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Volumn 390, Issue 1, 2005, Pages 189-197

Identification of a functional hypoxia-responsive element that regulates the expression of the egl nine homologue 3 (egln3/phd3) gene

Author keywords

EGL nine homologous protein 3 (EGLN3); HIF proline hydroxylase 3 (HPH3); Hypoxia response element (HRE); Hypoxia inducible factor (HIF); Proline hydroxylase domain 3 (PHD3); Prolyl hydroxylase

Indexed keywords

ENZYMES; GENES; OXYGEN; PRECIPITATION (CHEMICAL);

EID: 23944454868     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20042121     Document Type: Article
Times cited : (182)

References (47)
  • 1
    • 0036320934 scopus 로고    scopus 로고
    • Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression
    • Wenger, R. H. (2002) Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression. FASEB J. 16, 1151-1162
    • (2002) FASEB J. , vol.16 , pp. 1151-1162
    • Wenger, R.H.1
  • 2
    • 0029051439 scopus 로고
    • Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
    • Wang, G. L., Jiang, B. H., Rue, E. A. and Semenza, G. L. (1995) Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc. Natl. Acad. Sci. U.S.A. 92, 5510-5514
    • (1995) Proc. Natl. Acad. Sci. U.S.A. , vol.92 , pp. 5510-5514
    • Wang, G.L.1    Jiang, B.H.2    Rue, E.A.3    Semenza, G.L.4
  • 3
    • 0031000736 scopus 로고    scopus 로고
    • A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1 alpha regulates the VEGF expression and is potentially involved in lung and vascular development
    • Ema, M., Taya, S., Yokotani, N., Sogawa, K., Matsuda, Y. and Fujii-Kuriyama, Y. (1997) A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1 alpha regulates the VEGF expression and is potentially involved in lung and vascular development. Proc. Natl. Acad. Sci. U.S.A. 94, 4273-4278
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , pp. 4273-4278
    • Ema, M.1    Taya, S.2    Yokotani, N.3    Sogawa, K.4    Matsuda, Y.5    Fujii-Kuriyama, Y.6
  • 4
    • 0033870281 scopus 로고    scopus 로고
    • The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages
    • Talks, K. L., Turley, H., Gatter, K. C., Maxwell, P. H., Pugh, C. W., Ratcliffe, P. J. and Harris, A. L. (2000) The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages. Am. J. Pathol. 157, 411-421
    • (2000) Am. J. Pathol. , vol.157 , pp. 411-421
    • Talks, K.L.1    Turley, H.2    Gatter, K.C.3    Maxwell, P.H.4    Pugh, C.W.5    Ratcliffe, P.J.6    Harris, A.L.7
  • 6
    • 0141988698 scopus 로고    scopus 로고
    • Predominant role of hypoxia-inducible transcription factor (Hif)-1{alpha} versus Hif-2{alpha} in regulation of the transcriptional response to hypoxia
    • Sowter, H. M., Raval, R., Moore, J., Ratcliffe, P. J. and Harris, A. L. (2003) Predominant role of hypoxia-inducible transcription factor (Hif)-1{alpha} versus Hif-2{alpha} in regulation of the transcriptional response to hypoxia. Cancer Res. 63, 6130-6134
    • (2003) Cancer Res. , vol.63 , pp. 6130-6134
    • Sowter, H.M.1    Raval, R.2    Moore, J.3    Ratcliffe, P.J.4    Harris, A.L.5
  • 7
    • 0345491599 scopus 로고    scopus 로고
    • Differential roles of hypoxia-inducible factor 1{alpha} (HIF-1{alpha}) and HIF-2{alpha} in hypoxic gene regulation
    • Hu, C.-J., Wang, L.-Y., Chodosh, L. A., Keith, B. and Simon, M. C. (2003) Differential roles of hypoxia-inducible factor 1{alpha} (HIF-1{alpha}) and HIF-2{alpha} in hypoxic gene regulation. Mol. Cell. Biol. 23, 9361-9374
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 9361-9374
    • Hu, C.-J.1    Wang, L.-Y.2    Chodosh, L.A.3    Keith, B.4    Simon, M.C.5
  • 11
    • 0035903468 scopus 로고    scopus 로고
    • Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation
    • Masson, N., Willam, C., Maxwell, P. H., Pugh, C. W. and Ratcliffe, P. J. (2001) Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation. EMBO J. 20, 5197-5206
    • (2001) EMBO J. , vol.20 , pp. 5197-5206
    • Masson, N.1    Willam, C.2    Maxwell, P.H.3    Pugh, C.W.4    Ratcliffe, P.J.5
  • 13
    • 0035834409 scopus 로고    scopus 로고
    • A conserved family of prolyl-4-hydroxylases that modify HIF
    • Bruick, R. K. and McKnight, S. L. (2001) A conserved family of prolyl-4-hydroxylases that modify HIF. Science 294, 1337-1340
    • (2001) Science , vol.294 , pp. 1337-1340
    • Bruick, R.K.1    McKnight, S.L.2
  • 14
    • 0036469038 scopus 로고    scopus 로고
    • Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch
    • Lando, D., Peet, D. J., Whelan, D. A., Gorman, J. J. and Whitelaw, M. L. (2002) Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch. Science 295, 858-861
    • (2002) Science , vol.295 , pp. 858-861
    • Lando, D.1    Peet, D.J.2    Whelan, D.A.3    Gorman, J.J.4    Whitelaw, M.L.5
  • 16
    • 0043234538 scopus 로고    scopus 로고
    • Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor HIF
    • Hirsilä, M., Koivunen, P., Günzler, V., Kivirikko, K. I. and Myllyharju, J. (2003) Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor HIF. J. Biol. Chem. 278, 30772-30780
    • (2003) J. Biol. Chem. , vol.278 , pp. 30772-30780
    • Hirsilä, M.1    Koivunen, P.2    Günzler, V.3    Kivirikko, K.I.4    Myllyharju, J.5
  • 17
    • 1842416574 scopus 로고    scopus 로고
    • Oxygen(es) and the hypoxia-inducible factor-1
    • Wenger, R. H. and Gassmann, M. (1997) Oxygen(es) and the hypoxia-inducible factor-1. Biol. Chem. 378, 609-616
    • (1997) Biol. Chem. , vol.378 , pp. 609-616
    • Wenger, R.H.1    Gassmann, M.2
  • 19
    • 0035936886 scopus 로고    scopus 로고
    • HIF-1-dependent transcriptional activity is required for oxygen-mediated HIF-1a degradation
    • Berra, E., Richard, D. E., Gothie, E. and Pouyssegur, J. (2001) HIF-1-dependent transcriptional activity is required for oxygen-mediated HIF-1a degradation. FEBS Lett. 491, 85-90
    • (2001) FEBS Lett. , vol.491 , pp. 85-90
    • Berra, E.1    Richard, D.E.2    Gothie, E.3    Pouyssegur, J.4
  • 20
    • 1542300383 scopus 로고    scopus 로고
    • The von Hippel Lindau/hypoxia-inducible factor (HIF) pathway regulates the transcription of the HIF-proline hydroxylase genes in response to low oxygen
    • del Peso, L., Castellanos, M. C., Temes, E., Martin-Puig, S., Cuevas, Y., Olmos, G. and Landazuri, M. O. (2003) The von Hippel Lindau/hypoxia-inducible factor (HIF) pathway regulates the transcription of the HIF-proline hydroxylase genes in response to low oxygen. J. Biol. Chem. 278, 48690-48695
    • (2003) J. Biol. Chem. , vol.278 , pp. 48690-48695
    • Peso, L.1    Castellanos, M.C.2    Temes, E.3    Martin-Puig, S.4    Cuevas, Y.5    Olmos, G.6    Landazuri, M.O.7
  • 24
    • 0032478823 scopus 로고    scopus 로고
    • Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 alpha-subunit (HIF-1 alpha). Characterization of hif-1alpha-dependent and -independent hypoxia-inducible gene expression
    • Wood, S. M., Wiesener, M. S., Yeates, K. M., Okada, N., Pugh, C. W., Maxwell, P. H. and Ratcliffe, P. J. (1998) Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 alpha-subunit (HIF-1 alpha). Characterization of hif-1alpha-dependent and -independent hypoxia-inducible gene expression. J. Biol. Chem. 273, 8360-8368
    • (1998) J. Biol. Chem. , vol.273 , pp. 8360-8368
    • Wood, S.M.1    Wiesener, M.S.2    Yeates, K.M.3    Okada, N.4    Pugh, C.W.5    Maxwell, P.H.6    Ratcliffe, P.J.7
  • 25
    • 0035971220 scopus 로고    scopus 로고
    • Evidence for the involvement of diacylglycerol kinase in the activation of hypoxia-inducible transcription factor 1 by low oxygen tension
    • Aragones, J., Jones, D. R., Martin, S., San Juan, M. A., Alfranca, A., Vidai, F., Vara, A., Merida, I. and Landazuri, M. O. (2001) Evidence for the involvement of diacylglycerol kinase in the activation of hypoxia-inducible transcription factor 1 by low oxygen tension. J. Biol. Chem. 276, 10548-10555
    • (2001) J. Biol. Chem. , vol.276 , pp. 10548-10555
    • Aragones, J.1    Jones, D.R.2    Martin, S.3    San Juan, M.A.4    Alfranca, A.5    Vidai, F.6    Vara, A.7    Merida, I.8    Landazuri, M.O.9
  • 26
    • 0029103274 scopus 로고
    • Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Identification of a 5′ enhancer
    • Liu, Y., Cox, S. R., Morita, T. and Kourembanas, S. (1995) Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Identification of a 5′ enhancer. Circ. Res. 77, 638-643
    • (1995) Circ. Res. , vol.77 , pp. 638-643
    • Liu, Y.1    Cox, S.R.2    Morita, T.3    Kourembanas, S.4
  • 27
    • 0029039195 scopus 로고
    • Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia
    • Levy, A. P., Levy, N. S., Wegner, S. and Goldberg, M. A. (1995) Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia. J. Biol. Chem. 270, 13333-13340
    • (1995) J. Biol. Chem. , vol.270 , pp. 13333-13340
    • Levy, A.P.1    Levy, N.S.2    Wegner, S.3    Goldberg, M.A.4
  • 28
    • 0029761644 scopus 로고    scopus 로고
    • Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
    • Forsythe, J. A., Jiang, B. H., Iyer, N. V., Agani, F., Leung, S. W., Koos, R. D. and Semenza, G. L. (1996) Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol. Cell. Biol. 16, 4604-4613
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 4604-4613
    • Forsythe, J.A.1    Jiang, B.H.2    Iyer, N.V.3    Agani, F.4    Leung, S.W.5    Koos, R.D.6    Semenza, G.L.7
  • 29
    • 0028068606 scopus 로고
    • Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
    • Semenza, G., Roth, P., Fang, H. and Wang, G. (1994) Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J. Biol. Chem. 269, 23757-23763
    • (1994) J. Biol. Chem. , vol.269 , pp. 23757-23763
    • Semenza, G.1    Roth, P.2    Fang, H.3    Wang, G.4
  • 30
    • 0030460724 scopus 로고    scopus 로고
    • Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase a gene promoters contain essential binding sites for hypoxia-inducible factor 1
    • Semenza, G. L., Jiang, B. H., Leung, S. W., Passantino, R., Concordet, J. P., Maire, P. and Giallongo, A. (1996) Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1. J. Biol. Chem. 271, 32529-32537
    • (1996) J. Biol. Chem. , vol.271 , pp. 32529-32537
    • Semenza, G.L.1    Jiang, B.H.2    Leung, S.W.3    Passantino, R.4    Concordet, J.P.5    Maire, P.6    Giallongo, A.7
  • 31
    • 0028359320 scopus 로고
    • Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase a genes: Similarities with the erythropoietin 3′ enhancer
    • Firth, J. D., Ebert, B. L., Pugh, C. W. and Ratcliffe, P. J. (1994) Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3′ enhancer. Proc. Natl. Acad. Sci. U.S.A. 91, 6496-6500
    • (1994) Proc. Natl. Acad. Sci. U.S.A. , vol.91 , pp. 6496-6500
    • Firth, J.D.1    Ebert, B.L.2    Pugh, C.W.3    Ratcliffe, P.J.4
  • 32
    • 0026049416 scopus 로고
    • Enhancer element at the 3′-flanking region controls transcriptional response to hypoxia in the human erythropoietin gene
    • Beck, I., Ramirez, S., Weinmann, R. and Caro, J. (1991) Enhancer element at the 3′-flanking region controls transcriptional response to hypoxia in the human erythropoietin gene. J. Biol. Chem. 266, 15563-15566
    • (1991) J. Biol. Chem. , vol.266 , pp. 15563-15566
    • Beck, I.1    Ramirez, S.2    Weinmann, R.3    Caro, J.4
  • 33
    • 0026494916 scopus 로고
    • Hypoxic induction of the human erythropoietin gene: Cooperation between the promoter and enhancer, each of which contains steroid receptor response elements
    • Blanchard, K. L., Acquaviva, A. M., Galson, D. L. and Bunn, H. F. (1992) Hypoxic induction of the human erythropoietin gene: cooperation between the promoter and enhancer, each of which contains steroid receptor response elements. Mol. Cell. Biol. 12, 5373-5385
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 5373-5385
    • Blanchard, K.L.1    Acquaviva, A.M.2    Galson, D.L.3    Bunn, H.F.4
  • 34
    • 0026468180 scopus 로고
    • A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
    • Semenza, G. L. and Wang, G. L. (1992) A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol. Cell. Biol. 12, 5447-5454
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 5447-5454
    • Semenza, G.L.1    Wang, G.L.2
  • 35
    • 0027230099 scopus 로고
    • A 24-base-pair sequence 3′ to the human erythropoietin gene contains a hypoxia-responsive transcriptional enhancer
    • Madan, A. and Curtin, P. T. (1993) A 24-base-pair sequence 3′ to the human erythropoietin gene contains a hypoxia-responsive transcriptional enhancer. Proc. Natl. Acad. Si. U.S.A. 90, 3928-3932
    • (1993) Proc. Natl. Acad. Si. U.S.A. , vol.90 , pp. 3928-3932
    • Madan, A.1    Curtin, P.T.2
  • 36
    • 0031041377 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia
    • Lee, P. J., Jiang, B. H., Chin, B. Y., Iyer, N. V., Alam, J., Semenza, G. L. and Choi, A. M. (1997) Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia. J. Biol. Chem. 272, 5375-5381
    • (1997) J. Biol. Chem. , vol.272 , pp. 5375-5381
    • Lee, P.J.1    Jiang, B.H.2    Chin, B.Y.3    Iyer, N.V.4    Alam, J.5    Semenza, G.L.6    Choi, A.M.7
  • 37
    • 2442502748 scopus 로고    scopus 로고
    • Hypoxia-induced activation of the retinoic acid receptor-related orphan receptor {alpha}4 gene by an interaction between hypoxia-inducible factor-1 and Sp1
    • Miki, N., Ikuta, M. and Matsui, T. (2004) Hypoxia-induced activation of the retinoic acid receptor-related orphan receptor {alpha}4 gene by an interaction between hypoxia-inducible factor-1 and Sp1. Biol. Chem. 279, 15025-15031
    • (2004) Biol. Chem. , vol.279 , pp. 15025-15031
    • Miki, N.1    Ikuta, M.2    Matsui, T.3
  • 38
    • 0028805375 scopus 로고
    • Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct cis-acting sequences
    • Ebert, B. L., Firth, J. D. and Ratcliffe, P. J. (1995) Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct cis-acting sequences. J. Biol. Chem. 270, 29083-29089
    • (1995) J. Biol. Chem. , vol.270 , pp. 29083-29089
    • Ebert, B.L.1    Firth, J.D.2    Ratcliffe, P.J.3
  • 39
    • 0034640269 scopus 로고    scopus 로고
    • Hypoxic induction of prolyl 4-hydroxylase alpha (I) in cultured cells
    • Takahashi, Y., Takahashi, S., Shiga, Y., Yoshimi, T. and Miura, T. (2000) Hypoxic induction of prolyl 4-hydroxylase alpha (I) in cultured cells. J. Biol. Chem. 275, 14139-14146
    • (2000) J. Biol. Chem. , vol.275 , pp. 14139-14146
    • Takahashi, Y.1    Takahashi, S.2    Shiga, Y.3    Yoshimi, T.4    Miura, T.5
  • 40
    • 0034255036 scopus 로고    scopus 로고
    • Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia
    • Bruick, R. K. (2000) Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia. Proc. Natl. Acad. Sci. U.S.A. 97, 9082-9087
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 9082-9087
    • Bruick, R.K.1
  • 43
    • 4444364399 scopus 로고    scopus 로고
    • Bioinformatics for the 'bench biologist': How to find regulatory regions in genomic DNA
    • Nardone, J., Lee, D. U., Ansel, K. M. and Rao, A. (2004) Bioinformatics for the 'bench biologist': how to find regulatory regions in genomic DNA. Nat. Immunol. 5, 768-774
    • (2004) Nat. Immunol. , vol.5 , pp. 768-774
    • Nardone, J.1    Lee, D.U.2    Ansel, K.M.3    Rao, A.4
  • 44
    • 0344897665 scopus 로고    scopus 로고
    • Nongenic transcription, gene regulation and action at a distance
    • Cook, P. R. (2003) Nongenic transcription, gene regulation and action at a distance. J. Cell Sci. 116, 4483-4491
    • (2003) J. Cell Sci. , vol.116 , pp. 4483-4491
    • Cook, P.R.1
  • 45
    • 0346500512 scopus 로고    scopus 로고
    • A cross-talk between hypoxia and TGF-beta orchestrates erythropoietin gene regulation through SP1 and Smads
    • Sanchez-Elsner, T., Ramirez, J. R., Sanz-Rodriguez, F., Varela, E., Bernabeu, C. and Botella, L. M. (2004) A cross-talk between hypoxia and TGF-beta orchestrates erythropoietin gene regulation through SP1 and Smads. J. Mol. Biol. 336, 9-24
    • (2004) J. Mol. Biol. , vol.336 , pp. 9-24
    • Sanchez-Elsner, T.1    Ramirez, J.R.2    Sanz-Rodriguez, F.3    Varela, E.4    Bernabeu, C.5    Botella, L.M.6
  • 46
    • 0035910429 scopus 로고    scopus 로고
    • Identification of hypoxia-inducible factor-1 (HIF-1) ancillary sequence and its function in vascular endothelial growth factor gene induction by hypoxia and nitric oxide
    • Kimura, H., Weisz, A., Ogura, T., Hitomi, Y., Kurashima, Y., Hashimoto, K., D'Acquisto, F., Makuuchi, M. and Esumi, H. (2001) Identification of hypoxia-inducible factor-1 (HIF-1) ancillary sequence and its function in vascular endothelial growth factor gene induction by hypoxia and nitric oxide. J. Biol. Chem. 276, 2292-2298
    • (2001) J. Biol. Chem. , vol.276 , pp. 2292-2298
    • Kimura, H.1    Weisz, A.2    Ogura, T.3    Hitomi, Y.4    Kurashima, Y.5    Hashimoto, K.6    D'Acquisto, F.7    Makuuchi, M.8    Esumi, H.9
  • 47
    • 0030713446 scopus 로고    scopus 로고
    • Activator-protein-1 binding potentiates the hypoxia-induciblefactor-1- mediated hypoxia-induced transcriptional activation of vascular-endothelial growth factor expression in C6 glioma cells
    • Damert, A., Ikeda, E. and Risau, W. (1997) Activator-protein-1 binding potentiates the hypoxia-induciblefactor-1-mediated hypoxia-induced transcriptional activation of vascular-endothelial growth factor expression in C6 glioma cells. Biochem. J. 327, 419-423
    • (1997) Biochem. J. , vol.327 , pp. 419-423
    • Damert, A.1    Ikeda, E.2    Risau, W.3


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