AID is essential for immunoglobulin V gene conversion in a cultured B cell line

Current Biology

Volumn 12, Issue 5, 2002, Pages 435-438

  Harris, Reuben S ^a   Sale, Julian E ^a   Petersen Mahrt, Svend K ^a   Neuberger, Michael S ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GALLUS GALLUS; ORYCTOLAGUS CUNICULUS;

AICDA (ACTIVATION INDUCED CYTIDINE DEAMINASE); AICDA (ACTIVATION-INDUCED CYTIDINE DEAMINASE); CYTIDINE DEAMINASE;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; B LYMPHOCYTE; CELL LINE; CHICKEN; ENZYMOLOGY; GENE CONVERSION; GENE TARGETING; GENETICS; HUMAN; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGY; MOLECULAR GENETICS; MOUSE; RABBIT; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; B-LYMPHOCYTES; CELL LINE; CHICKENS; CYTIDINE DEAMINASE; GENE CONVERSION; GENE TARGETING; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; MICE; MOLECULAR SEQUENCE DATA; RABBITS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0037022540     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(02)00717-0     Document Type: Article

References (14)

1. Early B-cell development in chickens, sheep and rabbits
2. Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells
3. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
4. Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)
5. Cell lines derived from avian lymphomas exhibit two distinct phenotypes
6. Light chain gene conversion continues at high rate in an ALV-induced cell line
7. Ongoing diversification of the rearranged immunoglobulin light-chain gene in a bursal lymphoma cell line
8. Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation
9. Somatic hypermutation: How many mechanisms diversify V region sequences?
10. Rearrangement/hypermutation/gene conversion: When, where and why?
11. Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: Parallels with somatic hypermutation
12. Antibody diversification and selection in the mature B-cell compartment
13. AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching
14. Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting