Mismatch repair co-opted by hypermutation

Science

Volumn 279, Issue 5354, 1998, Pages 1207-1210

  Cascalho, Marilia ^a   Wong, Jamie ^a   Steinberg, Charles ^a   Wabl, Matthias ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LAMBDA CHAIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; BASE MISPAIRING; CONTROLLED STUDY; DNA REPAIR; GENE DISRUPTION; HETEROZYGOTE; HOMOZYGOTE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SOMATIC MUTATION;

ADENOSINE TRIPHOSPHATASES; ALLELES; AMINO ACID SEQUENCE; ANIMALS; B-LYMPHOCYTES; BASE COMPOSITION; BASE SEQUENCE; CLONING, MOLECULAR; CROSSES, GENETIC; DNA REPAIR; DNA REPAIR ENZYMES; DNA-BINDING PROTEINS; FEMALE; GENE REARRANGEMENT; GENES, IMMUNOGLOBULIN; HETEROZYGOTE; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN LAMBDA-CHAINS; IMMUNOGLOBULIN VARIABLE REGION; MALE; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; MUTATION; PROTEINS;

ANIMALIA;

EID: 0032549125     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.279.5354.1207     Document Type: Article

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32. We thank T. Imanishi-Kari for providing antibodies to the idiotype VH17.2.25; G. Wu and M. Liskay for comments on the manuscript; and S. Baker and M. Liskay for providing Pms2 knockout mice. This work was supported by NIH grant 1R01 GM37699; by the Engalitcheff Award of the Arthritis Foundation; by funds from the Markey Trust; by a Howard Hughes grant for transgenic mice; and by a grant from the Junta Nacional de Investigação Científica e Tecnológica, Praxis XXI-BD 3763/94 to M.C.