L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system

Journal of Biological Chemistry

Volumn 278, Issue 38, 2003, Pages 36588-36595

  Miller, David W ^d   Ahmad, Rili ^d   Hague, Stephen ^d   Baptista, Melisa J ^d   Canet Aviles, Rosa ^d   McLendon, Chris ^d   Carter, Donald M ^d   Zhu, Peng Peng ^a   Stadler, Julia ^a   Chandran, Jayanth ^d   Klinefelter, Gary R ^b   Blackstone, Craig ^a   Cookson, Mark R ^c  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c NATIONAL INSTITUTE ON AGING   (United States)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; DISEASES; GENES; MUTAGENESIS; PROTEINS;

PROTEIN STABILITY;

BIOCHEMISTRY;

LYSINE; PROTEASOME; UBIQUITIN;

ANIMAL CELL; ARTICLE; CELLULAR DISTRIBUTION; CHROMOSOME 1; CONTROLLED STUDY; GENE; GENE DJ 1; GENE MUTATION; GENETIC STABILITY; HUMAN; HUMAN CELL; KNOCKOUT GENE; NONHUMAN; PARKINSON DISEASE; PATHOGENESIS; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; RECESSIVE INHERITANCE;

ANIMALS; BLOTTING, WESTERN; CELL LINE; CHROMATOGRAPHY; COS CELLS; CYSTEINE ENDOPEPTIDASES; CYTOSOL; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE DELETION; GENES, RECESSIVE; GREEN FLUORESCENT PROTEINS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LUMINESCENT PROTEINS; LYSINE; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA; MULTIENZYME COMPLEXES; MUTATION; ONCOGENE PROTEINS; PARKINSON DISEASE; POINT MUTATION; PRECIPITIN TESTS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SUBCELLULAR FRACTIONS; TRANSFECTION; TWO-HYBRID SYSTEM TECHNIQUES; UBIQUITIN;

ANIMALIA;

EID: 0141704202     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M304272200     Document Type: Article

References (35)

1. Hardy, J., Cookson, M. R., and Singleton, A. B. (2003) Lancet Neurol. 2, 221-228
2. Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., Stenroos, E. S., Chandrasekharappa, S., Athanassiadou, A., Papapetropoulos, T., Johnson, W. G., Lazzarini, A. M., Duvoisin, R. C., Di Iorio, G., Golbe, L. I., and Nussbaum, R. L. (1997) Science 276, 2045-2047
3. Kruger, R., Kuhn, W., Muller, T., Woitalla, D., Graeber, M., Kosel, S., Przuntek, H., Epplen, J. T., Schols, L., and Riess, O. (1998) Nat. Genet. 18, 106-108
4. Kitada, T., Asakawa, S., Hattori, N., Matsumine, H., Yamamura, Y., Minoshima, S., Yokochi, M., Mizuno, Y., and Shimizu, N. (1998) Nature 392, 605-608
5. Bonifati, V., Rizzu, P., van Baren, M. J., Schaap, O., Breedveld, G. J., Krieger, E., Dekker, M. C., Squitieri, F., Ibanez, P., Joosse, M., van Dongen, J. W., Vanacore, N., van Swieten, J. C., Brice, A., Meco, G., van Duijn, C. M., Oostra, B. A., and Heutink, P. (2003) Science 299, 256-259
6. Petrucelli, L., O'Farrell, C., Lockhart, P. J., Baptista, M., Kehoe, K., Vink, L., Choi, P., Wolozin, B., Farrer, M., Hardy, J., and Cookson, M. R. (2002) Neuron 36, 1007-1019
7. Yang, Y., Nishimura, I., Imai, Y., Takahashi, R., and Lu, B. (2003) Neuron 37, 911-924
8. Cookson, M. R. (2003) Neuron 37, 7-10
9. Nagakubo, D., Taira, T., Kitaura, H., Ikeda, M., Tamai, K., Iguchi-Ariga, S. M., and Ariga, H. (1997) Biochem. Biophys. Res. Commun. 231, 509-513
10. Hod, Y., Pentyala, S. N., Whyard, T. C., and El-Maghrabi, M. R. (1999) J. Cell. Biochem. 72, 435-444
11. Wagenfeld, A., Gromoll, J., and Cooper, T. G. (1998) Biochem. Biophys. Res. Commun. 251, 545-549
12. Niki, T., Takahashi-Niki, K., Taira, T., Iguchi-Ariga, S. M., and Ariga, H. (2003) Mol. Cancer Res. 1, 247-261
13. Takahashi, K., Taira, T., Niki, T., Seino, C., Iguchi-Ariga, S. M., and Ariga, H. (2001) J. Biol. Chem. 276, 37556-37563
14. Mitsumoto, A., and Nakagawa, Y. (2001) Free Radic. Res. 35, 885-893
15. Mitsumoto, A., Nakagawa, Y., Takeuchi, A., Okawa, K., Iwamatsu, A., and Takanezawa, Y. (2001) Free Radic. Res. 35, 301-310
16. Quigley, P. M., Korotkov, K., Baneyx, F., and Hol, W. G. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 3137-3142
17. Honbou, K., Suzuki, N. N., Horiuchi, M., Niki, T., Taira, T., Ariga, H., and Inagaki, F. (2003) J. Biol. Chem. 278, 31380-31384
18. Tao, X., and Tong, L. (2003) J. Biol. Chem. 278, 31372-31379
19. Blackstone, C., Roberts, R. G., Seeburg, D. P., and Sheng, M. (2003) Biochem. Biophys. Res. Commun. 305, 345-352
20. Klinefelter, G. R., Welch, J. E., Perreault, S. D., Moore, H. D., Zucker, R. M., Suarez, J. D., Roberts, N. L., Bobseine, K., and Jeffay, S. (2002) J. Androl. 23, 48-63
21. Darios, F., Corti, O., Lucking, C. B., Hampe, C., Muriel, M. P., Abbas, N., Gu, W. J., Hirsch, E. C., Rooney, T., Ruberg, M., and Brice, A. (2003) Hum. Mol. Genet. 12, 517-526
22. Baptista, M. J., O'Farrell, C., Daya, S., Miller, D. W., Hardy, J., Farrer, M. J., and Cookson, M. R. (2003) J. Neurochem. 85, 957-958
23. Pexinou, E., Chen, Q., Weisse, M., Giasson, B. I., Norris, E. H., Rueter, S. M., Trojanowski, J. Q., Lee, V. M., and Ischiropoulos, H. (2001) J. Neurosci. 21, 8053-8061
24. Hoege, C., Pfander, B., Moldovan, G. L., Pyrowolakis, G., and Jentsch, S. (2002) Nature 419, 135-141
25. Du, X., Choi, I. G., Kim, R., Wang, W., Jancarik, J., Yokota, H., and Kim, S. H. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 14079-14084
26. Gray, T. M., Arnoys, E. J., Blankespoor, S., Born, T., Jagar, R., Everman, R., Plowman, D., Stair, A., and Zhang, D. (1996) Protein Sci 5, 742-751
27. Glickman, M. H., and Ciechanover, A. (2002) Physiol. Rev. 82, 373-428
28. Gelman, M. S., Kannegaard, E. S., and Kopito, R. R. (2002) J. Biol. Chem. 277, 11709-11714
29. Gautreau, A., Manent, J., Fievet, B., Louvard, D., Giovannini, M., and Arpin, M. (2002) J. Biol. Chem. 277, 31279-31282
30. Galbiati, F., Volonte, D., Minetti, C., Bregman, D. B., and Lisanti, M. P. (2000) J. Biol. Chem. 275, 37702-37711
31. Hwu, W. L., Chiou, Y. W., Lai, S. Y., and Lee, Y. M. (2000) Ann. Neurol. 48, 609-613
32. Conway, K. A., Lee, S. J., Rochet, J. C., Ding, T. T., Williamson, R. E., and Lansbury, P. T., Jr. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 571-576
33. Giasson, B. I., Uryu, K., Trojanowski, J. Q., and Lee, V. M. (1999) J. Biol. Chem. 274, 7619-7622
34. Zhang, Y., Gao, J., Chung, K. K., Huang, H., Dawson, V. L., and Dawson, T. M. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 13354-13359
35. Shimura, H., Hattori, N., Kubo, S., Mizuno, Y., Asakawa, S., Minoshima, S., Shimuzu, N., Iwai, K., Chiba, T., Tanaka, K., and Suzuki, T. (2000) Nat. Genet. 25, 302-305