Aggregation and motor neuron toxicity of an ALS-linked SOD1 mutant independent from wild-type SOD1

Science

Volumn 281, Issue 5384, 1998, Pages 1851-1854

  Bruijn, Lucie I ^a,d   Houseweart, Megan K ^a   Kato, Shinsuke ^b   Anderson, Karen L ^a   Anderson, Scott D ^a   Ohama, Eisaku ^b   Reaume, Andrew G ^c   Scott, Rick W ^c   Cleveland, Don W ^a  

^a LUDWIG INSTITUTE FOR CANCER RESEARCH   (United States)

^b TOTTORI UNIVERSITY   (Japan)

^c CEPHALON INC   (United States)

^d BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MUTANT PROTEIN; SUPEROXIDE; SUPEROXIDE DISMUTASE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; MOTOR NEURON DISEASE; MOUSE; NERVE CELL NECROSIS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SPINAL CORD; SPINAL ROOT; TRANSGENIC MOUSE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; ASTROCYTES; DISEASE PROGRESSION; FEMALE; HUMANS; HYDROGEN PEROXIDE; INCLUSION BODIES; MALE; MICE; MICE, TRANSGENIC; MOTOR NEURONS; MUTATION; NERVE DEGENERATION; OXIDATIVE STRESS; SUPEROXIDE DISMUTASE; SUPEROXIDES;

ANIMALIA; MUS MUSCULUS;

EID: 0032544674     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.281.5384.1851     Document Type: Article

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38. We are grateful to L. B. Corson for critical reading of the manuscript and to H. Hwang for her technical assistance. This work was supported by grants to D.W.C. from NIH (NS 27036) and the ALS Association. L.I.B. was supported by a postdoctoral fellowship from the Muscular Dystrophy Association. Salary support for D.W.C is provided by the Ludwig Institute for Cancer Research. S.K. is supported by a Grant-in-Aid for Scientific Research (09680744) from the Ministry of Education, Science, Sports and Culture of Japan.