Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1α

Journal of Biological Chemistry

Volumn 278, Issue 3, 2003, Pages 1802-1806

  Elkins, Jonathan M ^a   Hewitson, Kirsty S ^a   McNeill, Luke A ^a   Seibel, Jürgen F ^a   Schlemminger, Imre ^a   Pugh, Christopher W ^b   Ratcliffe, Peter J ^b   Schofield, Christopher J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b Henry Wellcome Bldg of Genomic Med   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CRYSTAL STRUCTURE; GENES; HYDROXYLATION; OXIDATION;

GENE REGULATION;

ENZYMES;

2 OXOGLUTARIC ACID; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IRON; PROTEIN SUBUNIT; ZINC ION; DNA BINDING PROTEIN; HYPOXIA INDUCIBLE FACTOR 1; NUCLEAR PROTEIN; TRANSCRIPTION FACTOR;

ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; GENE CONTROL; HYDROXYLATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; TRANSCRIPTION REGULATION; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; MOLECULAR GENETICS; OXIDATION REDUCTION REACTION; SEQUENCE HOMOLOGY; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; CRYSTALLOGRAPHY, X-RAY; DNA-BINDING PROTEINS; HYPOXIA-INDUCIBLE FACTOR 1; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; OXIDATION-REDUCTION; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID; TRANSCRIPTION FACTORS;

EID: 0037449811     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.C200644200     Document Type: Article

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