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Volumn 88, Issue 2, 2004, Pages 401-410

Axonal transport of human α-synuclein slows with aging but is not affected by familial Parkinson's disease-linked mutations

Author keywords

Axonal transport; Lewy bodies; Lewy neurites; Parkinson's disease; Transgenic mice; synucleinopathy

Indexed keywords

ALPHA SYNUCLEIN;

EID: 0347717732     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2003.02166.x     Document Type: Article
Times cited : (66)

References (62)
  • 1
    • 0034077041 scopus 로고    scopus 로고
    • Mice lacking α-synuclein display functional deficits in the nigrostriatal dopamine system
    • Abeliovich A., Schmitz Y., Farinas I. et al. (2000) Mice lacking α-synuclein display functional deficits in the nigrostriatal dopamine system. Neuron 25, 239-252.
    • (2000) Neuron , vol.25 , pp. 239-252
    • Abeliovich, A.1    Schmitz, Y.2    Farinas, I.3
  • 2
    • 0037127216 scopus 로고    scopus 로고
    • Tubulin seeds α-synuclein fibril formation
    • Alim M. A., Hossain M. S., Arima K. et al. (2002) Tubulin seeds α-synuclein fibril formation. J. Biol. Chem. 277, 2112-2117.
    • (2002) J. Biol. Chem. , vol.277 , pp. 2112-2117
    • Alim, M.A.1    Hossain, M.S.2    Arima, K.3
  • 3
    • 0037428241 scopus 로고    scopus 로고
    • Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
    • Bonifati V., Rizzu P., van Baren M. J. et al. (2003) Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. Science 299, 256-259.
    • (2003) Science , vol.299 , pp. 256-259
    • Bonifati, V.1    Rizzu, P.2    Van Baren, M.J.3
  • 5
    • 0032126386 scopus 로고    scopus 로고
    • Axonal transport of mutant superoxide dismutase 1 and focal axonal abnormalities in the proximal axons of transgenic mice
    • Borchelt D. R., Wong P. C., Becher M. W. et al. (1998) Axonal transport of mutant superoxide dismutase 1 and focal axonal abnormalities in the proximal axons of transgenic mice. Neurobiol. Dis. 5, 27-35.
    • (1998) Neurobiol. Dis. , vol.5 , pp. 27-35
    • Borchelt, D.R.1    Wong, P.C.2    Becher, M.W.3
  • 7
    • 0033215063 scopus 로고    scopus 로고
    • Synucleins in synaptic plasticity and neurodegenerative disorders
    • Clayton D. F. and George J. M. (1999) Synucleins in synaptic plasticity and neurodegenerative disorders. J. Neurosci. Res. 58, 120-129.
    • (1999) J. Neurosci. Res. , vol.58 , pp. 120-129
    • Clayton, D.F.1    George, J.M.2
  • 8
    • 84940364788 scopus 로고    scopus 로고
    • α-synuclein and the lewy body disorders
    • Dickson D. W. (2001) α-Synuclein and the lewy body disorders. Curr. Opin. Neurol. 14, 423-432.
    • (2001) Curr. Opin. Neurol. , vol.14 , pp. 423-432
    • Dickson, D.W.1
  • 9
    • 0033678217 scopus 로고    scopus 로고
    • Widespread nitration of pathological inclusions in neurodegenerative synucleinopathies
    • Duda J. E., Giasson B. I., Chen Q. et al. (2000a) Widespread nitration of pathological inclusions in neurodegenerative synucleinopathies. Am. J. Pathol. 157, 1439-1445.
    • (2000) Am. J. Pathol. , vol.157 , pp. 1439-1445
    • Duda, J.E.1    Giasson, B.I.2    Chen, Q.3
  • 10
    • 0033800039 scopus 로고    scopus 로고
    • Immunohistochemical and biochemical studies demonstrate a distinct profile of α-synuclein permutations in multiple system atrophy
    • Duda J. E., Giasson B. I., Gur T. L. et al. (2000b) Immunohistochemical and biochemical studies demonstrate a distinct profile of α-synuclein permutations in multiple system atrophy. J. Neuropathol. Exp. Neurol. 59, 830-841.
    • (2000) J. Neuropathol. Exp. Neurol. , vol.59 , pp. 830-841
    • Duda, J.E.1    Giasson, B.I.2    Gur, T.L.3
  • 11
    • 0003148419 scopus 로고    scopus 로고
    • Parkinsonism
    • (Rowland L. P., ed.). Lippincott Williams & Wilkins, New York
    • Fahn S. and Przedborski S. (2000) Parkinsonism. In: Merritt's Neurology (Rowland L. P., ed.), pp. 679-695. Lippincott Williams & Wilkins, New York.
    • (2000) Merritt's Neurology , pp. 679-695
    • Fahn, S.1    Przedborski, S.2
  • 12
    • 0034704752 scopus 로고    scopus 로고
    • A Drosophila model of Parkinson's disease
    • Feany M. B. and Bender W. W. (2000) A Drosophila model of Parkinson's disease. Nature 404, 394-398.
    • (2000) Nature , vol.404 , pp. 394-398
    • Feany, M.B.1    Bender, W.W.2
  • 13
    • 0032692501 scopus 로고    scopus 로고
    • α-synuclein immunoisolation of glial inclusions from multiple system atrophy brain tissue reveals multiprotein components
    • Gai W. P., Power J. H., Blumbergs P. C., Culvenor J. G. and Jensen P. H. (1999) α-Synuclein immunoisolation of glial inclusions from multiple system atrophy brain tissue reveals multiprotein components. J. Neurochem. 73, 2093-2100.
    • (1999) J. Neurochem. , vol.73 , pp. 2093-2100
    • Gai, W.P.1    Power, J.H.2    Blumbergs, P.C.3    Culvenor, J.G.4    Jensen, P.H.5
  • 14
    • 0033539664 scopus 로고    scopus 로고
    • Axon pathology in Parkinson's disease and Lewy body dementia hippocampus contains α-, β-, and γ-synuclein
    • Galvin J. E., Uryu K., Lee V. M. and Trojanowski J. Q. (1999) Axon pathology in Parkinson's disease and Lewy body dementia hippocampus contains α-, β-, and γ-synuclein. Proc. Natl Acad. Sci. USA 96, 13450-13455.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 13450-13455
    • Galvin, J.E.1    Uryu, K.2    Lee, V.M.3    Trojanowski, J.Q.4
  • 16
    • 0036150971 scopus 로고    scopus 로고
    • The synucleins
    • George J. M. (2002) The synucleins. Genome Biol. 3, 3002.1-3002.6.
    • (2002) Genome Biol. , vol.3 , pp. 30021-30026
    • George, J.M.1
  • 17
    • 0001477529 scopus 로고    scopus 로고
    • Songbirds, synelfin, and neurodegenerative disease
    • George J. M. and Clayton D. F. (1998) Songbirds, synelfin, and neurodegenerative disease. Neurosci. News 1, 12-17.
    • (1998) Neurosci. News , vol.1 , pp. 12-17
    • George, J.M.1    Clayton, D.F.2
  • 19
    • 0037118259 scopus 로고    scopus 로고
    • Neuronal α-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein
    • Giasson B. I., Duda J. E., Quinn S. M., Zhang B., Trojanowski J. Q. and Lee V. M. (2002) Neuronal α-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein. Neuron 34, 521-533.
    • (2002) Neuron , vol.34 , pp. 521-533
    • Giasson, B.I.1    Duda, J.E.2    Quinn, S.M.3    Zhang, B.4    Trojanowski, J.Q.5    Lee, V.M.6
  • 20
    • 0031576074 scopus 로고    scopus 로고
    • The awakening of α-synuclein
    • Goedert M. (1997) The awakening of α-synuclein. Nature 388, 232-233.
    • (1997) Nature , vol.388 , pp. 232-233
    • Goedert, M.1
  • 21
    • 0031789960 scopus 로고    scopus 로고
    • Lewy body diseases and multiple system atrophy as α -synucleinopathies
    • Goedert M. and Spillantini M. G. (1998) Lewy body diseases and multiple system atrophy as α-synucleinopathies. Mol. Psychiatry 3, 462-465.
    • (1998) Mol. Psychiatry , vol.3 , pp. 462-465
    • Goedert, M.1    Spillantini, M.G.2
  • 22
    • 0030727581 scopus 로고    scopus 로고
    • The mechanisms of fast and slow transport in neurons: Identification and characterization of the new kinesin superfamily motors
    • Hirokawa N. (1997) The mechanisms of fast and slow transport in neurons: identification and characterization of the new kinesin superfamily motors. Curr. Opin. Neurobiol. 7, 605-614.
    • (1997) Curr. Opin. Neurobiol. , vol.7 , pp. 605-614
    • Hirokawa, N.1
  • 23
    • 0016541063 scopus 로고
    • The slow component of axonal transport. Identification of major structural polypeptides of the axon and their generality among mammalian neurons
    • Hoffman P. N. and Lasek R. J. (1975) The slow component of axonal transport. Identification of major structural polypeptides of the axon and their generality among mammalian neurons. J. Cell Biol. 66, 351-366.
    • (1975) J. Cell Biol. , vol.66 , pp. 351-366
    • Hoffman, P.N.1    Lasek, R.J.2
  • 24
    • 0020962034 scopus 로고
    • Slowing of the axonal transport of neurofilament proteins during development
    • Hoffman P. N., Lasek R. J., Griffin J. W. and Price D. L. (1983) Slowing of the axonal transport of neurofilament proteins during development. J. Neurosci. 3, 1694-1700.
    • (1983) J. Neurosci. , vol.3 , pp. 1694-1700
    • Hoffman, P.N.1    Lasek, R.J.2    Griffin, J.W.3    Price, D.L.4
  • 25
    • 0026764984 scopus 로고
    • Axonal transport of class II and III β-tubulin: Evidence that the slow component wave represents the movement of only a small fraction of the tubulin in mature motor axons
    • Hoffman P. N., Lopata M. A., Watson D. F. and Luduena R. F. (1992) Axonal transport of class II and III β-tubulin: evidence that the slow component wave represents the movement of only a small fraction of the tubulin in mature motor axons. J. Cell Biol. 119, 595-604.
    • (1992) J. Cell Biol. , vol.119 , pp. 595-604
    • Hoffman, P.N.1    Lopata, M.A.2    Watson, D.F.3    Luduena, R.F.4
  • 26
    • 0032500599 scopus 로고    scopus 로고
    • Binding of α-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation
    • Jensen P. H., Nielsen M. S., Jakes R., Dotti C. G. and Goedert M. (1998) Binding of α-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation. J. Biol. Chem. 273, 26292-26294.
    • (1998) J. Biol. Chem. , vol.273 , pp. 26292-26294
    • Jensen, P.H.1    Nielsen, M.S.2    Jakes, R.3    Dotti, C.G.4    Goedert, M.5
  • 27
    • 0032824809 scopus 로고    scopus 로고
    • Axonal transport of synucleins is mediated by all rate components
    • Jensen P. H., Li J. Y., Dahlstrom A. and Dotti C. G. (1999) Axonal transport of synucleins is mediated by all rate components. Eur. J. Neurosci. 11, 3369-3376.
    • (1999) Eur. J. Neurosci. , vol.11 , pp. 3369-3376
    • Jensen, P.H.1    Li, J.Y.2    Dahlstrom, A.3    Dotti, C.G.4
  • 28
    • 0035191413 scopus 로고    scopus 로고
    • Selective insolubility of α-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model
    • Kahle P. J., Neumann M., Ozmen L. et al. (2001) Selective insolubility of α-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model. Am. J. Pathol. 159, 2215-2225.
    • (2001) Am. J. Pathol. , vol.159 , pp. 2215-2225
    • Kahle, P.J.1    Neumann, M.2    Ozmen, L.3
  • 31
    • 0346460948 scopus 로고    scopus 로고
    • Oxidative dimer formation is the critical rate-limiting step for Parkinson's disease α-synuclein fibrillogenesis
    • Krishnan S., Chi E. Y., Wood S. J. et al. (2003) Oxidative dimer formation is the critical rate-limiting step for Parkinson's disease α-synuclein fibrillogenesis. Biochemistry 42, 829-837.
    • (2003) Biochemistry , vol.42 , pp. 829-837
    • Krishnan, S.1    Chi, E.Y.2    Wood, S.J.3
  • 32
    • 0031990490 scopus 로고    scopus 로고
    • Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease
    • Kruger R., Kuhn W., Muller T. et al. (1998) Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease. Nat. Genet 18, 106-108.
    • (1998) Nat. Genet. , vol.18 , pp. 106-108
    • Kruger, R.1    Kuhn, W.2    Muller, T.3
  • 33
    • 0027212960 scopus 로고
    • The maximum rate of neurofilament transport in axons: A view of molecular transport mechanisms continuously engaged
    • Lasek R. J., Paggi P. and Katz M. J. (1993) The maximum rate of neurofilament transport in axons: a view of molecular transport mechanisms continuously engaged. Brain Res. 616, 58-64.
    • (1993) Brain Res. , vol.616 , pp. 58-64
    • Lasek, R.J.1    Paggi, P.2    Katz, M.J.3
  • 35
    • 0035066885 scopus 로고    scopus 로고
    • Direct binding and functional coupling of α-synuclein to the dopamine transproters accelerate dopamine induced apoptosis
    • Lee F. J. S., Liu F., Pristupa Z. B. and Niznik H. B. (2001) Direct binding and functional coupling of α-synuclein to the dopamine transproters accelerate dopamine induced apoptosis. FASEB. J. 15, 926.
    • (2001) FASEB J. , vol.15 , pp. 926
    • Lee, F.J.S.1    Liu, F.2    Pristupa, Z.B.3    Niznik, H.B.4
  • 36
    • 0037173006 scopus 로고    scopus 로고
    • Human α-synuclein-harboring familial Parkinson's disease-linked Ala-53→Thr mutation causes neurodegenerative disease with α-synuclein aggregation in transgenic mice
    • Lee M. K., Stirling W., Xu Y. et al. (2002) Human α -synuclein-harboring familial Parkinson's disease-linked Ala-53→Thr mutation causes neurodegenerative disease with α-synuclein aggregation in transgenic mice. Proc. Natl Acad. Sci. USA 99, 8968-8973.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 8968-8973
    • Lee, M.K.1    Stirling, W.2    Xu, Y.3
  • 37
    • 0034759869 scopus 로고    scopus 로고
    • α-synuclein in familial Alzheimer disease: Epitope mapping parallels dementia with Lewy bodies and Parkinson disease
    • Lippa C. F., Schmidt M. L., Lee V. M. and Trojanowski J. Q. (2001) α-Synuclein in familial Alzheimer disease: epitope mapping parallels dementia with Lewy bodies and Parkinson disease. Arch. Neurol. 58, 1817-1820.
    • (2001) Arch. Neurol. , vol.58 , pp. 1817-1820
    • Lippa, C.F.1    Schmidt, M.L.2    Lee, V.M.3    Trojanowski, J.Q.4
  • 38
    • 0036679197 scopus 로고    scopus 로고
    • α-synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease
    • Lo B. C., Ridet J. L., Schneider B. L., Deglon N. and Aebischer P. (2002) α-Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease. Proc. Natl Acad. Sci. USA 99, 10813-10818.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 10813-10818
    • Lo, B.C.1    Ridet, J.L.2    Schneider, B.L.3    Deglon, N.4    Aebischer, P.5
  • 39
    • 0034654503 scopus 로고    scopus 로고
    • Axonal transport of microtubule-associated protein 1B (MAP1B) in the sciatic nerve of adult rat: Distinct transport rates of different isoforms
    • Ma D., Himes B. T., Shea T. B. and Fischer I. (2000) Axonal transport of microtubule-associated protein 1B (MAP1B) in the sciatic nerve of adult rat: distinct transport rates of different isoforms. J. Neurosci. 20, 2112-2120.
    • (2000) J. Neurosci. , vol.20 , pp. 2112-2120
    • Ma, D.1    Himes, B.T.2    Shea, T.B.3    Fischer, I.4
  • 40
    • 0024462479 scopus 로고
    • Retardation in the slow axonal transport of cytoskeletal elements during maturation and aging
    • McQuarrie I. G., Brady S. T. and Lasek R. J. (1989) Retardation in the slow axonal transport of cytoskeletal elements during maturation and aging. Neurobiol. Aging 10, 359-365.
    • (1989) Neurobiol. Aging , vol.10 , pp. 359-365
    • McQuarrie, I.G.1    Brady, S.T.2    Lasek, R.J.3
  • 41
    • 0023722437 scopus 로고
    • Synuclein: A neuron-specific protein localized to the nucleus and pre-synaptic nerve terminal
    • Maroteaux L., Campanelli J. T. and Scheller R. H. (1988) Synuclein: a neuron-specific protein localized to the nucleus and pre-synaptic nerve terminal. J. Neurosci. 8, 2804-2815.
    • (1988) J. Neurosci. , vol.8 , pp. 2804-2815
    • Maroteaux, L.1    Campanelli, J.T.2    Scheller, R.H.3
  • 43
  • 44
    • 0036855635 scopus 로고    scopus 로고
    • Misfolded proteinase K-resistant hyperphosphorylated α-synuclein in aged transgenic mice with locomotor deterioration and in human α-synucleinopathies
    • Neumann M., Kahle P. J., Giasson B. I. et al. (2002) Misfolded proteinase K-resistant hyperphosphorylated α-synuclein in aged transgenic mice with locomotor deterioration and in human α-synucleinopathies. J. Clin. Invest. 110, 1429-1439.
    • (2002) J. Clin. Invest. , vol.110 , pp. 1429-1439
    • Neumann, M.1    Kahle, P.J.2    Giasson, B.I.3
  • 45
    • 0015775646 scopus 로고
    • Effect of maturation and aging on the rate of fast axoplasmic transport in mammalian nerve
    • Ochs S. (1973) Effect of maturation and aging on the rate of fast axoplasmic transport in mammalian nerve. Prog. Brain Res. 40, 349-362.
    • (1973) Prog. Brain Res. , vol.40 , pp. 349-362
    • Ochs, S.1
  • 47
    • 0037092442 scopus 로고    scopus 로고
    • A role for α-synuclein in the regulation of dopamine biosynthesis
    • Perez R. G., Waymire J. C., Lin E., Liu J. J., Guo F. and Zigmond M. J. (2002) A role for α-synuclein in the regulation of dopamine biosynthesis. J. Neurosci. 22, 3090-3099.
    • (2002) J. Neurosci. , vol.22 , pp. 3090-3099
    • Perez, R.G.1    Waymire, J.C.2    Lin, E.3    Liu, J.J.4    Guo, F.5    Zigmond, M.J.6
  • 48
    • 0030744876 scopus 로고    scopus 로고
    • Mutation in the α-synuclein gene identified in families with Parkinson's disease
    • Polymeropoulos M. H., Lavedan C., Leroy E. et al. (1997) Mutation in the α-synuclein gene identified in families with Parkinson's disease. Science 276, 2045-2047.
    • (1997) Science , vol.276 , pp. 2045-2047
    • Polymeropoulos, M.H.1    Lavedan, C.2    Leroy, E.3
  • 49
    • 0034609561 scopus 로고    scopus 로고
    • Inhibition of fibrillization and accumulation of prefibrillar oligomers in mixtures of human and mouse α-synuclein
    • Rochet J. C., Conway K. A. and Lansbury P. T. Jr (2000) Inhibition of fibrillization and accumulation of prefibrillar oligomers in mixtures of human and mouse α-synuclein. Biochemistry 39, 10619-10626.
    • (2000) Biochemistry , vol.39 , pp. 10619-10626
    • Rochet, J.C.1    Conway, K.A.2    Lansbury Jr., P.T.3
  • 50
    • 0034666282 scopus 로고    scopus 로고
    • Neurofilaments are transported rapidly but intermittently in axons: Implications for slow axonal transport
    • Roy S., Coffee P., Smith G., Liem R. K. H., Brady S. T. and Black M. M. (2000) Neurofilaments are transported rapidly but intermittently in axons: implications for slow axonal transport. J. Neurosci. 20, 6849-6861.
    • (2000) J. Neurosci. , vol.20 , pp. 6849-6861
    • Roy, S.1    Coffee, P.2    Smith, G.3    Liem, R.K.H.4    Brady, S.T.5    Black, M.M.6
  • 51
    • 0036468394 scopus 로고    scopus 로고
    • Slow axonal transport: Fast motors in the slow lane
    • Shah J. V. and Cleveland D. W. (2002) Slow axonal transport: fast motors in the slow lane. Curr. Opin. Cell Biol. 14, 58-62.
    • (2002) Curr. Opin. Cell Biol. , vol.14 , pp. 58-62
    • Shah, J.V.1    Cleveland, D.W.2
  • 52
    • 0035510709 scopus 로고    scopus 로고
    • Kinesin, dynein and neurofilament transport
    • Shea T. B. and Flanagan L. A. (2001) Kinesin, dynein and neurofilament transport. Trends Neurosci. 24, 644-648.
    • (2001) Trends Neurosci. , vol.24 , pp. 644-648
    • Shea, T.B.1    Flanagan, L.A.2
  • 53
    • 0034674652 scopus 로고    scopus 로고
    • Dityrosine cross-linking promotes formation of stable α-synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies
    • Souza J. M., Giasson B. I., Chen Q., Lee V. M. and Ischiropoulos H. (2000) Dityrosine cross-linking promotes formation of stable α-synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies. J. Biol. Chem. 275, 18344-18349.
    • (2000) J. Biol. Chem. , vol.275 , pp. 18344-18349
    • Souza, J.M.1    Giasson, B.I.2    Chen, Q.3    Lee, V.M.4    Ischiropoulos, H.5
  • 55
    • 0032568534 scopus 로고    scopus 로고
    • α-synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies
    • Spillantini M. G., Crowther R. A., Jakes R., Hasegawa M. and Goedert M. (1998) α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies. Proc. Natl Acad. Sci. USA 95, 6469-6473.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 6469-6473
    • Spillantini, M.G.1    Crowther, R.A.2    Jakes, R.3    Hasegawa, M.4    Goedert, M.5
  • 56
    • 0019965340 scopus 로고
    • Axoplasmic transport in aged rats
    • Stromska D. P. and Ochs S. (1982) Axoplasmic transport in aged rats. Neurol. 77, 215-224.
    • (1982) Neurol. , vol.77 , pp. 215-224
    • Stromska, D.P.1    Ochs, S.2
  • 57
    • 0026045905 scopus 로고
    • Maturation and aging of the axonal cytoskeleton: Biochemical analysis of transported tubulin
    • Tashiro T. and Komiya Y. (1991) Maturation and aging of the axonal cytoskeleton: biochemical analysis of transported tubulin. J. Neurosci. Res. 30, 192-200.
    • (1991) J. Neurosci. Res. , vol.30 , pp. 192-200
    • Tashiro, T.1    Komiya, Y.2
  • 58
    • 0029788486 scopus 로고    scopus 로고
    • Differential axonal transport of soluble and insoluble τ in the rat sciatic nerve
    • Tashiro T., Sun X. Y., Tsuda M. and Komiya Y. (1996) Differential axonal transport of soluble and insoluble τ in the rat sciatic nerve. J. Neurochem. 67, 1566-1574.
    • (1996) J. Neurochem. , vol.67 , pp. 1566-1574
    • Tashiro, T.1    Sun, X.Y.2    Tsuda, M.3    Komiya, Y.4
  • 59
    • 0027489773 scopus 로고
    • Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer's disease
    • Ueda K., Fukushima H., Masliah E. et al. (1993) Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer's disease. Proc. Natl Acad. Sci. USA 90, 11282-11286.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 11282-11286
    • Ueda, K.1    Fukushima, H.2    Masliah, E.3
  • 60
    • 0034663176 scopus 로고    scopus 로고
    • Neuropathology in mice expressing human α-synuclein
    • Van der Putten H., Wiederhold K. H., Probst A. et al. (2000) Neuropathology in mice expressing human α-synuclein. J. Neurosci. 20, 6021-6029.
    • (2000) J. Neurosci. , vol.20 , pp. 6021-6029
    • Van Der Putten, H.1    Wiederhold, K.H.2    Probst, A.3
  • 61
    • 0033776708 scopus 로고    scopus 로고
    • Rapid movement of axonal neurofilaments interrupted by prolonged pauses
    • Wang L., Ho C. L., Sun D., Liem R. K. and Brown A. (2000) Rapid movement of axonal neurofilaments interrupted by prolonged pauses. Nat. Cell Biol. 2, 137-141.
    • (2000) Nat. Cell Biol. , vol.2 , pp. 137-141
    • Wang, L.1    Ho, C.L.2    Sun, D.3    Liem, R.K.4    Brown, A.5
  • 62
    • 0033366384 scopus 로고    scopus 로고
    • Slowing of axonal transport is a very early event in the toxicity of ALS-linked SOD1 mutants to motor neurons
    • Williamson T. L. and Cleveland D. W. (1999) Slowing of axonal transport is a very early event in the toxicity of ALS-linked SOD1 mutants to motor neurons. Nat. Neurosci. 2, 50-56.
    • (1999) Nat. Neurosci. , vol.2 , pp. 50-56
    • Williamson, T.L.1    Cleveland, D.W.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.