Multiple sequences from downstream of the J(κ) cluster can combine to recruit somatic hypermutation to a heterologous, upstream mutation domain

European Journal of Immunology

Volumn 28, Issue 1, 1998, Pages 317-326

  Klix, Norman ^a   Jolly, Christopher J ^a   Davies, Sarah L ^a   Brüggemann, Marianne ^b   Williams, Gareth T ^a   Neuberger, Michael S ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^b BABRAHAM INSTITUTE   (United Kingdom)

Author keywords

Antibody hypermutation; Somatic mutation

Indexed keywords

BETA GLOBIN; IMMUNOGLOBULIN J CHAIN; IMMUNOGLOBULIN KAPPA CHAIN;

ANIMAL EXPERIMENT; ARTICLE; CHIMERA; DNA SEQUENCE; EXON; GENE CLUSTER; IMMUNOGLOBULIN GENE; MOUSE; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; START CODON; TRANSGENE;

ANIMALS; ENHANCER ELEMENTS (GENETICS); GENE REARRANGEMENT, B-LYMPHOCYTE; GENES, IMMUNOGLOBULIN; IMMUNOGLOBULIN J-CHAINS; IMMUNOGLOBULIN KAPPA-CHAINS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; MICE, TRANSGENIC; MUTATION; TRANSGENES;

EID: 0031975171     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199801)28:01<317::AID-IMMU317>3.0.CO;2-S     Document Type: Article

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