The translesion DNA polymerase θ plays a dominant role in immunoglobulin gene somatic hypermutation

EMBO Journal

Volumn 24, Issue 21, 2005, Pages 3757-3769

  Zan, Hong ^a   Shima, Naoko ^b   Xu, Zhenming ^a   Al Qahtani, Ahmed ^a   Evinger III, Albert J ^a   Zhong, Yuan ^a   Schimenti, John C ^b   Casali, Paolo ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Department of Obstetrics Gynecology   (United States)

Author keywords

Antibody; DNA polymerase ; DNA repair; Somatic hypermutation; Translesion DNA polymerase

Indexed keywords

DNA DIRECTED DNA POLYMERASE; DNA DIRECTED DNA POLYMERASE THETA; IMMUNOGLOBULIN; IMMUNOGLOBULIN HEAVY CHAIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY AFFINITY; ARTICLE; CONTROLLED STUDY; DNA REPAIR; DNA SYNTHESIS; GENE DELETION; GENE SEQUENCE; HUMAN; HUMAN CELL; IMMUNOGLOBULIN GENE; INDUCED MUTATION; INTRON; MISMATCH REPAIR; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN GLYCOSYLATION; SOMATIC HYPERMUTATION;

ANIMALS; B-LYMPHOCYTES; BASE SEQUENCE; CYTIDINE DEAMINASE; DNA REPAIR; DNA-DIRECTED DNA POLYMERASE; GENE DELETION; GENES, IMMUNOGLOBULIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN JOINING REGION; IMMUNOGLOBULIN VARIABLE REGION; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; MUTATION; RNA, MESSENGER; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN; T-LYMPHOCYTES;

ANIMALIA;

EID: 27744483444     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/sj.emboj.7600833     Document Type: Article

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