The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis

Nature Genetics

Volumn 29, Issue 2, 2001, Pages 160-165

  Yang, Yi ^a   Hentati, Afif ^a   Deng, Han Xiang ^a   Dabbagh, Omar ^b   Sasaki, Toru ^a   Hirano, Makito ^a   Hung, Wu Yen ^a   Ouahchi, Karim ^a   Yan, Jianhua ^a   Azim, Anser C ^a   Cole, Natalie ^a   Gascon, Generoso ^c   Yagmour, Ayesha ^d   Ben Hamida, Mongi ^e   Pericak Vance, Margaret ^f   Hentati, Fayçal ^e   Siddique, Teepu ^a,g  

^a NORTHWESTERN UNIVERSITY   (United States)

^b KING FAISAL SPECIALIST HOSPITAL AND RESEARCH CENTER   (Saudi Arabia)

^c BROWN UNIVERSITY   (United States)

^d KING FAHD ARMED FORCES HOSPITAL   (Saudi Arabia)

^e Institut National de Neurologie Tunisia   (Tunisia)

^f DUKE UNIVERSITY MEDICAL CENTER   (United States)

^g NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALSIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE TRIPHOSPHATASE; PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CHROMOSOME 2Q; FEMALE; GENE DELETION; GENE LOCUS; GENE MUTATION; GENETIC LINKAGE; HUMAN; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PEDIGREE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN;

AMINO ACID SEQUENCE; AMYOTROPHIC LATERAL SCLEROSIS; BASE SEQUENCE; CLONING, MOLECULAR; DNA PRIMERS; FEMALE; GENES, RECESSIVE; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; LINKAGE (GENETICS); MALE; MOLECULAR SEQUENCE DATA; MUTATION; PEDIGREE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION;

EID: 0034785509     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng1001-160     Document Type: Article

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