The 1.1-Å resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Parkinson's disease

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 16, 2003, Pages 9256-9261

  Wilson, Mark A ^a   Collins, Jennifer L ^a   Hod, Yaacov ^b   Ringe, Dagmar ^a   Petsko, Gregory A ^a  

^a BRANDEIS UNIVERSITY   (United States)

^b STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; CATALASE; CYSTEINE PROTEINASE; DJ 1 PROTEIN; GENE PRODUCT; MUTANT PROTEIN; PROTEIN PFPL; UNCLASSIFIED DRUG; ARCHAEAL PROTEIN; CYSTEINE; HYBRID PROTEIN; ONCOPROTEIN; PARK7 PROTEIN, HUMAN; PEPTIDE HYDROLASE; PROTEASE I, PYROCOCCUS FURIOSUS; PROTEINASE; SIGNAL PEPTIDE;

ARTICLE; AUTOSOMAL RECESSIVE DISORDER; CRYSTAL STRUCTURE; DEGENERATIVE DISEASE; DJ 1 GENE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PURIFICATION; GENE; GENE MUTATION; HUMAN; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE; SEQUENCE HOMOLOGY; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; DIMERIZATION; ESCHERICHIA COLI; GEL CHROMATOGRAPHY; GENETICS; METABOLISM; MUTATION; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE; RECESSIVE GENE;

BACTERIA (MICROORGANISMS);

ARCHAEAL PROTEINS; CATALYSIS; CHROMATOGRAPHY, GEL; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; DIMERIZATION; ENDOPEPTIDASES; ESCHERICHIA COLI; GENES, RECESSIVE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MODELS, MOLECULAR; MUTATION; ONCOGENE PROTEINS; OXIDATIVE STRESS; PARKINSON DISEASE; PEPTIDE HYDROLASES; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS;

EID: 0042130551     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.1133288100     Document Type: Article

References (51)

1. Olanow, C. W. & Tatton, W. G. (1999) Annu. Rev. Neurosci. 22, 123-144.
2. Parkinson, J. (1817) An Essay on the Shaking Palsy (Sherwood, Neely, and Jones, London).
3. Langston, J. W., Ballard, P., Tetrud, J. W. & Irwin, I. (1983) Science 219, 979-980.
4. Gershanik, O. S. (2002) in Parkinson's Disease and Movement Disorders, eds. Jankovic, J. J. & Tolosa, E. (Lippincott, Williams & Wilkins, Baltimore), pp. 331-357.
5. Tretiakoff, C. (1919) Thèse de Médicine (University of Paris, Paris).
6. Lewy, F. (1912) in Handbuch der Neurologie, eds. Lewandowski, M. & Abelsdorff, G. (Springer, Berlin), Vol. 3, pp. 920-933.
7. Kotzbauer, P. T., Trojanowski, J. Q. & Lee, V. M. (2001) J. Mol. Neurosci. 17, 225-232.
8. Schrag, A. (2002) in Parkinson's Disease and Movement Disorders, eds. Jankovic, J. J. & Tolosa, E. (Lippincott, Williams & Wilkins, Baltimore), pp. 73-89.
9. Lang, A. E. & Lozano, A. M. (1998) N. Engl. J. Med. 339, 1044-1053.
10. Dawson, T. M. & Dawson, V. L. (2003) J. Clin. Invest. 111, 145-151.
11. Hicks, A. A., Petursson, H., Jonsson, T., Stefansson, H., Johannsdottir, H. S., Sainz, J., Frigge, M. L., Kong, A., Gulcher, J. R., Stefansson, K. & Sveinbjornsdottir, S. (2002) Ann. Neurol. 52, 549-555.
12. Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., et al. (1997) Science 276, 2045-2047.
13. Spillantini, M. G., Schmidt, M. L., Lee, V. M., Trojanowski, J. Q., Jakes, R. & Goedert, M. (1997) Nature 388, 839-840.
14. Leroy, E., Boyer, R., Auburger, G., Leube, B., Ulm, G., Mezey, E., Harta, G., Brownstein, M. J., Jonnalagada, S., Chernova, T., et al. (1998) Nature 395, 451-452.
15. Shimura, H., Hattori, N., Kubo, S., Mizuno, Y., Asakawa, S., Minoshima, S., Shimizu, N., Iwai, K., Chiba, T., Tanaka, K. & Suzuki, T. (2000) Nat. Genet. 25, 302-305.
16. Bonifati, V., Rizzu, P., van Baren, M. J., Schaap, O., Breedveld, G. J., Krieger, E., Dekker, M. C., Squitieri, F., Ibanez, P., Joosse, M., et al. (2003) Science 299, 256-259.
17. Nagakubo, D., Taira, T., Kitaura, H., Ikeda, M., Tamai, K., Iguchi-Ariga, S. M. & Ariga, H. (1997) Biochem. Biophys. Res. Commun. 231, 509-513.
18. Niki, T., Takahashi-Niki, K., Taira, T., Iguchi-Ariga, S. M. & Ariga, H. (2003) Mol. Cancer Res. 1, 247-261.
19. Hod, Y., Pentyala, S. N., Whyard, T. C. & El-Maghrabi, M. R. (1999) J. Cell Biochem. 72, 435-444.
20. Welch, J. E., Barbee, R. R., Roberts, N. L., Suarez, J. D. & Klinefelter, G. R. (1998) 19, 385-393.
21. Wagenfeld, A., Gromoll, J. & Cooper, T. G. (1998) Biochem. Biophys. Res. Commun. 251, 545-549.
22. Mitsumoto, A., Nakagawa, Y., Takeuchi, A., Okawa, K., Iwamatsu, A. & Takanezawa, Y. (2001) Free Radical Res. 35, 301-310.
23. Mitsumoto, A. & Nakagawa, Y. (2001) Free Radical Res. 35, 885-893.
24. Cookson, M. R. (2003) Neuron 37, 7-10.
25. Mizote, T., Tsuda, M., Nakazawa, T. & Nakayama, H. (1996) Microbiology 142, 2969-2974.
26. Osmani, A. H., May, G. S. & Osmani, S. A. (1999) J. Biol. Chem. 274, 23565-23569.
27. Bilski, P., Li, M. Y., Ehrenshaft, M., Daub, M. E. & Chignell, C. F. (2000) Photochem. Photobiol. 71, 129-134.
28. Halio, S. B., Blumentals, I. I., Short, S. A., Merrill, B. M. & Kelly, R. M. (1996) J. Bacteriol. 178, 2605-2612.
29. Du, X., Choi, I. G., Kim, R., Wang, W., Jancarik, J., Yokota, H. & Kim, S. H. (2000) Proc. Natl. Acad. Sci. USA 97, 14079-14084.
30. Raushel, F. M., Thoden, J. B. & Holden, H. M. (1999) Biochemistry 38, 7891-7899.
31. Zalkin, H. & Smith, J. L. (1998) Adv. Enzymol. Relat. Areas Mol. Biol. 72, 87-144.
32. Ikeda, H., Ishikawa, J., Hanamoto, A., Shinose, M., Kikuchi, H., Shiba, T., Sakaki, Y., Hattori, M. & Omura, S. (2003) Nat. Biotechnol. 21, 526-531.
33. Quigley, P. M., Korotkov, K., Baneyx, F. & Hol, W. G. (2003) Proc. Natl. Acad. Sci. USA 100, 3137-3142.
34. Trotter, E. W., Kao, C. M., Berenfeld, L., Botstein, D., Petsko, G. A. & Gray, J. V. (2002) J. Biol. Chem. 277, 44817-44825.
35. Otwinowski, Z. & Minor, W. (1997) Methods Enzymol. 276, 307-326.
36. Terwilliger, T. C. & Berendzen, J. (1999) Acta Crystallogr. D 55, 849-861.
37. Terwilliger, T. C., Kim, S. H. & Eisenberg, D. (1987) Acta Crystallogr. A 43, 1-5.
38. Terwilliger, T. C. (2001) Acta Crystallogr. D 57, 1763-1775.
39. Jones, T. A., Zou, J. Y., Cowan, S. W. & Kjeldgaard, M. (1991) Acta Crystallogr. A 47, 110-119.
40. Sheldrick, G. M. & Schneider, T. R. (1997) Methods Enzymol. 277, 319-343.
41. Laskowski, R. A., Macarthur, M. W., Moss, D. S. & Thornton, J. M. (1993) J. Appl. Crystallogr. 26, 283-291.
42. Horvath, M. M. & Grishin, N. V. (2001) Proteins 42, 230-236.
43. Loewen, P. (1996) Gene 179, 39-44.
44. Ondrechen, M. J., Clifton, J. G. & Ringe, D. (2001) Proc. Natl. Acad. Sci. USA 98, 12473-12478.
45. Takahashi, K., Taira, T., Niki, T., Seino, C., Iguchi-Ariga, S. M. & Ariga, H. (2001) J. Biol. Chem. 276, 37556-37563.
46. Lowther, W. T., Brot, N., Weissbach, H. & Matthews, B. W. (2000) Biochemistry 39, 13307-13312.
47. Weissbach, H., Etienne, F., Hoshi, T., Heinemann, S. H., Lowther, W. T., Matthews, B., St. John, G., Nathan, C. & Brot, N. (2002) Arch. Biochem. Biophys. 397, 172-178.
48. Miller, D. W., Ahmad, R., Hague, S., Baptista, M. J., Canet-Aviles, R., McLendon, C., Carter, D. M., Zhu, P.-P., Stadler, J., Klinefelter, G. R., et al. (2003) J. Biol. Chem., in press.
49. Sherman, M. Y. & Goldberg, A. L. (2001) Neuron 29, 15-32.
50. Fenn, T. D., Ringe, D. & Petsko, G. A. (2003) J. Appl. Crystallogr. 36, 944-947.
51. Tao, X. & Tong, L. (2003) J. Biol. Chem., in press.