Examination of Msh6- and Msh3-deficient mice in class switching reveals overlapping and distinct roles of MutS homologues in antibody diversification

Journal of Experimental Medicine

Volumn 200, Issue 1, 2004, Pages 47-59

  Li, Ziqiang ^a   Scherer, Stefan J ^a   Ronai, Diana ^a   Iglesias Ussel, Maria D ^a   Peled, Jonathan U ^a   Bardwell, Philip D ^a   Zhuang, Min ^b   Lee, KyeRyoung ^a   Martin, Alberto ^a,c   Edelmann, Winfried ^a   Scharff, Matthew D ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b MONTEFIORE MEDICAL CENTER   (United States)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Isotype switching; Mismatch repair; Somatic hypermutation; Switch region mutation; Switching junction

Indexed keywords

DNA; IMMUNOGLOBULIN CLASS; LIPOPOLYSACCHARIDE;

ANIMAL CELL; ANIMAL MODEL; ANTIGEN BINDING; ARTICLE; B LYMPHOCYTE; BASE PAIRING; BINDING SITE; CELL PROLIFERATION; CLASS SWITCH RECOMBINATION; CONTROLLED STUDY; DNA REPAIR; GENETIC RECOMBINATION; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN ISOTYPE SWITCHING; IMMUNOGLOBULIN VARIABLE REGION; MISMATCH REPAIR; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SOMATIC HYPERMUTATION; SPLEEN CELL; SWITCH REGION MUTATION; SWITCHING JUNCTION;

ANIMALS; ANTIBODY DIVERSITY; B-LYMPHOCYTES; BASE PAIR MISMATCH; DNA MUTATIONAL ANALYSIS; DNA REPAIR; DNA-BINDING PROTEINS; IMMUNOGLOBULIN CLASS SWITCHING; INTERLEUKIN-4; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PROTEINS; RECOMBINATION, GENETIC;

EID: 3142674907     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20040355     Document Type: Article

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