Somatic mutation of the CD95 gene in human B cells as a side-effect of the germinal center reaction

Journal of Experimental Medicine

Volumn 192, Issue 12, 2000, Pages 1833-1839

  Müschen, Markus ^a,b   Re, Daniel ^a   Jungnickel, Berit ^a   Diehl, Volker ^a   Rajewsky, Klaus ^a   Küppers, Ralf ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

Apoptosis; B lymphocytes; CD95 (Apo 1 Fas); Germinal center; Somatic hypermutation

Indexed keywords

FAS ANTIGEN;

ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; B LYMPHOCYTE ACTIVATION; BASE PAIRING; GENE REARRANGEMENT; GENE TARGETING; GERMINAL CENTER; HUMAN; HUMAN CELL; IMMUNOGLOBULIN GENE; MALIGNANT TRANSFORMATION; MEMORY CELL; MOLECULAR CLONING; PRIORITY JOURNAL; SOMATIC MUTATION;

ANTIGENS, CD95; APOPTOSIS; B-LYMPHOCYTES; CLONING, MOLECULAR; DNA MUTATIONAL ANALYSIS; EXONS; FLOW CYTOMETRY; GENES, TUMOR SUPPRESSOR; GERMINAL CENTER; HUMANS; IMMUNOLOGIC MEMORY; MUTAGENESIS; POLYMERASE CHAIN REACTION; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION;

EID: 0034684682     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.192.12.1833     Document Type: Article

References (27)

1. Clonal selection and learning in the antibody system
2. Somatic hypermutation in normal and transformed human B cells
3. Mutation of the bcl-6 gene in normal B cells by the process of somatic hypermutation of Ig genes
4. BCL-6 mutations in normal germinal center B cells: Evidence of somatic hypermutation acting outside Ig loci
5. Defining CD95 as a tumor suppressor gene
6. Fas is highly expressed in the germinal center but is not required for regulation of the B-cell response to antigen
7. Human germinal center B cells express the apoptosis-inducing genes Fas, c-myc, p53 and Bax but not the survival gene bcl-2
8. Regulation of germinal center B cell differentiation. Role of the human Apo-1/Fas (CD95) molecule
9. Opposing roles of CD95 (Fas/Apo-1) and CD40 in the death and rescue of human low density tonsillar B cells
10. Cellular and molecular factors that regulate the differentiation and apoptosis of germinal center B cells. Anti-Ig downregulates Fas expression of CD40 ligand-stimulated germinal center B cells and inhibits Fas-mediated apoptosis
11. Mechanisms of selection and differentiation in germinal centers
12. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
13. Spontaneous development of plasmacytoid tumors in mice with defective Fas-Fas ligand interactions
14. Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome
15. Pathological findings in human autoimmune lymphoproliferative syndrome
16. Mutations in the Fas antigen in patients with multiple myeloma
17. Somatic Fas mutations in non-Hodgkin's lymphoma: Assocation with extranodal disease and autoimmunity
18. CD95 (Apo-1/Fas)-mediated apoptosis: Live and let die
19. Frequent occurrence of deletions and duplications during somatic hypermutation: Implications for oncogene translocations and heavy chain disease
20. Clonal deleterious mutations in the IκBα gene in the malignant cells in Hodgkin's lymphoma
21. Whole genome amplification of a single cell: Implication for genetic analysis
22. + germinal center B lymphocytes after rescue from apoptosis
23. Sensitivity of Epstein-Barr virus induced B cell tumor to apoptosis mediated by anti-CD95/Apo-1/Fas antibody
24. Protection against Fas-dependent Th1-mediated apoptosis by antigen receptor engagement in B cells
25. Soluble antigen can cause enhanced apoptosis of germinal centre B cells
26. Somatic mutations of the CD95 gene in Hodgkin- and Reed-Sternberg cells
27. Cellular origin of human B-cell lymphomas