Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein

Journal of Experimental Medicine

Volumn 187, Issue 11, 1998, Pages 1745-1750

  Phung, Quy H ^a,b   Winter, David B ^a   Cranston, Aaron ^c   Tarone, Robert E ^d   Bohr, Vilhelm A ^a   Fishel, Richard ^c   Gearhart, Patricia J ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Biological sciences; DNA repair; Genes, immunoglobulin; Genetics; Mutation

Indexed keywords

DNA POLYMERASE; HETERODUPLEX;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE ACTIVATION; BASE MISPAIRING; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DNA STRAND BREAKAGE; GENE MUTATION; GENE REARRANGEMENT; GERM LINE; IMMUNOGLOBULIN GENE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

ANIMALS; BASE COMPOSITION; BASE SEQUENCE; CYTOSINE; DNA REPAIR; DNA-BINDING PROTEINS; GENE DELETION; GENE REARRANGEMENT, B-LYMPHOCYTE; GUANINE; IMMUNOGLOBULIN KAPPA-CHAINS; IMMUNOGLOBULIN VARIABLE REGION; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; MUTATION; MUTS HOMOLOG 2 PROTEIN; NUCLEIC ACID HETERODUPLEXES; OXAZOLONE; PROTO-ONCOGENE PROTEINS;

EID: 0032101611     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.187.11.1745     Document Type: Article

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