Lactase gene transcription is activated in response to hypoxia in intestinal epithelial cells

Molecular Genetics and Metabolism

Volumn 75, Issue 1, 2002, Pages 65-69

  Lee, So Young ^a   Madan, Ashima ^a   Furuta, Glenn T ^b   Colgan, Sean P ^b   Sibley, Eric ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Enterocyte; Hypoxia inducible factor; Lactase phlorizin hydrolase; LPH; Transcription factor

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 1BETA; LACTASE; MESSENGER RNA; PROTEIN SUBUNIT; UNCLASSIFIED DRUG;

ARTICLE; CELL HYPOXIA; CELL STRAIN CACO 2; CONTROLLED STUDY; DNA FLANKING REGION; DNA MICROARRAY; GENE ACTIVITY; GENE EXPRESSION; GENE INDUCTION; GENETIC LINKAGE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INTESTINE EPITHELIUM CELL; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION INITIATION;

EID: 0036354281     PISSN: 10967192     EISSN: None     Source Type: Journal    
DOI: 10.1006/mgme.2001.3263     Document Type: Article

References (10)

1. Control of lactase in human adult-type hypolactasia and in weaning rabbits and rats
2. Effects of fetal hypoxia on postnatal intestinal growth and digestive enzyme levels
3. HIF-1 and human disease: One highly involved factor
4. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
5. The homeodomain protein Cdx2 regulates lactase gene promoter activity during enterocyte differentiation
6. Expression monitoring by hybridization to high-density oligonucleotide arrays
7. Hypoxia-inducible factor 1-dependent induction of intestinal trefoil factor protects barrier function during hypoxia
8. Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1
9. Regulation of hypoxia-inducible factor 1 alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway
10. Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1