The cytidine deaminase AID exhibits similar functional properties in yeast and mammals

Molecular Immunology

Volumn 43, Issue 9, 2006, Pages 1481-1484

  Rogozin, Igor B ^a   Pavlov, Youri I ^b,c  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

DNA context; Mutation frequency; Mutation hotspots; Polynucleotide (deoxy)cytidine deaminase; Somatic hypermutation

Indexed keywords

APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 1; CYTIDINE DEAMINASE; CYTOSINE DEAMINASE; URACIL DNA GLYCOSYLTRANSFERASE;

AMINO ACID SEQUENCE; ARTICLE; B LYMPHOCYTE; DNA SEQUENCE; ENZYME ACTIVITY; GENE MUTATION; IMMUNOGLOBULIN GENE; IN VITRO STUDY; MAMMAL; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; YEAST;

ANIMALS; CYTIDINE DEAMINASE; CYTOSINE DEAMINASE; DNA, FUNGAL; GENES, FUNGAL; HUMANS; MICE; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN; SPECIES SPECIFICITY;

MAMMALIA;

EID: 33644827615     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2005.09.002     Document Type: Article

References (21)

1. R.C. Beale, S.K. Petersen-Mahrt, I.N. Watt, R.S. Harris, C. Rada, and M.S. Neuberger Comparison of the differential context-dependence of DNA deamination by APOBEC enzymes: correlation with mutation spectra in vivo J. Mol. Biol. 337 2004 585 596
2. G.V. Glazko, L. Milanesi, and I.B. Rogozin The subclass approach for mutational spectrum analysis: application of the SEM algorithm J. Theor. Biol. 192 1998 475 487
3. T. Honjo, M. Muramatsu, and S. Fagarasan AID: how does it aid antibody diversity? Immunity 20 2004 659 668
4. T. Honjo, S. Nakai, Y. Nishida, T. Kataoka, Y. Yamawaki-Kataoka, N. Takahashi, M. Obata, A. Shimizu, Y. Yaoita, T. Nikaido, and N. Ishida Rearrangements of immunoglobulin genes during differentiation and evolution Immunol. Rev. 59 1981 33 67
5. N. Kim, G. Bozek, J.C. Lo, and U. Storb Different mismatch repair deficiencies all have the same effects on somatic hypermutation: intact primary mechanism accompanied by secondary modifications J. Exp. Med. 190 1999 21 30
6. K. Kinoshita, and T. Honjo Linking class-switch recombination with somatic hypermutation Nat. Rev. Mol. Cell. Biol. 2 2001 493 503
7. K. Krause, K.B. Marcu, and J. Greeve The cytidine deaminases AID and APOBEC-1 exhibit distinct functional properties in a novel yeast selectable system Mol. Immunol. 43 2006 295 307
8. A. Martin, P.D. Bardwell, C.J. Woo, M. Fan, M.J. Shulman, and M.D. Scharff Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas Nature 415 2002 802 806
9. V.I. Mayorov, I.B. Rogozin, L.R. Adkison, C.R. Frahm, T.A. Kunkel, and Y.I. Pavlov Expression of human AID in yeast induces mutations in context similar to the context of somatic hypermutation at G-C pairs in immunoglobulin genes BMC Immunol. 6 2005 10
10. M.S. Neuberger, R.S. Harris, J. Di Noia, and S.K. Petersen-Mahrt Immunity through DNA deamination Trends Biochem. Sci. 28 2003 305 312
11. S.K. Petersen-Mahrt, R.S. Harris, and M.S. Neuberger AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification Nature 418 2002 99 103
12. P. Pham, R. Bransteitter, J. Petruska, and M.F. Goodman Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation Nature 424 2003 103 107
13. P. Pham, R. Bransteitter, and M.F. Goodman Reward versus risk: DNA cytidine deaminases triggering immunity and disease Biochemistry 44 2005 2703 2715
14. V.P. Poltoratsky, S.H. Wilson, T.A. Kunkel, and Y.I. Pavlov Recombinogenic phenotype of human activation-induced cytosine deaminase J. Immunol. 172 2004 4308 4313
15. I.B. Rogozin, and M. Diaz Cutting edge: DGYW/WRCH is a better predictor of mutability at G:C bases in Ig hypermutation than the widely accepted RGYW/WRCY motif and probably reflects a two-step activation-induced cytidine deaminase-triggered process J. Immunol. 172 2004 3382 3384
16. I.B. Rogozin, Kondrashov, and G.V. Glazko Use of mutation spectra analysis software Hum. Mutat. 17 2001 83 102
17. I.B. Rogozin, and Y.I. Pavlov Theoretical analysis of mutational hotspots and their DNA sequence context specificity Mutat. Res. 544 2003 65 85
18. H.M. Shen, and U. Storb Activation-induced cytidine deaminase (AID) can target both DNA strands when the DNA is supercoiled Proc. Natl. Acad. Sci. USA 101 2004 12997 13002
19. U. Storb, E.L. Klotz, J. Hackett, K. Kage, G. Bozek, and T.E. Martin A hypermutable insert in an immunoglobulin transgene contains hotspots of somatic mutation and sequences predicting highly stable structures in the RNA transcript J. Exp. Med. 188 1998 689 698
20. C.L. Wang, R.A. Harper, and M. Wabl Genome-wide somatic hypermutation Proc. Natl. Acad. Sci. USA 101 2004 7352 7356
21. K. Yoshikawa, I.M. Okazaki, T. Eto, K. Kinoshita, M. Muramatsu, H. Nagaoka, and T. Honjo AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts Science 296 2002 2033 2036