;

ANIMALS; BEHAVIOR, ANIMAL; BODY WEIGHT; CYTOSOL; ENDOCYTOSIS; ENDOSOMES; GUANINE NUCLEOTIDE EXCHANGE FACTORS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOTOR ACTIVITY; MOTOR NEURONS; MOTOR SKILLS DISORDERS; PHYSICAL CONDITIONING, ANIMAL; PROTEIN TRANSPORT; RECEPTOR, TRKB; TIME FACTORS;

ANIMALIA;

EID: 33745473350     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0510197103     Document Type: Article

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