The translesion DNA polymerase ζ plays a major role in Ig and bcl-6 somatic hypermutation

Immunity

Volumn 14, Issue 5, 2001, Pages 643-653

  Zan, Hong ^a   Komori, Atsumasa ^a   Li, Zongdong ^a   Cerutti, Andrea ^a   Schaffer, András ^a,c   Flajnik, Martin F ^d   Diaz, Marilyn ^e   Casali, Paolo ^a,b,c  

^a Division of Allergy and Immunology   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c Weill Cornell Graduate School of Biomedical Sciences   (United States)

^d UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^e SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; DNA POLYMERASE; IMMUNOGLOBULIN; OLIGONUCLEOTIDE; PHOSPHOROTHIOIC ACID DERIVATIVE; POLYMERASE ETA; POLYMERASE ZETA REV3 CATALYTIC SUBUNIT; PROTEIN BCL 6; TRANSLESION DNA POLYMERASE ZETA; UNCLASSIFIED DRUG;

ARTICLE; B LYMPHOCYTE; BASE MISPAIRING; CELL ACTIVATION; COCULTURE; DNA REPAIR; DNA REPLICATION; DOWN REGULATION; ENZYME INHIBITION; HUMAN; MOUSE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; SOMATIC MUTATION; T LYMPHOCYTE; TONSIL CELL; ULTRAVIOLET RADIATION;

EID: 0035005241     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(01)00142-X     Document Type: Article

References (79)

1. Two novel human and mouse DNA polymerases of the pol X family
2. Hypermutation in T cells questioned
3. Proofreading of DNA polymerase η-dependent replication errors
4. Disruption of mouse polymerase zeta (Rev3) leads to embryonic lethality and impairs blastocyst development in vitro
5. Probing immunoglobulin gene hypermutation with microsatellites suggests a nonreplicative short patch DNA synthesis process
6. DNA double-strand breaks in immunoglobulin genes undergoing somatic hypermutation
7. Eukaryotic DNA polymerases in DNA replication and DNA repair
8. Inhibition of gene expression and cell proliferation by triple helix-forming oligonucleotides directed to the c-myc gene
9. + B cell line
10. CD30 is a CD40-inducible molecule that negatively regulates CD40-mediated immunoglobulin class switching in non-antigen-selected human B cells
11. + B cells
12. Triplex DNA: Fundamentals, advances, and potential applications for gene therapy
13. H genes are inherently susceptible to amino acid replacement
14. Association of increased spontaneous mutation rates with high levels of transcription in yeast
15. Evolution of somatic hypermutation and gene conversion in adaptive immunity
16. DNA polymerase mu (Pol μ), homologous to TdT, could act as a DNA mutator in eukaryotic cells
17. Disruption of the Rev3-encoded catalytic subunit of polymerase zeta in mice results in early embryonic lethality
18. Mice reconstituted with DNA polymerase beta-deficient fetal liver cells are able to mount a T cell-dependent immune response and mutate their Ig genes normally
19. Targeted inhibition of transcription elongation in cells mediated by triplex-forming oligonucleotides
20. Somatic hypermutation in the heavy chain locus correlates with transcription
21. DNA polymerase lambda (Pol lambda), a novel eukaryotic DNA polymerase with a potential role in meiosis
22. Nucleic acid therapeutics: State of the art and future prospects
23. A human homolog of the Saccharomyces cerevisiae REV3 gene, which encodes the catalytic subunit of DNA polymerase zeta
24. The function of the human homolog of Saccharomyces cerevisiae REV1 is required for mutagenesis induced by UV light
25. Efficient and accurate replication in the presence of 7, 8-dihydro-8-oxoguanine by DNA polymerase η
26. A role for REV3 in mutagenesis during double-strand break repair in Saccharomyces cerevisiae
27. H3 segments and somatic hypermutation
28. Clonal analysis of a human antibody response. III. Nucleotide sequences of human monoclonal IgM, IgG and IgA to rabies virus reveal Vκ gene utilization, junctional Vκ-Jκ and Vλ-Jλ heterogeneity, and somatic hypermutation
29. Bridging the gap: A family of novel DNA polymerases that replicate faulty DNA
30. hRAD30 mutations in the variant form of Xeroderma pigmentosum
31. Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase η
32. The human DINB1 gene encodes the DNA polymerase θ
33. Eukaryotic polymerases ι and ζ act sequentially to bypass DNA lesions
34. Fidelity of human DNA polymerase η
35. DNA polymerase zeta and the control of DNA damage induced mutagenesis in eukaryotes
36. A serum-resistant cytofectin for cellular delivery of antisense oligodeoxynucleotides and plasmid DNA
37. A full-length cDNA of hREV3 is predicted to encode DNA polymerase ζ for damage-induced mutagenesis in humans
38. - germinal center B cells can express up to 80 mutations in the variable region of their IgD transcripts
39. Xeroderma pigmentosum variant (XP-V) correcting protein from HeLa cells has a thymidine dimer by pass DNA polymerase activity
40. The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase η
41. Mechanisms of accurate translesion synthesis by human DNA polymerase η
42. Low fidelity DNA synthesis by human DNA polymerase η
43. Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin
44. REV3, a Saccharomyces cerevisiae gene whose function is required for induced mutagenesis, is predicted to encode a nonessential DNA polymerase
45. A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2
46. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential rna editing enzyme
47. Thymine-thymine dimer bypass by yeast DNA polymerase ζ
48. Monitoring and interpreting the intrinsic features of somatic hypermutation
49. Use of flow cytometry for DNA analysis
50. Error-prone bypass of certain DNA lesions by the human DNA polymerase κ
51. Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes
52. Analysis of somatic mutation in five B cell subsets of human tonsil
53. BCL-6 mutations in normal germinal center B cells: Evidence of somatic hypermutation acting outside Ig loci
54. Somatic hypermutation of immunoglobulin genes is linked to transcription initiation
55. Error-prone candidates vie for somatic mutation
56. Specific interaction of DNA polymerase and DNA ligase I in a multiprotein base excision repair complex from bovine testis
57. Triple helix formation and the antigene strategy for sequence-specific control of gene expression
58. Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting
59. Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the hyper-IgM syndrome (HIGM2)
60. TdT-accessibe breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line
61. The evolutionary conserved sequence upstream of the human Ig Sγ3 region is an inducible promoter: Synergistic activation by CD40 ligand and IL-4 via cooperative NF-κB and STAT-6 binding sites
62. Detection and characterization of mutations in mammalian cells with the pSP189 shuttle vector system
63. Fixing mismatches
64. Mutation of the bcl-6 gene in normal B cells by the process of somatic hypermutation of Ig genes
65. Di- and trinucleotide target preferences of somatic mutagenesis in normal and autoreactive B cells
66. Requirement of mammalian DNA polymerase beta in base-excision repair
67. A hypermutable insert in an immunoglobulin transgene contains hotspots of somatic mutation and sequences predicting highly stable structures in the RNA transcript
68. Somatic hypermutation of immunoglobulin genes is linked to transcription
69. DNA synthesis errors associated with double-strand-break repair
70. pol ι, a remarkably error-prone human DNA polymerase
71. Clonal analysis of a human antibody response. Quantitation of precursors of antibody-producing cells and generation and characterization of monoclonal IgM, IgG, and IgA to rabies virus
72. Fidelity and processivity of Saccharomyces cerevisiae DNA polymerase eta
73. The functional roles of mammalian DNA polymerase
74. Receptor revision of immunoglobulin heavy chain variable region genes in normal human B lymphocytes
75. Complementation of defective translesion synthesis and UV light sensitivity in Xeroderma pigmentosum variant cells by human and mouse DNA polymerase eta
76. CD40 engagement triggers switching to IgA1 and IgA2 in human B cells through induction of endogenous TGF-β. Evidence for TGF-β but not IL-10-dependent direct Sμ→Sα and sequential Sμ→Sγ, Sγ→Sα DNA recombination
77. + cell line in vitro: Definition of the requirements and the modalities of hypermutation
78. BCR engagement and T cell contact induce bcl-6 hypermutation in human B cells: Association with initiation of transcription and identity with Ig hypermutation
79. BCR-engagement induces downregulation of the error-free DNA polymerase η in human B cells. Association with the introduction of Ig mutations by the translesion DNA polymerase ζ