-
1
-
-
0029796904
-
Unifying theory of hypoxia tolerance: molecular/metabolic defence and rescue mechanisms for surviving oxygen lack
-
Hochachka P.W., Buck L.T., Doll C.J., and Land S.C. Unifying theory of hypoxia tolerance: molecular/metabolic defence and rescue mechanisms for surviving oxygen lack. Proc Natl Acad Sci USA 93 (1996) 9493-9498
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 9493-9498
-
-
Hochachka, P.W.1
Buck, L.T.2
Doll, C.J.3
Land, S.C.4
-
2
-
-
0032539713
-
Our ancestral physiological phenotype: an adaptation for hypoxia tolerance and for endurance performance?
-
Hochachka P.W., Gunga H.C., and Kirsh K. Our ancestral physiological phenotype: an adaptation for hypoxia tolerance and for endurance performance?. Proc Natl Acad Sci USA 95 (1998) 1915-1920
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 1915-1920
-
-
Hochachka, P.W.1
Gunga, H.C.2
Kirsh, K.3
-
3
-
-
0037699955
-
Angiogenesis in health and disease
-
Carmeliet P. Angiogenesis in health and disease. Nat Med 9 (2003) 653-660
-
(2003)
Nat Med
, vol.9
, pp. 653-660
-
-
Carmeliet, P.1
-
4
-
-
4444257379
-
The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease
-
Giaccia A.J., Simon M.C., and Johnson R. The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease. Genes Dev 18 (2004) 2183-2194
-
(2004)
Genes Dev
, vol.18
, pp. 2183-2194
-
-
Giaccia, A.J.1
Simon, M.C.2
Johnson, R.3
-
6
-
-
0028803509
-
Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity
-
Alon T., Hemo I., Itin A., Pe'er J., Stone J., and Keshet E. Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity. Nat Med 1 (1995) 1024-1028
-
(1995)
Nat Med
, vol.1
, pp. 1024-1028
-
-
Alon, T.1
Hemo, I.2
Itin, A.3
Pe'er, J.4
Stone, J.5
Keshet, E.6
-
8
-
-
0026846928
-
The role of angiogenesis in tumor growth
-
Folkman J. The role of angiogenesis in tumor growth. Semin Cancer Biol 3 (1992) 65-71
-
(1992)
Semin Cancer Biol
, vol.3
, pp. 65-71
-
-
Folkman, J.1
-
9
-
-
0034531766
-
HIF-1: using two hands to flip the angiogenic switch
-
Semenza G.L. HIF-1: using two hands to flip the angiogenic switch. Cancer Metastasis Rev 19 (2000) 59-65
-
(2000)
Cancer Metastasis Rev
, vol.19
, pp. 59-65
-
-
Semenza, G.L.1
-
11
-
-
0026468180
-
A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
-
Semenza G.L., and Wang G.L. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 12 (1992) 5447-5454
-
(1992)
Mol Cell Biol
, vol.12
, pp. 5447-5454
-
-
Semenza, G.L.1
Wang, G.L.2
-
12
-
-
0028816847
-
Purification and characterization of hypoxia-inducible factor 1
-
Wang G.L., and Semenza G.L. Purification and characterization of hypoxia-inducible factor 1. J Biol Chem 270 (1995) 1230-1237
-
(1995)
J Biol Chem
, vol.270
, pp. 1230-1237
-
-
Wang, G.L.1
Semenza, G.L.2
-
14
-
-
0029944965
-
Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1
-
Jiang B.H., Rue E., Wang G.L., Roe R., and Semenza G.L. Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1. J Biol Chem 271 (1996) 17771-17778
-
(1996)
J Biol Chem
, vol.271
, pp. 17771-17778
-
-
Jiang, B.H.1
Rue, E.2
Wang, G.L.3
Roe, R.4
Semenza, G.L.5
-
15
-
-
0031020884
-
Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
-
Tian H., McKnight S.L., and Russel D.W. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev 11 (1997) 72-82
-
(1997)
Genes Dev
, vol.11
, pp. 72-82
-
-
Tian, H.1
McKnight, S.L.2
Russel, D.W.3
-
16
-
-
0031733828
-
Molecular characterization and chromosomal localization of a third α-class hypoxia-inducible factor subunit, HIF3α
-
Gu Y.Z., Moran S.M., Hogenesch J.B., Wartman L., and Bradfield C.A. Molecular characterization and chromosomal localization of a third α-class hypoxia-inducible factor subunit, HIF3α. Gene Expression 7 (1998) 205-213
-
(1998)
Gene Expression
, vol.7
, pp. 205-213
-
-
Gu, Y.Z.1
Moran, S.M.2
Hogenesch, J.B.3
Wartman, L.4
Bradfield, C.A.5
-
17
-
-
0032189844
-
Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1α
-
Wiesener M.S., Turley H., Allen W.E., et al. Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1α. Blood 92 (1998) 2260-2268
-
(1998)
Blood
, vol.92
, pp. 2260-2268
-
-
Wiesener, M.S.1
Turley, H.2
Allen, W.E.3
-
18
-
-
0345491599
-
Differential roles of hypoxia-inducible factor 1α (HIF-1α) and HIF-2α in hypoxic gene regulation
-
Hu C.J., Wang L.Y., Chodosh L.A., Keith B., and Simon M.C. Differential roles of hypoxia-inducible factor 1α (HIF-1α) and HIF-2α in hypoxic gene regulation. Mol Cell Biol 23 (2003) 9361-9374
-
(2003)
Mol Cell Biol
, vol.23
, pp. 9361-9374
-
-
Hu, C.J.1
Wang, L.Y.2
Chodosh, L.A.3
Keith, B.4
Simon, M.C.5
-
19
-
-
20744445650
-
Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma
-
Raval R.R., Lau K.W., Tran M.G., et al. Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma. Mol Cell Biol 25 (2005) 5675-5686
-
(2005)
Mol Cell Biol
, vol.25
, pp. 5675-5686
-
-
Raval, R.R.1
Lau, K.W.2
Tran, M.G.3
-
20
-
-
0035812789
-
Expression and characterization of hypoxia-inducible factor (HIF)-3α in human kidney: suppression of HIF-mediated gene expression by HIF-3α
-
Hara S., Hamada J., Kobayashi C., Kondo Y., and Imura N. Expression and characterization of hypoxia-inducible factor (HIF)-3α in human kidney: suppression of HIF-mediated gene expression by HIF-3α. Biochem Biophys Res Commun 287 (2001) 808-813
-
(2001)
Biochem Biophys Res Commun
, vol.287
, pp. 808-813
-
-
Hara, S.1
Hamada, J.2
Kobayashi, C.3
Kondo, Y.4
Imura, N.5
-
21
-
-
0035969508
-
Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression
-
Makino Y., Cao R., Svensson K., et al. Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression. Nature 414 (2001) 550-554
-
(2001)
Nature
, vol.414
, pp. 550-554
-
-
Makino, Y.1
Cao, R.2
Svensson, K.3
-
22
-
-
11244315697
-
Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1
-
Manalo D.J., Rowan A., Lavoie T., et al. Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1. Blood 105 (2005) 659-669
-
(2005)
Blood
, vol.105
, pp. 659-669
-
-
Manalo, D.J.1
Rowan, A.2
Lavoie, T.3
-
24
-
-
0030961006
-
Hypoxia-inducible factor 1α (HIF-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes
-
Salceda S., and Caro J. Hypoxia-inducible factor 1α (HIF-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes. J Biol Chem 272 (1997) 22642-22647
-
(1997)
J Biol Chem
, vol.272
, pp. 22642-22647
-
-
Salceda, S.1
Caro, J.2
-
25
-
-
0033587146
-
The tumor suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
Maxwell P.H., Wiesener M.S., Chang G.W., et al. The tumor suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399 (1999) 271-275
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.W.3
-
27
-
-
14044257943
-
Role of CBP in regulating HIF-1-mediated activation of transcription
-
Ruas J.L., Poellinger L., and Pereira T. Role of CBP in regulating HIF-1-mediated activation of transcription. J Cell Sci 118 (2005) 301-311
-
(2005)
J Cell Sci
, vol.118
, pp. 301-311
-
-
Ruas, J.L.1
Poellinger, L.2
Pereira, T.3
-
28
-
-
3843095197
-
HIF-1's relationship to oxygen: simple yet sophisticated
-
Maxwell P.H. HIF-1's relationship to oxygen: simple yet sophisticated. Cell Cycle 3 (2004) 156-159
-
(2004)
Cell Cycle
, vol.3
, pp. 156-159
-
-
Maxwell, P.H.1
-
29
-
-
22244440847
-
Proline hydroxylation and gene expression
-
Kaelin W.G. Proline hydroxylation and gene expression. Annu Rev Biochem 74 (2005) 115-128
-
(2005)
Annu Rev Biochem
, vol.74
, pp. 115-128
-
-
Kaelin, W.G.1
-
31
-
-
17944375360
-
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
-
Epstein A.C., Gleadle J.M., McNeill L.A., et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 107 (2001) 43-54
-
(2001)
Cell
, vol.107
, pp. 43-54
-
-
Epstein, A.C.1
Gleadle, J.M.2
McNeill, L.A.3
-
32
-
-
0035834409
-
A conserved family of prolyl-4-hydroxylases that modify HIF
-
Bruick R., and McKnight S. A conserved family of prolyl-4-hydroxylases that modify HIF. Science 294 (2001) 1337-1340
-
(2001)
Science
, vol.294
, pp. 1337-1340
-
-
Bruick, R.1
McKnight, S.2
-
33
-
-
13944276440
-
OS-9 interacts with hypoxia-inducible factor 1α and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1α
-
Baek J.H., Mahon P.C., Oh J., et al. OS-9 interacts with hypoxia-inducible factor 1α and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1α. Mol Cell 17 (2005) 503-512
-
(2005)
Mol Cell
, vol.17
, pp. 503-512
-
-
Baek, J.H.1
Mahon, P.C.2
Oh, J.3
-
34
-
-
0037449811
-
Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1α
-
Elkins J.M., Hewitson K.S., McNeill L.A., et al. Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1α. J Biol Chem 278 (2003) 1802-1806
-
(2003)
J Biol Chem
, vol.278
, pp. 1802-1806
-
-
Elkins, J.M.1
Hewitson, K.S.2
McNeill, L.A.3
-
35
-
-
0037097861
-
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
-
Lando D., Peet D.J., Gorman J.J., Whelan D.A., Whitelaw M.L., and Bruick R.K. FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev 16 (2002) 1466-1471
-
(2002)
Genes Dev
, vol.16
, pp. 1466-1471
-
-
Lando, D.1
Peet, D.J.2
Gorman, J.J.3
Whelan, D.A.4
Whitelaw, M.L.5
Bruick, R.K.6
-
36
-
-
0037470162
-
Structure of human FIH-1 reveals a unique active site pocket and interaction sites for HIF-1 and von Hippel-Lindau
-
Lee C., Kim S.J., Jeong D.G., Lee S.M., and Ryu S.E. Structure of human FIH-1 reveals a unique active site pocket and interaction sites for HIF-1 and von Hippel-Lindau. J Biol Chem 278 (2003) 7558-7563
-
(2003)
J Biol Chem
, vol.278
, pp. 7558-7563
-
-
Lee, C.1
Kim, S.J.2
Jeong, D.G.3
Lee, S.M.4
Ryu, S.E.5
-
37
-
-
0035887011
-
FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity
-
Mahon P.C., Hirota K., and Semenza G.L. FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev 15 (2001) 2675-2686
-
(2001)
Genes Dev
, vol.15
, pp. 2675-2686
-
-
Mahon, P.C.1
Hirota, K.2
Semenza, G.L.3
-
38
-
-
0032760945
-
Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes
-
Schofield C.J., and Zhang Z. Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes. Curr Opin Struct Biol 9 (1999) 722-731
-
(1999)
Curr Opin Struct Biol
, vol.9
, pp. 722-731
-
-
Schofield, C.J.1
Zhang, Z.2
-
39
-
-
0043234538
-
Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor
-
Hirsila M., Koivunen P., Gunzler V., Kivirikko K.I., and Myllyharju J. Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor. J Biol Chem 278 (2003) 30772-30780
-
(2003)
J Biol Chem
, vol.278
, pp. 30772-30780
-
-
Hirsila, M.1
Koivunen, P.2
Gunzler, V.3
Kivirikko, K.I.4
Myllyharju, J.5
-
40
-
-
1642315195
-
Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases
-
Koivunen P., Hirsila M., Gunzler V., Kivirikko K.I., and Myllyharju J. Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases. J Biol Chem 279 (2004) 9899-9904
-
(2004)
J Biol Chem
, vol.279
, pp. 9899-9904
-
-
Koivunen, P.1
Hirsila, M.2
Gunzler, V.3
Kivirikko, K.I.4
Myllyharju, J.5
-
41
-
-
0035012605
-
HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1α (HIF-1α) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
-
Laughner E., Taghavi P., Chiles K., Mahon P.C., and Semenza G.L. HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1α (HIF-1α) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Mol Cell Biol 21 (2001) 3995-4004
-
(2001)
Mol Cell Biol
, vol.21
, pp. 3995-4004
-
-
Laughner, E.1
Taghavi, P.2
Chiles, K.3
Mahon, P.C.4
Semenza, G.L.5
-
42
-
-
0037064010
-
Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells
-
Fukuda R., Hirota K., Fan F., Jung Y.D., Ellis L.M., and Semenza G.L. Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. J Biol Chem 277 (2002) 38205-38211
-
(2002)
J Biol Chem
, vol.277
, pp. 38205-38211
-
-
Fukuda, R.1
Hirota, K.2
Fan, F.3
Jung, Y.D.4
Ellis, L.M.5
Semenza, G.L.6
-
43
-
-
0034282388
-
Non-hypoxic pathway mediates the induction of hypoxia-inducible factor 1α in vascular smooth muscle cells
-
Richard D.E., Berra E., and Pouyssegur J. Non-hypoxic pathway mediates the induction of hypoxia-inducible factor 1α in vascular smooth muscle cells. J Biol Chem 275 (2000) 26765-26771
-
(2000)
J Biol Chem
, vol.275
, pp. 26765-26771
-
-
Richard, D.E.1
Berra, E.2
Pouyssegur, J.3
-
44
-
-
0037073695
-
Induction of hypoxia-inducible factor-1α by transcriptional and translational mechanisms
-
Page E.L., Robitaille G.A., Pouyssegur J., and Richard D.E. Induction of hypoxia-inducible factor-1α by transcriptional and translational mechanisms. J Biol Chem 277 (2002) 48403-48409
-
(2002)
J Biol Chem
, vol.277
, pp. 48403-48409
-
-
Page, E.L.1
Robitaille, G.A.2
Pouyssegur, J.3
Richard, D.E.4
-
45
-
-
4744365128
-
Induction of hypoxia-inducible factor 1 activity by muscarinic acetylcholine receptor signaling
-
Hirota K., Fukuda R., Takabuchi S., et al. Induction of hypoxia-inducible factor 1 activity by muscarinic acetylcholine receptor signaling. J Biol Chem 279 (2004) 41521-41528
-
(2004)
J Biol Chem
, vol.279
, pp. 41521-41528
-
-
Hirota, K.1
Fukuda, R.2
Takabuchi, S.3
-
46
-
-
1642453685
-
Nitric oxide induces hypoxia-inducible factor 1 activation that is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling
-
Kasuno K., Takabuchi S., Fukuda K., et al. Nitric oxide induces hypoxia-inducible factor 1 activation that is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling. J Biol Chem 279 (2004) 2550-2558
-
(2004)
J Biol Chem
, vol.279
, pp. 2550-2558
-
-
Kasuno, K.1
Takabuchi, S.2
Fukuda, K.3
-
47
-
-
0042469448
-
Nitric oxide impairs normoxic degradation of HIF-1α by inhibition of prolyl hydroxylases
-
Metzen E., Zhou J., Jelkmann W., Fandrey J., and Brune B. Nitric oxide impairs normoxic degradation of HIF-1α by inhibition of prolyl hydroxylases. Mol Cell Biol 14 (2003) 3470-3481
-
(2003)
Mol Cell Biol
, vol.14
, pp. 3470-3481
-
-
Metzen, E.1
Zhou, J.2
Jelkmann, W.3
Fandrey, J.4
Brune, B.5
-
48
-
-
0348134741
-
Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF-1α
-
Hagen T., Taylor C.T., Lam F., and Moncada S. Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF-1α. Science 302 (2003) 1975-1978
-
(2003)
Science
, vol.302
, pp. 1975-1978
-
-
Hagen, T.1
Taylor, C.T.2
Lam, F.3
Moncada, S.4
-
49
-
-
18844413584
-
Nitric oxide reverses desferrioxamine- and hypoxia-evoked HIF-1α accumulation-implications for prolyl hydroxylase activity and iron
-
Callapina M., Zhou J., Schnitzer S., et al. Nitric oxide reverses desferrioxamine- and hypoxia-evoked HIF-1α accumulation-implications for prolyl hydroxylase activity and iron. Exp Cell Res 306 (2005) 274-284
-
(2005)
Exp Cell Res
, vol.306
, pp. 274-284
-
-
Callapina, M.1
Zhou, J.2
Schnitzer, S.3
-
50
-
-
0033571682
-
Overexpression of hypoxia-inducible factor 1α in common human cancers and their metastases
-
Zhong H., De Marzo A.M., Laughner E., et al. Overexpression of hypoxia-inducible factor 1α in common human cancers and their metastases. Cancer Res 59 (1999) 5830-5835
-
(1999)
Cancer Res
, vol.59
, pp. 5830-5835
-
-
Zhong, H.1
De Marzo, A.M.2
Laughner, E.3
-
51
-
-
0033870281
-
The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages
-
Talks K.L., Turley H., Gatter K.C., et al. The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol 157 (2000) 411-421
-
(2000)
Am J Pathol
, vol.157
, pp. 411-421
-
-
Talks, K.L.1
Turley, H.2
Gatter, K.C.3
-
52
-
-
0029761644
-
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
-
Forsythe J.A., Jiang B.H., Iyer N.V., et al. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol 16 (1996) 4604-4613
-
(1996)
Mol Cell Biol
, vol.16
, pp. 4604-4613
-
-
Forsythe, J.A.1
Jiang, B.H.2
Iyer, N.V.3
-
53
-
-
0035027828
-
Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells
-
Seagroves T.N., Ryan H.E., Lu H., et al. Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells. Mol Cell Biol 21 (2001) 3436-3444
-
(2001)
Mol Cell Biol
, vol.21
, pp. 3436-3444
-
-
Seagroves, T.N.1
Ryan, H.E.2
Lu, H.3
-
55
-
-
33745162703
-
-
Elsevier Publishing Company, Amsterdam
-
Warburg O. The oxygen-transferring ferment of respiration: Nobel lecture, December 10, from Nobel lectures, physiology or medicine, 1922-1941 (1965), Elsevier Publishing Company, Amsterdam
-
(1965)
The oxygen-transferring ferment of respiration: Nobel lecture, December 10, from Nobel lectures, physiology or medicine, 1922-1941
-
-
Warburg, O.1
-
56
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza G.L. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3 (2003) 721-732
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
58
-
-
0036088478
-
Mechanisms of normal and tumor-derived angiogenesis
-
Papetti M., and Herman I.M. Mechanisms of normal and tumor-derived angiogenesis. Am J Physiol 282 (2002) C947-C970
-
(2002)
Am J Physiol
, vol.282
-
-
Papetti, M.1
Herman, I.M.2
-
59
-
-
0032581277
-
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumor angiogenesis
-
Carmeliet P., Dor Y., Herbert J., et al. Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumor angiogenesis. Nature 394 (1998) 485-490
-
(1998)
Nature
, vol.394
, pp. 485-490
-
-
Carmeliet, P.1
Dor, Y.2
Herbert, J.3
-
60
-
-
0030943461
-
Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT
-
Maltepe E., Schmidt J.V., Baunoch D., Bradfield C., and Simon M.C. Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT. Nature 386 (1997) 403-407
-
(1997)
Nature
, vol.386
, pp. 403-407
-
-
Maltepe, E.1
Schmidt, J.V.2
Baunoch, D.3
Bradfield, C.4
Simon, M.C.5
-
61
-
-
0033562569
-
Defective vascularization of HIF-1α-null embryos is not associated with VEGF deficiency but with mesenchymal cell death
-
Kotch L.E., Iyer N.V., Laughner E., and Semenza G.L. Defective vascularization of HIF-1α-null embryos is not associated with VEGF deficiency but with mesenchymal cell death. Develop Biol 209 (1999) 254-267
-
(1999)
Develop Biol
, vol.209
, pp. 254-267
-
-
Kotch, L.E.1
Iyer, N.V.2
Laughner, E.3
Semenza, G.L.4
-
62
-
-
0141669198
-
Defective brain development in mice lacking the HIF-1α gene in neural cells
-
Tomita S., Ueno M., Sakamoto M., et al. Defective brain development in mice lacking the HIF-1α gene in neural cells. Mol Cell Biol 23 (2003) 6739-6749
-
(2003)
Mol Cell Biol
, vol.23
, pp. 6739-6749
-
-
Tomita, S.1
Ueno, M.2
Sakamoto, M.3
-
63
-
-
7944224442
-
Loss of HIF-1α in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis
-
Tang N., Wang L., Esko J., et al. Loss of HIF-1α in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis. Cancer Cell 6 (2004) 485-495
-
(2004)
Cancer Cell
, vol.6
, pp. 485-495
-
-
Tang, N.1
Wang, L.2
Esko, J.3
-
64
-
-
0344874751
-
Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1
-
Kelly B.D., Hackett S.F., Hirota K., et al. Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1. Circ Res 93 (2003) 1074-1081
-
(2003)
Circ Res
, vol.93
, pp. 1074-1081
-
-
Kelly, B.D.1
Hackett, S.F.2
Hirota, K.3
-
65
-
-
0034682513
-
The transcription factor EPAS-1/hypoxia-inducible factor 2α plays an important role in vascular remodelling
-
Peng J., Zhang L., Drysdale L., and Fong G.H. The transcription factor EPAS-1/hypoxia-inducible factor 2α plays an important role in vascular remodelling. Proc Natl Acad Sci USA 97 (2000) 8386-8391
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 8386-8391
-
-
Peng, J.1
Zhang, L.2
Drysdale, L.3
Fong, G.H.4
-
66
-
-
0032213236
-
The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development
-
Tian H., Hammer R.E., Matsumoto A.M., Russell D.W., and McKnight S.L. The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development. Genes Dev 12 (1998) 3320-3324
-
(1998)
Genes Dev
, vol.12
, pp. 3320-3324
-
-
Tian, H.1
Hammer, R.E.2
Matsumoto, A.M.3
Russell, D.W.4
McKnight, S.L.5
-
67
-
-
0035983324
-
Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice
-
Compernolle V., Brusselmans K., Acker T., et al. Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice. Nat Med 8 (2002) 702-710
-
(2002)
Nat Med
, vol.8
, pp. 702-710
-
-
Compernolle, V.1
Brusselmans, K.2
Acker, T.3
-
68
-
-
0142023866
-
Regional angiogenesis with vascular endothelial growth factor in peripheral arterial disease: a phase II randomized, double-blind, controlled study of adenoviral delivery of vascular endothelial growth factor 121 in patients with disabling intermittent claudication
-
Rajagopalan S., Mohler E., Lederman R., et al. Regional angiogenesis with vascular endothelial growth factor in peripheral arterial disease: a phase II randomized, double-blind, controlled study of adenoviral delivery of vascular endothelial growth factor 121 in patients with disabling intermittent claudication. Circulation 108 (2003) 1933-1938
-
(2003)
Circulation
, vol.108
, pp. 1933-1938
-
-
Rajagopalan, S.1
Mohler, E.2
Lederman, R.3
-
69
-
-
84934909628
-
Therapeutic angiogenesis with recombinant fibroblast growth factor-2 for intermittent claudication (the TRAFFIC study): a randomized trial
-
Lederman R.J., Mendelsohn F.O., Anderson R.D., et al. Therapeutic angiogenesis with recombinant fibroblast growth factor-2 for intermittent claudication (the TRAFFIC study): a randomized trial. Lancet 359 (2000) 2953-2958
-
(2000)
Lancet
, vol.359
, pp. 2953-2958
-
-
Lederman, R.J.1
Mendelsohn, F.O.2
Anderson, R.D.3
-
70
-
-
0034712939
-
Hypoxia-inducible factor 1α protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations
-
Sutter C.H., Laughner E., and Semenza G.L. Hypoxia-inducible factor 1α protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations. Proc Natl Acad Sci USA 97 (2000) 4748-4753
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 4748-4753
-
-
Sutter, C.H.1
Laughner, E.2
Semenza, G.L.3
-
71
-
-
0035476509
-
Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1α
-
Elson D.A., Thurston G., Huang L.E., et al. Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1α. Genes Dev 15 (2001) 2520-2532
-
(2001)
Genes Dev
, vol.15
, pp. 2520-2532
-
-
Elson, D.A.1
Thurston, G.2
Huang, L.E.3
-
72
-
-
0036873485
-
Harnessing the response to tissue hypoxia: HIF-1α and therapeutic angiogenesis
-
Vincent K.A., Feron O., and Kelly R.A. Harnessing the response to tissue hypoxia: HIF-1α and therapeutic angiogenesis. Trends Cardiovasc Med 12 (2002) 362-367
-
(2002)
Trends Cardiovasc Med
, vol.12
, pp. 362-367
-
-
Vincent, K.A.1
Feron, O.2
Kelly, R.A.3
-
73
-
-
0036275028
-
Intramyocardial injection of naked DNA encoding HIF-1α/VP16 hybrid to enhance angiogenesis in an acute myocardial infarction model in the rat
-
Shyu K., Wang M., Wang B., et al. Intramyocardial injection of naked DNA encoding HIF-1α/VP16 hybrid to enhance angiogenesis in an acute myocardial infarction model in the rat. Cardiovasc Res 54 (2002) 576-583
-
(2002)
Cardiovasc Res
, vol.54
, pp. 576-583
-
-
Shyu, K.1
Wang, M.2
Wang, B.3
-
74
-
-
24344433563
-
Constitutively active HIF-1α improves perfusion and arterial remodeling in an endovascular model of limb ischemia
-
Patel T.H., Kimura H., Weiss C.R., Semenza G.L., and Hofmann L.V. Constitutively active HIF-1α improves perfusion and arterial remodeling in an endovascular model of limb ischemia. Cardiovasc Res 68 (2005) 144-154
-
(2005)
Cardiovasc Res
, vol.68
, pp. 144-154
-
-
Patel, T.H.1
Kimura, H.2
Weiss, C.R.3
Semenza, G.L.4
Hofmann, L.V.5
-
75
-
-
0033970878
-
PR39, a peptide regulator of angiogenesis
-
Li J., Post M., Volk R., et al. PR39, a peptide regulator of angiogenesis. Nat Med 61 (2000) 49-55
-
(2000)
Nat Med
, vol.61
, pp. 49-55
-
-
Li, J.1
Post, M.2
Volk, R.3
-
76
-
-
6444242574
-
-
Milkiewicz M, Pugh CW, Egginton S. Inhibition of endogenous HIF inactivation induces angiogenesis in ischaemic skeletal muscles of mice. J Physiol 2004;560:21-6.
-
-
-
-
77
-
-
23744461969
-
Hypoxia-inducible factor 1α polymorphism and coronary collaterals in patients with ischemic heart disease
-
Resar J.R., Roguin A., Voner J., et al. Hypoxia-inducible factor 1α polymorphism and coronary collaterals in patients with ischemic heart disease. Chest 128 (2005) 787-791
-
(2005)
Chest
, vol.128
, pp. 787-791
-
-
Resar, J.R.1
Roguin, A.2
Voner, J.3
-
78
-
-
2942685341
-
Role of hypoxia-inducible factor 1α in gastric cancer cell growth, angiogenesis, and vessel maturation
-
Stoeltzing O., McCarty M.F., Wey J.S., et al. Role of hypoxia-inducible factor 1α in gastric cancer cell growth, angiogenesis, and vessel maturation. J Natl Cancer Inst 96 (2004) 946-956
-
(2004)
J Natl Cancer Inst
, vol.96
, pp. 946-956
-
-
Stoeltzing, O.1
McCarty, M.F.2
Wey, J.S.3
-
79
-
-
0033954247
-
Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α
-
Ravi R., Mookerjee B., Bhujwalla Z.M., et al. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α. Genes Dev 14 (2000) 34-44
-
(2000)
Genes Dev
, vol.14
, pp. 34-44
-
-
Ravi, R.1
Mookerjee, B.2
Bhujwalla, Z.M.3
-
80
-
-
0036682284
-
Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway
-
Rapisarda A., Uranchimeg B., Scudiero D.A., et al. Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway. Cancer Res 62 (2002) 4316-4324
-
(2002)
Cancer Res
, vol.62
, pp. 4316-4324
-
-
Rapisarda, A.1
Uranchimeg, B.2
Scudiero, D.A.3
-
81
-
-
1242271198
-
Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: mechanism and therapeutic implications
-
Rapisarda A., Uranchimeg B., Sordet O., Pommier Y., Shoemaker R.H., and Melillo G. Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: mechanism and therapeutic implications. Cancer Res 64 (2004) 1475-1482
-
(2004)
Cancer Res
, vol.64
, pp. 1475-1482
-
-
Rapisarda, A.1
Uranchimeg, B.2
Sordet, O.3
Pommier, Y.4
Shoemaker, R.H.5
Melillo, G.6
-
82
-
-
10744231706
-
2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF
-
Mabjeesh N.J., Escuin D., LaVallee T.M., et al. 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. Cancer Cell 3 (2003) 363-375
-
(2003)
Cancer Cell
, vol.3
, pp. 363-375
-
-
Mabjeesh, N.J.1
Escuin, D.2
LaVallee, T.M.3
-
83
-
-
21644445092
-
Small molecule-mediated anti-cancer therapy via hypoxia-inducible factor-1 blockade
-
Macpherson G.R., and Figg W.D. Small molecule-mediated anti-cancer therapy via hypoxia-inducible factor-1 blockade. Cancer Biol Ther 3 (2004) 503-504
-
(2004)
Cancer Biol Ther
, vol.3
, pp. 503-504
-
-
Macpherson, G.R.1
Figg, W.D.2
-
84
-
-
4444369682
-
Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1α
-
Welsh S., Williams R., Kirkpatrick L., Paine-Murrieta G., and Powis G. Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1α. Mol Cancer Ther 3 (2004) 233-244
-
(2004)
Mol Cancer Ther
, vol.3
, pp. 233-244
-
-
Welsh, S.1
Williams, R.2
Kirkpatrick, L.3
Paine-Murrieta, G.4
Powis, G.5
-
85
-
-
3142622930
-
Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway
-
Kung A.L., Zabludoff S.D., France D.S., et al. Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway. Cancer Cell 6 (2004) 33-34
-
(2004)
Cancer Cell
, vol.6
, pp. 33-34
-
-
Kung, A.L.1
Zabludoff, S.D.2
France, D.S.3
-
86
-
-
0043288724
-
Heat shock protein 90 as a molecular target for cancer therapeutics
-
Isaacs J.S., Xu W., and Neckers L. Heat shock protein 90 as a molecular target for cancer therapeutics. Cancer Cell 3 (2003) 213-217
-
(2003)
Cancer Cell
, vol.3
, pp. 213-217
-
-
Isaacs, J.S.1
Xu, W.2
Neckers, L.3
-
87
-
-
0034654174
-
Modulation of hypoxia-inducible factor 1α expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics
-
Zhong H., Chiles K., Feldser D., et al. Modulation of hypoxia-inducible factor 1α expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res 60 (2000) 1541-1545
-
(2000)
Cancer Res
, vol.60
, pp. 1541-1545
-
-
Zhong, H.1
Chiles, K.2
Feldser, D.3
-
88
-
-
0036528246
-
Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein
-
Kondo K., Klco J., Nakamura E., Lechpammer M., and Kaelin Jr. W.G. Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein. Cancer Cell 1 (2002) 237-246
-
(2002)
Cancer Cell
, vol.1
, pp. 237-246
-
-
Kondo, K.1
Klco, J.2
Nakamura, E.3
Lechpammer, M.4
Kaelin Jr., W.G.5
-
89
-
-
0036527785
-
The contribution of VHL substrate binding and HIF-1α to the phenotype of VHL loss in renal cell carcinoma
-
Maranchie J.K., Vasselli J.R., Riss J., Bonifacino J.S., Linehan W.M., and Klausner R.D. The contribution of VHL substrate binding and HIF-1α to the phenotype of VHL loss in renal cell carcinoma. Cancer Cell 1 (2002) 247-255
-
(2002)
Cancer Cell
, vol.1
, pp. 247-255
-
-
Maranchie, J.K.1
Vasselli, J.R.2
Riss, J.3
Bonifacino, J.S.4
Linehan, W.M.5
Klausner, R.D.6
-
90
-
-
23644453277
-
Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity
-
Moeller B.J., Dreher M.R., Rabbani Z.N., et al. Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity. Cancer Cell 8 (2005) 99-110
-
(2005)
Cancer Cell
, vol.8
, pp. 99-110
-
-
Moeller, B.J.1
Dreher, M.R.2
Rabbani, Z.N.3
-
91
-
-
2642526992
-
The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme
-
Krishnamurthy P., Ross D.D., Nakanishi T., et al. The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme. J Biol Chem 279 (2004) 24218-24225
-
(2004)
J Biol Chem
, vol.279
, pp. 24218-24225
-
-
Krishnamurthy, P.1
Ross, D.D.2
Nakanishi, T.3
-
92
-
-
0030611360
-
1B-adrenergic receptor gene promoter region and hypoxia regulatory elements in vascular smooth muscle
-
1B-adrenergic receptor gene promoter region and hypoxia regulatory elements in vascular smooth muscle. Proc Natl Acad Sci USA 94 (1997) 9487-9492
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 9487-9492
-
-
Eckhart, A.D.1
Yang, N.2
Xin, X.3
Faber, J.E.4
-
93
-
-
0032504165
-
Adrenomedullin gene expression is developmentally regulated and induced by hypoxia in rat ventricular cardiac myocytes
-
Cormier-Regard S., Nguyen S.V., and Claycomb W.C. Adrenomedullin gene expression is developmentally regulated and induced by hypoxia in rat ventricular cardiac myocytes. J Biol Chem 273 (1998) 17787-17792
-
(1998)
J Biol Chem
, vol.273
, pp. 17787-17792
-
-
Cormier-Regard, S.1
Nguyen, S.V.2
Claycomb, W.C.3
-
94
-
-
0032100732
-
HIF-1α is required for solid tumor formation and embryonic vascularization
-
Ryan H.E., Lo J., and Johnson R.S. HIF-1α is required for solid tumor formation and embryonic vascularization. EMBO J 17 (1998) 3005-3015
-
(1998)
EMBO J
, vol.17
, pp. 3005-3015
-
-
Ryan, H.E.1
Lo, J.2
Johnson, R.S.3
-
95
-
-
0037442536
-
Hypoxic activation of the atrial natriuretic peptide gene promoter through direct and indirect actions of hypoxia-inducible factor-1
-
Chun Y.S., Hyun J.Y., Kwak Y.G., et al. Hypoxic activation of the atrial natriuretic peptide gene promoter through direct and indirect actions of hypoxia-inducible factor-1. Biochem J 370 (2003) 149-157
-
(2003)
Biochem J
, vol.370
, pp. 149-157
-
-
Chun, Y.S.1
Hyun, J.Y.2
Kwak, Y.G.3
-
96
-
-
0034649507
-
Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumor suppressor by mRNA differential expression profiling
-
Wykoff C.C., Pugh C.W., Maxwell P.H., Harris A.L., and Ratcliffe P.H. Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumor suppressor by mRNA differential expression profiling. Oncogene 19 (2000) 6297-6305
-
(2000)
Oncogene
, vol.19
, pp. 6297-6305
-
-
Wykoff, C.C.1
Pugh, C.W.2
Maxwell, P.H.3
Harris, A.L.4
Ratcliffe, P.H.5
-
98
-
-
0034647742
-
Role of hypoxia-inducible factor-1 in transcriptional activation of ceruloplasmin by iron deficiency
-
Mukhopadhyay C.K., Mazumder B., and Fox P.L. Role of hypoxia-inducible factor-1 in transcriptional activation of ceruloplasmin by iron deficiency. J Biol Chem 275 (2000) 21048-21054
-
(2000)
J Biol Chem
, vol.275
, pp. 21048-21054
-
-
Mukhopadhyay, C.K.1
Mazumder, B.2
Fox, P.L.3
-
99
-
-
0037478437
-
Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene
-
Pennacchietti S., Michieli P., Galluzzo M., Mazzone M., Giordano S., and Comoglio P.M. Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene. Cancer Cell 3 (2003) 347-361
-
(2003)
Cancer Cell
, vol.3
, pp. 347-361
-
-
Pennacchietti, S.1
Michieli, P.2
Galluzzo, M.3
Mazzone, M.4
Giordano, S.5
Comoglio, P.M.6
-
100
-
-
8644229386
-
Hypoxic induction of Ctgf is directly mediated by HIF-1
-
Higgins D.F., Biju M.P., Akai Y., Wutz A., Johnson R.S., and Haase V.H. Hypoxic induction of Ctgf is directly mediated by HIF-1. Am J Physiol 287 (2004) F1223-F1232
-
(2004)
Am J Physiol
, vol.287
-
-
Higgins, D.F.1
Biju, M.P.2
Akai, Y.3
Wutz, A.4
Johnson, R.S.5
Haase, V.H.6
-
101
-
-
0344826040
-
Hypoxia-inducible factor-1 and activator protein-1 modulate the upregulation of CYP3A6 induced by hypoxia
-
Fradette C., and du Souich P. Hypoxia-inducible factor-1 and activator protein-1 modulate the upregulation of CYP3A6 induced by hypoxia. Br J Pharmacol 140 (2003) 1146-1154
-
(2003)
Br J Pharmacol
, vol.140
, pp. 1146-1154
-
-
Fradette, C.1
du Souich, P.2
-
102
-
-
22244470409
-
Stromal cell-derived factor-1α and CXCR4 expression in hemangioblastoma and clear-cell-renal cell carcinoma: von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor
-
Zagzag D., Krishnamachary B., Yee H., et al. Stromal cell-derived factor-1α and CXCR4 expression in hemangioblastoma and clear-cell-renal cell carcinoma: von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor. Cancer Res 65 (2005) 6178-6188
-
(2005)
Cancer Res
, vol.65
, pp. 6178-6188
-
-
Zagzag, D.1
Krishnamachary, B.2
Yee, H.3
-
103
-
-
0141828145
-
Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumor suppressor pVHL
-
Staller P., Sulitkova J., Lisztwan J., Moch H., Oakeley E.J., and Krek W. Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumor suppressor pVHL. Nature 425 (2003) 307-311
-
(2003)
Nature
, vol.425
, pp. 307-311
-
-
Staller, P.1
Sulitkova, J.2
Lisztwan, J.3
Moch, H.4
Oakeley, E.J.5
Krek, W.6
-
104
-
-
10744219598
-
Regulation of the chemokine receptor CXCR4 by hypoxia
-
Schioppa T., Uranchimeg B., Saccani A., et al. Regulation of the chemokine receptor CXCR4 by hypoxia. J Exp Med 198 (2003) 1391-1402
-
(2003)
J Exp Med
, vol.198
, pp. 1391-1402
-
-
Schioppa, T.1
Uranchimeg, B.2
Saccani, A.3
-
105
-
-
0037033095
-
Identification of functional hypoxia response elements in the promoter region of the DEC1 and DEC2 genes
-
Miyazaki K., Kawamoto T., Tanimoto K., Nishiyama M., Honda H., and Kato Y. Identification of functional hypoxia response elements in the promoter region of the DEC1 and DEC2 genes. J Biol Chem 277 (2002) 47014-47021
-
(2002)
J Biol Chem
, vol.277
, pp. 47014-47021
-
-
Miyazaki, K.1
Kawamoto, T.2
Tanimoto, K.3
Nishiyama, M.4
Honda, H.5
Kato, Y.6
-
106
-
-
85047685683
-
Ecto-5′-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia
-
Synnestvedt K., Furuta G.T., Comerford K.M., et al. Ecto-5′-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia. J Clin Invest 110 (2002) 993-1002
-
(2002)
J Clin Invest
, vol.110
, pp. 993-1002
-
-
Synnestvedt, K.1
Furuta, G.T.2
Comerford, K.M.3
-
107
-
-
0035974803
-
Identification of an angiogenic mitogen selective for endocrine gland endothelium
-
LeCouter J., Kowalski J., Foster J., et al. Identification of an angiogenic mitogen selective for endocrine gland endothelium. Nature 412 (2001) 877-884
-
(2001)
Nature
, vol.412
, pp. 877-884
-
-
LeCouter, J.1
Kowalski, J.2
Foster, J.3
-
108
-
-
0037113959
-
Endoglin expression is regulated by transcriptional cooperation between the hypoxia and transforming growth factor-β pathways
-
Sanchez-Elsner T., Botella L.M., Velasco B., Langa C., and Bernabeu C. Endoglin expression is regulated by transcriptional cooperation between the hypoxia and transforming growth factor-β pathways. J Biol Chem 277 (2002) 43799-43808
-
(2002)
J Biol Chem
, vol.277
, pp. 43799-43808
-
-
Sanchez-Elsner, T.1
Botella, L.M.2
Velasco, B.3
Langa, C.4
Bernabeu, C.5
-
109
-
-
0032576971
-
Hypoxia regulates expression of the endothelin-1 gene through a proximal hypoxia-inducible factor-1 binding site on the antisense strand
-
Hu J., Discher D.J., Bishopric N.H., and Webster K.A. Hypoxia regulates expression of the endothelin-1 gene through a proximal hypoxia-inducible factor-1 binding site on the antisense strand. Biochem Biophys Res Commun 245 (1998) 894-899
-
(1998)
Biochem Biophys Res Commun
, vol.245
, pp. 894-899
-
-
Hu, J.1
Discher, D.J.2
Bishopric, N.H.3
Webster, K.A.4
-
110
-
-
0030460724
-
Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1
-
Semenza G.L., Jiang B.H., Leung S.W., et al. Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1. J Biol Chem 271 (1996) 32529-32537
-
(1996)
J Biol Chem
, vol.271
, pp. 32529-32537
-
-
Semenza, G.L.1
Jiang, B.H.2
Leung, S.W.3
-
111
-
-
0344012597
-
Identification of hypoxia-response element in the human endothelial nitric-oxide synthase gene promoter
-
Coulet F., Nadaud S., Agrapart M., and Soubrier F. Identification of hypoxia-response element in the human endothelial nitric-oxide synthase gene promoter. J Biol Chem 278 (2003) 46230-46240
-
(2003)
J Biol Chem
, vol.278
, pp. 46230-46240
-
-
Coulet, F.1
Nadaud, S.2
Agrapart, M.3
Soubrier, F.4
-
112
-
-
0035941117
-
Hypoxia induces transcription factor ETS-1 via the activity of hypoxia-inducible factor-1
-
Oikawa M., Abe M., Kurosawa H., Hida W., Shirato K., and Sato Y. Hypoxia induces transcription factor ETS-1 via the activity of hypoxia-inducible factor-1. Biochem Biophys Res Commun 289 (2001) 39-43
-
(2001)
Biochem Biophys Res Commun
, vol.289
, pp. 39-43
-
-
Oikawa, M.1
Abe, M.2
Kurosawa, H.3
Hida, W.4
Shirato, K.5
Sato, Y.6
-
113
-
-
0032478823
-
Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 α-subunit (HIF-1α). Characterization of HIF-1α-dependent and -independent hypoxia-inducible gene expression
-
Wood S.M., Wiesener M.S., Yeates K.M., et al. Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 α-subunit (HIF-1α). Characterization of HIF-1α-dependent and -independent hypoxia-inducible gene expression. J Biol Chem 273 (1998) 8360-8368
-
(1998)
J Biol Chem
, vol.273
, pp. 8360-8368
-
-
Wood, S.M.1
Wiesener, M.S.2
Yeates, K.M.3
-
114
-
-
0032741858
-
Identification of an oxygen responsive enhancer element in the glyceraldehyde-3-phosphate dehydrogenase gene
-
Graven K.K., Yu Q., Pan D., Roncarati J.S., and Farber H.W. Identification of an oxygen responsive enhancer element in the glyceraldehyde-3-phosphate dehydrogenase gene. Biochim Biophys Acta 1447 (1999) 208-218
-
(1999)
Biochim Biophys Acta
, vol.1447
, pp. 208-218
-
-
Graven, K.K.1
Yu, Q.2
Pan, D.3
Roncarati, J.S.4
Farber, H.W.5
-
115
-
-
0037133736
-
Identification of an additional hypoxia responsive element in the glyceraldehyde-3-phosphate dehydrogenase gene promoter
-
Lu S., Gu X., Hoestje S., and Epner D.E. Identification of an additional hypoxia responsive element in the glyceraldehyde-3-phosphate dehydrogenase gene promoter. Biochim Biophys Acta 1574 (2002) 152-156
-
(2002)
Biochim Biophys Acta
, vol.1574
, pp. 152-156
-
-
Lu, S.1
Gu, X.2
Hoestje, S.3
Epner, D.E.4
-
116
-
-
11144307479
-
Up-regulation of 94-kDa glucose-regulated protein by hypoxia-inducible factor-1 in human endothelial cells in response to hypoxia
-
Paris S., Denis H., Delaive E., et al. Up-regulation of 94-kDa glucose-regulated protein by hypoxia-inducible factor-1 in human endothelial cells in response to hypoxia. FEBS Lett 579 (2005) 105-114
-
(2005)
FEBS Lett
, vol.579
, pp. 105-114
-
-
Paris, S.1
Denis, H.2
Delaive, E.3
-
117
-
-
0031041377
-
Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia
-
Lee P.J., Jiang B.H., Chin B.Y., et al. Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia. J Biol Chem 272 (1997) 5375-5381
-
(1997)
J Biol Chem
, vol.272
, pp. 5375-5381
-
-
Lee, P.J.1
Jiang, B.H.2
Chin, B.Y.3
-
118
-
-
23944454868
-
Identification of a functional hypoxia-responsive element that regulates the expression of the egl nine homologue 3 (egln3/phd3) gene
-
Pescador N., Cuevas Y., Naranjo S., et al. Identification of a functional hypoxia-responsive element that regulates the expression of the egl nine homologue 3 (egln3/phd3) gene. Biochem J 390 (2005) 189-197
-
(2005)
Biochem J
, vol.390
, pp. 189-197
-
-
Pescador, N.1
Cuevas, Y.2
Naranjo, S.3
-
119
-
-
18844408840
-
Regulation of the prolyl hydroxylase domain protein 2 (phd2/egln-1) gene: identification of a functional hypoxia-responsive element
-
Metzen E., Stiehl D.P., Doege K., Marxsen J.H., Hellwig-Burgel T., and Jelkmann W. Regulation of the prolyl hydroxylase domain protein 2 (phd2/egln-1) gene: identification of a functional hypoxia-responsive element. Biochem J 387 (2005) 711-717
-
(2005)
Biochem J
, vol.387
, pp. 711-717
-
-
Metzen, E.1
Stiehl, D.P.2
Doege, K.3
Marxsen, J.H.4
Hellwig-Burgel, T.5
Jelkmann, W.6
-
120
-
-
1942453828
-
Identification of the hypoxia-inducible factor 1α-responsive HGTD-P gene as a mediator in the mitochondrial apoptotic pathway
-
Lee M.J., Kim J.Y., Suk K., and Park J.H. Identification of the hypoxia-inducible factor 1α-responsive HGTD-P gene as a mediator in the mitochondrial apoptotic pathway. Mol Cell Biol 24 (2004) 3918-3927
-
(2004)
Mol Cell Biol
, vol.24
, pp. 3918-3927
-
-
Lee, M.J.1
Kim, J.Y.2
Suk, K.3
Park, J.H.4
-
121
-
-
4544361863
-
Induction of ID2 expression by hypoxia-inducible factor-1: a role in dedifferentiation of hypoxic neuroblastoma cells
-
Lofstedt T., Jogi A., Sigvardsson M., et al. Induction of ID2 expression by hypoxia-inducible factor-1: a role in dedifferentiation of hypoxic neuroblastoma cells. J Biol Chem 279 (2004) 39223-39231
-
(2004)
J Biol Chem
, vol.279
, pp. 39223-39231
-
-
Lofstedt, T.1
Jogi, A.2
Sigvardsson, M.3
-
122
-
-
0035821249
-
Hypoxia-inducible factor 1-dependent induction of intestinal trefoil factor protects barrier function during hypoxia
-
Furuta G.T., Turner J.R., Taylor C.T., et al. Hypoxia-inducible factor 1-dependent induction of intestinal trefoil factor protects barrier function during hypoxia. J Exp Med 193 (2001) 1027-1034
-
(2001)
J Exp Med
, vol.193
, pp. 1027-1034
-
-
Furuta, G.T.1
Turner, J.R.2
Taylor, C.T.3
-
123
-
-
0036354281
-
Lactase gene transcription is activated in response to hypoxia in intestinal epithelial cells
-
Lee S.Y., Madan A., Furuta G.T., Colgan S.P., and Sibley E. Lactase gene transcription is activated in response to hypoxia in intestinal epithelial cells. Mol Genet Metab 75 (2002) 65-69
-
(2002)
Mol Genet Metab
, vol.75
, pp. 65-69
-
-
Lee, S.Y.1
Madan, A.2
Furuta, G.T.3
Colgan, S.P.4
Sibley, E.5
-
124
-
-
0037044813
-
Hypoxia-inducible factor 1 transactivates the human leptin gene promoter
-
Grosfeld A., Andre J., Hauguel-De Mouzon S., Berra E., Pouyssegur J., and Guerre-Millo M. Hypoxia-inducible factor 1 transactivates the human leptin gene promoter. J Biol Chem 277 (2002) 42953-42957
-
(2002)
J Biol Chem
, vol.277
, pp. 42953-42957
-
-
Grosfeld, A.1
Andre, J.2
Hauguel-De Mouzon, S.3
Berra, E.4
Pouyssegur, J.5
Guerre-Millo, M.6
-
125
-
-
13944252559
-
Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2α in von Hippel-Lindau renal cell carcinoma
-
Petrella B.L., Lohi J., and Brinckerhoff C.E. Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2α in von Hippel-Lindau renal cell carcinoma. Oncogene 24 (2005) 1043-1052
-
(2005)
Oncogene
, vol.24
, pp. 1043-1052
-
-
Petrella, B.L.1
Lohi, J.2
Brinckerhoff, C.E.3
-
126
-
-
0037096732
-
Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene
-
Comerford K.M., Wallace T.J., Karhausen J., Louis N.A., Montalto M.C., and Colgan S.P. Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene. Cancer Res 62 (2002) 3387-3394
-
(2002)
Cancer Res
, vol.62
, pp. 3387-3394
-
-
Comerford, K.M.1
Wallace, T.J.2
Karhausen, J.3
Louis, N.A.4
Montalto, M.C.5
Colgan, S.P.6
-
127
-
-
15744369062
-
Hypoxia-inducible factor-1-dependent overexpression of myeloid cell factor-1 protects hypoxic cells against tert-butyl hydroperoxide-induced apoptosis
-
Piret J.P., Minet E., Cosse J.P., et al. Hypoxia-inducible factor-1-dependent overexpression of myeloid cell factor-1 protects hypoxic cells against tert-butyl hydroperoxide-induced apoptosis. J Biol Chem 280 (2005) 9336-9344
-
(2005)
J Biol Chem
, vol.280
, pp. 9336-9344
-
-
Piret, J.P.1
Minet, E.2
Cosse, J.P.3
-
128
-
-
0028786601
-
A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter
-
Melillo G., Musso T., Sica A., Taylor L.S., Cox G.W., and Varesio L. A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter. J Exp Med 182 (1995) 1683-1693
-
(1995)
J Exp Med
, vol.182
, pp. 1683-1693
-
-
Melillo, G.1
Musso, T.2
Sica, A.3
Taylor, L.S.4
Cox, G.W.5
Varesio, L.6
-
129
-
-
0034255036
-
Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia
-
Bruick R.K. Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia. Proc Natl Acad Sci USA 97 (2000) 9082-9087
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 9082-9087
-
-
Bruick, R.K.1
-
130
-
-
1642494853
-
Nur77 activated by hypoxia-inducible factor-1α overproduces proopiomelanocortin in von Hippel-Lindau-mutated renal cell carcinoma
-
Choi J., Park S., Kang G., Liu J., and Youn H. Nur77 activated by hypoxia-inducible factor-1α overproduces proopiomelanocortin in von Hippel-Lindau-mutated renal cell carcinoma. Cancer Res 64 (2004) 35-39
-
(2004)
Cancer Res
, vol.64
, pp. 35-39
-
-
Choi, J.1
Park, S.2
Kang, G.3
Liu, J.4
Youn, H.5
-
131
-
-
0032900610
-
Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1
-
Bhattacharya S., Michels C.L., Leung M.K., Arany Z.P., Kung A.L., and Livingston D.M. Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1. Genes Dev 13 (1999) 64-75
-
(1999)
Genes Dev
, vol.13
, pp. 64-75
-
-
Bhattacharya, S.1
Michels, C.L.2
Leung, M.K.3
Arany, Z.P.4
Kung, A.L.5
Livingston, D.M.6
-
132
-
-
0028359320
-
Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3′ enhancer
-
Firth J.D., Ebert B.L., Pugh C.W., and Ratcliffe P.J. Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3′ enhancer. Proc Natl Acad Sci USA 91 (1994) 6496-6500
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 6496-6500
-
-
Firth, J.D.1
Ebert, B.L.2
Pugh, C.W.3
Ratcliffe, P.J.4
-
133
-
-
0037155247
-
Hypoxia-inducible factor-1-mediated expression of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) gene. Its possible role in the Warburg effect
-
Minchenko A., Leshchinsky I., Opentanova I., et al. Hypoxia-inducible factor-1-mediated expression of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) gene. Its possible role in the Warburg effect. J Biol Chem 277 (2002) 6183-6187
-
(2002)
J Biol Chem
, vol.277
, pp. 6183-6187
-
-
Minchenko, A.1
Leshchinsky, I.2
Opentanova, I.3
-
134
-
-
9144236903
-
Identification and characterization of the hypoxia-responsive element of the human placental 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene
-
Fukasawa M., Tsuchiya T., Takayama E., et al. Identification and characterization of the hypoxia-responsive element of the human placental 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene. J Biochem (Tokyo) 136 (2004) 273-277
-
(2004)
J Biochem (Tokyo)
, vol.136
, pp. 273-277
-
-
Fukasawa, M.1
Tsuchiya, T.2
Takayama, E.3
-
135
-
-
0242710750
-
Hypoxic regulation of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene family (PFKFB-1-4) expression in vivo
-
Minchenko O., Opentanova I., and Caro J. Hypoxic regulation of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene family (PFKFB-1-4) expression in vivo. FEBS Lett 554 (2003) 264-270
-
(2003)
FEBS Lett
, vol.554
, pp. 264-270
-
-
Minchenko, O.1
Opentanova, I.2
Caro, J.3
-
136
-
-
0032795850
-
Induction of the plasminogen activator inhibitor-1 gene expression by mild hypoxia via a hypoxia response element binding the hypoxia-inducible factor-1 in rat hepatocytes
-
Kietzmann T., Roth U., and Jungermann K. Induction of the plasminogen activator inhibitor-1 gene expression by mild hypoxia via a hypoxia response element binding the hypoxia-inducible factor-1 in rat hepatocytes. Blood 94 (1999) 4177-4185
-
(1999)
Blood
, vol.94
, pp. 4177-4185
-
-
Kietzmann, T.1
Roth, U.2
Jungermann, K.3
-
137
-
-
0034640269
-
Hypoxic induction of prolyl 4-hydroxylase α(I) in cultured cells
-
Takahashi Y., Takahashi S., Shiga Y., Yoshimi T., and Miura T. Hypoxic induction of prolyl 4-hydroxylase α(I) in cultured cells. J Biol Chem 275 (2000) 14139-14146
-
(2000)
J Biol Chem
, vol.275
, pp. 14139-14146
-
-
Takahashi, Y.1
Takahashi, S.2
Shiga, Y.3
Yoshimi, T.4
Miura, T.5
-
138
-
-
2442502748
-
Hypoxia-induced activation of the retinoic acid receptor-related orphan receptor α4 gene by an interaction between hypoxia-inducible factor-1 and Sp1
-
Miki N., Ikuta M., and Matsui T. Hypoxia-induced activation of the retinoic acid receptor-related orphan receptor α4 gene by an interaction between hypoxia-inducible factor-1 and Sp1. J Biol Chem 279 (2004) 15025-15031
-
(2004)
J Biol Chem
, vol.279
, pp. 15025-15031
-
-
Miki, N.1
Ikuta, M.2
Matsui, T.3
-
139
-
-
9444283789
-
The gene encoding human retinoic acid-receptor-related orphan receptor α is a target for hypoxia-inducible factor 1
-
Chauvet C., Bois-Joyeux B., Berra E., Pouyssegur J., and Danan J.L. The gene encoding human retinoic acid-receptor-related orphan receptor α is a target for hypoxia-inducible factor 1. Biochem J 384 (2004) 79-85
-
(2004)
Biochem J
, vol.384
, pp. 79-85
-
-
Chauvet, C.1
Bois-Joyeux, B.2
Berra, E.3
Pouyssegur, J.4
Danan, J.L.5
-
140
-
-
4043184065
-
Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1
-
Ceradini D.J., Kulkarni A.R., Callaghan M.J., et al. Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nat Med 10 (2004) 858-864
-
(2004)
Nat Med
, vol.10
, pp. 858-864
-
-
Ceradini, D.J.1
Kulkarni, A.R.2
Callaghan, M.J.3
-
141
-
-
2942709631
-
Hypoxia-inducible factor 1 mediates upregulation of telomerase (hTERT)
-
Nishi H., Nakada T., Kyo S., Inoue M., Shay J.W., and Isaka K. Hypoxia-inducible factor 1 mediates upregulation of telomerase (hTERT). Mol Cell Biol 24 (2004) 6076-6083
-
(2004)
Mol Cell Biol
, vol.24
, pp. 6076-6083
-
-
Nishi, H.1
Nakada, T.2
Kyo, S.3
Inoue, M.4
Shay, J.W.5
Isaka, K.6
-
142
-
-
0030792094
-
Oxygen-regulated transferrin expression is mediated by hypoxia-inducible factor-1
-
Rolfs A., Kvietikova I., Gassmann M., and Wenger R.H. Oxygen-regulated transferrin expression is mediated by hypoxia-inducible factor-1. J Biol Chem 272 (1997) 20055-20062
-
(1997)
J Biol Chem
, vol.272
, pp. 20055-20062
-
-
Rolfs, A.1
Kvietikova, I.2
Gassmann, M.3
Wenger, R.H.4
-
143
-
-
0000655498
-
Identification of a hypoxia response element in the transferrin receptor gene
-
Lok C.N., and Ponka P. Identification of a hypoxia response element in the transferrin receptor gene. J Biol Chem 274 (1999) 24147-24152
-
(1999)
J Biol Chem
, vol.274
, pp. 24147-24152
-
-
Lok, C.N.1
Ponka, P.2
-
144
-
-
0036291808
-
Transferrin receptor gene expression and transferrin-bound iron uptake are increased during postischemic rat liver reperfusion
-
Tacchini L., Fusar Poli D., Bernelli-Zazzera A., and Cairo G. Transferrin receptor gene expression and transferrin-bound iron uptake are increased during postischemic rat liver reperfusion. Hepatology 36 (2002) 103-111
-
(2002)
Hepatology
, vol.36
, pp. 103-111
-
-
Tacchini, L.1
Fusar Poli, D.2
Bernelli-Zazzera, A.3
Cairo, G.4
-
145
-
-
0034100836
-
Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3)
-
Caniggia I., Mostachfi H., Winter J., et al. Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3). J Clin Invest 105 (2000) 577-587
-
(2000)
J Clin Invest
, vol.105
, pp. 577-587
-
-
Caniggia, I.1
Mostachfi, H.2
Winter, J.3
-
146
-
-
0030751493
-
Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia
-
Gerber H.P., Condorelli F., Park J., and Ferrara N. Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia. J Biol Chem 272 (1997) 23659-23667
-
(1997)
J Biol Chem
, vol.272
, pp. 23659-23667
-
-
Gerber, H.P.1
Condorelli, F.2
Park, J.3
Ferrara, N.4
-
147
-
-
0036176874
-
Diverse effects of mutations in exon II of the von Hippel-Lindau (VHL) tumor suppressor gene on the interaction of pVHL with the cytosolic chaperonin and pVHL-dependent ubiquitin ligase activity
-
Hansen W.J., Ohh M., Moslehi J., Kondo K., Kaelin W.G., and Welch W.J. Diverse effects of mutations in exon II of the von Hippel-Lindau (VHL) tumor suppressor gene on the interaction of pVHL with the cytosolic chaperonin and pVHL-dependent ubiquitin ligase activity. Mol Cell Biol 22 (2002) 1947-1960
-
(2002)
Mol Cell Biol
, vol.22
, pp. 1947-1960
-
-
Hansen, W.J.1
Ohh, M.2
Moslehi, J.3
Kondo, K.4
Kaelin, W.G.5
Welch, W.J.6
-
148
-
-
3142626559
-
Molecular genetic analysis of FIH-1, FH, and SDHB candidate tumor suppressor genes in renal cell carcinoma
-
Morris M.R., Maina E., Morgan N.V., et al. Molecular genetic analysis of FIH-1, FH, and SDHB candidate tumor suppressor genes in renal cell carcinoma. J Clin Pathol 57 (2004) 706-711
-
(2004)
J Clin Pathol
, vol.57
, pp. 706-711
-
-
Morris, M.R.1
Maina, E.2
Morgan, N.V.3
-
149
-
-
26444570010
-
Accumulation of Krebs cycle intermediates and over-expression of HIF-1α in tumors which result from germline FH and SDH mutations
-
Pollard P.J., Briere J.J., Alam N.A., et al. Accumulation of Krebs cycle intermediates and over-expression of HIF-1α in tumors which result from germline FH and SDH mutations. Hum Mol Genet 14 (2005) 2231-2239
-
(2005)
Hum Mol Genet
, vol.14
, pp. 2231-2239
-
-
Pollard, P.J.1
Briere, J.J.2
Alam, N.A.3
-
150
-
-
19944433653
-
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase
-
Selak M.A., Armour S.M., MacKenzie E.D., et al. Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase. Cancer Cell 7 (2005) 77-85
-
(2005)
Cancer Cell
, vol.7
, pp. 77-85
-
-
Selak, M.A.1
Armour, S.M.2
MacKenzie, E.D.3
-
151
-
-
0034050050
-
Loss of PTEN facilitates HIF-1-mediated gene expression
-
Zundel W., Schindler C., Haas-Kogan D., et al. Loss of PTEN facilitates HIF-1-mediated gene expression. Genes Dev 14 (2000) 391-396
-
(2000)
Genes Dev
, vol.14
, pp. 391-396
-
-
Zundel, W.1
Schindler, C.2
Haas-Kogan, D.3
-
152
-
-
0037842275
-
Up-regulation of hypoxia-inducible factor 2α in renal cell carcinoma associated with loss of Tsc-2 tumor suppressor gene
-
Liu M.Y., Poellinger L., and Walker C.L. Up-regulation of hypoxia-inducible factor 2α in renal cell carcinoma associated with loss of Tsc-2 tumor suppressor gene. Cancer Res 63 (2003) 2675-2680
-
(2003)
Cancer Res
, vol.63
, pp. 2675-2680
-
-
Liu, M.Y.1
Poellinger, L.2
Walker, C.L.3
-
153
-
-
0035958932
-
ARF tumor suppressor protein facilitates nucleolar sequestration of hypoxia-inducible factor-1α (HIF-1α) and inhibits HIF-1-mediated transcription
-
ARF tumor suppressor protein facilitates nucleolar sequestration of hypoxia-inducible factor-1α (HIF-1α) and inhibits HIF-1-mediated transcription. J Biol Chem 276 (2001) 28421-28429
-
(2001)
J Biol Chem
, vol.276
, pp. 28421-28429
-
-
Fatyol, K.1
Szalay, A.A.2
-
154
-
-
0037131271
-
Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1α
-
Chan D.A., Sutphin P.D., Denko N.C., and Giaccia A.J. Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1α. J Biol Chem 277 (2002) 40112-40117
-
(2002)
J Biol Chem
, vol.277
, pp. 40112-40117
-
-
Chan, D.A.1
Sutphin, P.D.2
Denko, N.C.3
Giaccia, A.J.4
-
155
-
-
0037044578
-
Activated pp60c-Src leads to elevated hypoxia-inducible factor (HIF)-1α expression under normoxia
-
Karni R., Dor Y., Keshet E., Meyuhas O., and Levitzki A. Activated pp60c-Src leads to elevated hypoxia-inducible factor (HIF)-1α expression under normoxia. J Biol Chem 277 (2002) 42919-42925
-
(2002)
J Biol Chem
, vol.277
, pp. 42919-42925
-
-
Karni, R.1
Dor, Y.2
Keshet, E.3
Meyuhas, O.4
Levitzki, A.5
-
156
-
-
2942707871
-
Hypoxia-inducible factor 1α/vascular endothelial growth factor axis in astrocytomas: associations with microvessel morphometry, proliferation and prognosis
-
Korkolopoulou P., Patsouris E., Konstantinidou A., et al. Hypoxia-inducible factor 1α/vascular endothelial growth factor axis in astrocytomas: associations with microvessel morphometry, proliferation and prognosis. Neuropathol Appl Neurobiol 3 (2004) 267-278
-
(2004)
Neuropathol Appl Neurobiol
, vol.3
, pp. 267-278
-
-
Korkolopoulou, P.1
Patsouris, E.2
Konstantinidou, A.3
-
157
-
-
14144250813
-
Evaluation of hypoxia-inducible factor 1α overexpression as a predictor of tumor recurrence and progression in superficial urothelial bladder carcinoma
-
Theodoropoulos V.E., Lazaris A.C., Kastriotis I., et al. Evaluation of hypoxia-inducible factor 1α overexpression as a predictor of tumor recurrence and progression in superficial urothelial bladder carcinoma. BJU Int 95 (2005) 425-431
-
(2005)
BJU Int
, vol.95
, pp. 425-431
-
-
Theodoropoulos, V.E.1
Lazaris, A.C.2
Kastriotis, I.3
-
158
-
-
3142534607
-
Hypoxia-inducible factor 1α expression correlates with angiogenesis and unfavorable prognosis in bladder cancer
-
Theodoropoulos V.E., Lazaris A., Sofras F., et al. Hypoxia-inducible factor 1α expression correlates with angiogenesis and unfavorable prognosis in bladder cancer. Eur Urol 46 (2004) 200-208
-
(2004)
Eur Urol
, vol.46
, pp. 200-208
-
-
Theodoropoulos, V.E.1
Lazaris, A.2
Sofras, F.3
-
159
-
-
0035925072
-
Levels of hypoxia-inducible factor-1α during breast carcinogenesis
-
Bos R., Zhong H., Hanrahan C.F., et al. Levels of hypoxia-inducible factor-1α during breast carcinogenesis. J Natl Cancer Inst 93 (2001) 309-314
-
(2001)
J Natl Cancer Inst
, vol.93
, pp. 309-314
-
-
Bos, R.1
Zhong, H.2
Hanrahan, C.F.3
-
160
-
-
9744250235
-
c-erbB-2 related aggressiveness in breast cancer is hypoxia-inducible factor-1α dependent
-
Giatromanolaki A., Koukourakis M.I., Simopoulos C., et al. c-erbB-2 related aggressiveness in breast cancer is hypoxia-inducible factor-1α dependent. Clin Cancer Res 10 (2004) 7972-7977
-
(2004)
Clin Cancer Res
, vol.10
, pp. 7972-7977
-
-
Giatromanolaki, A.1
Koukourakis, M.I.2
Simopoulos, C.3
-
161
-
-
0036278899
-
Overexpression of hypoxia-inducible factor 1α is associated with an unfavorable prognosis in lymph node-positive breast cancer
-
Schindl M., Schoppmann S.F., Samonigg H., et al. Overexpression of hypoxia-inducible factor 1α is associated with an unfavorable prognosis in lymph node-positive breast cancer. Clin Cancer Res 8 (2002) 1831-1837
-
(2002)
Clin Cancer Res
, vol.8
, pp. 1831-1837
-
-
Schindl, M.1
Schoppmann, S.F.2
Samonigg, H.3
-
162
-
-
0037443587
-
Levels of hypoxia-inducible factor-1α independently predict prognosis in patients with lymph node negative breast carcinoma
-
Bos R., van der Groep P., Greijer A.E., et al. Levels of hypoxia-inducible factor-1α independently predict prognosis in patients with lymph node negative breast carcinoma. Cancer 97 (2003) 1573-1581
-
(2003)
Cancer
, vol.97
, pp. 1573-1581
-
-
Bos, R.1
van der Groep, P.2
Greijer, A.E.3
-
163
-
-
0034282518
-
Overexpression of hypoxia-inducible factor 1α is a marker for an unfavorable prognosis in early-stage invasive cervical cancer
-
Birner P., Schindl M., Obermair A., Plank C., Breitenecker G., and Oberhuber G. Overexpression of hypoxia-inducible factor 1α is a marker for an unfavorable prognosis in early-stage invasive cervical cancer. Cancer Res 60 (2000) 4693-4696
-
(2000)
Cancer Res
, vol.60
, pp. 4693-4696
-
-
Birner, P.1
Schindl, M.2
Obermair, A.3
Plank, C.4
Breitenecker, G.5
Oberhuber, G.6
-
164
-
-
0038300418
-
Significant correlation of hypoxia-inducible factor-1α with treatment outcome in cervical cancer treated with radical radiotherapy
-
Burri P., Djonov V., Aebersold D.M., et al. Significant correlation of hypoxia-inducible factor-1α with treatment outcome in cervical cancer treated with radical radiotherapy. Int J Radiat Oncol Biol Phys 56 (2003) 494-501
-
(2003)
Int J Radiat Oncol Biol Phys
, vol.56
, pp. 494-501
-
-
Burri, P.1
Djonov, V.2
Aebersold, D.M.3
-
165
-
-
0037500967
-
Overexpression of hypoxia-inducible factor 1α indicates diminished response to radiotherapy and unfavorable prognosis in patients receiving radical radiotherapy for cervical cancer
-
Bachtiary B., Schindl M., Potter R., et al. Overexpression of hypoxia-inducible factor 1α indicates diminished response to radiotherapy and unfavorable prognosis in patients receiving radical radiotherapy for cervical cancer. Clin Cancer Res 9 (2003) 2234-2240
-
(2003)
Clin Cancer Res
, vol.9
, pp. 2234-2240
-
-
Bachtiary, B.1
Schindl, M.2
Potter, R.3
-
166
-
-
0037431557
-
Expression of hypoxia-inducible factor-1α is associated with tumor vascularization in human colorectal carcinoma
-
Kuwai T., Kitadai Y., Tanaka S., et al. Expression of hypoxia-inducible factor-1α is associated with tumor vascularization in human colorectal carcinoma. Int J Cancer 105 (2003) 176-181
-
(2003)
Int J Cancer
, vol.105
, pp. 176-181
-
-
Kuwai, T.1
Kitadai, Y.2
Tanaka, S.3
-
167
-
-
3843107242
-
Expression of hypoxia-inducible factor (HIF)-1α is associated with vascular endothelial growth factor expression and tumor angiogenesis in human esophageal squamous cell carcinoma
-
Kimura S., Kitadai Y., Tanaka S., et al. Expression of hypoxia-inducible factor (HIF)-1α is associated with vascular endothelial growth factor expression and tumor angiogenesis in human esophageal squamous cell carcinoma. Eur J Cancer 40 (2004) 1904-1912
-
(2004)
Eur J Cancer
, vol.40
, pp. 1904-1912
-
-
Kimura, S.1
Kitadai, Y.2
Tanaka, S.3
-
168
-
-
20244374424
-
Expression of hypoxia-inducible factor-1α in esophageal squamous cell carcinoma
-
Matsuyama T., Nakanishi K., Hayashi T., et al. Expression of hypoxia-inducible factor-1α in esophageal squamous cell carcinoma. Cancer Sci 96 (2005) 176-182
-
(2005)
Cancer Sci
, vol.96
, pp. 176-182
-
-
Matsuyama, T.1
Nakanishi, K.2
Hayashi, T.3
-
169
-
-
0036721256
-
Association of hypoxia-inducible factors 1α and 2α with activated angiogenic pathways and prognosis in patients with endometrial carcinoma
-
Sivridis E., Giatromanolaki A., Gatter K.C., Harris A.L., and Koukourakis M.I. Association of hypoxia-inducible factors 1α and 2α with activated angiogenic pathways and prognosis in patients with endometrial carcinoma. Cancer 95 (2002) 1055-1063
-
(2002)
Cancer
, vol.95
, pp. 1055-1063
-
-
Sivridis, E.1
Giatromanolaki, A.2
Gatter, K.C.3
Harris, A.L.4
Koukourakis, M.I.5
-
170
-
-
0142175222
-
Hypoxia-inducible factor-1α expression and angiogenesis in gastrointestinal stromal tumor of the stomach
-
Takahashi R., Tanaka S., Hiyama T., et al. Hypoxia-inducible factor-1α expression and angiogenesis in gastrointestinal stromal tumor of the stomach. Oncol Rep 10 (2003) 797-802
-
(2003)
Oncol Rep
, vol.10
, pp. 797-802
-
-
Takahashi, R.1
Tanaka, S.2
Hiyama, T.3
-
171
-
-
0035860147
-
Relation of hypoxia-inducible factor 1α and 2α in operable non-small cell lung cancer to angiogenic/molecular profile of tumors and survival
-
Giatromanolaki A., Koukourakis M., Sivridis E., et al. Relation of hypoxia-inducible factor 1α and 2α in operable non-small cell lung cancer to angiogenic/molecular profile of tumors and survival. Br J Cancer 85 (2001) 881-890
-
(2001)
Br J Cancer
, vol.85
, pp. 881-890
-
-
Giatromanolaki, A.1
Koukourakis, M.2
Sivridis, E.3
-
172
-
-
0142120661
-
Hypoxia-inducible factors 1α and 2α are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin
-
Giatromanolaki A., Sivridis E., and Kouskoukis C. Hypoxia-inducible factors 1α and 2α are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin. Melanoma Res 13 (2003) 493-501
-
(2003)
Melanoma Res
, vol.13
, pp. 493-501
-
-
Giatromanolaki, A.1
Sivridis, E.2
Kouskoukis, C.3
-
173
-
-
0035395098
-
Expression of hypoxia-inducible factor-1α in oligodendrogliomas: its impact on prognosis and on neoangiogenesis
-
Birner P., Gatterbauer B., Oberhuber G., et al. Expression of hypoxia-inducible factor-1α in oligodendrogliomas: its impact on prognosis and on neoangiogenesis. Cancer 92 (2001) 165-171
-
(2001)
Cancer
, vol.92
, pp. 165-171
-
-
Birner, P.1
Gatterbauer, B.2
Oberhuber, G.3
-
174
-
-
0035300410
-
Expression of hypoxia-inducible factor-1α: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer
-
Aebersold D.M., Burri P., Beer K.T., et al. Expression of hypoxia-inducible factor-1α: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer. Cancer Res 61 (2001) 2911-2961
-
(2001)
Cancer Res
, vol.61
, pp. 2911-2961
-
-
Aebersold, D.M.1
Burri, P.2
Beer, K.T.3
-
175
-
-
0034896068
-
Expression of hypoxia-inducible factor 1α in epithelial ovarian tumors: its impact on prognosis and on response to chemotherapy
-
Birner P., Schindl M., Obermair A., Breitenecker G., and Oberhuber G. Expression of hypoxia-inducible factor 1α in epithelial ovarian tumors: its impact on prognosis and on response to chemotherapy. Clin Cancer Res 7 (2001) 1661-1668
-
(2001)
Clin Cancer Res
, vol.7
, pp. 1661-1668
-
-
Birner, P.1
Schindl, M.2
Obermair, A.3
Breitenecker, G.4
Oberhuber, G.5
-
176
-
-
0347478156
-
Clinicopathological significance of hypoxia-inducible factor-1α expression in human pancreatic carcinoma
-
Kitada T., Seki S., Sakaguchi H., Sawada T., Hirakawa K., and Wakasa K. Clinicopathological significance of hypoxia-inducible factor-1α expression in human pancreatic carcinoma. Histopathology 43 (2003) 550-555
-
(2003)
Histopathology
, vol.43
, pp. 550-555
-
-
Kitada, T.1
Seki, S.2
Sakaguchi, H.3
Sawada, T.4
Hirakawa, K.5
Wakasa, K.6
-
177
-
-
0842333201
-
Prognostic significance of HIF-1α overexpression in human pancreatic cancer
-
Shibaji T., Nagao M., Ikeda N., et al. Prognostic significance of HIF-1α overexpression in human pancreatic cancer. Anticancer Res 23 (2003) 4721-4727
-
(2003)
Anticancer Res
, vol.23
, pp. 4721-4727
-
-
Shibaji, T.1
Nagao, M.2
Ikeda, N.3
-
178
-
-
0033668677
-
Coexpression of hypoxia-inducible factor 1α and vascular endothelial growth factor in Wilms' tumor
-
Karth J., Ferrer F.A., Perlman E., et al. Coexpression of hypoxia-inducible factor 1α and vascular endothelial growth factor in Wilms' tumor. J Pediatr Surg 35 (2000) 1749-1753
-
(2000)
J Pediatr Surg
, vol.35
, pp. 1749-1753
-
-
Karth, J.1
Ferrer, F.A.2
Perlman, E.3
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