Hypoxia-inducible factor-1 and activator protein-1 modulate the upregulation of CYP3A6 induced by hypoxia

British Journal of Pharmacology

Volumn 140, Issue 6, 2003, Pages 1146-1154

  Fradette, Caroline ^a   Du Souich, Patrick ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

AP 1; CYP1A1; CYP1A2; CYP3A6; Enzyme induction; HIF 1; Hypoxia; MAPKs

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; COBALT CHLORIDE; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450; CYTOCHROME P450 3A6; GENISTEIN; HORMONE RECEPTOR; HYPOXIA INDUCIBLE FACTOR 1; LEAD ACETATE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PREGNANE X RECEPTOR; PROTEIN C JUN; PROTEIN TYROSINE KINASE INHIBITOR; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; HYPOXIA; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; MALE; NONHUMAN; OLIGONUCLEOTIDE PROBE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; RABBIT; REPRODUCIBILITY; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; ANOXIA; ARYL HYDROCARBON HYDROXYLASES; COBALT; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; DNA-BINDING PROTEINS; HEPATOCYTES; HYPOXIA-INDUCIBLE FACTOR 1; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MITOGEN-ACTIVATED PROTEIN KINASES; NUCLEAR PROTEINS; OLIGONUCLEOTIDE PROBES; ORGANOMETALLIC COMPOUNDS; PROTEIN BINDING; RABBITS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 0344826040     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705543     Document Type: Article

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