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Volumn 35, Issue 1-2, 2006, Pages 75-87

Antibody diversification: Mutational mechanisms and oncogenesis

Author keywords

Activation induced cytidine deaminase; Antibody; Class switch recombination; Gene conversion; Immunoglobulin; Somatic hypermutation

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; ANTIBODY; CYTIDINE; CYTIDINE DEAMINASE; DNA; IMMUNOGLOBULIN; UNCLASSIFIED DRUG;

EID: 33749606999     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1385/IR:35:1:75     Document Type: Review
Times cited : (13)

References (116)
  • 1
    • 0034264851 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the hyper-IgM syndrome (HIGM2)
    • Revy P, Muto T, Levy Y, et al: Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the hyper-IgM syndrome (HIGM2). Cell 2000;102:565-575.
    • (2000) Cell , vol.102 , pp. 565-575
    • Revy, P.1    Muto, T.2    Levy, Y.3
  • 2
    • 0036674618 scopus 로고    scopus 로고
    • AID and mismatch repair in antibody diversification
    • Martin A, Scharff MD: AID and mismatch repair in antibody diversification. Nature Rev Immunol 2002;2:605-614.
    • (2002) Nature Rev Immunol , vol.2 , pp. 605-614
    • Martin, A.1    Scharff, M.D.2
  • 3
    • 23944475626 scopus 로고    scopus 로고
    • Mechanisms of, and barriers to, horizontal gene transfer between bacteria
    • Thomas CM, Nielsen KM: Mechanisms of, and barriers to, horizontal gene transfer between bacteria. Nat Rev Microbiol 2005;3:711-721.
    • (2005) Nat Rev Microbiol , vol.3 , pp. 711-721
    • Thomas, C.M.1    Nielsen, K.M.2
  • 4
    • 0344936724 scopus 로고    scopus 로고
    • The origins of V(D)J recombination
    • Lewis SM, Wu GE: The origins of V(D)J recombination. Cell 1997;88:159-162.
    • (1997) Cell , vol.88 , pp. 159-162
    • Lewis, S.M.1    Wu, G.E.2
  • 5
    • 0035997348 scopus 로고    scopus 로고
    • V(D)J recombination: RAG proteins, repair factors, and regulation
    • Gellert M: V(D)J recombination: RAG proteins, repair factors, and regulation. Annu Rev Biaochem 2002;71:101-132.
    • (2002) Annu Rev Biaochem , vol.71 , pp. 101-132
    • Gellert, M.1
  • 6
    • 1542348470 scopus 로고    scopus 로고
    • Immunoglobulin gene conversion: Insights from bursal B cells and the DT40 cell line
    • Arakawa H, Buerstedde JM: Immunoglobulin gene conversion: insights from bursal B cells and the DT40 cell line. Dev Dyn 2004;229:458-464.
    • (2004) Dev Dyn , vol.229 , pp. 458-464
    • Arakawa, H.1    Buerstedde, J.M.2
  • 7
    • 0347758541 scopus 로고    scopus 로고
    • The generation of antibody diversity through somatic hypermutation and class switch recombination
    • Li Z, Woo CJ, Iglesias-Ussel MD, Ronai D, Scharff MD: The generation of antibody diversity through somatic hypermutation and class switch recombination. Genes Dev 2004;18:1-11.
    • (2004) Genes Dev , vol.18 , pp. 1-11
    • Li, Z.1    Woo, C.J.2    Iglesias-Ussel, M.D.3    Ronai, D.4    Scharff, M.D.5
  • 8
    • 13444301307 scopus 로고    scopus 로고
    • Mechanism and control of V(D)J recombination versus class switch recombination: Similarities and differences
    • Dudley DD, Chaudhuri J, Bassing CH, Alt FW: Mechanism and control of V(D)J recombination versus class switch recombination: similarities and differences. Adv Immunol 2005;86:43-112.
    • (2005) Adv Immunol , vol.86 , pp. 43-112
    • Dudley, D.D.1    Chaudhuri, J.2    Bassing, C.H.3    Alt, F.W.4
  • 10
    • 0033603340 scopus 로고    scopus 로고
    • Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells
    • Muramatsu M, Sankaranand VS, Anant S, et al: Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells. J Biol Chem 1999;274:18470-18476.
    • (1999) J Biol Chem , vol.274 , pp. 18470-18476
    • Muramatsu, M.1    Sankaranand, V.S.2    Anant, S.3
  • 11
    • 0034268780 scopus 로고    scopus 로고
    • Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
    • Muramatsu M, Kinoshita K, Fagarasan S, Yamada S, Shinkai Y, Honjo T: Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 2000;102:553-563.
    • (2000) Cell , vol.102 , pp. 553-563
    • Muramatsu, M.1    Kinoshita, K.2    Fagarasan, S.3    Yamada, S.4    Shinkai, Y.5    Honjo, T.6
  • 12
    • 0037083364 scopus 로고    scopus 로고
    • Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion
    • Arakawa H, Hauschild J, Buerstedde JM: Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion. Science 2002;295: 1301-1306.
    • (2002) Science , vol.295 , pp. 1301-1306
    • Arakawa, H.1    Hauschild, J.2    Buerstedde, J.M.3
  • 13
    • 0037022540 scopus 로고    scopus 로고
    • AID is essential for immunoglobulin V gene conversion in a cultured B cell line
    • Harris RS, Sale JE, Petersen-Mahrt SK, Neuberger MS: AID is essential for immunoglobulin V gene conversion in a cultured B cell line. Curr Biol 2002;12:435-438.
    • (2002) Curr Biol , vol.12 , pp. 435-438
    • Harris, R.S.1    Sale, J.E.2    Petersen-Mahrt, S.K.3    Neuberger, M.S.4
  • 14
    • 0034662773 scopus 로고    scopus 로고
    • Isolation, tissue distribution, and chromosomal localization of the human activation-induced cytidine deaminase (AID) gene
    • Muto T, Muramatsu M, Taniwaki M, Kinoshita K, Honjo T: Isolation, tissue distribution, and chromosomal localization of the human activation-induced cytidine deaminase (AID) gene. Genomics 2000;68:85-88.
    • (2000) Genomics , vol.68 , pp. 85-88
    • Muto, T.1    Muramatsu, M.2    Taniwaki, M.3    Kinoshita, K.4    Honjo, T.5
  • 15
    • 0037074975 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas
    • Martin A, Bardwell PD, Woo CJ, Fan M, Shulman MJ, Scharff MD: Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas. Nature 2002;415:802-806.
    • (2002) Nature , vol.415 , pp. 802-806
    • Martin, A.1    Bardwell, P.D.2    Woo, C.J.3    Fan, M.4    Shulman, M.J.5    Scharff, M.D.6
  • 16
    • 0037076967 scopus 로고    scopus 로고
    • AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts
    • Yoshikawa K, Okazaki IM, Eto T, et al: AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts. Science 2002;296:2033-2036.
    • (2002) Science , vol.296 , pp. 2033-2036
    • Yoshikawa, K.1    Okazaki, I.M.2    Eto, T.3
  • 18
    • 0037126038 scopus 로고    scopus 로고
    • Somatic hypermutation of the AID transgene in B and non-B cells
    • Martin A, Scharff MD: Somatic hypermutation of the AID transgene in B and non-B cells. Proc Natl Acad Sci USA 2002;99:12304-12308.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 12304-12308
    • Martin, A.1    Scharff, M.D.2
  • 19
    • 0037026482 scopus 로고    scopus 로고
    • Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase
    • Di Noia J, Neuberger MS: Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase. Nature 2002;419:43-48.
    • (2002) Nature , vol.419 , pp. 43-48
    • Di Noia, J.1    Neuberger, M.S.2
  • 20
    • 1642406222 scopus 로고    scopus 로고
    • Recombinogenic phenotype of human activation-induced cytosine deaminase
    • Poltoratsky VP, Wilson SH, Kunkel TA, Pavlov YI: Recombinogenic phenotype of human activation-induced cytosine deaminase. J Immunol 2004;172:4308-4313.
    • (2004) J Immunol , vol.172 , pp. 4308-4313
    • Poltoratsky, V.P.1    Wilson, S.H.2    Kunkel, T.A.3    Pavlov, Y.I.4
  • 21
    • 27944507366 scopus 로고    scopus 로고
    • The cytidine deaminases AID and APOBEC-1 exhibit distinct functional properties in a novel yeast selectable system
    • Krause K, Marcu KB, Greeve J: The cytidine deaminases AID and APOBEC-1 exhibit distinct functional properties in a novel yeast selectable system. Mol Immunol 2006;43:295-307.
    • (2006) Mol Immunol , vol.43 , pp. 295-307
    • Krause, K.1    Marcu, K.B.2    Greeve, J.3
  • 22
    • 33644827615 scopus 로고    scopus 로고
    • The cytidine deaminase AID exhibits similar functional properties in yeast and mammals
    • Rogozin IB, Pavlov YI: The cytidine deaminase AID exhibits similar functional properties in yeast and mammals. Mol Immunol 2006;43:1481-1484.
    • (2006) Mol Immunol , vol.43 , pp. 1481-1484
    • Rogozin, I.B.1    Pavlov, Y.I.2
  • 23
    • 0037108463 scopus 로고    scopus 로고
    • Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice
    • Rada C, Williams GT, Nilsen H, Barnes DE, Lindahl T, Neuberger MS: Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice. Curr Biol 2002;12:1748-1755.
    • (2002) Curr Biol , vol.12 , pp. 1748-1755
    • Rada, C.1    Williams, G.T.2    Nilsen, H.3    Barnes, D.E.4    Lindahl, T.5    Neuberger, M.S.6
  • 24
    • 0037926476 scopus 로고    scopus 로고
    • Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation
    • Pham P, Bransteitter R, Petruska J, Goodman MF: Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation. Nature 2003;424:103-107.
    • (2003) Nature , vol.424 , pp. 103-107
    • Pham, P.1    Bransteitter, R.2    Petruska, J.3    Goodman, M.F.4
  • 25
    • 0037388165 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase
    • Bransteitter R, Pham P, Scharff MD, Goodman MF: Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase. Proc Natl Acad Sci USA 2003;100: 4102-4107.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 4102-4107
    • Bransteitter, R.1    Pham, P.2    Scharff, M.D.3    Goodman, M.F.4
  • 26
    • 17144424674 scopus 로고    scopus 로고
    • The mutation spectrum of purified AID is similar to the mutability index in Ramos cells and in ung-/-msh2-/- mice
    • Larijani M, Frieder D, Basit W, Martin A: The mutation spectrum of purified AID is similar to the mutability index in Ramos cells and in ung-/-msh2-/- mice. Immunogenetics 2005;56:840-845.
    • (2005) Immunogenetics , vol.56 , pp. 840-845
    • Larijani, M.1    Frieder, D.2    Basit, W.3    Martin, A.4
  • 28
    • 0037901850 scopus 로고    scopus 로고
    • Human activation-induced cytidine deaminase causes transcription- dependent, strand-biased C to U deaminations
    • Sohail A, Klapacz J, Samaranayake M, Ullah A, Bhagwat AS: Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations. Nucleic Acids Res 2003;31:2990-2994.
    • (2003) Nucleic Acids Res , vol.31 , pp. 2990-2994
    • Sohail, A.1    Klapacz, J.2    Samaranayake, M.3    Ullah, A.4    Bhagwat, A.S.5
  • 29
    • 2942613670 scopus 로고    scopus 로고
    • AID: How does it aid antibody diversity?
    • Honjo T, Muramatsu M, Fagarasan S: AID: how does it aid antibody diversity? Immunity 2004;20:659-668.
    • (2004) Immunity , vol.20 , pp. 659-668
    • Honjo, T.1    Muramatsu, M.2    Fagarasan, S.3
  • 30
    • 0030063726 scopus 로고    scopus 로고
    • Somatic hypermutation of immunoglobulin genes is linked to transcription initiation
    • Peters A, Storb U: Somatic hypermutation of immunoglobulin genes is linked to transcription initiation. Immunity 1996;4:57-65.
    • (1996) Immunity , vol.4 , pp. 57-65
    • Peters, A.1    Storb, U.2
  • 31
    • 0033898483 scopus 로고    scopus 로고
    • The TATA binding protein, c-Myc and survivin genes are not somatically hypermutated, while Ig and BCL6 genes are hypermutated in human memory B cells
    • Shen HM, Michael N, Kim N, Storb U: The TATA binding protein, c-Myc and survivin genes are not somatically hypermutated, while Ig and BCL6 genes are hypermutated in human memory B cells. Int Immunol 2000;12:1085-1093.
    • (2000) Int Immunol , vol.12 , pp. 1085-1093
    • Shen, H.M.1    Michael, N.2    Kim, N.3    Storb, U.4
  • 32
    • 0042757483 scopus 로고    scopus 로고
    • Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand
    • Ramiro AR, Stavropoulos P, Jankovic M, Nussenzweig MC: Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand. Nat Immunol 2003;14:14.
    • (2003) Nat Immunol , vol.14 , pp. 14
    • Ramiro, A.R.1    Stavropoulos, P.2    Jankovic, M.3    Nussenzweig, M.C.4
  • 33
    • 0037452080 scopus 로고    scopus 로고
    • Transcription-targeted DNA deamination by the AID antibody diversification enzyme
    • Chaudhuri J, Tian M, Khuong C, Chua K, Pinaud E, Alt FW: Transcription-targeted DNA deamination by the AID antibody diversification enzyme. Nature 2003;422:726-730.
    • (2003) Nature , vol.422 , pp. 726-730
    • Chaudhuri, J.1    Tian, M.2    Khuong, C.3    Chua, K.4    Pinaud, E.5    Alt, F.W.6
  • 34
    • 11844264903 scopus 로고    scopus 로고
    • The double-edged sword of activation-induced cytidine deaminase
    • Wu X, Geraldes P, Platt JL, Cascalho M: The double-edged sword of activation-induced cytidine deaminase. J Immunol 2005;174:934-941.
    • (2005) J Immunol , vol.174 , pp. 934-941
    • Wu, X.1    Geraldes, P.2    Platt, J.L.3    Cascalho, M.4
  • 35
    • 4344700569 scopus 로고    scopus 로고
    • Replication protein A interacts with AID to promote deamination of somatic hypermutation targets
    • Chaudhuri J, Khuong C, Alt FW: Replication protein A interacts with AID to promote deamination of somatic hypermutation targets. Nature 2004;430:992-998.
    • (2004) Nature , vol.430 , pp. 992-998
    • Chaudhuri, J.1    Khuong, C.2    Alt, F.W.3
  • 36
    • 28544438261 scopus 로고    scopus 로고
    • The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation
    • Basu U, Chaudhuri J, Alpert C, et al: The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation. Nature 2005;438:508-511.
    • (2005) Nature , vol.438 , pp. 508-511
    • Basu, U.1    Chaudhuri, J.2    Alpert, C.3
  • 37
    • 0141992113 scopus 로고    scopus 로고
    • C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion
    • Barreto V, Reina-San-Martin B, Ramiro AR, McBride KM, Nussenzweig MC: C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion. Mol Cell 2003; 12:501-508.
    • (2003) Mol Cell , vol.12 , pp. 501-508
    • Barreto, V.1    Reina-San-Martin, B.2    Ramiro, A.R.3    McBride, K.M.4    Nussenzweig, M.C.5
  • 38
    • 3242795967 scopus 로고    scopus 로고
    • Separate domains of AID are required for somatic hypermutation and class-switch recombination
    • Shinkura R, Ito S, Begum NA, et al: Separate domains of AID are required for somatic hypermutation and class-switch recombination. Nat Immunol 2004;5:707-712.
    • (2004) Nat Immunol , vol.5 , pp. 707-712
    • Shinkura, R.1    Ito, S.2    Begum, N.A.3
  • 39
    • 0023652339 scopus 로고
    • A hyperconversion mechanism generates the chicken light chain preimmune repertoire
    • Reynaud CA, Anquez V, Grimal H, Weill JC: A hyperconversion mechanism generates the chicken light chain preimmune repertoire. Cell 1987;48:379-388.
    • (1987) Cell , vol.48 , pp. 379-388
    • Reynaud, C.A.1    Anquez, V.2    Grimal, H.3    Weill, J.C.4
  • 41
    • 0035974862 scopus 로고    scopus 로고
    • Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation
    • Sale JE, Calandrini DM, Takata M, Takeda S, Neuberger MS: Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation. Nature 2001;412:921-926.
    • (2001) Nature , vol.412 , pp. 921-926
    • Sale, J.E.1    Calandrini, D.M.2    Takata, M.3    Takeda, S.4    Neuberger, M.S.5
  • 42
    • 0030982261 scopus 로고    scopus 로고
    • Reduced X-ray resistance and homologous recombination frequencies in a RAD54-/-mutant of the chicken DT40 cell line
    • Bezzubova O, Silbergleit A, Yamaguchi-Iwai Y, Takeda S, Buerstedde JM: Reduced X-ray resistance and homologous recombination frequencies in a RAD54-/-mutant of the chicken DT40 cell line. Cell 1997;89:185-193.
    • (1997) Cell , vol.89 , pp. 185-193
    • Bezzubova, O.1    Silbergleit, A.2    Yamaguchi-Iwai, Y.3    Takeda, S.4    Buerstedde, J.M.5
  • 43
    • 0025194297 scopus 로고
    • Chicken IgL variable region gene conversions display pseudogene donor preference and 5′ to 3′ polarity
    • McCormack WT, Thompson CB: Chicken IgL variable region gene conversions display pseudogene donor preference and 5′ to 3′ polarity. Genes Dev 1990;4:548-558.
    • (1990) Genes Dev , vol.4 , pp. 548-558
    • McCormack, W.T.1    Thompson, C.B.2
  • 44
    • 0037115911 scopus 로고    scopus 로고
    • Uracil in DNA-occurrence, consequences and repair
    • Krokan HE, Drablos F, Slupphaug G: Uracil in DNA-occurrence, consequences and repair. Oncogene 2002;21:8935-8948.
    • (2002) Oncogene , vol.21 , pp. 8935-8948
    • Krokan, H.E.1    Drablos, F.2    Slupphaug, G.3
  • 45
    • 22144485580 scopus 로고    scopus 로고
    • The MRE11-RAD50-NBS1 complex accelerates somatic hypermutation and gene conversion of immunoglobulin variable regions
    • Yabuki M, Fujii MM, Maizels N: The MRE11-RAD50-NBS1 complex accelerates somatic hypermutation and gene conversion of immunoglobulin variable regions. Nat Immunol 2005;6:730-736.
    • (2005) Nat Immunol , vol.6 , pp. 730-736
    • Yabuki, M.1    Fujii, M.M.2    Maizels, N.3
  • 46
    • 3142765336 scopus 로고    scopus 로고
    • Class-switch recombination: Interplay of transcription, DNA deamination and DNA repair
    • Chaudhuri J, Alt FW: Class-switch recombination: interplay of transcription, DNA deamination and DNA repair. Nat Rev Immunol 2004;4:541-552.
    • (2004) Nat Rev Immunol , vol.4 , pp. 541-552
    • Chaudhuri, J.1    Alt, F.W.2
  • 47
    • 0034741932 scopus 로고    scopus 로고
    • Localization of the 3′ IgH locus elements that effect long-distance regulation of class switch recombination
    • Pinaud E, Khamlichi AA, Le Morvan C, et al: Localization of the 3′ IgH locus elements that effect long-distance regulation of class switch recombination. Immunity 2001;15:187-199.
    • (2001) Immunity , vol.15 , pp. 187-199
    • Pinaud, E.1    Khamlichi, A.A.2    Le Morvan, C.3
  • 48
    • 3042785608 scopus 로고    scopus 로고
    • Intracellular transcription of G-rich DNAs induces formation of G-loops, novel structures containing G4 DNA
    • Duquette ML, Handa P, Vincent JA, Taylor AF, Maizels N: Intracellular transcription of G-rich DNAs induces formation of G-loops, novel structures containing G4 DNA. Genes Dev 2004;18:1618-1629.
    • (2004) Genes Dev , vol.18 , pp. 1618-1629
    • Duquette, M.L.1    Handa, P.2    Vincent, J.A.3    Taylor, A.F.4    Maizels, N.5
  • 49
    • 0037650190 scopus 로고    scopus 로고
    • R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells
    • Yu K, Chedin F, Hsieh CL, Wilson TE, Lieber MR: R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells. Nat Immunol 2003;4:442-451.
    • (2003) Nat Immunol , vol.4 , pp. 442-451
    • Yu, K.1    Chedin, F.2    Hsieh, C.L.3    Wilson, T.E.4    Lieber, M.R.5
  • 50
    • 6344256944 scopus 로고    scopus 로고
    • Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation
    • Rada C, Di Noia JM, Neuberger MS: Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation. Mol Cell 2004;16:163-171.
    • (2004) Mol Cell , vol.16 , pp. 163-171
    • Rada, C.1    Di Noia, J.M.2    Neuberger, M.S.3
  • 51
    • 13444309097 scopus 로고    scopus 로고
    • Genomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1
    • Reina-San-Martin B, Nussenzweig MC, Nussenzweig A, Difilippantonio S: Genomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1. Proc Natl Acad Sci USA 2005;102:1590-1595.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 1590-1595
    • Reina-San-Martin, B.1    Nussenzweig, M.C.2    Nussenzweig, A.3    Difilippantonio, S.4
  • 52
    • 0032526290 scopus 로고    scopus 로고
    • Ku70 is required for late B cell development and immunoglobulin heavy chain class switching
    • Manis JP, Gu Y, Lansford R, et al: Ku70 is required for late B cell development and immunoglobulin heavy chain class switching. J Exp Med 1998;187:2081-2089.
    • (1998) J Exp Med , vol.187 , pp. 2081-2089
    • Manis, J.P.1    Gu, Y.2    Lansford, R.3
  • 53
    • 8644242383 scopus 로고    scopus 로고
    • Immunoglobulin class switch recombination is impaired in Atm-deficient mice
    • Lumsden JM, McCarty T, Petiniot LK, et al: Immunoglobulin class switch recombination is impaired in Atm-deficient mice. J Exp Med 2004;200:1111-1121.
    • (2004) J Exp Med , vol.200 , pp. 1111-1121
    • Lumsden, J.M.1    McCarty, T.2    Petiniot, L.K.3
  • 54
    • 8644238314 scopus 로고    scopus 로고
    • ATM is required for efficient recombination between immunoglobulin switch regions
    • Reina-San-Martin B, Chen HT, Nussenzweig A, Nussenzweig MC: ATM is required for efficient recombination between immunoglobulin switch regions. J Exp Med 2004;200:1103-1110.
    • (2004) J Exp Med , vol.200 , pp. 1103-1110
    • Reina-San-Martin, B.1    Chen, H.T.2    Nussenzweig, A.3    Nussenzweig, M.C.4
  • 55
    • 0037866984 scopus 로고    scopus 로고
    • H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation
    • Reina-San-Martin B, Difilippantonio S, Hanitsch L, Masilamani RF, Nussenzweig A, Nussenzweig MC: H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation. J Exp Med 2003;197:1767-1778.
    • (2003) J Exp Med , vol.197 , pp. 1767-1778
    • Reina-San-Martin, B.1    Difilippantonio, S.2    Hanitsch, L.3    Masilamani, R.F.4    Nussenzweig, A.5    Nussenzweig, M.C.6
  • 56
    • 20444426249 scopus 로고    scopus 로고
    • Deoxyuridine is generated preferentially in the non-transcribed strand of DNA from cells expressing activation-induced cytidine deaminase
    • Martomo SA, Fu D, Yang WW, Joshi NS, Gearhart PJ: Deoxyuridine is generated preferentially in the non-transcribed strand of DNA from cells expressing activation-induced cytidine deaminase. J Immunol 2005; 174:7787-7791.
    • (2005) J Immunol , vol.174 , pp. 7787-7791
    • Martomo, S.A.1    Fu, D.2    Yang, W.W.3    Joshi, N.S.4    Gearhart, P.J.5
  • 58
    • 0032127804 scopus 로고    scopus 로고
    • Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting
    • Rada C, Ehrenstein MR, Neuberger MS, Milstein C: Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting. Immunity 1998;9:135-141.
    • (1998) Immunity , vol.9 , pp. 135-141
    • Rada, C.1    Ehrenstein, M.R.2    Neuberger, M.S.3    Milstein, C.4
  • 59
    • 0032101611 scopus 로고    scopus 로고
    • Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein
    • Phung QH, Winter DB, Cranston A, et al: Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein. J Exp Med 1998;187:1745-1751.
    • (1998) J Exp Med , vol.187 , pp. 1745-1751
    • Phung, Q.H.1    Winter, D.B.2    Cranston, A.3
  • 60
    • 0034614916 scopus 로고    scopus 로고
    • Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern
    • Wiesendanger M, Kneitz B, Edelmann W, Scharff MD: Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern. J Exp Med 2000;191: 579-584.
    • (2000) J Exp Med , vol.191 , pp. 579-584
    • Wiesendanger, M.1    Kneitz, B.2    Edelmann, W.3    Scharff, M.D.4
  • 61
    • 0032143823 scopus 로고    scopus 로고
    • Probing immunoglobulin gene hypermutation with microsatellites suggests a nonreplicative short patch DNA synthesis process
    • Bertocci B, Quint L, Delbos F, Garcia C, Reynaud CA, Weill JC: Probing immunoglobulin gene hypermutation with microsatellites suggests a nonreplicative short patch DNA synthesis process. Immunity 1998;9:257-265.
    • (1998) Immunity , vol.9 , pp. 257-265
    • Bertocci, B.1    Quint, L.2    Delbos, F.3    Garcia, C.4    Reynaud, C.A.5    Weill, J.C.6
  • 62
    • 0142250270 scopus 로고    scopus 로고
    • Msh2 ATPase activity is essential for somatic hypermutation at A-T basepairs and for efficient class switch recombination
    • Martin A, Li Z, Lin DP, et al: Msh2 ATPase activity is essential for somatic hypermutation at A-T basepairs and for efficient class switch recombination. J Exp Med 2003;198:1171-1178.
    • (2003) J Exp Med , vol.198 , pp. 1171-1178
    • Martin, A.1    Li, Z.2    Lin, D.P.3
  • 63
    • 0030882381 scopus 로고    scopus 로고
    • Mutations predisposing to hereditary nonpolyposis colorectal cancer: Database and results of a collaborative study
    • The International Collaborative Group on Hereditary Nonpolyposis Colorectal Cancer
    • Peltomaki P, Vasen HF: Mutations predisposing to hereditary nonpolyposis colorectal cancer: database and results of a collaborative study. The International Collaborative Group on Hereditary Nonpolyposis Colorectal Cancer. Gastroenterology 1997;113:1146-1158.
    • (1997) Gastroenterology , vol.113 , pp. 1146-1158
    • Peltomaki, P.1    Vasen, H.F.2
  • 64
    • 0036303398 scopus 로고    scopus 로고
    • Mouse models of human DNA mismatch repair gene defects
    • Wei K, Kucherlapati R, Edelmann W: Mouse models of human DNA mismatch repair gene defects. Trends Mol Med 2002;8:346-353.
    • (2002) Trends Mol Med , vol.8 , pp. 346-353
    • Wei, K.1    Kucherlapati, R.2    Edelmann, W.3
  • 65
    • 1142299546 scopus 로고    scopus 로고
    • Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice
    • Bardwell PD, Woo CJ, Wei K, et al: Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice. Nat Immunol 2004;5:224-229.
    • (2004) Nat Immunol , vol.5 , pp. 224-229
    • Bardwell, P.D.1    Woo, C.J.2    Wei, K.3
  • 66
    • 0035005241 scopus 로고    scopus 로고
    • The translesion DNA polymerase zeta plays a major role in Ig and bcl-6 somatic hypermutation
    • Zan H, Komori A, Li Z, et al: The translesion DNA polymerase zeta plays a major role in Ig and bcl-6 somatic hypermutation. Immunity 2001;14:643-653.
    • (2001) Immunity , vol.14 , pp. 643-653
    • Zan, H.1    Komori, A.2    Li, Z.3
  • 67
    • 0035399804 scopus 로고    scopus 로고
    • Decreased frequency of somatic hypermutation and impaired affinity maturation but intact germinal center formation in mice expressing antisense RNA to DNA polymerase zeta
    • Diaz M, Verkoczy LK, Flajnik MF, Klinman NR: Decreased frequency of somatic hypermutation and impaired affinity maturation but intact germinal center formation in mice expressing antisense RNA to DNA polymerase zeta. J Immunol 2001;167:327-335.
    • (2001) J Immunol , vol.167 , pp. 327-335
    • Diaz, M.1    Verkoczy, L.K.2    Flajnik, M.F.3    Klinman, N.R.4
  • 68
    • 0035377269 scopus 로고    scopus 로고
    • DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes
    • Zeng X, Winter DB, Kasmer C, Kraemer KH, Lehmann AR, Gearhart PJ: DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes. Nat Immunol 2001;2:537-541.
    • (2001) Nat Immunol , vol.2 , pp. 537-541
    • Zeng, X.1    Winter, D.B.2    Kasmer, C.3    Kraemer, K.H.4    Lehmann, A.R.5    Gearhart, P.J.6
  • 70
    • 0037206851 scopus 로고    scopus 로고
    • Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota
    • Faili A, Aoufouchi S, Flatter E, Gueranger Q, Reynaud CA, Weill JC: Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota. Nature 2002;419:944-947.
    • (2002) Nature , vol.419 , pp. 944-947
    • Faili, A.1    Aoufouchi, S.2    Flatter, E.3    Gueranger, Q.4    Reynaud, C.A.5    Weill, J.C.6
  • 71
    • 27744483444 scopus 로고    scopus 로고
    • The translesion DNA polymerase theta plays a dominant role in immunoglobulin gene somatic hypermutation
    • Zan H, Shima N, Xu Z, et al: The translesion DNA polymerase theta plays a dominant role in immunoglobulin gene somatic hypermutation. EMBO J 2005;24:3757-3769.
    • (2005) EMBO J , vol.24 , pp. 3757-3769
    • Zan, H.1    Shima, N.2    Xu, Z.3
  • 72
    • 0037162552 scopus 로고    scopus 로고
    • Correlation of somatic hypermutation specificity and A-T base pair substitution errors by DNA polymerase eta during copying of a mouse immunoglobulin kappa light chain transgene
    • Pavlov YI, Rogozin IB, Galkin AP, et al: Correlation of somatic hypermutation specificity and A-T base pair substitution errors by DNA polymerase eta during copying of a mouse immunoglobulin kappa light chain transgene. Proc Natl Acad Sci USA 2002;99: 9954-9959.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 9954-9959
    • Pavlov, Y.I.1    Rogozin, I.B.2    Galkin, A.P.3
  • 73
    • 1642499721 scopus 로고    scopus 로고
    • DNA polymerase eta is involved in hypermutation occurring during immunoglobulin class switch recombination
    • Faili A, Aoufouchi S, Weller S, et al: DNA polymerase eta is involved in hypermutation occurring during immunoglobulin class switch recombination. J Exp Med 2004;199:265-270.
    • (2004) J Exp Med , vol.199 , pp. 265-270
    • Faili, A.1    Aoufouchi, S.2    Weller, S.3
  • 74
    • 3142674907 scopus 로고    scopus 로고
    • Examination of Msh6- and Msh3-deficient mice in class switching reveals overlapping and distinct roles of MutS homologues in antibody diversification
    • Li Z, Scherer SJ, Ronai D, et al: Examination of Msh6- and Msh3-deficient mice in class switching reveals overlapping and distinct roles of MutS homologues in antibody diversification. J Exp Med 2004; 200:47-59.
    • (2004) J Exp Med , vol.200 , pp. 47-59
    • Li, Z.1    Scherer, S.J.2    Ronai, D.3
  • 75
    • 0032549125 scopus 로고    scopus 로고
    • Mismatch repair co-opted by hypermutation
    • Cascalho M, Wong J, Steinberg C, Wabl M: Mismatch repair co-opted by hypermutation. Science 1998; 279:1207-1210.
    • (1998) Science , vol.279 , pp. 1207-1210
    • Cascalho, M.1    Wong, J.2    Steinberg, C.3    Wabl, M.4
  • 76
    • 0033558532 scopus 로고    scopus 로고
    • Hypermutation in Ig V genes from mice deficient in the MLH1 mismatch repair protein
    • Phung QH, Winter DB, Alrefai R, Gearhart PJ: Hypermutation in Ig V genes from mice deficient in the MLH1 mismatch repair protein. J Immunol 1999;162: 3121-3124.
    • (1999) J Immunol , vol.162 , pp. 3121-3124
    • Phung, Q.H.1    Winter, D.B.2    Alrefai, R.3    Gearhart, P.J.4
  • 77
    • 0033564878 scopus 로고    scopus 로고
    • Deficiency in msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: Parallels with somatic hypermutation
    • Ehrenstein MR, Neuberger MS: Deficiency in msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: parallels with somatic hypermutation. EMBO J 1999;18: 3484-3490.
    • (1999) EMBO J , vol.18 , pp. 3484-3490
    • Ehrenstein, M.R.1    Neuberger, M.S.2
  • 78
    • 0033517129 scopus 로고    scopus 로고
    • Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes
    • Schrader CE, Edelmann W, Kucherlapati R, Stavnezer J: Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes. J Exp Med 1999;190:323-330.
    • (1999) J Exp Med , vol.190 , pp. 323-330
    • Schrader, C.E.1    Edelmann, W.2    Kucherlapati, R.3    Stavnezer, J.4
  • 79
    • 0035807955 scopus 로고    scopus 로고
    • Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination
    • Ehrenstein MR, Rada C, Jones AM, Milstein C, Neuberger MS: Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination. Proc Natl Acad Sci USA 2001;98:14553-14558.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 14553-14558
    • Ehrenstein, M.R.1    Rada, C.2    Jones, A.M.3    Milstein, C.4    Neuberger, M.S.5
  • 80
    • 0037017390 scopus 로고    scopus 로고
    • Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions
    • Schrader CE, Vardo J, Stavnezer J: Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions. J Exp Med 2002;195: 367-373.
    • (2002) J Exp Med , vol.195 , pp. 367-373
    • Schrader, C.E.1    Vardo, J.2    Stavnezer, J.3
  • 81
    • 29244470804 scopus 로고    scopus 로고
    • Lack of MSH2 involvement differentiates V(D)J recombination from other non-homologous end joining events
    • Larijani M, Zaheen A, Frieder D, et al: Lack of MSH2 involvement differentiates V(D)J recombination from other non-homologous end joining events. Nucleic Acids Res 2005;33:6733-6742.
    • (2005) Nucleic Acids Res , vol.33 , pp. 6733-6742
    • Larijani, M.1    Zaheen, A.2    Frieder, D.3
  • 82
    • 13144259651 scopus 로고    scopus 로고
    • BCL-6 mutations in normal germinal center B cells: Evidence of somatic hypermutation acting outside Ig loci
    • Pasqualucci L, Migliazza A, Fracchiolla N, et al: BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci. Proc Natl Acad Sci USA 1998;95:11816-11821.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 11816-11821
    • Pasqualucci, L.1    Migliazza, A.2    Fracchiolla, N.3
  • 83
    • 2642623612 scopus 로고    scopus 로고
    • Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes
    • Shen HM, Peters A, Baron B, Zhu X, Storb U: Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes. Science 1998;280:1750-1752.
    • (1998) Science , vol.280 , pp. 1750-1752
    • Shen, H.M.1    Peters, A.2    Baron, B.3    Zhu, X.4    Storb, U.5
  • 84
    • 0034684682 scopus 로고    scopus 로고
    • Somatic mutation of the CD95 gene in human B cells as a side-effect of the germinal center reaction
    • Muschen M, Re D, Jungnickel B, Diehl V, Rajewsky K, Kuppers R: Somatic mutation of the CD95 gene in human B cells as a side-effect of the germinal center reaction. J Exp Med 2000;192:1833-1840.
    • (2000) J Exp Med , vol.192 , pp. 1833-1840
    • Muschen, M.1    Re, D.2    Jungnickel, B.3    Diehl, V.4    Rajewsky, K.5    Kuppers, R.6
  • 85
    • 0037388211 scopus 로고    scopus 로고
    • Somatic hypermutation of the B cell receptor genes B29 (Igbeta, CD79b) and mb1 (Igalpha, CD79a)
    • Gordon MS, Kanegai CM, Doerr JR, Wall R: Somatic hypermutation of the B cell receptor genes B29 (Igbeta, CD79b) and mb1 (Igalpha, CD79a). Proc Natl Acad Sci USA 2003;100:4126-4131.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 4126-4131
    • Gordon, M.S.1    Kanegai, C.M.2    Doerr, J.R.3    Wall, R.4
  • 86
    • 0035913362 scopus 로고    scopus 로고
    • Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas
    • Pasqualucci L, Neumeister P, Goossens T, et al: Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas. Nature 2001;412:341-346.
    • (2001) Nature , vol.412 , pp. 341-346
    • Pasqualucci, L.1    Neumeister, P.2    Goossens, T.3
  • 87
    • 0035871625 scopus 로고    scopus 로고
    • Increased transcription levels induce higher mutation rates in a hypermutating cell line
    • Bachl J, Carlson C, Gray-Schopfer V, Dessing M, Olsson C: Increased transcription levels induce higher mutation rates in a hypermutating cell line. J Immunol 2001;166:5051-5057.
    • (2001) J Immunol , vol.166 , pp. 5051-5057
    • Bachl, J.1    Carlson, C.2    Gray-Schopfer, V.3    Dessing, M.4    Olsson, C.5
  • 88
    • 0142188274 scopus 로고    scopus 로고
    • Induction of somatic hypermutation is associated with modifications in immunoglobulin variable region chromatin
    • Woo CJ, Martin A, Scharff MD: Induction of somatic hypermutation is associated with modifications in immunoglobulin variable region chromatin. Immunity 2003;19:479-489.
    • (2003) Immunity , vol.19 , pp. 479-489
    • Woo, C.J.1    Martin, A.2    Scharff, M.D.3
  • 89
    • 7444234734 scopus 로고    scopus 로고
    • Differential regulation of histone acetylation and generation of mutations in switch regions is associated with Ig class switching
    • Li Z, Luo Z, Scharff MD: Differential regulation of histone acetylation and generation of mutations in switch regions is associated with Ig class switching. Proc Natl Acad Sci USA 2004;101:15428-15433.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 15428-15433
    • Li, Z.1    Luo, Z.2    Scharff, M.D.3
  • 90
    • 0041931059 scopus 로고    scopus 로고
    • The e box motif CAGGTG enhances somatic hypermutation without enhancing transcription
    • Michael N, Shen HM, Longerich S, Kim N, Longacre A, Storb U: The E box motif CAGGTG enhances somatic hypermutation without enhancing transcription. Immunity 2003;19:235-242.
    • (2003) Immunity , vol.19 , pp. 235-242
    • Michael, N.1    Shen, H.M.2    Longerich, S.3    Kim, N.4    Longacre, A.5    Storb, U.6
  • 91
    • 1342282983 scopus 로고    scopus 로고
    • DNA substrate length and surrounding sequence affect the activation-induced deaminase activity at cytidine
    • Yu K, Huang FT, Lieber MR: DNA substrate length and surrounding sequence affect the activation-induced deaminase activity at cytidine. J Biol Chem 2004;279: 6496-6500.
    • (2004) J Biol Chem , vol.279 , pp. 6496-6500
    • Yu, K.1    Huang, F.T.2    Lieber, M.R.3
  • 92
    • 0028270307 scopus 로고
    • Elements regulating somatic hypermutation of an immunoglobulin kappa gene: Critical role for the intron enhancer/matrix attachment region
    • Betz AG, Milstein C, Gonzalez-Fernandez A, Pannell R, Larson T, Neuberger MS: Elements regulating somatic hypermutation of an immunoglobulin kappa gene: critical role for the intron enhancer/matrix attachment region. Cell 1994;77:239-248.
    • (1994) Cell , vol.77 , pp. 239-248
    • Betz, A.G.1    Milstein, C.2    Gonzalez-Fernandez, A.3    Pannell, R.4    Larson, T.5    Neuberger, M.S.6
  • 93
    • 0031009483 scopus 로고    scopus 로고
    • Cells strongly expressing Ig(kappa) transgenes show clonal recruitment of hypermutation: A role for both MAR and the enhancers
    • Goyenechea B, Klix N, Yelamos J, et al: Cells strongly expressing Ig(kappa) transgenes show clonal recruitment of hypermutation: a role for both MAR and the enhancers. EMBO J 1997;16:3987-3994.
    • (1997) EMBO J , vol.16 , pp. 3987-3994
    • Goyenechea, B.1    Klix, N.2    Yelamos, J.3
  • 94
    • 0031975171 scopus 로고    scopus 로고
    • Multiple sequences from downstream of the Jk cluster can combine to recruit somatic hypermutation to a heterologous, upstream mutation domain
    • Klix N, Jolly CJ, Davies SL, Bruggerman M, Williams GT, Neuberger M: Multiple sequences from downstream of the Jk cluster can combine to recruit somatic hypermutation to a heterologous, upstream mutation domain. Eur J Immunol 1998;28:317-326.
    • (1998) Eur J Immunol , vol.28 , pp. 317-326
    • Klix, N.1    Jolly, C.J.2    Davies, S.L.3    Bruggerman, M.4    Williams, G.T.5    Neuberger, M.6
  • 95
    • 0029067875 scopus 로고
    • Targeting of non-Ig sequences in place of the V segment by somatic hypermutation
    • Yelamos J, Klix N, Goyenechea B, et al: Targeting of non-Ig sequences in place of the V segment by somatic hypermutation. Nature 1995;376:225-229.
    • (1995) Nature , vol.376 , pp. 225-229
    • Yelamos, J.1    Klix, N.2    Goyenechea, B.3
  • 96
    • 0035169027 scopus 로고    scopus 로고
    • The PU.1 and NF-EM5 binding motifs in the Igkappa 3′ enhancer are responsible for directing somatic hypermutations to the intrinsic hotspots in the transgenic Vkappa gene
    • Kodama M, Hayashi R, Nishizumi H, Nagawa F, Takemori T, Sakano H: The PU.1 and NF-EM5 binding motifs in the Igkappa 3′ enhancer are responsible for directing somatic hypermutations to the intrinsic hotspots in the transgenic Vkappa gene. Int Immunol 2001;13:1415-1422.
    • (2001) Int Immunol , vol.13 , pp. 1415-1422
    • Kodama, M.1    Hayashi, R.2    Nishizumi, H.3    Nagawa, F.4    Takemori, T.5    Sakano, H.6
  • 97
    • 0030992768 scopus 로고    scopus 로고
    • Sequence dependent hypermutation of the immunoglobulin heavy chain in cultured B cells
    • Lin MM, Zhu M, Scharff MD: Sequence dependent hypermutation of the immunoglobulin heavy chain in cultured B cells. Proc Natl Acad Sci USA 1997;94: 5284-5289.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 5284-5289
    • Lin, M.M.1    Zhu, M.2    Scharff, M.D.3
  • 98
    • 0031879422 scopus 로고    scopus 로고
    • The effects of Eμ, 3′α (hs, 1,2) and 3′κ enhancers on mutation of an lg-VDJ-Cγ2a immunoglobulin heavy gene in cultured B cells
    • Lin MM, Green NS, Zhang W, Scharff MD: The effects of Eμ, 3′α (hs, 1,2) and 3′κ enhancers on mutation of an lg-VDJ-Cγ2a immunoglobulin heavy gene in cultured B cells. Internat Immunol 1998;10:1121-1129.
    • (1998) Internat Immunol , vol.10 , pp. 1121-1129
    • Lin, M.M.1    Green, N.S.2    Zhang, W.3    Scharff, M.D.4
  • 100
    • 0032478269 scopus 로고    scopus 로고
    • The Ig mutator is dependent on the presence, position, and orientation of the large intron enhancer
    • Bachl J, Olsson C, Chitkara N, Wabl M: The Ig mutator is dependent on the presence, position, and orientation of the large intron enhancer. Proc Natl Acad Sci USA 1998;95:2396-2399.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 2396-2399
    • Bachl, J.1    Olsson, C.2    Chitkara, N.3    Wabl, M.4
  • 101
    • 0031041632 scopus 로고    scopus 로고
    • The transcriptional promoter regulates hypermutation of the antibody heavy chain locus
    • Tumas-Brundage K, Manser T: The transcriptional promoter regulates hypermutation of the antibody heavy chain locus. J Exp Med 1997;185:239-250.
    • (1997) J Exp Med , vol.185 , pp. 239-250
    • Tumas-Brundage, K.1    Manser, T.2
  • 102
    • 0032127810 scopus 로고    scopus 로고
    • Somatic hypermutation in the heavy chain locus correlates with transcription
    • Fukita Y, Jacobs H, Rajewsky K: Somatic hypermutation in the heavy chain locus correlates with transcription. Immunity 1998;9:105-114.
    • (1998) Immunity , vol.9 , pp. 105-114
    • Fukita, Y.1    Jacobs, H.2    Rajewsky, K.3
  • 103
    • 0034744191 scopus 로고    scopus 로고
    • The 3′ Igkappa enhancer contains RNA polymerase II promoters: Implications for endogenous and transgenic kappa gene expression
    • Shen HM, Peters A, Kao D, Storb U: The 3′ Igkappa enhancer contains RNA polymerase II promoters: implications for endogenous and transgenic kappa gene expression. Int Immunol 2001;13:665-674.
    • (2001) Int Immunol , vol.13 , pp. 665-674
    • Shen, H.M.1    Peters, A.2    Kao, D.3    Storb, U.4
  • 104
    • 0029965649 scopus 로고    scopus 로고
    • Enhancers of hypermutation
    • Bachl J, Wabl M: Enhancers of hypermutation. Immunogenetics 1996;45:59-64.
    • (1996) Immunogenetics , vol.45 , pp. 59-64
    • Bachl, J.1    Wabl, M.2
  • 105
    • 0032435650 scopus 로고    scopus 로고
    • TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line
    • Sale JE, Neuberger MS: TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line. Immunity 1998;9:859-869.
    • (1998) Immunity , vol.9 , pp. 859-869
    • Sale, J.E.1    Neuberger, M.S.2
  • 106
  • 107
    • 10744225444 scopus 로고    scopus 로고
    • High expression of activation-induced cytidine deaminase (AID) and splice variants is a distinctive feature of poor-prognosis chronic lymphocytic leukemia
    • McCarthy H, Wierda WG, Barron LL, et al: High expression of activation-induced cytidine deaminase (AID) and splice variants is a distinctive feature of poor-prognosis chronic lymphocytic leukemia. Blood 2003;101:4903-4908.
    • (2003) Blood , vol.101 , pp. 4903-4908
    • McCarthy, H.1    Wierda, W.G.2    Barron, L.L.3
  • 108
    • 0021829149 scopus 로고
    • Clustering of breakpoints on chromosome 11 in human B-cell neoplasms with the t(11;14) chromosome translocation
    • Tsujimoto Y, Jaffe E, Cossman J, Gorham J, Nowell PC, Croce CM: Clustering of breakpoints on chromosome 11 in human B-cell neoplasms with the t(11;14) chromosome translocation. Nature 1985;315: 340-343.
    • (1985) Nature , vol.315 , pp. 340-343
    • Tsujimoto, Y.1    Jaffe, E.2    Cossman, J.3    Gorham, J.4    Nowell, P.C.5    Croce, C.M.6
  • 109
    • 0034667427 scopus 로고    scopus 로고
    • BCL-6 mutations are associated with immunoglobulin variable heavy chain mutations in B-cell chronic lymphocytic leukemia
    • Pasqualucci L, Neri A, Baldini L, Dalla-Favera R, Migliazza A: BCL-6 mutations are associated with immunoglobulin variable heavy chain mutations in B-cell chronic lymphocytic leukemia. Cancer Res 2000;60:5644-5648.
    • (2000) Cancer Res , vol.60 , pp. 5644-5648
    • Pasqualucci, L.1    Neri, A.2    Baldini, L.3    Dalla-Favera, R.4    Migliazza, A.5
  • 110
    • 0037881911 scopus 로고    scopus 로고
    • Constitutive expression of AID leads to tumorigenesis
    • Okazaki IM, Hiai H, Kakazu N, et al: Constitutive expression of AID leads to tumorigenesis. J Exp Med 2003;197:1173-1181.
    • (2003) J Exp Med , vol.197 , pp. 1173-1181
    • Okazaki, I.M.1    Hiai, H.2    Kakazu, N.3
  • 111
    • 0037069331 scopus 로고    scopus 로고
    • Negative autoregulation of BCL-6 is bypassed by genetic alterations in diffuse large B cell lymphomas
    • Wang X, Li Z, Naganuma A, Ye BH: Negative autoregulation of BCL-6 is bypassed by genetic alterations in diffuse large B cell lymphomas. Proc Natl Acad Sci USA 2002;99:15018-15023.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 15018-15023
    • Wang, X.1    Li, Z.2    Naganuma, A.3    Ye, B.H.4
  • 112
    • 0029585240 scopus 로고
    • BCL6 gene rearrangement and other cytogenetic abnormalities in diffuse large cell lymphoma
    • Offit K, Louie DC, Parsa NZ, et al: BCL6 gene rearrangement and other cytogenetic abnormalities in diffuse large cell lymphoma. Leuk Lymphoma 1995;20:85-89.
    • (1995) Leuk Lymphoma , vol.20 , pp. 85-89
    • Offit, K.1    Louie, D.C.2    Parsa, N.Z.3
  • 113
    • 0001292985 scopus 로고
    • Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells
    • Taub R, Kirsch I, Morton C, et al: Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells. Proc Natl Acad Sci USA 1982;79: 7837-7841.
    • (1982) Proc Natl Acad Sci USA , vol.79 , pp. 7837-7841
    • Taub, R.1    Kirsch, I.2    Morton, C.3
  • 114
    • 0027299245 scopus 로고
    • Cloning of bcl-6, the locus involved in chromosome translocations affecting band 3q27 in B-cell lymphoma
    • Ye BH, Rao PH, Chaganti RS, Dalla-Favera R: Cloning of bcl-6, the locus involved in chromosome translocations affecting band 3q27 in B-cell lymphoma. Cancer Res 1993;53:2732-2735.
    • (1993) Cancer Res , vol.53 , pp. 2732-2735
    • Ye, B.H.1    Rao, P.H.2    Chaganti, R.S.3    Dalla-Favera, R.4
  • 115
    • 4644257592 scopus 로고    scopus 로고
    • AID is required for c-myc/IgH chromosome translocations in vivo
    • Ramiro AR, Jankovic M, Eisenreich T, et al: AID is required for c-myc/IgH chromosome translocations in vivo. Cell 2004;118:431-438.
    • (2004) Cell , vol.118 , pp. 431-438
    • Ramiro, A.R.1    Jankovic, M.2    Eisenreich, T.3
  • 116
    • 9244241060 scopus 로고    scopus 로고
    • Identification of an AID-independent pathway for chromosomal translocations between the Igh switch region and Myc
    • Unniraman S, Zhou S, Schatz DG: Identification of an AID-independent pathway for chromosomal translocations between the Igh switch region and Myc. Nat Immunol 2004;5:1117-1123.
    • (2004) Nat Immunol , vol.5 , pp. 1117-1123
    • Unniraman, S.1    Zhou, S.2    Schatz, D.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.