The AID enzyme induces class switch recombination in fibroblasts

Nature

Volumn 416, Issue 6878, 2002, Pages 340-345

  Okazaki, Il Mi ^a   Kinoshita, Kazuo ^a   Muramatsu, Masamichi ^a   Yoshikawa, Klyotsugu ^a   Honjo, Tasuku ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GENES; MUTAGENESIS; RNA;

ARTIFICIAL SWITCHES;

ENZYMES;

CYTIDINE DEAMINASE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN CLASS; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN M; RNA;

MEDICINE;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CELL STRAIN 3T3; CONTROLLED STUDY; FIBROBLAST; GENE REARRANGEMENT; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN VARIABLE REGION; LYMPHOMA CELL LINE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RNA EDITING;

3T3 CELLS; ANIMALS; ANTIGENS, CD8; B-LYMPHOCYTES; BASE SEQUENCE; CYTIDINE DEAMINASE; DNA; FIBROBLASTS; GREEN FLUORESCENT PROTEINS; IMMUNOGLOBULIN CLASS SWITCHING; LUMINESCENT PROTEINS; MICE; MOLECULAR SEQUENCE DATA; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); RECOMBINANT FUSION PROTEINS; RECOMBINATION, GENETIC; THYMIDINE KINASE; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0037149473     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature727     Document Type: Article

References (30)

1. Molecular mechanism of class switch recombination: Linkage with somatic hypermutation
2. Linking class-switch recombination with somatic hypermutation
3. Somatic hypermutation
4. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
5. Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)
6. Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching
7. Secondary genomic rearrangement events in pre-B cells: VHDJH replacement by a LINE- 1 sequence and directed class switching
8. Quantitative regulation of class switch recombination by switch region transcription
9. The SCID but not the RAG-2 gene product is required for Sα-εSe heavy, chain class switching
10. Ku80 is required for immunoglobulin isotype switching
11. Ku70 is required for late B cell development and immunoglobulin heavy chain class switching
12. Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells
13. AID is required to initiate Nbsl/γ-H 2AX focus formation and mutations at sites of class switching
14. + cells
15. Target specificity of immunoglobulin class switch recombination is not determined by nucleotide sequences of S regions
16. Palindromic but not G-rich sequences are targets of class switch recombination
17. Variable deletion and duplication at recombination junction ends: Implication for staggered double-strand cleavage in class-switch recombination
18. Dominant positive and negative selection using a hygromycin phosphotransferase-thymidine kinase fusion gene
19. Tetracyclines inhibit activated B cell function
20. In situ class switching and differentiation to IgA-producing cells in the gut lamina propria
21. Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-IoxP-mediated gene targeting
22. Shutdown of class switch recombination by deletion of a switch region control element
23. Replacement of germ-line e promoter by gene targeting alters control of immunoglobulin heavy chain class switching
24. A selective defect in IgG2b switching as a result of targeted mutation of the Iγ 2b promoter and exon
25. DNA sequences at immunoglobulin switch region recombination sites
26. Biased distribution of recombination sites within S regions upon immunoglobulin class switch recombination induced by transforming growth factor β and lipopolvsaccharide
27. Structure of a rearranged γ 1 chain gene and its implication to immunoglobulin classswitch mechanism
28. Directed Ig class switch recombination in activated murine B cells
29. Understanding, improving and using green fluorescent proteins
30. New experimental approaches in retrovirus-mediated expression screening