Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions

Journal of Experimental Medicine

Volumn 195, Issue 3, 2002, Pages 367-373

  Schrader, Carol E ^a   Vardo, Joycelyn ^a   Stavnezer, Janet ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Antibody heavy chain isotypes; DNA recombination; DNA repair; Mismatch repair; Splenic B cells

Indexed keywords

IMMUNOGLOBULIN; IMMUNOGLOBULIN HEAVY CHAIN; MISMATCH REPAIR PROTEIN PMS2; PROTEIN; PROTEIN MLH1; PROTEIN MSH2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CELL CYCLE; CELL VIABILITY; CONTROLLED STUDY; FEMALE; GENE INSERTION; GENE REARRANGEMENT; GENETIC RECOMBINATION; MALE; MISMATCH REPAIR; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FUNCTION; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SPLEEN;

ADENOSINE TRIPHOSPHATASES; ANIMALS; B-LYMPHOCYTES; BASE PAIR MISMATCH; BASE SEQUENCE; CARRIER PROTEINS; DNA; DNA REPAIR; DNA REPAIR ENZYMES; DNA-BINDING PROTEINS; IMMUNOGLOBULIN CLASS SWITCHING; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; MUTS HOMOLOG 2 PROTEIN; NEOPLASM PROTEINS; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS; RECOMBINATION, GENETIC; SEQUENCE HOMOLOGY, NUCLEIC ACID;

EID: 0037017390     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20011877     Document Type: Article

References (28)

1. Molecular processes that regulate class switching
2. DNA sequences at immunoglobulin switch region recombination sites
3. The liaison of isotype class switch and mismatch repair: An illegitimate affair
4. Ku70 is required for late B cell development and immunoglobulin heavy chain switching
5. Ku80 is required for immunoglobulin isotype switching
6. Mutations, duplication, and deletion of recombined switch regions suggest a role for DNA replication in the immunoglobulin heavy-chain switch
7. Ig Sg3 DNA-specific double strand breaks are induced in mitogen-activated B cells and are implicated in switch recombination
8. Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes
9. DNA double-strand breaks in immunoglobulin genes undergoing somatic hypermutation
10. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
11. Multiple functions of MutS- and MutL-related heterocomplexes
12. Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2
13. Mismatch repair co-opted by hypermutation
14. Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting
15. Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern
16. Mismatch repair proteins and mitotic genome stability
17. Saccharomyces cerevisiae MSH2/6 complex interacts with Holliday junctions and facilitates their cleavage by phage resolution enzymes
18. Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis
19. Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over
20. Role of Saccharomyces cerevisiae Msh2 and Msh3 repair proteins in double-strand break-induced recombination
21. Two pathways for removal of nonhomologous DNA ends during double-strand break repair in Saccharomyces cerevisiae
22. Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes
23. Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: Parallels with somatic hypermutation
24. Severe attenuation of the B cell immune response in Msh2-deficient mice
25. Somatic Apc mutations are selected upon their capacity to inactivate the β-catenin downregulating activity
26. Enhancement of MSH2-MSH3-mediated mismatch recognition by the yeast MLH1-PMS1 complex
27. High affinity cooperative DNA binding by the yeast Mlh1-Pms1 heterodimer