Molecular mechanisms of blood vessel growth

Cardiovascular Research

Volumn 49, Issue 3, 2001, Pages 507-521

  Conway, Edward M ^a   Collen, Désiré ^a   Carmeliet, Peter ^a  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

Author keywords

Angiogenesis; Arteries; Developmental biology; Veins

Indexed keywords

ANGIOGENESIS INHIBITOR; ANGIOGENIC FACTOR; BASIC FIBROBLAST GROWTH FACTOR; CD31 ANTIGEN; CD34 ANTIGEN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GROWTH FACTOR; GROWTH FACTOR RECEPTOR; HELIX LOOP HELIX PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ETS 1; VASCULOTROPIN RECEPTOR;

ALLOTRANSPLANTATION; ANGIOGENESIS; ARTERY ENDOTHELIUM; ARTERY OCCLUSION; ATHEROSCLEROSIS; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; ENDOTHELIUM CELL; GENE EXPRESSION; GRAFT OCCLUSION; HEART MUSCLE ISCHEMIA; HUMAN; PRIORITY JOURNAL; REVIEW; TISSUE REPAIR; WOUND HEALING;

ANIMALS; ARTERIES; BLOOD VESSELS; CELL DIFFERENTIATION; CELL DIVISION; ENDOTHELIUM, VASCULAR; GENE EXPRESSION; GROWTH SUBSTANCES; MORPHOGENESIS; OXYGEN; SIGNAL TRANSDUCTION; STRESS, MECHANICAL; VEINS; YOLK SAC;

EID: 0035895737     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(00)00281-9     Document Type: Review

References (140)

1. Embryonic origins and assembly of blood vessels
2. Pericytes in the microvasculature
3. Angiogenesis in cancer and other diseases
4. Mechanisms of angiogenesis and arteriogenesis
5. Hemangioblast development and regulation
6. Induction of vasculogenesis in quail blastodisc-derived embryoid bodies
7. Developmental biology. Controlling the cellular brakes
8. Complementary patterns of expression of c-ets 1, c-myb and c-myc in the blood-forming system of the chick embryo
9. Hex: A homeobox gene revealing peri-implantation asymmetry in the mouse embryo and an early transient marker of endothelial cell precursors
10. Vezf1: A Zn finger transcription factor restricted to endothelial cells and their precursors
11. Expression and modulation of homeobox genes from cluster B in endothelial cells
12. Induction of the angiogenic phenotype by Hox D3
13. Hematopoietic-specific genes are not induced during in vitro differentiation of scl-null embryonic stem cells
14. A transitional stage in the commitment of mesoderm to hematopoiesis requiring the transcription factor SCL/tal-1
15. Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts
16. flk-1, an flt-related receptor tyrosine kinase is an early marker for endothelial cell precursors
17. Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
18. VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells
19. Vascular endothelial growth factor(165) gene transfer augments circulating endothelial progenitor cells in human subjects
20. Circulating endothelial precursors: Mystery, reality, and promise
21. Origins of circulating endothelial cells and endothelial outgrowth from blood
22. Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization
23. Ephrin-A1 is expressed at sites of vascular development in the mouse
24. Role of vascular endothelial growth factor in the regulation of angiogenesis
25. Abnormal blood vessel development and lethality in embryos lacking a single vascular endothelial growth factor allele
26. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
27. A requirement for Flk-1 in primitive and definitive hematopoiesis and vasculogenesis
28. Increased hemangioblast commitment, not vascular disorganization, is the primary defect in flt-1 knock-out mice
29. Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: Control of hypoxia-inducible factor-1 activity by nitric oxide
30. Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability
31. Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development
32. Angiopoietin-1 protects the adult vasculature against plasma leakage
33. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis
34. Matrix metalloproteinases: Biologic activity and clinical implications
35. Tissue inhibitors of metalloproteinases: Evolution, structure and function
36. Angiopoietin-1 induces endothelial cell sprouting through the activation of focal adhesion kinase and plasmin secretion
37. MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes
38. Disruption of angiogenesis by PEX, a non-catalytic metalloproteinase fragment with integrin binding activity
39. Elevated matrix metalloprotease and angiostatin levels in integrin alpha 1 knockout mice cause reduced tumor vascularization
40. Thrombospondin type 1 repeats interact with matrix metalloproteinase 2. Regulation of metalloproteinase activity
41. Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis
42. Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure
43. Development and disease in proteinase-deficient mice: Role of the plasminogen, matrix metalloproteinase and coagulation system
44. A peptide derived from the non-receptor binding region of urokinase plasminogen activator (uPA) inhibits tumor progression and angiogenesis and induces tumor cell death in vivo
45. Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization
46. Vascular endothelial growth factor and the regulation of angiogenesis
47. Regulation of angiogenesis via vascular endothelial growth factor receptors
48. Structure, expression and receptor-binding properties of placenta growth factor (PlGF)
49. Mice lacking the vascular endothelial growth factor-B gene (Vegfb) have smaller hearts, dysfunctional coronary vasculature, and impaired recovery from cardiac ischemia
50. Structure, expression and receptor-binding properties of novel vascular endothelial growth factors
51. Cardiovascular failure in mouse embryos deficient in VEGF receptor-3
52. Increased vascularization in mice overexpressing angiopoietin-1
53. Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis
54. Fibroblast growth factor-1 stimulates branching and survival of myocardial arteries: A goal for therapeutic angiogenesis?
55. Endothelial-perivascular cell signaling in vascular development: Lessons from knockout mice
56. Role of platelet-derived growth factors in angiogenesis and alveogenesis
57. Nitric oxide synthase modulates angiogenesis in response to tissue ischemia
58. Transforming growth factor-beta: Vasculogenesis, angiogenesis, and vessel wall integrity
59. Tumor-host interactions in the gallbladder suppress distal angiogenesis and tumor growth: Involvement of transforming growth factor beta1
60. Tumor necrosis factor employs a protein-tyrosine phosphatase to inhibit activation of KDR and vascular endothelial cell growth factor-induced endothelial cell proliferation
61. CXC chemokines in angiogenesis
62. The role of alphav integrins during angiogenesis: Insights into potential mechanisms of action and clinical development
63. PECAM-1 (CD31) functions as a reservoir for and a modulator of tyrosine-phosphorylated beta-catenin
64. Surface densities of ephrin-B1 determine EphB1-coupled activation of cell attachment through alphavbeta3 and alpha5beta1 integrins
65. Vascular developmental biology: Getting nervous
66. Eph receptors and ephrins: Regulators of guidance and assembly
67. Vascular endothelial-cadherin is an important determinant of microvascular integrity in vivo
68. A role for cadherins in cellular signaling and differentiation
69. Review: The integrin αvβ3: Angiogenesis and apoptosis
70. Angiogenesis in cancer and other diseases
71. Chondromodulin-I as a novel cartilage-specific growth-modulating factor
72. Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma
73. Endostatin: An endogenous inhibitor of angiogenesis and tumor growth
74. Fractals and cancer
75. RGD-dependent vacuolation and lumen formation observed during endothelial cell morphogenesis in three-dimensional fibrin matrices involves the alpha(v)beta(3) and alpha(5)beta(1) integrins
76. Tubedown-1, a novel acetyl-transferase associated with blood vessel development
77. Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis
78. Endothelial apoptosis: Could it have a role in the pathogenesis and treatment of disease?
79. The role of apoptosis in vascular disease
80. Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity
81. VEGF deprivation-induced apoptosis is a component of programmed capillary regression
82. Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF
83. Angiopoietin-1 inhibits endothelial cell apoptosis via the Akt/survivin pathway
84. Shear stress inhibits apoptosis of human endothelial cells
85. Signaling angiogenesis via p42/p44 MAP kinase cascade
86. The cell biology of the blood-brain barrier
87. Occludin and claudins in tight-junction strands: Leading or supporting players?
88. Molecular structure and functional role of vascular tight junctions
89. Differentiation of endothelium
90. Development and differentiation of endothelium
91. Vascular channel formation by human melanoma cells in vivo and in vitro: Vasculogenic mimicry
92. Mosaic blood vessels in tumors: Frequency of cancer cells in contact with flowing blood
93. Vasculogenic mimicry and tumor angiogenesis
94. Intussusceptive angiogenesis: Its role in embryonic vascular network formation
95. Intussusceptive microvascular growth in a human colon adenocarcinoma xenograft: A novel mechanism of tumor angiogenesis
96. Mechanisms of angiogenesis and arteriogenesis
97. Heterogeneity of the angiogenic response induced in different normal adult tissues by vascular permeability factor/vascular endothelial growth factor
98. Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188
99. Role of angiotensin in renal vascular development
100. Transgenic myocardial overexpression of fibroblast growth factor-1 increases coronary artery density and branching
101. An antisense oligonucleotide to the notch ligand jagged enhances fibroblast growth factor-induced angiogenesis in vitro
102. Notch signaling is essential for vascular morphogenesis in mice
103. Embryonic lethality and vascular defects in mice lacking the notch ligand jagged1
104. gridlock, an HLH gene required for assembly of the aorta in zebrafish
105. Dll4, a novel notch ligand expressed in arterial endothelium
106. Analysis of HeyL expression in wild-type and Notch pathway mutant mouse embryos
107. Ephrin-A1 is expressed at sites of vascular development in the mouse
108. The receptor tyrosine kinase EphB4 and ephrin-B ligands restrict angiogenic growth of embryonic veins in Xenopus laevis
109. Roles of ephrinB ligands and EphB receptors in cardiovascular development: Demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis
110. Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4
111. Bmx tyrosine kinase is specifically expressed in the endocardium and the endothelium of large arteries
112. Determinants of endothelial cell phenotype in venules
113. A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF
114. One cell, two fates
115. Common epicardial origin of coronary vascular smooth muscle, perivascular fibroblasts, and intermyocardial fibroblasts in the avian heart
116. Role of cardiac neural crest cells in cardiovascular development
117. Embryonic stem cell-derived Flk1-positive cells serve as vascular progenitors
118. Cellular mechanisms of CNS pericytes
119. Supermodels and disease: Insights from the HHT mice
120. Defective angiogenesis in mice lacking endoglin
121. The basic helix-loop-helix transcription factor, dHAND, is required for vascular development
122. Requirement of vascular integrin alpha v beta 3 for angiogenesis
123. Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels
124. Requirement of the MADS-box transcription factor MEF2C for vascular development
125. Targetting of the gene encoding fibrillin-1 recapitulates the vascular aspect of Marfan syndrome
126. Elastin is an essential determinant of arterial morphogenesis
127. Molecular mechanisms of coronary collateral vessel growth
128. The pathophysiology of the collateral circulation (arteriogenesis)
129. Upregulation of vascular endothelial growth factor expression induced by myocardial ischaemia: Implications for coronary angiogenesis
130. HIF-1 and human disease: One highly involved factor
131. Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Identification of a 5′ enhancer
132. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
133. Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT
134. Expression of hypoxia-inducible factor 1: Mechanisms and consequences
135. Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
136. PR39, a peptide regulator of angiogenesis
137. Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth
138. Wall remodeling during luminal expansion of mesenteric arterial collaterals in the rat
139. MEKK-1, a component of the stress (stress-activated protein kinase/c-Jun N-terminal kinase) pathway, can selectively activate Smad2-mediated transcriptional activation in endothelial cells
140. Blood flow and vascular gene expression: Fluid shear stress as a modulator of endothelial phenotype