Aid: How does it aid antibody diversity?

Immunity

Volumn 20, Issue 6, 2004, Pages 659-668

  Honjo, Tasuku ^a   Muramatsu, Masamichi ^a   Fagarasan, Sidonia ^b  

^a KYOTO UNIVERSITY   (Japan)

^b RIKEN YOKOHAMA INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CYTIDINE DEAMINASE;

DEAMINATION; DNA CLEAVAGE; DNA RECOMBINATION; DNA STRAND BREAKAGE; ENZYME STRUCTURE; EXCISION REPAIR; GENE CONVERSION; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; REVIEW; RNA EDITING; SOMATIC HYPERMUTATION;

ANIMALS; ANTIBODY DIVERSITY; B-LYMPHOCYTES; CYTIDINE DEAMINASE; DNA; HUMANS; RNA EDITING; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN;

EID: 2942613670     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.immuni.2004.05.011     Document Type: Review

References (81)

1. Arakawa H., Buerstedde J.M. Immunoglobulin gene conversion. insights from bursal B cells and the DT40 cell line Dev. Dyn. 229:2004;458-464
2. Arakawa H., Hauschild J., Buerstedde J.M. Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion. Science. 295:2002;1301-1306
3. Bardwell P.D., Woo C.J., Wei K., Li Z., Martin A., Sack S.Z., Parris T., Edelmann W., Scharff M.D. Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice. Nat. Immunol. 5:2004;224-229
4. Bemark M., Sale J.E., Kim H.J., Berek C., Cosgrove R.A., Neuberger M.S. Somatic hypermutation in the absence of DNA-dependent protein kinase catalytic subunit (DNA-PK(cs)) or recombination-activating gene (RAG)1 activity. J. Exp. Med. 192:2000;1509-1514
5. Bosma G.C., Kim J., Urich T., Fath D.M., Cotticelli M.G., Ruetsch N.R., Radic M.Z., Bosma M.J. DNA-dependent protein kinase activity is not required for immunoglobulin class switching. J. Exp. Med. 196:2002;1483-1495
6. Bransteitter R., Pham P., Scharff M.D., Goodman M.F. Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase. Proc. Natl. Acad. Sci. USA. 100:2003;4102-4107
7. Bross L., Muramatsu M., Kinoshita K., Honjo T., Jacobs H. DNA double-strand breaks. prior to but not sufficient in targeting hypermutation J. Exp. Med. 195:2002;1187-1192
8. Casellas R., Nussenzweig A., Wuerffel R., Pelanda R., Reichlin A., Suh H., Qin X.F., Besmer E., Kenter A., Rajewsky K., et al. Ku80 is required for immunoglobulin isotype switching. EMBO J. 17:1998;2404-2411
9. Catalan N., Selz F., Imai K., Revy P., Fischer A., Durandy A. The block in immunoglobulin class switch recombination caused by activation-induced cytidine deaminase deficiency occurs prior to the generation of DNA double strand breaks in switch μ region. J. Immunol. 171:2003;2504-2509
10. Celeste A., Petersen S., Romanienko P.J., Fernandez-Capetillo O., Chen H.T., Sedelnikova O.A., Reina-San-Martin B., Coppola V., Meffre E., Difilippantonio M.J., et al. Genomic instability in mice lacking histone H2AX. Science. 296:2002;922-927
11. Chaudhuri J., Tian M., Khuong C., Chua K., Pinaud E., Alt F.W. Transcription-targeted DNA deamination by the AID antibody diversification enzyme. Nature. 422:2003;726-730
12. Chen X., Kinoshita K., Honjo T. Variable deletion and duplication at recombination junction ends. implication for staggered double-strand cleavage in class switch recombination Proc. Natl. Acad. Sci. USA. 98:2001;13860-13865
13. Chester A., Somasekaram A., Tzimina M., Jarmuz A., Gisbourne J., O'Keefe R., Scott J., Navaratnam N. The apolipoprotein B mRNA editing complex performs a multifunctional cycle and suppresses nonsense-mediated decay. EMBO J. 22:2003;3971-3982
14. De Silva F.S., Moss B. Vaccinia virus uracil DNA glycosylase has an essential role in DNA synthesis that is independent of its glycosylase activity. catalytic site mutations reduce virulence but not virus replication in cultured cells J. Virol. 77:2003;159-166
15. Di Noia J., Neuberger M.S. Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase. Nature. 419:2002;43-48
16. Diaz M., Verkoczy L.K., Flajnik M.F., Klinman N.R. Decreased frequency of somatic hypermutation and impaired affinity maturation but intact germinal center formation in mice expressing antisense RNA to DNA polymerase ζ J. Immunol. 167:2001;327-335
17. Diaz M., Ray M., Wheeler L.J., Verkoczy L.K., Mathews C.K. Mutagenesis by AID, a molecule critical to immunoglobulin hypermutation, is not caused by an alteration of the precursor nucleotide pool. Mol. Immunol. 40:2003;261-268
18. Dickerson S.K., Market E., Besmer E., Papavasiliou F.N. AID mediates hypermutation by deaminating single stranded DNA. J. Exp. Med. 197:2003;1291-1296
19. Doi T., Kinoshita K., Ikegawa M., Muramatsu M., Honjo T. De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination. Proc. Natl. Acad. Sci. USA. 100:2003;2634-2638
20. Durandy A., Honjo T. Human genetic defects in class-switch recombination (hyper-IgM syndromes). Curr. Opin. Immunol. 13:2001;543-548
21. Eto T., Kinoshita K., Yoshikawa K., Muramatsu M., Honjo T. RNA-editing cytidine deaminase Apobec-1 is unable to induce somatic hypermutation in mammalian cells. Proc. Natl. Acad. Sci. USA. 100:2003;12895-12898
22. Fagarasan S., Honjo T. Intestinal IgA synthesis. regulation of front-line body defences Nat. Rev. Immunol. 3:2003;63-72
23. Fagarasan S., Kinoshita K., Muramatsu M., Ikuta K., Honjo T. In situ class switching and differentiation to IgA-producing cells in the gut lamina propria. Nature. 413:2001;639-643
24. Fagarasan S., Muramatsu M., Suzuki K., Nagaoka H., Hiai H., Honjo T. Critical roles of activation-induced cytidine deaminase (AID) in the homeostasis of gut flora. Science. 298:2002;1424-1427
25. Faili A., Aoufouchi S., Gueranger Q., Zober C., Leon A., Bertocci B., Weill J.C., Reynaud C.A. AID-dependent somatic hypermutation occurs as a DNA single-strand event in the BL2 cell line. Nat. Immunol. 3:2002;815-821
26. Fugmann S.D., Rush J.S., Schatz D.G. Non-redundancy of cytidine deaminases in class switch recombination. Eur. J. Immunol. 34:2004;844-849
27. Harada Y., Muramatsu M., Shibata T., Honjo T., Kuroda K. Unmutated immunoglobulin M can protect mice from death by influenza virus infection. J. Exp. Med. 197:2003;1779-1785
28. Harris R.S., Petersen-Mahrt S.K., Neuberger M.S. RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators. Mol. Cell. 10:2002;1247-1253
29. Honjo T., Kinoshita K., Muramatsu M. Molecular mechanism of class switch recombination. linkage with somatic hypermutation Annu. Rev. Immunol. 20:2002;165-196
30. Imai K., Slupphaug G., Lee W.I., Revy P., Nonoyama S., Catalan N., Yel L., Forveille M., Kavli B., Krokan H.E., et al. Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination. Nat. Immunol. 4:2003;1023-1028
31. Ito S., Nagaoka H., Shinkura R., Begum N., Muramatsu M., Nakata M., Honjo T. Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1. Proc. Natl. Acad. Sci. USA. 101:2004;1975-1980
32. Krokan H.E., Drablos F., Slupphaug G. Uracil in DNA - occurrence, consequences and repair. Oncogene. 21:2002;8935-8948
33. Lau P.P., Zhu H.J., Baldini A., Charnsangavej C., Chan L. Dimeric structure of a human apolipoprotein B mRNA editing protein and cloning and chromosomal localization of its gene. Proc. Natl. Acad. Sci. USA. 91:1994;8522-8526
34. Maizels N. Secret sharers in the immune system. a novel RNA editing activity links switch recombination and somatic hypermutation Genome Biol. 1:2000;1025
35. Manis J.P., Gu Y., Lansford R., Sonoda E., Ferrini R., Davidson L., Rajewsky K., Alt F.W. Ku70 is required for late B cell development and immunoglobulin heavy chain switching. J. Exp. Med. 187:1998;2081-2089
36. Manis J.P., Dudley D., Kaylor L., Alt F.W. IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells. Immunity. 16:2002;607-617
37. Martin A., Scharff M.D. AID and mismatch repair in antibody diversification. Nat. Rev. Immunol. 2:2002;605-614. a
38. Martin A., Scharff M.D. Somatic hypermutation of the AID transgene in B and non-B cells. Proc. Natl. Acad. Sci. USA. 99:2002;12304-12308. b
39. Martin A., Bardwell P.D., Woo C.J., Fan M., Shulman M.J., Scharff M.D. Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas. Nature. 415:2002;802-806
40. Martin A., Li Z., Lin D.P., Bardwell P.D., Iglesias-Ussel M.D., Edelmann W., Scharff M.D. Msh2 ATPase activity is essential for somatic hypermutation at a-T basepairs and for efficient class switch recombination. J. Exp. Med. 198:2003;1171-1178
41. Mehta A., Kinter M.T., Sherman N.E., Driscoll D.M. Molecular cloning of apobec-1 complementation factor, a novel RNA-binding protein involved in the editing of apolipoprotein B mRNA. Mol. Cell. Biol. 20:2000;1846-1854
42. Mol C.D., Arvai A.S., Sanderson R.J., Slupphaug G., Kavli B., Krokan H.E., Mosbaugh D.W., Tainer J.A. Crystal structure of human uracil-DNA glycosylase in complex with a protein inhibitor. protein mimicry of DNA Cell. 82:1995;701-708. a
43. Mol C.D., Arvai A.S., Slupphaug G., Kavli B., Alseth I., Krokan H.E., Tainer J.A. Crystal structure and mutational analysis of human uracil-DNA glycosylase. structural basis for specificity and catalysis Cell. 80:1995;869-878. b
44. Muramatsu M., Sankaranand V.S., Anant S., Sugai M., Kinoshita K., Davidson N.O., Honjo T. Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells. J. Biol. Chem. 274:1999;18470-18476
45. Muramatsu M., Kinoshita K., Fagarasan S., Yamada S., Shinkai Y., Honjo T. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell. 102:2000;553-563
46. Muto T., Muramatsu M., Taniwaki M., Kinoshita K., Honjo T. Isolation, tissue distribution and chromosomal localization of the human activation-induced cytidine deaminase (hAID) gene. Genomics. 68:2000;85-88
47. Nilsen H., Rosewell I., Robins P., Skjelbred C.F., Andersen S., Slupphaug G., Daly G., Krokan H.E., Lindahl T., Barnes D.E. Uracil-DNA glycosylase (UNG)-deficient mice reveal a primary role of the enzyme during DNA replication. Mol. Cell. 5:2000;1059-1065
48. Nilsen H., Stamp G., Andersen S., Hrivnak G., Krokan H.E., Lindahl T., Barnes D.E. Gene-targeted mice lacking the Ung uracil-DNA glycosylase develop B-cell lymphomas. Oncogene. 22:2003;5381-5386
49. Oettinger M.A., Schatz D.G., Gorka C., Baltimore D. RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science. 248:1990;1517-1523
50. Okazaki I.M., Kinoshita K., Muramatsu M., Yoshikawa K., Honjo T. The AID enzyme induces class switch recombination in fibroblasts. Nature. 416:2002;340-345
51. Okazaki I.M., Hiai H., Kakazu N., Yamada S., Muramatsu M., Kinoshita K., Honjo T. Constitutive expression of AID leads to tumorigenesis. J. Exp. Med. 197:2003;1173-1181
52. Papavasiliou F.N., Schatz D.G. Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes. Nature. 408:2000;216-221
53. Papavasiliou F.N., Schatz D.G. The activation-induced deaminase functions in a postcleavage step of the somatic hypermutation process. J. Exp. Med. 195:2002;1193-1198
54. Parikh S.S., Putnam C.D., Tainer J.A. Lessons learned from structural results on uracil-DNA glycosylase. Mutat. Res. 460:2000;183-199
55. Petersen S., Casellas R., Reina-San-Martin B., Chen H.T., Difilippantonio M.J., Wilson P.C., Hanitsch L., Celeste A., Muramatsu M., Pilch D.R., et al. AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching. Nature. 414:2001;660-665
56. Petersen-Mahrt S.K., Harris R.S., Neuberger M.S. AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification. Nature. 418:2002;99-104
57. Pham P., Bransteitter R., Petruska J., Goodman M.F. Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation. Nature. 424:2003;103-107
58. Phung Q.H., Winter D.B., Cranston A., Tarone R.E., Bohr V.A., Fishel R., Gearhart P.J. Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein. J. Exp. Med. 187:1998;1745-1751
59. Rada C., Ehrenstein M.R., Neuberger M.S., Milstein C. Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting. Immunity. 9:1998;135-141
60. Rada C., Williams G.T., Nilsen H., Barnes D.E., Lindahl T., Neuberger M.S. Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice. Curr. Biol. 12:2002;1748-1755
61. Ramiro A.R., Stavropoulos P., Jankovic M., Nussenzweig M.C. Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand. Nat. Immunol. 4:2003;452-456
62. Revy P., Muto T., Levy Y., Geissmann F., Plebani A., Sanal O., Catalan N., Forveille M., Dufourcq-Labelouse R., Gennery A., et al. Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2). Cell. 102:2000;565-575
63. Reynaud C.A., Aoufouchi S., Faili A., Weill J.C. What role for AID. mutator, or assembler of the immunoglobulin mutasome? Nat. Immunol. 4:2003;631-638
64. Rolink A., Melchers F., Andersson J. The SCID but not the RAG-2 gene product is required for Sμ-Sε heavy chain class switching. Immunity. 5:1996;319-330
65. Rush J.S., Fugmann S.D., Schatz D.G. Staggered AID-dependent DNA double strand breaks are the predominant DNA lesions targeted to S μ in Ig class switch recombination. Int. Immunol. 16:2004;549-557
66. Sale J.E., Calandrini D.M., Takata M., Takeda S., Neuberger M.S. Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation. Nature. 412:2001;921-926
67. Schatz D.G., Oettinger M.A., Baltimore D. The V(D)J recombination activating gene, RAG-1. Cell. 59:1989;1035-1048
68. Sekiguchi J., Alt F., Oettinger M.A. The mechanisms of V(D)J recombination. Honjo T., Alt F., Neuberger M. Molecular Biology of B Cells. 2004;62-71 Elsevier Academic Press, San Diego
69. Shinkura R., Ito S., Begum N., Nagaoka H., Muramatsu M., Kinoshita K., Sakakibara Y., Hijikata H., Honjo T. Separate domains of AID are required for somatic hypermutation and class switch recombination. Nat. Immunol. in press:2004
70. Sohail A., Klapacz J., Samaranayake M., Ullah A., Bhagwat A.S. Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations. Nucleic Acids Res. 31:2003;2990-2994
71. Stavnezer J., Kinoshita K., Muramatsu M., Honjo T. Molecular mechanisms of class switch recombination. Honjo T., Alt F., Neuberger M. Molecular Biology of B Cells. 2004;307-319 Elsevier Academic Press, San Diego
72. Suzuki K., Meek B., Doi Y., Muramatsu M., Chiba T., Honjo T., Fagarasan S. Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut. Proc. Natl. Acad. Sci. USA. 101:2004;1981-1986
73. Ta V.T., Nagaoka H., Catalan N., Durandy A., Fischer A., Imai K., Nonoyama S., Tashiro J., Ikegawa M., Ito S., et al. AID mutant analyses indicate requirement for class-switch-specific cofactors. Nat. Immunol. 4:2003;843-848
74. Teng B., Burant C.F., Davidson N.O. Molecular cloning of an apolipoprotein B messenger RNA editing protein. Science. 260:1993;1816-1819
75. Wang H., Lawrence C.W., Li G.M., Hays J.B. Specific binding of human MSH2.MSH6 mismatch-repair protein heterodimers to DNA incorporating thymine- or uracil-containing UV light photoproducts opposite mismatched bases. J. Biol. Chem. 274:1999;16894-16900
76. Yavuz S., Yavuz A.S., Kraemer K.H., Lipsky P.E. The role of polymerase η in somatic hypermutation determined by analysis of mutations in a patient with xeroderma pigmentosum variant. J. Immunol. 169:2002;3825-3830
77. Yoshikawa K., Okazaki I.M., Eto T., Kinoshita K., Muramatsu M., Nagaoka H., Honjo T. AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts. Science. 296:2002;2033-2036
78. Yu K., Huang F.T., Lieber M.R. DNA substrate length and surrounding sequence affect the activation-induced deaminase activity at cytidine. J. Biol. Chem. 279:2004;6496-6500
79. Zan H., Komori A., Li Z., Cerutti A., Schaffer A., Flajnik M.F., Diaz M., Casali P. The translesion DNA polymerase ζ plays a major role in Ig and bcl-6 somatic hypermutation. Immunity. 14:2001;643-653
80. Zan H., Wu X., Komori A., Holloman W.K., Casali P. AID-dependent generation of resected double-strand DNA breaks and recruitment of Rad52/Rad51 in somatic hypermutation. Immunity. 18:2003;727-738
81. Zeng X., Winter D.B., Kasmer C., Kraemer K.H., Lehmann A.R., Gearhart P.J. DNA polymerase η is an A-T mutator in somatic hypermutation of immunoglobulin variable genes. Nat. Immunol. 2:2001;537-541